[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthostatic-hypotension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthostatic-hypotension":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,56,84,108,137,159,185,208,239,266,289,318,349,393,422,442,466,491],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":37,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100644654","impact-of-transcutaneous-spinal-stimulation-on-blood-pressure-and-orthostasis-in-spinal-cord-injury-100644654",false,"NCT07674511","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury: Short and Long-Term Effects","(SCI)","Inclusion Criteria:\n\n* Individuals with a SCI ≥ 1 year after injury\n* Injury level ≥ T6 (thoracic level)\n* AIS grade A-C\n* Cardiovascular dysfunction characterized by one or more of the following:\n\n  1. Persistent hypotension (SBP \\\u003C 90mmHg)\n  2. Orthostatic hypotension (OH, a drop of 20\u002F10 mmHg in SBP\u002FDBP within 5 minutes of standing\u002Fupright positioning).\n\nAdditionally, experiencing orthostatic symptoms in daily life and\u002For requiring medication to manage OH.\n\nExclusion Criteria:\n\n* Current illness (e.g., infection, a pressure injury that might interfere with the intervention)\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* History of seizures\n* pregnancy\n* Insufficient mental capacity to understand and independently provide consent\n* Deemed unsuitable by the study physician","ALL","18 Years","75 Years",{"count":21,"type":22},10,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury.\n\nThe main questions this study attempts to solve:\n\n1. What are the immediate effects of spinal cord transcutaneous stimulation on BP?\n2. Does stimulation produce lasting improvements in BP regulation and subsequently, daily function?",[28,29,30,31,32,33,34,35,36],"Spinal Cord Injuries","Hypotension","Orthostatic Hypotension","Spinal Cord Diseases","Cardiovascular Diseases","Trauma, Nervous System","Central Nervous System Disease","Nervous System Diseases","Blood Pressure",[38,39,40,41,42],"transcutaneous spinal cord stimulation","spinal stimulations","orthostatic hypotension","blood pressure","neuromodulation","NOT_YET_RECRUITING","2026-06-24",{"date":46,"type":47},"2026-06-29","ACTUAL",{"date":49,"type":22},"2026-09",{"date":51,"type":22},"2028-12",{"name":53,"class":54},"Kessler Foundation","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":55},"100631585","fainting-detection-and-early-warning-in-syncope-evaluation-study-arise-100631585","NCT07502599","Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE)","Fainting Detection And Early Warning In Syncope Evaluation Study","ARISE","Inclusion Criteria:\n\n* Willing and capable to provide informed consent\n* Age 18 or above\n* Previously underwent a clinically indicated ARS assessment without complications (including deep breathing, Valsalva maneuver, and tilt table testing).\n* Previously diagnosed with OH, Vasovagal syncope, OR control subjects assessed as normal, based on the ARS assessment. Participant enrollment shall be based on the type of diagnosis.\n* Willing to complete all required study activities.\n\nExclusion Criteria:\n\n* Currently enrolled in another clinical trial that might interfere with data collection.\n* Subject is pregnant or planning to become pregnant during the study\n* Active Implantable Medical Device, e.g. cardiac implantable electronic devices, bladder stimulators, diaphragm stimulators, implantable neuro stimulator, implantable active monitoring devices, implantable active drug administration devices, etc.\n* Have a prosthetic cardiac valve or previously underwent cardiac valve surgery.\n* Known allergy to materials used in the study (adhesive, ECG electrodes)\n* Diagnosed with syncope due to cardiologic causes.\n* Have had a myocardial infarction in the previous 90 days\n* Have been diagnosed with tachycardia that requires current medical treatment\n* Have any contraindications for exercise testing, tilt table test, Valsalva maneuver test or deep breathing test (judged by the study Principal Investigator)",{"count":65,"type":22},40,"OBSERVATIONAL","To characterize the impact of orthostatic hypotension (OH) and Vasovagal syncope on signals measured using a wearable Holter monitor in the clinic and ambulatory setting.\n\nTo evaluate the relationship of signals measured from the Holter monitor with reported symptom severity of orthostatic intolerance per standard data collection, analysis, and questionnaires.",[30,69],"Reflex Syncope",[71,72],"tilt table test","valsalva","RECRUITING","2026-06-16",{"date":76,"type":47},"2026-06-17",{"date":78,"type":22},"2026-06",{"date":80,"type":22},"2028-08",{"name":82,"class":83},"Boston Scientific Corporation","INDUSTRY",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":17,"minAge":18,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":23,"phases":94,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":55},"100400372","deciphering-preserved-autonomic-function-after-spinal-cord-injury-100400372","NCT04493372","Deciphering Preserved Autonomic Function After Spinal Cord Injury","Inclusion Criteria:\n\nAll subjects\n\n\\- age 18-50 years old.\n\nParticipants with spinal cord injury\n\n* Adult onset, traumatic spinal cord injury.\n* American Spinal Injury Association Impairment Scale, A-D, to encompass a spectrum of autonomic dysfunction after spinal cord injury.\n* Neurological level of injury, C1-T12, as defined by the International Standards for Neurological Classification of Spinal Cord Injury. Incorporating level of injury down to T12 to encompass a broad range of autonomic dysfunction.\n\nExclusion Criteria:\n\n* History of cardiovascular disease, hypertension, neurologic disorders (with exception of spinal cord injury), or diabetes.\n* Women who are pregnant or lactating.\n* Currently taking blood thinners.\n* Pacemaker, implanted defibrillator, or intrathecal pump incompatible with MRI scanning.\n* Cognitive issues preventing informed consent for participation.\n* Body mass index \\>30 kg\u002Fm2 for controls, in an effort to limit effects of early cardiovascular disease and diabetes in control population. Body mass index has not proven to be a good estimate of these factors following spinal cord injury.",true,"50 Years",{"count":93,"type":22},69,[25],"This study looks to characterize gradients of dysfunction in the autonomic nervous system after spinal cord injury. The autonomic nervous system plays key roles in regulation of blood pressure, skin blood flow, and bladder health- all issues that individuals with spinal cord injury typically suffer. Focusing on blood pressure regulation, the most precise metric with broad clinical applicability, the investigators will perform laboratory-based tests to probe the body's ability to generate autonomic responses. For both individuals with spinal cord injury and uninjured controls, laboratory-based experiments will utilize multiple parallel recordings to identify how the autonomic nervous system is able to inhibit and activate signals. The investigators anticipate that those with autonomic dysfunction after spinal cord injury will exhibit abnormalities in these precise metrics. The investigators will further have research participants wear a smart watch that tracks skin electrical conductance, heart rate, and skin temperature, which can all provide clues as to the degree of autonomic dysfunction someone may suffer at home. The investigators will look to see if any substantial connections exist between different degrees of preserved autonomic function and secondary autonomic complications from spinal cord injury. In accomplishing this, the investigators hope to give scientists important insights to how the autonomic nervous system works after spinal cord injury and give physicians better tools to manage these secondary autonomic complications.",[28,97,98,30],"Autonomic Imbalance","Autonomic Dysreflexia","2026-05-26",{"date":101,"type":47},"2026-05-28",{"date":103,"type":47},"2020-11-13",{"date":105,"type":22},"2026-09-08",{"name":107,"class":54},"Mayo Clinic",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":115,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":135,"locationsCount":55},"100638110","effects-of-breathing-retraining-exercises-in-pregnant-females-with-postural-orthostatic-tachycardia-syndrome-100638110","NCT07579026","Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia Syndrome.","Effects of Breathing Retraining Exercises on Heartrate, Blood Pressure and Orthostatic Intolerance in Pregnant Females With Postural Orthostatic Tachycardia Syndrome.","Inclusion Criteria:\n\n* • Pregnant female between the age of 19 to 35 years.\n\n  * Active standing results in a sustained increase in heart rate (HR) of at least 30 bpm or ≥120 bpm.\n  * POTS patients with a subacute onset of lightheadedness, dizziness, and presyncope provoked by standing.\n  * palpitations with chest discomfort, breathing difficulties, or feeling faint\n\nExclusion Criteria:\n\n* • Uncontrolled hypertension\u002Fpre-eclampsia\n\n  * cardiovascular disorder\n  * Patients with uncontrolled diabetes\n  * Patient with Anemia, severe heart failure and neurodegenerative diseases.\n  * Females with the history of deep venous thrombosis.","FEMALE","19 Years","35 Years",{"count":119,"type":22},44,[25],"Postural orthostatic tachycardia POTS is characterized by excessive increase in heart rate when moving from lying to standing position, often accompanied by symptoms such as dizziness, fatigue, brain fog, lightheadedness, rapid heartbeat and palpitation.it most commonly effects the females of reproductive age and can be triggered by events like viral infections, trauma and hormonal changes. During pregnancy females may experience worsening of symptoms in first trimester due to hormonal changes and decreased blood volume later on in second and third trimester the blood volume begins to increase. However, breathing exercises helps to regulate the nervous system, improves parasympathetic activity and reduce sympathetic activity.\n\nThe study will be randomized clinical trial and will be conducted at Bashir hospital Sialkot and Fatima hospital Sialkot. The study will be completed in 10 months of duration after the approval of synopsis. Non probability convenience sampling will be used and 44 participants will be included in the study after randomization. The subjects will be divided into two groups. Group A (experimental group) will receive diaphragmatic breathing exercises whereas Group B (control group) will receive educational retraining whereas both groups will receive baseline treatments which includes progressive muscle relaxation techniques. The tools used for the study will be Vanderbilt orthostatic symptom score VOSS to evaluate orthostatic intolerance, blood pressure will be measured using non-invasive blood pressure measurement and pulse oximetry will be used to access the heart rate. After data completion data will be analyzed by using SPSS version 21.",[30,123,36],"Heart Rate",[125,41,126,127,128],"pregnancy","vital signs","orthostatic intolerance","postural orthostatic tachycardia syndrome","2026-05-05",{"date":131,"type":47},"2026-05-11",{"date":133,"type":47},"2025-08-31",{"date":49,"type":22},{"name":136,"class":54},"Riphah International University",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":90,"sex":17,"minAge":18,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":23,"phases":147,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":55},"100461988","hypercapnia-in-orthostatic-hypotension-100461988","NCT05295810","Hypercapnia in Orthostatic Hypotension","Investigating Hypercapnia to Treat Neurogenic Orthostatic Hypotension","Inclusion Criteria:\n\n* Age ≥18 years\n* Male and Female\n* Non - smokers.\n* Able and willing to provide informed consent.\n* Ability to travel to Libin Cardiovascular Institute Autonomic Testing Lab at the University of Calgary, Calgary, AB.\n\nExclusion Criteria:\n\n* Medical therapies or medications which could interfere with testing of autonomic function\n* Participants with somatization or severe anxiety symptoms will be excluded\n* Pregnant or breast-feeding females\n* Inability to tolerate mask for the duration of the study\n* Subjects who require portable oxygen at rest or with exercise\n* Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.\n* Presence of failure of other organ systems or systemic illness that can affect autonomic function or the participant's ability to cooperate. These include: dementia, alcohol and\u002For drug abuse, cerebrovascular disease, kidney or liver disease, surgical procedures where the nerves of the sympathetic nervous system have been cut.\n* Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.","100 Years",{"count":146,"type":22},80,[25],"The Autonomic (or \"automatic\") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP). When someone stands, and gravity tries to pull blood away from the brain, the ANS works to maintain BP and brain blood flow. Neurogenic Orthostatic Hypotension (NOH) occurs when our \"fight-or-flight\" part (\"sympathetic\") of the ANS fails. BP can drop a lot when upright, reducing blood flow and oxygen delivery to the brain, and this can cause symptoms of light-headedness, nausea, and fainting.\n\nOne solution to help counter the effects of NOH may be to increase sympathetic activity by breathing higher levels of carbon dioxide. In healthy volunteers, small increases in the amount of inhaled carbon dioxide has been shown to increase BP in the upright position, and this improves symptoms!\n\nThe objectives of the current study are to apply carbon dioxide in patients with NOH and healthy controls to: (a) evaluate the effects of breathing carbon dioxide on BP and brain blood flow, and (b) determine if a device that increases carbon dioxide while standing will work as a new therapy",[30,150],"Neurogenic Orthostatic Hypotension","2026-04-29",{"date":129,"type":47},{"date":154,"type":47},"2022-03-01",{"date":156,"type":22},"2030-05-31",{"name":158,"class":54},"University of Calgary",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":90,"sex":17,"minAge":116,"maxAge":91,"enrollmentInfo":165,"targetDuration":4,"studyType":23,"phases":167,"briefSummary":168,"conditions":169,"keywords":172,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":55},"100487006","the-effect-of-water-carbonation-on-orthostatic-tolerance-100487006","NCT05621460","The Effect of Water Carbonation on Orthostatic Tolerance","Inclusion Criteria:\n\n* healthy, English-speaking\n\nExclusion Criteria:\n\n* pregnancy or suspected pregnancy, history of cardiovascular disease, history of neurological disease, history of recurrent fainting (≥ 2 episodes of fainting with loss of consciousness in the prior 6 months)",{"count":166,"type":22},25,[25],"The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers. Orthostatic tolerance refers to the ability to maintain an adequate blood pressure when standing. In some individuals blood pressure can fall when standing, predisposing to dizzy spells or fainting episodes. Drinking water can boost blood pressure and making fainting episodes less likely. However, it is not clear whether the carbonation of the water has any further impact on the blood pressure response. This is important because it may be that carbonated water expands the stomach (gastric distension), provoking an increase in sympathetic activity. The increase in sympathetic nervous system activity boosts blood pressure. Resolving this question would have important implications for patients with syncope. This study will test whether carbonated water will have any further impact on blood pressure than the already known effect of non-carbonated water.",[30,170,171],"Syncope","Vasovagal Syncope",[173,174,175],"Tilt table","Osmopressor reflex","Gastropressor reflex","2026-04-22",{"date":178,"type":47},"2026-04-23",{"date":180,"type":47},"2023-09-01",{"date":182,"type":22},"2027-04",{"name":184,"class":54},"Simon Fraser University",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":17,"minAge":91,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":55},"100470003","blood-pressure-effects-on-cognition-and-brain-blood-flow-in-pd-100470003","NCT05400174","Blood Pressure Effects on Cognition and Brain Blood Flow in PD","Effects of Blood Pressure on Cognition and Cerebral Blood Flow in Parkinson Disease","Inclusion Criteria:\n\n1. Diagnosis of idiopathic Parkinson Disease using the Movement Disorders Society (MDS) Clinical Diagnostic Criteria\n2. Age at least 50 years old\n3. Hoehn \\& Yahr (H\\&Y) stages I-III (early to moderate-stage PD; able to walk without assistance\n4. Proficiency in the English language (native English speaker level)\n\nExclusion Criteria:\n\n1. Any involuntary movements (i.e., tremor or dyskinesia) \\> 3 cm in amplitude (ok if movements are treated with medication), since the motion artifact could interfere with blood pressure monitor data collection\n2. Dementia (including PD dementia)\n3. History of deep brain stimulation (DBS) surgery\n4. Any current unstable, active medical problem, e.g. decompensated heart failure, liver failure, pneumonia, etc.\n5. Moderate or severe carotid artery stenosis (according to North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria\n6. History of cerebral infarction or hemorrhage\n7. Uncontrolled diabetes or any other systemic disease causing autonomic failure\n8. Syncope (fainting) within the past week\n9. Illiteracy (unable to read)\n10. Taking antihypertensive medications or alpha-adrenergic blocking medications, since these can cause hypotension (see \\* below)\n11. Impairment of hearing or vision that is not corrected by devices (e.g., hearing aids or glasses)\n12. Currently pregnant (will be confirmed by women of child-bearing potential with a urine pregnancy test)\n13. Any other condition, which, in the opinion of the investigator, could place the participant at increased risk.\n\n    * Please note that persons may not participate if they are taking any of the following:\n\n      * medications to treat high blood pressure (called \"antihypertensives\") such as clonidine (Catapres), hydralazine, verapamil, diltiazem (Cartia), or medications ending in \"-olol\", \"-artan\", or \"-pril\")\n      * diuretics (also called \"water pills\") such as furosemide (Lasix), bumetanide (Bumex), hydrochlorothiazide (HCTZ; Microzide), or spironolactone (Aldactone)\n      * medications for enlarged prostate such as prazosin (Minipress), terazosin, doxazosin (Cardura), alfuzosin (Uroxatral), or tamsulosin (Flomax)\n\nIf persons are taking these medications and would like to participate in the study, they will be advised to discuss whether they may discontinue these medications for 48 hours before the study visit with their prescribing doctor.",{"count":193,"type":22},60,[25],"Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Besides causing symptoms that impair movement, PD also causes non-motor symptoms, such as problems thinking and orthostatic hypotension (OH), i.e., low blood pressure (BP) when standing. About one-third of people with PD have OH, which can cause sudden, temporary symptoms while upright, including lightheadedness, dizziness, and fainting. People with PD and OH can also experience problems thinking that happen only while upright and not while sitting - this can occur without other symptoms, such as feeling dizzy or faint. However, the level of low BP that can affect thinking remains unknown, and no guidelines exist for treating OH when it happens without symptoms. This is significant because OH could be a treatable risk factor for thinking problems in PD, but OH is often not treated if people do not report obvious symptoms.\n\nThis project's goal is to determine how BP affects brain function in PD. The proposed experiments will measure BP and brain blood flow continuously in real-time using innovative wearable technology. Persons with PD with OH and without OH will undergo repeated cognitive tests while supine (lying down) and while upright. I will study the associations between BP, thinking abilities, and brain blood flow, and will compare groups with and without OH. These findings could be important because if a certain level of BP correlates with thinking abilities, then treating OH in PD may prevent thinking problems, which would improve health-related quality of life and reduce disability and healthcare costs.",[197,30,198],"Parkinson Disease","Dysautonomia","2026-04-21",{"date":201,"type":47},"2026-04-27",{"date":203,"type":47},"2021-12-14",{"date":205,"type":22},"2026-08-15",{"name":207,"class":54},"University of California, San Diego",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":17,"minAge":216,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":219,"conditions":220,"keywords":222,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":55},"100630309","orthostatic-and-postprandial-hypotension-in-hospitalized-older-adults-hope65-100630309","NCT07485998","Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65)","Orthostatic And Postprandial Hypotension In Hospitalized Older Adults: Prevalence And Association With Medications, Comorbidities, And Adverse Clinical Outcomes","HOPE65","Inclusion Criteria:\n\n* Age 65 years or older\n* Hospitalization in internal medicine departments at the University Medical Centre Ljubljana\n* Duration of hospitalization ≥48 hours\n* Hemodynamic stability confirmed by the treating physician\n* Ability to participate in study procedures\n* Ability to stand (with or without assistive devices for walking)\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Medical condition preventing study procedures (e.g., need for continuous supine position)\n* Inability to provide informed consent\n* Refusal to participate\n* Severe cognitive impairment or delirium\n* Acute critical illness requiring intensive treatment\n* Participation in another clinical study that could affect safety or study outcomes","65 Years",{"count":218,"type":22},500,"The goal of this observational study is to determine how often orthostatic hypotension and postprandial hypotension occur in adults aged 65 years and older who are hospitalized in internal medicine departments.\n\nOrthostatic hypotension is defined as an excessive drop in blood pressure after standing up from a lying or sitting position. Postprandial hypotension is an excessive drop in blood pressure that occurs after eating a meal. These conditions can increase the risk of falls, fainting, loss of independence, and other health problems in older adults.\n\nThe main questions this study aims to answer are:\n\n* How common orthostatic hypotension and postprandial hypotension are in hospitalized adults aged 65 years and older.\n* Whether these conditions are associated with medication use, chronic diseases, and geriatric syndromes (such as frailty, cognitive impairment, and functional decline).\n\nParticipants will:\n\n* have blood pressure measured while lying down and standing\n* have blood pressure measured after a meal\n* undergo a comprehensive geriatric assessment, including evaluation of functional status, cognitive function, frailty, mobility, and nutritional status\n* provide information about medications and medical history\n* be followed for up to 12 months to record outcomes such as falls, syncope, hospitalization, and death",[30,221],"Postprandial Hypotension",[223,224,225,226,227,228,229],"Older Adults","Hospitalized Patients","Blood Pressure Regulation","Falls","Geriatric Syndromes","Comprehensive Geriatric Assessment","Antihypertensive Medication","2026-03-17",{"date":232,"type":47},"2026-03-20",{"date":234,"type":22},"2026-04",{"date":236,"type":22},"2030-06",{"name":238,"class":54},"University Medical Centre Ljubljana",{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":90,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":248,"conditions":249,"keywords":252,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":55},"100630037","autonomic-regulation-of-blood-pressure-and-heart-rate-during-orthostasis-and-exercise-in-healthy-and-hypertensive-individuals-100630037","NCT07482462","Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals","Assessment of Autonomic Regulation of Blood Pressure and Heart Rate in Healthy and Hypertensive Individuals During Orthostasis and Physical Exercise","Inclusion Criteria:\n\n* Healthy volunteers aged 18-35 years without known acute or chronic disease, non-smokers, body mass index (BMI) 20-24.9 kg\u002Fm², and negative orthostatic test\n* Participants aged ≥60 years with arterial hypertension followed at the Department of Hypertension\n* Hypertension group: controlled arterial hypertension, negative orthostatic test, without diabetes mellitus\n* Hypertension with orthostatic hypotension group: controlled arterial hypertension and positive orthostatic test indicating orthostatic hypotension\n* Hypertension with orthostatic hypertension group: controlled arterial hypertension and positive orthostatic test indicating a rise in blood pressure during orthostatic testing\n* Hypertension with diabetes mellitus group: controlled arterial hypertension and diabetes mellitus without previously diagnosed autonomic dysfunction\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Dementia, neurodegenerative disease, or cognitive impairment preventing understanding of study procedures\n* Known cardiovascular disease including heart failure (NYHA II-IV), myocardial infarction within the previous 6 months, clinically significant arrhythmias, or peripheral arterial occlusive disease\n* Uncontrolled arterial hypertension\n* Change in antihypertensive therapy within the previous 4 weeks\n* Presence of a cardiac pacemaker\n* Treatment with antiarrhythmic drugs (class I, III, or IV), digoxin, alpha-receptor blockers, or other medications known to significantly affect heart rate variability or autonomic function\n* Advanced renal failure (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m²) or advanced liver failure\n* Active malignancy\n* Body mass index ≥35 kg\u002Fm²\n* Acute illness within the previous 4 weeks\n* Current smoking\n* Inability to safely perform exercise testing on a cycle ergometer\n* Severe psychiatric disorders without stable treatment\n* Pregnancy or breastfeeding\n* Participation in another clinical study\n* Refusal or inability to provide written informed consent",{"count":247,"type":22},120,"The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical exercise. The main objective is to analyze cardiovascular responses to exercise on a cycle ergometer in different subgroups of participants with hypertension.\n\nThe study includes healthy young adults and older adults with hypertension. Participants undergo standardized assessments including orthostatic testing, graded exercise testing on a cycle ergometer, electrocardiography, and measurement of arterial stiffness parameters such as pulse wave velocity, as well as other vascular and hemodynamic parameters.\n\nThe results of this study are expected to improve understanding of cardiovascular physiology and autonomic regulation in people with hypertension and may contribute to earlier recognition of autonomic dysfunction and improved clinical management.",[250,251,30],"Hypertension","Autonomic Dysfunction",[253,254,255,256,257],"Orthostatic Test","Arterial Stiffness","Exercise Testing","Heart Rate Variability","Pulse Wave Velocity","2026-03-14",{"date":260,"type":47},"2026-03-19",{"date":262,"type":47},"2025-10-15",{"date":264,"type":22},"2027-03",{"name":238,"class":54},{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":274,"conditions":275,"keywords":276,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":55},"100616750","research-development-and-application-of-intelligent-diagnostic-system-for-orthostatic-hypotension-100616750","NCT07309666","Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension","Inclusion Criteria:\n\n1. Adult patients (≥18 years old).\n2. Clinical diagnosis of Parkinson's disease (PD) OR multiple system atrophy (MSA) OR diabetes mellitus (if diabetic, must be aged ≥50 years).\n3. Suspected or diagnosed with orthostatic hypotension (OH).\n4. Presence of adequate acoustic temporal bone windows for Transcranial Doppler (TCD) monitoring.\n5. Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n1. Significant intracranial or extracranial arterial stenosis (≥70% confirmed by ultrasound).\n2. Recent stroke or intracerebral hemorrhage (confirmed by CT\u002FMRI).\n3. Severe cardiac arrhythmias (e.g., atrial fibrillation) or severe valvular heart disease.\n4. Bilateral temporal bone windows insufficient for TCD monitoring.\n5. Pregnancy or lactation.\n6. Inability to cooperate with the testing procedures.\n7. Other systemic diseases that significantly affect cerebral blood flow regulation (e.g., severe thyroid or renal dysfunction).",{"count":273,"type":22},2000,"Orthostatic hypotension (OH) has a high incidence rate of 30%-50% in the elderly and populations with neurodegenerative diseases. The resulting cerebral hypoperfusion significantly increases the risk of cerebral ischemia, falls, and cognitive decline. Traditional OH diagnosis primarily relies on intermittent cuff blood pressure measurements, leading to low detection rates and an inability to provide scientifically effective OH classification. Furthermore, existing research often overlooks cerebral hemodynamic mechanisms, particularly the assessment of dynamic cerebral autoregulation (dCA), making it difficult to study the mechanisms behind OH and its associated symptoms.\n\nTo address these issues, the research team has preliminarily developed an \"Intelligent Diagnostic System for Orthostatic Hypotension\". This system innovatively integrates synchronous and continuous monitoring of multiple parameters, including non-invasive beat-to-beat blood pressure, transcranial Doppler (TCD) cerebral blood flow velocity, and electrocardiogram (ECG). It also enables the quantitative assessment of dynamic cerebral autoregulation function. The project will collaborate with fifteen high-level clinical centers in China to collect data from 2000 patients with orthostatic hypotension. The aim is to establish and externally validate a risk stratification model for OH. By integrating multimodal clinical and hemodynamic data, the investigators intend to construct an automated, precise intelligent system for the classification, subtyping, and risk stratification of OH. This initiative will establish a standardized diagnostic and management pathway covering early screening, precise classification, early warning, and stratified intervention. The goal is to provide key technological support for enhancing the early identification and standardized management of OH, thereby reducing its associated disability and mortality rates.",[30],[30,36,277,278,279],"Cerebral Blood Flow Velocity","Cerebral Autoregulation","Risk Stratification","2026-01-04",{"date":282,"type":47},"2026-01-07",{"date":284,"type":22},"2026-03-01",{"date":286,"type":22},"2029-02-01",{"name":288,"class":54},"Xuanwu Hospital, Beijing",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":17,"minAge":116,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":23,"phases":299,"briefSummary":300,"conditions":301,"keywords":306,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":317},"100467649","non-invasive-spinal-cord-stimulation-for-recovery-of-autonomic-function-after-spinal-cord-injury-100467649","NCT05369520","Non-invasive Spinal Cord Stimulation for Recovery of Autonomic Function After Spinal Cord Injury","Non-invasive Spinal Cord Stimulation for Recovery of Autonomic Function After Spinal Cord Injury: Moving From Mechanisms to Clinical Practice","Inclusion Criteria:\n\n1. Resident of British Columbia, Canada with active provincial medical services plan.\n2. Male or female, 19-60 years of age.\n3. Chronic traumatic SCI (non-progressive, with complete motor paralysis) at or above the T6 spinal segment.\n4. \\>1-year post injury, at least 6 months from any spinal surgery.\n5. American Spinal Injury Association Impairment Scale (AIS) A, B.\n6. Stable management of spinal cord related clinical issues (i.e., spasticity management).\n7. Experience bladder, or bowel, or sexual dysfunction.\n8. No painful musculoskeletal dysfunction, unhealed fracture, pressure sore, or active infection that may interfere with testing.\n9. For women of childbearing potential, not intending to become pregnant, currently pregnant, or lactating. The following conditions apply:\n\n   1. A confirmed negative pregnancy test prior to the baseline visit. During the trial, all women of childbearing potential will undergo urine pregnancy tests at their monthly clinic visits as outlined in the schedule of events.\n   2. Use adequate contraception, or complete abstinence from sexual activities, during the period of the trial and for at least 28 days after completion of treatment.\n   3. If using combined hormonal contraception, a stable regimen during the period of the trial and for at least 28 days after completion of treatment.\n10. For sexually active males with female partners of childbearing potential, use adequate contraception, or complete abstinence from sexual activities, during the period of the trial and for at least 28 days after completion of treatment.\n11. Must provide informed consent.\n12. Willing and able to comply with all clinic visits and study-related procedures.\n13. Able to understand and complete study-related questionnaires (must be able to understand and speak English or have access to an appropriate interpreter as judged by the investigator).\n\nExclusion Criteria:\n\n1. Ventilator dependent.\n2. Signs of lower motor neuron damage (i.e. concomitant conus medullaris\u002Fcauda equina injury).\n3. Severe anemia or hypovolemia as measured by hematocrit via blood test in the last six months.\n4. History of cardiovascular, respiratory, bladder, or renal disease unrelated to SCI or presence of hydronephrosis or presence of obstructive renal stones.\n5. History of seizures\u002Fepilepsy or recurring headaches.\n6. Clinically significant, unmanaged, depression (to be screened) or ongoing drug abuse.\n7. Intrathecal baclofen pump.\n8. Oral baclofen dose greater than 60mg.\n9. Individuals that have received intradetrusor or intrasphincter onabotulinumtoxinA injections within 6 months of baseline.\n10. Any implanted metal (other than dental implants) in the skull or presence of pacemakers, stimulators, or medication pumps in the trunk.\n11. Past electrode implantation surgery.\n12. Member of the investigational team or his\u002Fher immediate family.\n13. Presence of severe acute medical issue and use of any specific medication or treatment that, in the investigator's judgement, would adversely affect the participant's participation in the study.\n14. Known allergies or sensitivities to both blue dye and beetroot powder.\n15. Known or suspected gastrointestinal obstruction.\n16. Persons with active inflammatory bowel disease or a history of bowel perforation.","60 Years",{"count":298,"type":22},30,[25],"This study is a pilot clinical trial to explore the efficacy of transcutaneous spinal cord stimulation (TCSCS) (proof-of-concept) in mitigating crucial autonomic dysfunctions that impact the health-related quality of life of individuals with spinal cord injury (SCI).",[302,251,303,304,305,98,30],"Spinal Cord Injury","Sexual Dysfunction","Neurogenic Bladder Dysfunction","Neurogenic Bowel Dysfunction",[307,302],"Neurostimulation","2025-12-01",{"date":310,"type":47},"2025-12-08",{"date":312,"type":47},"2023-10-03",{"date":314,"type":22},"2027-10",{"name":316,"class":54},"University of British Columbia",2,{"id":319,"slug":320,"hasResults":11,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":11,"sex":17,"minAge":325,"maxAge":326,"enrollmentInfo":327,"targetDuration":4,"studyType":23,"phases":329,"briefSummary":331,"conditions":332,"keywords":336,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":55},"100277879","phase-1-effects-of-midodrine-and-droxidopa-on-splanchnic-capacitance-in-autonomic-failure-100277879","NCT02897063","Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure","The Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Aim 2 of RDCRN (Rare Diseases Clinical Research Network) Project 2","Inclusion Criteria:\n\n* Male and female subjects, age 40-80 years with possible or probable Multiple System Atrophy, Pure Autonomic Failure, or Parkinson disease, as defined by Consensus Criteria.\n* Neurogenic orthostatic hypotension defined as a ≥30-mmHg decrease in systolic blood pressure within 3 minutes of standing associated with impaired autonomic reflexes determined by autonomic testing in the absence of other identifiable causes.\n* Subjects able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* Supine hypertension, defined as systolic blood pressure of ≥ 160 mmHg measured on two separate occasions.\n* Pregnancy.\n* Systemic illnesses known to produce autonomic neuropathy, including but not limited to diabetes mellitus, amyloidosis, monoclonal gammopathies, and autoimmune neuropathies.\n* History of known aortic aneurisms, thoracic, abdominal or pelvic surgery in the past 6 months.\n* Symptomatic abdominal or inguinal hernias.\n* Severe gastroesophageal reflux.\n* Recent fractures or fissures of ribs, thoracic or lumbar spine.\n* Medical devices implanted on the abdominal wall or abdomen that would interfere with the abdominal compression.\n* Intolerance to any increase in intraabdominal pressure.\n* Clinically unstable coronary artery disease or major cardiovascular or neurological event in the past 6 months, and other factors which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical, mental or laboratory testing.","40 Years","80 Years",{"count":328,"type":22},34,[330],"PHASE1","The purpose of this study is to learn more about the effects of midodrine and droxidopa, two medications used for the treatment of orthostatic hypotension (low blood pressure on standing), on the veins of the abdomen of patients with autonomic failure. The study will be conducted at Vanderbilt University Medical Center, and consists of 2 parts: a screening and 2 testing days. The total length of the study will be about 5 days. About 34 participants will be screened for the study.",[333,334,335,197,30],"Autonomic Failure","Pure Autonomic Failure","Multiple System Atrophy",[337,338,339],"midodrine","droxidopa","splanchnic circulation","2025-10-08",{"date":342,"type":47},"2025-10-14",{"date":344,"type":4},"2016-09",{"date":346,"type":22},"2026-12",{"name":348,"class":54},"Vanderbilt University Medical Center",{"id":350,"slug":351,"hasResults":11,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":355,"eligibilityCriteria":356,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":357,"targetDuration":359,"studyType":66,"phases":4,"briefSummary":360,"conditions":361,"keywords":372,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":55},"100608041","polish-registry-of-cardioneuroablation-and-cardioneuromodulation-100608041","NCT07196397","POLish Registry of CArdioneuroablation and CArdioneuromodulation","POL-CA Registry: Multicenter Observational Study of Neuromodulatory Procedures in Cardiovascular Autonomic Dysfunction Syndromes","POL-CA","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosis of at least one of the following conditions:\n\n  * Inappropriate sinus tachycardia (IST)\n  * Postural orthostatic tachycardia syndrome (POTS)\n  * Vasovagal syncope (VVS)\n  * Cardioinhibitory carotid sinus syndrome (CSS)\n  * Symptomatic sinus bradycardia or functional AV block\n  * Orthostatic hypotension (OH)\n* History of recurrent autonomic symptoms (e.g., syncope, bradycardia, palpitations, orthostatic intolerance)\n* Undergoing or previously underwent interventional treatment affecting cardiac autonomic innervation (e.g., cardioneuroablation, SN-sparing ablation, cardiac sympathetic denervation)\n* Provided written informed consent (for prospective arm)\n\nExclusion Criteria:\n\n* Structural heart disease requiring surgical intervention\n* Permanent pacemaker or ICD implanted prior to enrollment\n* Inability to complete follow-up assessments or questionnaires\n* Severe psychiatric comorbidities impairing participation\n* Participation in another interventional clinical trial",{"count":358,"type":22},1000,"3 Years","The multicentre observational study POL-CA involves a wide spectrum of patients with a history of syncopy. The study recruits patients with diagnosed vasovagal syndrome, cardioinhibitory carotid sinus syndrome, symptomatic sinus bradycardia or atrioventricular block, postural orthostatic tachycardia syndrome, orthostatic hypotension, and inappropriate sinus tachycardia syndrome. This is an observational, controlled study with retrospective, clinical data analysis of previously treated patients and the analysis of syncopal patients prospectively recruited into the study. The aim of the POL-CA registry is to create a platform for physicians to record treatment data for patients undergoing procedures that affect innervation or modify cardiovascular reflexes (cardioneuroablation, cardioneuromodulation) in order to provide a multicentre summary of population characteristics and treatment outcomes based on a standardized POL-CA questionnaire and methodology for various arrhythmias.",[362,363,364,365,30,366,367,368,369,370,251,371],"Vasovagal Syndrome VVS","Cardioinhibitory Carotid Sinus Syndrome CSS","Symptomatic Sinus Bradycardia SB or Atrioventricular Block AV","Postural Orthostatic Tachycardia Syndrome POTS","Inappropriate Sinus Tachycardia Syndrome IST","Vasospastic Angina","Microvascular Angina","Ventricular Arrythmia","Raynaud Phenomena","Autonomic Diseases",[373,374,375,376,377,378,379,380,381,382],"cardioneuroablation","cardiac sympathetic denervation","sinoatrial node sparing hybrid ablation","catheter ablation","neural stimulation","cardioneuromodulation","percutaneus stellate ganglion blockage","cardiac rehabilitation","cardiovascular autonomic tests","syncope","2025-09-21",{"date":385,"type":47},"2025-09-29",{"date":387,"type":47},"2024-11-21",{"date":389,"type":22},"2031-12-31",{"name":391,"class":392},"SABAMED Medical Center Ltd.","NETWORK",{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":399,"eligibilityCriteria":400,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":401,"targetDuration":4,"studyType":23,"phases":403,"briefSummary":404,"conditions":405,"keywords":408,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":55},"100495499","spinal-cord-transcutaneous-stimulation-effect-on-blood-pressure-in-acute-spinal-cord-injury-sci-100495499","NCT05731986","Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)","Neuromodulation of Blood Pressure Using Transcutaneous Spinal Stimulation in Individuals With an Acute Spinal Cord Injury - A Safety, Feasibility and Efficacy Study","SCI","Inclusion Criteria:\n\n* 7-30 days after injury\n* Injury level ≥T2 (thoracic level)\n* American Spinal Injury Association Impairment Scale (AIS) A-C\n* Exhibits at least one of the following hypotensive symptoms:\n\n  1. Baseline hypotension - resting supine or seated SBP \\\u003C 90mmHg;\n  2. SBP drop ≥ 20 mmHg within 5 minutes of assuming seated position;\n  3. Symptoms of orthostasis with a drop of SBP (\\\u003C90mmHg) from supine to sitting.\n\nExclusion Criteria:\n\n* Current illness (e.g., a recent diagnosis of a deep vein thrombosis (DVT) or pulmonary embolism (PE), a pressure injury that might interfere with the intervention, etc.) or infection\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* Initiated on new cardiac medications within the past 5 days\n* Insufficient mental capacity to understand and independently provide consent\n* Pregnancy\n* Cancer\n* Deemed unsuitable by study physician",{"count":402,"type":22},12,[25],"The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury). Blood pressure instability, specifically orthostatic hypotension (a drop in blood pressure when moving lying flat on your back to an upright position), appears early after the injury and often significantly interferes with participation in the critical rehabilitation time period.\n\nThe main questions it aims to answer are:\n\n1. Can optimal spinal stimulation increase blood pressure and resolve orthostatic symptoms (such as dizziness and nausea) when individuals undergo an orthostatic provocation (a sit-up test)? Optimal stimulation and sham stimulation (which is similar to a placebo treatment) will be compared.\n2. What are the various spinal sites and stimulation parameters that can be used to increase and stabilize blood pressure to the normal range of 110-120 mmHg?\n\nParticipants will undergo orthostatic tests (lying on a bed that starts out flat and then moved into an upright seated position by raising the head of bed by 90° and dropping the base of the bed by 90° from the knee) with optimal and sham stimulation, and their blood pressure measurements will be evaluated and compared.",[28,31,33,35,406,29,30,32,407,36],"Central Nervous System Diseases","Acute Spinal Cord Injury",[409,410,30,36,411,412,29,413],"Transcutaneous Spinal Cord Stimulation","Spinal stimulation","Neuromodulation","Acute spinal cord injury","Acute inpatient rehabilitation","2025-08-29",{"date":416,"type":47},"2025-09-02",{"date":418,"type":47},"2023-12-01",{"date":420,"type":22},"2026-08",{"name":53,"class":54},{"id":423,"slug":424,"hasResults":11,"nctId":425,"briefTitle":426,"officialTitle":427,"acronym":399,"eligibilityCriteria":428,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":429,"targetDuration":4,"studyType":23,"phases":431,"briefSummary":432,"conditions":433,"keywords":434,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":436,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":55},"100495001","the-effect-of-transcutaneous-stimulation-on-blood-pressure-in-spinal-cord-injury-sci-100495001","NCT05725499","The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)","Neuromodulation of Blood Pressure Using Transcutaneous Spinal Stimulation in Chronic Spinal Cord Injury","Inclusion Criteria:\n\n* Spinal cord injury for greater than or equal to 6 months\n* Injury level ≥ T6 (thoracic level)\n* American Spinal Injury Association (ASIA) Impairment Scale (AIS) A-D\n* Exhibits at least one of the following hypotensive symptoms:\n\n  1. Baseline hypotension - resting supine or seated systolic blood pressure(SBP) \\\u003C 90mmHg;\n  2. SBP drop ≥ 20 mmHg within 5 minutes of assuming seated position;\n  3. Symptoms of orthostasis with a drop of SBP (\\\u003C90mmHg) from supine to sitting\n\nExclusion Criteria:\n\n* Current illness (infection, a pressure injury that might interfere with the intervention, a recent diagnosis of DVT\u002FPE, etc.)\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* Insufficient mental capacity to understand and independently provide consent\n* Pregnancy\n* Cancer\n* Deemed unsuitable by study physician",{"count":430,"type":22},5,[25],"This project will investigate the effect of spinal cord transcutaneous stimulation on blood pressure in individuals with a chronic spinal cord injury who experience blood pressure instability, specifically, orthostatic hypotension (a drop in blood pressure when moving from lying flat on your back to an upright position).\n\nThe main questions it aims to answer are:\n\n1. What are the various spinal sites and stimulation parameters that normalize and stabilize blood pressure during an orthostatic provocation (70 degrees tilt)?\n2. Does training, i.e., exposure to repeated stimulation sessions, have an effect on blood pressure stability?\n\nParticipants will undergo orthostatic tests (lying on a table that starts out flat, then tilts upward up to 70 degrees), with and without stimulation, and changes in their blood pressure will be evaluated.",[28,29,30,31,32,33,406,35,36],[409,435,30,36,411],"Spinal Stimulation",{"date":416,"type":47},{"date":438,"type":47},"2023-02-01",{"date":440,"type":22},"2026-08-01",{"name":53,"class":54},{"id":443,"slug":444,"hasResults":11,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":448,"eligibilityCriteria":449,"healthyVolunteers":90,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":450,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":452,"conditions":453,"keywords":454,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":55},"100603687","deciphering-the-mechanisms-of-central-bp-regulation-in-patients-with-pd-associated-with-orthostatic-hypotension-100603687","NCT07139756","Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension","Deciphering the Mechanisms of Central Blood Pressure Regulation in Patients With Parkinson Disease Associated With Orthostatic Hypotension: A 2-phase Observational Study With Healthy Participants and Patients With Parkinson's Disease","HYPOPARK","Phase 1:\n\nInclusion Criteria:\n\n* Signed informed consent\n* Age ≥ 18 years and \\\u003C75 years\n* Normal office blood pressure (\\\u003C140\u002F90 mmHg)\n* For women of childbearing potential: using or willing to use during the study a reliable contraception method compatible with MRI\n\nExclusion Criteria:\n\n* Schellong test showing OH (drop of Systolic BP \\>20 mmHg or Diastolic BP \\>10 mmHg)\n* Pregnant or lactating women\n* Refusal to be informed of incidental findings\n* Any medication (acute or chronic prescription) except oral contraception\n* Clinical significant abnormal blood test as assessed by the investigator\n* Chronic or acute illness\n* Concomitant participation in a clinical trial\n* Blood donation in the 60 previous days\n* Contra-indications for MRI\n* Unable to follow study procedures\n* Having a hierarchical relationship with the investigator or being family of the investigator\n\nPhase 2:\n\nInclusion Criteria:\n\n* Signed informed consent\n* Fulfilling Movement Disorder Society clinical criteria for \"clinically established PD\"\n* Age ≥18 years and \\\u003C75 years\n* PD treated by dopamine replacement therapy (DRT)\n* Willing and able to comply with the visit schedule and study procedures\n* Autonomous in daily life\n* Schellong test showing OH (drop of Systolic BP \\>20 mmHg or Diastolic BP \\>10 mmHg)(for study group with OH) or no OH (for studygroup without OH)\n* For women of childbearing potential: using or willing to use during the study a reliable contraception method compatible with MRI\n\nExclusion Criteria:\n\n* Unable to give an informed consent\n* BP \\> 180\u002F110 mmHg on 24-hour ambulatory blood pressure monitoring\n* eGFR \\\u003C 45 ml\u002Fmin\u002F1.73 ml\u002Fmin\u002Fm2 by CKD-EPI equation\n* having contra-indications for MRI\n* Pregnant or lactating women\n* Refusal to be informed of incidental findings\n* Allergy to components of contrast agent Sonovue®\n* Living in an institution\n* Dementia\n* Type 2 diabetes\n* Stroke or myocardial infarction in the past 6 months\n* Blood donation in the previous 6 months\n* Active oncology treatment\n* Having a hierarchical relationship with the investigator or being family of the investigator",{"count":451,"type":22},130,"Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants.\n\nPhase 2 primary objective: compare the brainstem responses to LBNP in patients with PD associated with OH to PD patients without OH using BOLD fMRI",[197,30],[455,456,40],"lower body negative pressure","parkinson disease","2025-08-18",{"date":459,"type":47},"2025-08-24",{"date":461,"type":22},"2025-10-01",{"date":463,"type":22},"2028-03-31",{"name":465,"class":54},"Centre Hospitalier Universitaire Vaudois",{"id":467,"slug":468,"hasResults":11,"nctId":469,"briefTitle":470,"officialTitle":470,"acronym":471,"eligibilityCriteria":472,"healthyVolunteers":11,"sex":17,"minAge":216,"maxAge":4,"enrollmentInfo":473,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":475,"conditions":476,"keywords":478,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":483,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":489,"locationsCount":55},"100571001","the-value-of-near-infrared-spectroscopy-and-blood-pressure-measurements-in-estimating-future-fall-risk-in-older-adults-100571001","NCT06714565","The Value of Near-infrared Spectroscopy and Blood Pressure Measurements in Estimating Future Fall Risk in Older Adults","NIRS-Fall","Inclusion Criteria:\n\n* 65 years or older\n* History of a fall (in the past year)\n* Ability to perform supine-to-stand manoeuvres.\n* Ability to sign informed consent.\n* a Mini-Mental State Examination (MMSE) score of 21 points or higher or a Montreal Cognitive Assessment (MOCA) - Dutch score of 16 points or higher.\n* Sufficient command of the Dutch language\n\nExclusion Criteria:\n\n* Physically not able to perform sit-to-stand and supine-to-stand manoeuvres.\n* Estimated life expectancy of less than one year.",{"count":474,"type":22},141,"The investigators aim to study which measurements\u002Fdefinitions from continuous blood pressures measurements (using a Finometer) and from cerebral oxygenation measurements (using near-infrared spectroscopy (NIRS)) are associated with future fall incidents in older adults at risk of falls.",[226,30,477],"Older Adults (65 Years and Older)",[479,40,41,480,481],"falls","NIRS","Older adults","2024-12-17",{"date":484,"type":47},"2024-12-19",{"date":486,"type":47},"2024-12-04",{"date":488,"type":22},"2026-12-05",{"name":490,"class":54},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":492,"slug":493,"hasResults":11,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":4,"eligibilityCriteria":497,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":498,"targetDuration":4,"studyType":23,"phases":500,"briefSummary":501,"conditions":502,"keywords":503,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":509,"lastUpdatePostDateStruct":510,"startDateStruct":512,"completionDateStruct":514,"leadSponsor":516,"locationsCount":55},"100513052","autonomic-effects-of-spinal-cord-stimulation-in-spinal-cord-injury-100513052","NCT05960448","Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury","Autonomic Effects of Transcutaneous Spinal Cord Stimulation in Veterans With Spinal Cord Injury (SCI)","Inclusion Criteria:\n\n* You are above the age of 18 years old\n* You have an SCI between C3-T6\n* You have been injured longer than 1 year\n* You participated in a prior experiment \"Targeted Transcutaneous Spinal Cord Stimulation to Restore Autonomic Cardiovascular Health in Individuals with Spinal Cord Injury\"\n* You have an American Spinal Injury Association injury classification scale (AIS) A, B, C\n* Your prescription medications have not changed for at least 30 days\n\nExclusion Criteria:\n\n* You have a history of seizures\n* You have an acute illness or infection\n* You have diabetes\n* You have untreated thyroid disease\n* You have a neurological condition other than SCI (Alzheimer's disease, dementia, stroke, multiple sclerosis, Parkinson's disease, etc.)\n* You have a history of heart or vascular disease (coronary artery disease, congestive heart failure, peripheral artery disease,)\n* You have a history of moderate or severe head trauma (TBI) or diagnosed with cognitive impairment\n* You have a present or history of a psychological disorder\n* You have contraindications to electricity over your spine\n* You are dependent on a ventilator to breathe or have an open tracheostomy site\n* You have a recent history of substance abuse (within the past 3 months)\n* You have open wounds over the spine at the level targeted for stimulation\n* You are pregnant",{"count":499,"type":22},20,[25],"The goal of this interventional crossover study is to determine the effects of transcutaneous spinal cord stimulation (TSCS) on the ability to perform moderate exercise and regulate core body temperature in the chronic spinal cord injury community. The main questions it aims to answer are:\n\n* What are the effects of active TSCS targeted for BP control on exercise endurance time and HR recovery during submaximal arm cycle ergometry (ACE) as compared to sham TSCS in participants with chronic, cervical SCI?\n* What are the effects of active TSCS on Tcore responses to cool ambient exposure and on subjective reporting of thermal comfort and thermal sensitivity as compared to sham TSCS.\n\nParticipants will receive sham and active stimulation while using an arm bicycle or while in a cold room. Participants are free to participate in either the exercise phase, the cold room phase, or both phases of this study.\n\nPlease note that there no expected long term benefits of this study.",[30],[42,504,505,506,507,508],"stimulation","exercise","hand bike","thermoregulation","cold room","2024-09-27",{"date":511,"type":47},"2024-10-01",{"date":513,"type":47},"2023-07-30",{"date":515,"type":22},"2026-07-30",{"name":517,"class":518},"James J. Peters Veterans Affairs Medical Center","FED"]