[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthopedic-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthopedic-surgery":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,49,74,97,133,168,191,229,252,281,305],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100644019","comparison-of-debridement-antibiotic-implant-retention-and-implant-exchange-in-early-stage-fracture-related-infections-100644019",false,"NCT07669714","Comparison of Debridement, Antibiotic, Implant Retention and Implant Exchange in Early-stage Fracture-related Infections","COMPARISON OF DEBRIDEMENT, ANTIBIOTIC, IMPLANT RETENTION (DAIR) AND IMPLANT EXCHANGE IN EARLY-STAGE FRACTURE-RELATED INFECTIONS: A RETROSPECTİVE COHORT STUDY","DAIR","Inclusion Criteria:\n\n* internal fixation after fracture\n* presence of fistula and\u002For sinus tract or purulent drainage with dehiscence at the incision site\n* at least 2 positive deep tissue cultures or at least 3 positive soft tissue cultures\n* early onset of symptoms (6 weeks)\n* DAIR or implant removal\u002Freplacement due to fracture-related infection\n\nExclusion Criteria:\n\n* Under 18 years old patients\n* prosthetic joint infection\n* only conservative treatment applied\n* pathological fracture due to primary bone tumor\n* simultaneous infection foci in the same extremity\n* fracture-related infection not confirmed by international consensus criteria\n* poor reduction after internal fixation\n* inappropriate or inadequate internal fixation\n* radiological images less than 1 year old\n* findings starting late (after 6 weeks)","ALL","18 Years",{"count":20,"type":21},75,"ESTIMATED","OBSERVATIONAL","This study aims to compare the clinical outcomes of debridement, antibiotics, and implant retention (DAIR) and implant removal\u002Freplacement methods used in the treatment of fracture-related infections, and to determine the infection-free fracture healing rates and the factors affecting treatment success.",[25,26,27,28,29],"Orthopedic Surgery","Fracture Related Infection","Debridement","Implant Retention","Implant Removal\u002FReplacement",[31,32,33,34,35],"orthopedic surgery","fracture-related infection","debridement","implant retention","implant removal\u002Freplacement","RECRUITING","2026-06-22",{"date":39,"type":40},"2026-06-25","ACTUAL",{"date":42,"type":40},"2026-04-16",{"date":44,"type":21},"2026-06-30",{"name":46,"class":47},"Antalya Health Sciences University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100628939","characteristic-electroencephalogram-of-general-anesthesia-100628939","NCT07468162","Characteristic Electroencephalogram of General Anesthesia","Analysis of the Characteristic Electroencephalogram of Patients Undergoing Orthopedic Surgery During the Induction of General Anesthesia and the Unconscious State and Recovery Period With Electroencephalogram Monitoring Device","Inclusion Criteria:\n\n* Age: 20 - 60 years old. BMI: 18 ≤ BMI ≤ 24 kg\u002Fm2. Right-handed. ASA classification: I - II. Patients scheduled for extremity surgery of upper and lower limbs and undergoing nerve block, those who understand and sign the informed consent form, and those receiving non-endotracheal general anesthesia with remimazolam or dexmedetomidine or midazolam, with Mallampati classification: I - II.\n\nExclusion Criteria:\n\n* Skin infection at the site of nerve block puncture; history of smoking and alcohol abuse, history of brain surgery, history of cerebral infarction, mental and neurological disorders (MMSE \\\u003C 18, 3D-CAM positive), history of taking any psychotropic or opioid drugs within 2 weeks, hearing impairment, cardiovascular disease, expected difficulty in airway management or sleep apnea syndrome, drug (including those with a history of allergic reaction to the test drug or contraindications for use) or food allergies, pregnant or lactating patients, patients or family members who refuse to participate, and those who refuse to undergo nerve block.",true,"20 Years","60 Years",{"count":60,"type":21},48,"Patients were enrolled according to predefined inclusion and exclusion criteria. Following surgical admission, standard monitoring was initiated, including continuous assessment of heart rate, blood pressure, electrocardiogram (ECG), and peripheral capillary oxygen saturation (SpO₂). A peripheral intravenous line was established. Bispectral index (BIS) monitoring was performed continuously using a BIS monitor to assess frontal lobe electroencephalographic activity. Based on the type of surgical procedure, regional nerve block was administered. Upon confirmation of adequate block efficacy, patients were assigned to treatment groups according to sealed envelope randomization, and corresponding intravenous sedative regimens were initiated. Sedative induction agents were administered as follows: Group A received remimazolam at 0.08 mg\u002Fkg; Group B received dexmedetomidine at 1 μg\u002Fkg over 10 minutes; Group C received midazolam at 0.05 mg\u002Fkg. Maintenance infusions were as follows: Group A received remimazolam at 1 mg\u002Fkg·h; Group B received dexmedetomidine at 0.2-0.7 μg\u002Fkg·h; for Group C, if consciousness was not sufficiently suppressed with the initial dose, midazolam was supplemented in increments of 0.01 mg\u002Fkg, not exceeding a total dose of 0.1 mg\u002Fkg. Following induction, sedation depth was assessed every 2 minutes using the Observer's Assessment of Alertness\u002FSedation (OAA\u002FS) scale, with auditory stimulation applied every 30 seconds until the patient no longer responded. The time to loss of response to auditory stimuli and the time to loss of consciousness were recorded. Surgical intervention was then performed. Ten minutes prior to anticipated completion of surgery, sedative infusion was discontinued. Sedation depth was reassessed every 2 minutes using the OAA\u002FS scale, with repeated auditory stimulation every 30 seconds to determine the time to return of response and time to recovery of consciousness. If the patient had not achieved an OAA\u002FS score of 5 within 30 minutes after discontinuation of sedation, flumazenil was administered as a reversal agent. Once the OAA\u002FS score reached 5 or spontaneous responses to auditory stimuli were observed-indicating transition back to a responsive state-and complete electroencephalographic data had been collected, no further intervention was required.",[63,25],"EEG Data Analysis","NOT_YET_RECRUITING","2026-03-09",{"date":67,"type":40},"2026-03-12",{"date":69,"type":21},"2026-03-20",{"date":71,"type":21},"2028-01-12",{"name":73,"class":47},"First Affiliated Hospital of Zhejiang University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":48},"100619042","femoral-vein-diameter-to-predict-intraoperative-hypotension-in-geriatric-patients-undergoing-orthopedic-surgery-under-spinal-anesthesia-100619042","NCT07339475","Femoral Vein Diameter to Predict Intraoperative Hypotension in Geriatric Patients Undergoing Orthopedic Surgery Under Spinal Anesthesia","Evaluation of Femoral Vein Diameter to Predict Intraoperative Hypotension in Geriatric Patients Undergoing Orthopedic Surgery Under Spinal Anesthesia: A Prospective Observational Study","Inclusion Criteria:\n\n* Age \\> 60 years.\n* American Society of Anesthesiologists (ASA) physical state I-II.\n* Body mass index (BMI) ≤35 kg\u002Fm². Patients above this value will be excluded because obesity may cause technical difficulty and poor image quality in femoral vein ultrasound assessment.\n* Elective lower-limb orthopedic surgery under spinal anesthesia.\n\nExclusion Criteria:\n\n* Patients refusing to participate.\n* History of psychiatric illness or seizures.\n* Absolute contraindications to spinal anesthesia: infection at the puncture site, severe coagulopathy\u002Fanticoagulation \\[defined as platelet count \\\u003C75,000\u002FµL, International Normalized Ratio (INR) \\>1.5, Activated Partial Thromboplastin Time (aPTT) \\>1.5 times control, or the use of anticoagulants such as warfarin, heparin, low molecular weight heparin, or direct oral anticoagulants within the recommended safety interval for neuraxial anesthesia\\], severe hypovolemia, increased intracranial pressure, or known allergy to local anesthetics.\n* Severe cardiac disease, including left ventricular ejection fraction \\\u003C30%, Severe valvular heart disease (e.g., critical aortic stenosis), clinically significant arrhythmias (atrial fibrillation with uncontrolled ventricular rate \\>120 bpm, frequent ventricular ectopy or sustained ventricular tachyarrhythmia) and congestive heart failure such as New York Heart Association (NYHA) class III-IV.\n* Severe uncontrolled hypertension, defined as persistent mean arterial pressure (MAP) ≥120 mmHg or systolic blood pressure (SBP) ≥180 mmHg and\u002For diastolic blood pressure (DBP) ≥110 mmHg despite medical therapy.\n* Severe respiratory diseases (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage III-IV chronic obstructive pulmonary disease, or forced vital capacity (FVC) \\\u003C50% predicted).\n* Baseline bradycardia (\\\u003C50) or mean arterial blood pressure less than 60mmHg.\n* Emergency surgeries.",{"count":82,"type":21},43,"The study aims to assess whether the transverse diameter of the right common femoral vein (RCFV) in the inguinal region could reflect the degree of post-spinal hypotension during elective orthopedic surgery.",[85,86,25,87],"Femoral Vein Diameter","Intraoperative Hypotension","Spinal Anesthesia","2026-01-05",{"date":90,"type":40},"2026-01-14",{"date":92,"type":40},"2025-12-01",{"date":94,"type":21},"2026-07-01",{"name":96,"class":47},"Cairo University",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":105,"targetDuration":4,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":119,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":48},"100601981","phase-4-d-fab-pour-trial-dexmedetomidine-vs-fentanyl-as-adjuvants-to-bupivacaine-on-postoperative-urinary-retention-100601981","NCT07117565","D-FAB-POUR Trial: Dexmedetomidine vs Fentanyl as Adjuvants to Bupivacaine on Postoperative Urinary Retention","Comparison of Intrathecal Dexmedetomidine Versus Intrathecal Fentanyl as Adjuvants to Bupivacaine on Post-Operative Urinary Retention in Lower Limb Surgery","D-FAB-POUR","Inclusion Criteria:\n\n* Adults aged 18 to 60 years\n* Scheduled for elective lower limb surgery under spinal anesthesia\n* Classified as American Society of Anesthesiologists (ASA) physical status II or III\n* Minimum height of 150 cm (to ensure uniform drug volume)\n* Able to understand the study procedures and provide written informed consent (in English or Nepali)\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia (e.g., coagulopathy, infection at injection site, hemodynamic instability)\n* Known allergy or hypersensitivity to bupivacaine, fentanyl, or dexmedetomidine\n* Chronic pain conditions or long-term opioid use\n* Neurological, Cardiac, Renal, or uncontrolled diabetic conditions\n* Current treatment for prostatic pathology or use of alpha-2 blockers\n* Presence of a Foley's catheter preoperatively\n* Estimated surgical duration: \\>2.5 hours\n* Inability or unwillingness to provide informed consent",{"count":106,"type":21},190,"INTERVENTIONAL",[109],"PHASE4","This study aims to compare two medications, dexmedetomidine and fentanyl, when used alongside a commonly used spinal anesthetic called bupivacaine in patients undergoing lower limb surgery. The main focus of the study is to see which combination causes fewer problems with urination after surgery - a condition known as postoperative urinary retention (POUR). POUR can lead to discomfort, delayed recovery, and a need for catheterization. Dexmedetomidine is a newer drug that may help reduce this problem compared to fentanyl, which is more commonly used but may increase the risk of urinary retention. This trial will help determine which medication combination provides better pain relief while reducing urinary side effects. The study is being conducted as a randomized, double-blind trial at a hospital in Nepal and will include 190 adult patients.\n\n\\-",[87,112,113,114,115,116,117,25,118],"Postoperative Complications","Dexmedetomidine","Fentanyl","Anesthesia, Spinal","Bupivacaine","POUR","Urinary Retention Postoperative",[120,121,122,113,114,123],"Postoperative urinary retention","Spinal anesthesia","Intrathecal adjuvants","Perioperative complications","2025-08-09",{"date":126,"type":40},"2025-08-12",{"date":128,"type":21},"2025-09-15",{"date":130,"type":21},"2026-11-25",{"name":132,"class":47},"Tribhuvan University Teaching Hospital, Institute Of Medicine.",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":107,"phases":142,"briefSummary":144,"conditions":145,"keywords":148,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":48},"100592612","ketamine-for-preventing-post-spinal-hypotension-in-orthopedic-surgery-100592612","NCT06995690","Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery","Impact of Sub-anesthetic Dose of Ketamine in the Prevention of Post Spinal Hypotension in Patients Undergoing Orthopedic Surgeries","Inclusion Criteria:\n\n* Patients American Society of Anesthesiologists Physical Status (ASA) I to II undergoing orthopedic surgeries under spinal anesthesia.\n* Both Sexes.\n* Patients aged equal to or above 18 years.\n* Body mass index \\\u003C35 kg\u002Fm2\n* Duration of operation from 1 hour to 3 hours\n\nExclusion Criteria:\n\n* Patients' refusal of procedure or participation in the study.\n* Patients with contraindication to spinal anesthesia.\n* Patients with cardiovascular or pulmonary disease.\n* Patients with pre-procedural hypotension (systolic arterial pressure less than 90 mmHg and\u002For mean arterial pressure less than 60 mmHg).\n* Patients aged below 18 years.\n* Duration of operation below 1 hour or above 3 hours.",{"count":141,"type":21},30,[143],"NA","This randomized, double-blind, controlled clinical trial investigates the efficacy of a sub-anesthetic dose of ketamine (0.5 mg\u002Fkg IV) in preventing post-spinal hypotension in patients undergoing elective orthopedic surgeries under spinal anesthesia. The study compares ketamine with placebo (normal saline) in terms of blood pressure stability and incidence of hypotensive episodes following spinal anesthesia.",[146,25,147],"Post-spinal Hypotension","Spinal Aneshtesia",[149,150,151,152,153,154,155,156,157,158],"Ketamine","Sub-anesthetic dose","Hypotension prevention","Neuraxial anesthesia","Hemodynamic stability","regional anesthesia","ASA I-II","Double-blind randomized trial","Blood pressure monitoring","Ephedrine use","2025-06-15",{"date":161,"type":40},"2025-06-18",{"date":163,"type":40},"2025-06-01",{"date":165,"type":21},"2025-11-01",{"name":167,"class":47},"Ain Shams University",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":107,"phases":177,"briefSummary":178,"conditions":179,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":187,"leadSponsor":189,"locationsCount":4},"100591898","effect-of-earplugs-and-eye-masks-used-after-orthopedic-surgery-on-comfort-and-quality-of-recovery-100591898","NCT06986408","Effect of Earplugs and Eye Masks Used After Orthopedic Surgery on Comfort and Quality of Recovery","Effect of Earplugs and Eye Masks Used After Orthopedic Surgery on Comfort and Quality of Recovery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who can speak and understand Turkish,\n* At least 18 years old,\n* No hearing impairment and not using hearing aids,\n* No psychiatric diagnosis and not using psychiatric medication regularly,\n* Patients who agree to participate in the study and have given written consent.\n\nExclusion Criteria:\n\n* Patients who do not agree to participate in the study and for whom written consent was not obtained.",{"count":176,"type":21},60,[143],"This research will be conducted as a randomized controlled trial to determine the effects of earplugs and eye masks used after orthopedic surgery on comfort and quality of recovery. This study is a single-center, parallel-group, open-label, randomized controlled clinical trial. This study will be conducted with 60 patients who underwent orthopedic surgery between June 2025 and October 2025. Participants will be randomized into two equal groups as the intervention group (n=30) and the control group (n=30). The patients in the experimental group will be administered the \"Informed Consent Form\" and the \"Patient Introduction Form\" after obtaining permission before surgery. Patients will be given an eye mask and earplugs on the nights following surgery and will be ensured to use them correctly. The \"General Comfort Scale\" and the \"Quality of Recovery Questionnaire (Qor-40)\" will be administered 24 and 48 hours after surgery. The patients in the control group will also be administered the \"Informed Consent Form\" and the \"Patient Introduction Form\" after obtaining permission before surgery. The \"General Comfort Scale\" and the \"Quality of Recovery Questionnaire (Qor-40)\" will be administered 24 and 48 hours after surgery. At the end of the study, the difference between the groups will be evaluated. In the analysis of this study, descriptive statistics, Shapiro-Wilk test, Chi-square test, t-test in independent groups, ANOVA test in repeated measures will be used.\n\nThe main questions it aims to answer:\n\nDo earplugs and eye masks used after orthopedic surgery have an effect on comfort level? Do earplugs and eye masks used after orthopedic surgery have an effect on the quality of recovery?",[25,180,181,182],"Nursing Care","Quality of Recovery 40","Comfort","2025-05-21",{"date":185,"type":40},"2025-05-23",{"date":163,"type":21},{"date":188,"type":21},"2025-11-20",{"name":190,"class":47},"Ankara Yildirim Beyazıt University",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":107,"phases":199,"briefSummary":200,"conditions":201,"keywords":203,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":228},"100585726","the-effect-of-operating-room-introduction-with-virtual-reality-glasses-on-anxiety-surgical-fear-and-satisfaction-levels-in-patients-undergoing-orthopedic-surgery-100585726","NCT06906120","The Effect of Operating Room Introduction With Virtual Reality Glasses on Anxiety, Surgical Fear, and Satisfaction Levels in Patients Undergoing Orthopedic Surgery","Inclusion Criteria:\n\n* Individuals aged 18-65 years\n* Patients scheduled for arthroscopic surgery\n* Those who have not undergone any previous surgical procedures\n* Patients who will undergo surgery under general anesthesia\n* Individuals without communication barriers\n* Patients with clear consciousness, and orientation to person, place, and time\n* Those with no neurological or psychiatric disorders\n* Individuals with no severe visual or auditory impairments\n\nExclusion Criteria:\n\n* Inability to communicate with the patients\n* Development of a life-threatening health problem after surgery\n* Transition to open surgery during the procedure\n* Patients who wish to withdraw from the study","65 Years",{"count":176,"type":21},[143],"This study aims to evaluate the effects of an operating room tour conducted using virtual reality (VR) goggles on anxiety, surgical fear, post-operative pain, satisfaction levels, and physiological parameters in patients undergoing orthopedic surgery.\n\nThe intervention will involve a 360 degree educational video introducing the operating room environment, surgical team roles, and expected patient experience during the perioperative period. This video will be presented using Meta Quest 3 VR goggles. Participants in the intervention group will watch this video before surgery, while the control group will receive standard preoperative education.\n\nThe primary outcomes include changes in preoperative anxiety (STAI-I), surgical fear (Surgical Fear Scale), and physiological parameters (e.g., heart rate, blood pressure, and electrodermal activity). Secondary outcomes include post-operative pain and patient satisfaction. Data will be collected at multiple time points, including before and after the intervention, on the day of surgery, and during the postoperative period.\n\nThe study is designed as a randomized controlled trial with a sample size of 60 participants, equally distributed between intervention and control groups. Data analysis will include appropriate statistical tests based on variable distribution and group comparisons.",[202,25],"Artroscopic Surgery",[204,205,206,207,208,209,210,211,212,213,214,215,216,217,218],"virtual reality illustration","Orthopedic surgery","Virtual reality","Surgical anxiety","Surgical fear","Preoperative education","Patient satisfaction","Pain management","Physiological parameters","Surgical preparation","VR intervention","Pain assessment","Electrodermal activity","Patient education tools","Preoperative anxiety reduction","2025-04-15",{"date":221,"type":40},"2025-04-18",{"date":223,"type":21},"2025-04-20",{"date":225,"type":21},"2025-11-15",{"name":227,"class":47},"Acibadem University",2,{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":236,"enrollmentInfo":237,"targetDuration":4,"studyType":107,"phases":239,"briefSummary":241,"conditions":242,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":48},"100503137","phase-3-intraoperative-methadone-for-the-prevention-of-postoperative-pain-100503137","NCT05831345","Intraoperative Methadone for the Prevention of Postoperative Pain","Intraoperative Methadone for the Prevention of Postoperative Pain: a Randomized, Double-blind Clinical Study in Orthopedic Surgery","Inclusion Criteria:\n\n* Age between 18 and 80 years old\n* ASA 1-3 status\n* Elective partial or total hip and knee arthroplasty\n\nExclusion Criteria:\n\n* Patient refusal\n* Preoperative renal failure (serum creatinine \\> 2 mg\u002FdL or 1.5-fold\n* Increase in basal plasma creatinine or GFR \\\u003C 90 ml\u002Fmin\u002F1.73m2)\n* Significant hepatic dysfunction (PT \\\u003C50% or increase in 3 times basal transaminases)\n* Known heart failure\n* Preoperative hemodynamic instability (preoperative use of inotropes or vasopressors)\n* Known methadone or sufentanil allergy\n* Preoperative opioid use or history of opioid abuse\n* Pregnancy and breastfeeding.","80 Years",{"count":238,"type":21},80,[240],"PHASE3","The pain felt after orthopedic surgery in the absence of adequate locoregional anesthesia is often insufficiently controlled, especially during the first 24 hours postoperatively.\n\nMethadone, due to its long half-life, may provide better pain control after orthopedic surgery when associated locoregional anesthesia cannot be performed.\n\nIt may be impossible to perform loco-regional anesthesia in various contexts: patient refusal, pre-existing neurological impairment, infection at the injection site, coagulopathies, inability to cooperate, total language barrier, allergy to anesthetics, unavailability of equipment (ultrasound, etc.) or equipped room, lack of experience of nursing staff in performing the block and in the postoperative management of the patient.\n\nIntraoperative administration of methadone in these settings may be superior to sufentanil for pain control during the 24 hours post orthopedic surgery, and the pain control provided by methadone does not appear to imply a higher likelihood of adverse events related to opioids.",[25],"2025-02-05",{"date":245,"type":40},"2025-02-07",{"date":247,"type":40},"2023-02-28",{"date":249,"type":21},"2025-12",{"name":251,"class":47},"Brugmann University Hospital",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":107,"phases":261,"briefSummary":262,"conditions":263,"keywords":269,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":48},"100497676","intermittent-fasting-versus-carbohydrate-drinks-before-surgery-100497676","NCT05760339","Intermittent Fasting Versus Carbohydrate Drinks Before Surgery","Preoperative Intermittent Fasting Versus Carbohydrate Loading to Reduce Insulin Resistance: a Randomised Controlled Trial","PRINCESS","Inclusion Criteria:\n\n* Undergoing elective orthopaedic surgery;\n* Intermediate, major or complex surgery according to the Surgical Outcome Risk Tool (SORT; http:\u002F\u002Fwww.sortsurgery.com\u002F) severity of surgery classification;\n* Scheduled for surgery at least 17 days from the date of screening;\n* Motivated to follow a time restricted feeding regimen.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* History of diabetes mellitus;\n* History of feeding or eating disorders;\n* History of delayed gastric emptying or gastro-oesophageal reflux\n* Active malignancy\n* Patients classified as ASA IV by the attending anaesthetist;\n* BMI \\\u003C 18.5 or ≥ 35;\n* Outpatient or day case surgery;\n* Palliative surgery;\n* Participation in another clinical trial that is interfering with the procedures or outcomes of the PRINCESS trial;\n* Patients unable to fully comply to study needs (e.g. legally incapable patients or patients unable to communicate in Dutch).",{"count":20,"type":21},[143],"The purpose of this study is to investigate whether time-restricted feeding, a form of intermittent fasting, before surgery improves insulin resistance around the time of surgery, compared to carbohydrate drinks and standard fasting before surgery.",[264,265,266,267,25,268],"Perioperative Care","Intermittent Fasting","Carbohydrate Loading","Preoperative Fasting","Insulin Resistance",[264,266,25,268,270,271],"HOMA-IR","Time Restricted Feeding","2024-10-18",{"date":274,"type":40},"2024-10-22",{"date":276,"type":40},"2023-03-20",{"date":278,"type":21},"2025-09",{"name":280,"class":47},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":288,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":290,"conditions":291,"keywords":293,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":4},"100565167","postoperative-complications-of-orthopedic-surgery-in-patients-from-high-altitude-regions-100565167","NCT06638658","Postoperative Complications of Orthopedic Surgery in Patients From High-altitude Regions","Postoperative Complications of Orthopedic Surgery in Patients From High-altitude Regions: a Cohort Study.","Inclusion Criteria:\n\n1. Age ≥ 18 years;\n2. ASA classification I-III;\n3. Patients who have lived at an altitude above 2500 meters for more than 6 months ;\n4. Patients scheduled for elective orthopedic surgery.\n\nExclusion Criteria:\n\n1. Urgent or emergent surgery;\n2. Expected hospital stay \\\u003C 48 hours;\n3. Inability to provide informed consent；\n4. Patients who have been out of high-altitude regions for over three months.",{"count":289,"type":21},400,"This study will focus on orthopedic surgery patients from high-altitude regions, utilizing smart wearables and monitoring tools to gather perioperative data, including heart rate, oxygen saturation, sleep quality, stress levels, and other relevant metrics. Regular follow-ups will assess recovery and complications, in addition to collecting medical records, lab results, imaging data, and other pertinent records. The ultimate goal is to establish a comprehensive follow-up cohort of orthopedic surgery patients from high-altitude areas.",[25,112,292],"High Altitude",[294,295,205],"High-altitude population","Perioperative cohort","2024-10-10",{"date":298,"type":40},"2024-10-15",{"date":300,"type":21},"2024-11-15",{"date":302,"type":21},"2029-10-31",{"name":304,"class":47},"West China Hospital",{"id":306,"slug":307,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":312,"enrollmentInfo":313,"targetDuration":4,"studyType":107,"phases":315,"briefSummary":316,"conditions":317,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":48},"100554326","effect-of-spinal-needle-type-on-optic-nerve-sheath-diameter-100554326","NCT06497634","Effect of Spinal Needle Type on Optic Nerve Sheath Diameter","Effect of Needle Types and Diameters Using in Spinal Anesthesia on Optic Nerve Sheath Diameter; Prospective Randomized Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) I-II Risk Classification\n* Elective orthopedic lower extremity surgery\n* Using a tourniquet\n* Spinal anesthesia\n\nExclusion Criteria:\n\n* Bilateral tourniquet usage\n* History of orbital trauma\n* Optic nerve pathology\n* Glaucoma\n* Asthma\n* Coronary obstructive or pulmonary disease\n* Previous corneal or intraocular surgery\n* Increased intracranial pressure\n* Coagulopathy\n* Local site infection\n* Refusing to participate in the study","40 Years",{"count":314,"type":21},165,[143],"The optic nerve sheath is a continuation of the dura mater, extending along the subarachnoid space surrounding the optic nerve. Consequently, changes in intracranial pressure cause an augmentation or contraction in the diameter of the optic nerve sheath, which is coreleted with intracranial pressure. Participants undergoing lower extremity operations (ankle, distal tibia and fibula surgeries) using a tourniquet under spinal anesthesia will be investigated. Spinal anesthesia will be performed with a 25 G Whitacre, 25 G Quincke, or 27 G Quincke needle, depending on the study group. Optic nerve sheath diameter (ONSD) measurements will be performed before spinal anesthesia; and 5 minutes, 15 minutes,,24 hours after spinal block, respectively.The 4th measurement will be performed after tourniquet is opened. Measurements will be done with 15 MHz linear ultrasound (US) probe in B mode, 3 mm behind the posterior globe in the transverse plane from both eyes, on upper eyelid. Values will be recorded numerically. The impact of spinal anesthesia administered using various needle designs (Quincke and Whitacre) and sizes (25G-27G) on intracranial pressure will be investigated.",[87,318,319,25,320],"Intracranial Pressure Change","Optic Nerve Sheath Diameter","Cerebrospinal Fluid Leak","2024-07-29",{"date":323,"type":40},"2024-07-30",{"date":325,"type":21},"2024-08-15",{"date":327,"type":21},"2024-12-30",{"name":329,"class":330},"Bagcilar Training and Research Hospital","OTHER_GOV"]