[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthostatic-intolerance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthostatic-intolerance":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,46,67,94,118,138,165,187],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100383378","hypercapnia-and-orthostatic-tolerance-in-postural-orthostatic-tachycardia-syndrome-100383378",false,"NCT04271878","Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome","Inclusion Criteria:\n\n* Physician diagnosis of Postural Tachycardia Syndrome (POTS)\n* Age 18-60 years\n* Male and Female\n* Non - smokers.\n* Able and willing to provide informed consent.\n* Ability to travel to Libin Cardiovascular Institute of Alberta Autonomic Testing Lab at the University of Calgary, Calgary, AB.\n\nExclusion Criteria:\n\n* Overt cause for postural tachycardia, i.e., acute dehydration\n* Participants with somatization or severe anxiety symptoms will be excluded\n* Pregnant\n* Inability to tolerate mask for the duration of the study\n* Subjects who require portable oxygen at rest or with exercise\n* Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.\n* Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.","ALL","18 Years","60 Years",{"count":19,"type":20},26,"ESTIMATED","INTERVENTIONAL",[23],"NA","The mechanism behind postural orthostatic tachycardia syndrome (POTS) involves many causes including a sympathetic nervous system problem. Blood gases, like carbon dioxide (CO2), have an important effect on sympathetic activation.\n\nThe purpose of this research study is to determine if higher CO2 levels have any effect in lowering heart rate and reducing POTS symptoms when upright\u002Fstanding. The investigators are also searching for the ideal CO2 concentration to achieve the most effective response",[26,27],"Postural Tachycardia Syndrome","Orthostatic Intolerance",[29,30,31,32],"postural tachycardia","autonomic","orthostatic intolerance","dysautonomia","RECRUITING","2026-04-30",{"date":36,"type":37},"2026-05-07","ACTUAL",{"date":39,"type":37},"2022-02-02",{"date":41,"type":20},"2030-12-31",{"name":43,"class":44},"University of Calgary","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":45},"100588265","effects-of-age-sex-and-isometric-exercise-on-ventricular-vascular-interactions-during-cardiac-unloading-100588265","NCT06939153","Effects of Age, Sex and Isometric Exercise on Ventricular-Vascular Interactions During Cardiac Unloading","Unload heart","Inclusion Criteria\n\n* People aged 18-35 years or aged ≥ 65 years\n* Healthy without symptons of orthostatic intolerance (i.e., nausea, sweating, weakness, visual disturbance)\n* Seated systolic and\u002For diastolic BP \\\u003C140\u002F90 mmHg;\n* Body mass index \\\u003C35 kg\u002Fm2\n* Recreationally active (≤ 2 days of structured physical activity)\n* Regular menstrual cycles in young females\n\nExclusion Criteria:\n\n* People diagnosed with cardiovascular, diabetes, inflammatory or renal diseases and neurodegenerative-related dementia\n* Tobacco users\n* People prescribed with beta-blockers\n* Pregnant females\n* People unable to fit or get into the lower body negative pressure chamber",true,{"count":55,"type":20},64,[23],"As people get older, especially women, they often feel dizzy or even faint when they go from sitting or lying down to standing up. This happens because their blood pressure (BP) drops, which can lead to falls, heart problems, and even death in older adults. When BP changes, it affects how well the heart works and how it talks with blood vessels. However, little research has been done on how the heart and blood vessels talk during times of low BP. The crosstalk between the heart and blood vessels is important, as it allows enough blood and oxygen to reach the brain and other vital organs. Some research shows that as we get older, the crosstalk does not work as well. This can make it harder for blood to flow properly or put extra pressure on the heart and arteries. That's why we want to study how the heart and blood vessels talk during a laboratory-simulated situation of low BP in young and older men and women. In our study, participants will lie down with their lower body in a chamber that creates a vacuum around their legs. This safely mimics what happens when you stand up quickly. We can then measure heart function, the stress on arteries, and BP while your legs are in that vacuum. We'll use an ultrasound to check the heart and a finger cuff to measure BP. We'll also see if gripping something firmly can help protect from sudden drops in blood pressure. This study will help us understand more about a condition called orthostatic hypotension and might even suggest that handgrip exercise could prevent it.\n\nThe main questions the current study aims to address are:\n\n* Does the cross-talk between the heart and vessels become more impaired with aging during laboratory-simulated conditions of low BP?\n* Do women have worse crosstalk between the heart and blood vessels during laboratory-simulated conditions of BP?\n* Does hand gripping protect against drops in BP during conditions of low BP?\n\nAll participants will be asked to\n\n* Complete two laboratory conditions on two separate days with a randomized order (like flipping a coin):\n* Exposure to a lower body negative pressure (LBNP) chamber to safely simulate low BP (control)\n* Exposure to a lower body negative pressure (LBNP) while conducting hand-squeezingexercise (experimental).\n\nThe investigators will examine how heart and blood vessel interactions, as well as blood pressure (BP) responses, differ in young and older adults of both sexes when exposed to a laboratory-simulated low BP condition (LBNP), both with and without hand squeezing exercise.",[27],"2026-04-28",{"date":34,"type":37},{"date":62,"type":37},"2025-05-01",{"date":64,"type":20},"2026-12-15",{"name":66,"class":44},"Tracy Baynard",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":53,"sex":15,"minAge":73,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":76,"phases":4,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":45},"100636372","association-between-sarcopenia-fatigue-and-orthostatic-intolerance-in-geriatric-patients-a-case-control-study-100636372","NCT07564830","Association Between Sarcopenia, Fatigue and Orthostatic Intolerance in Geriatric Patients: A Case Control Study","Inclusion Criteria:\n\n* Patients (males or females) aged 65 or above years old.\n* Participants who are willing to participate in the study.\n\nExclusion Criteria:\n\n* Patients who are not willing to participate in the study.\n* patients with end organ damage (CHF NYHA III\u002FIV), end-stage renal disease, Liver cell failure, respiratory failure.\n* Patients with arrhythmia or using pacemakers\n* patients diagnosed with parkinsonism, Diabetes mellitus, or peripheral neuropathy.\n* Active infections or inflammatory conditions (e.g., sepsis, rheumatoid flare-up)\n* Patient with acute stroke, Critically ill patients, Terminal illness, Bedridden or completely immobile patients,\n* Medications Influencing Fatigue\u002FOI: High-dose opioids, sedatives, or drugs causing significant orthostatic hypotension (e.g., alpha-blockers, diuretics without stable control)","65 Years",{"count":75,"type":20},90,"OBSERVATIONAL","This study aims to explore the relationship between sarcopenia, fatigue, and orthostatic intolerance in older adults. It will be conducted among geriatric patients attending Ain Shams University Hospitals.\n\nParticipants aged 65 years and older will be divided into two groups: those with sarcopenia, diagnosed according to the European Working Group on Sarcopenia in Older People 2, and age- and sex-matched controls without sarcopenia. The study will compare levels of fatigue and the presence of orthostatic intolerance between the two groups.\n\nThe findings are expected to improve understanding of how sarcopenia is associated with fatigue and orthostatic symptoms in the elderly population, which may help guide better clinical assessment and management.",[79,80,27],"Sarcopenia","Fatigue",[82,83,31],"geriatric","sarcopenia","NOT_YET_RECRUITING","2026-04-27",{"date":87,"type":37},"2026-05-04",{"date":89,"type":20},"2026-05",{"date":91,"type":20},"2027-04",{"name":93,"class":44},"Ain Shams University",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":15,"minAge":101,"maxAge":16,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":104,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":45},"100487944","postural-sway-and-counterpressure-maneuvers-for-pediatric-syncope-100487944","NCT05633693","Postural Sway and Counterpressure Maneuvers for Pediatric Syncope","Impact of Postural Sway on Cardiovascular Control in Pediatric Patients With Syncope","Inclusion Criteria:\n\nWe are looking for English speaking pediatric patients aged 6-18 years with a diagnosis of recurrent fainting (at least two episodes of fainting with loss of consciousness or near loss of consciousness in the last year) of a vasovagal origin or associated with the postural orthostatic tachycardia syndrome (POTS) (as determined by a paediatric cardiologist) to take part in this study.\n\nExclusion Criteria:\n\nThose with a diagnosis of recurrent fainting accompanied by any of the following will not be eligible to take part:\n\nKnown history of:\n\n* Suspected or confirmed cardiac arrhythmia (e.g., Wolff-Parkinson-White, Long QT)\n* Traumatic head injury\n* New presentation of a seizure disorder OR epilepsy recurrence\n* Overdose or intoxication\n* Structural heart disease\n* Cardiovascular disease including hypertension, diabetes, or renal disease\n* Hypoglycemia\n* Physical and\u002For psychological disability that impact their ability to complete the tests\n\nFemale participants of childbearing age will be excluded if they are pregnant, or think they might be. Participants who are taking any cardiovascular acting medications, including treatment for cardiovascular disease, or medications for orthostatic syncope (e.g. fludrocortisone, slow-release sodium chloride, β-blockers, midodrine) will be excluded from the study.\n\nIn order to reduce the likelihood of transmission of COVID-19, participants will only be eligible to participate in the study if they have received full immunisation against COVID-19 according to current Health Canada guidelines. Accordingly, participants will be asked to provide evidence of their vaccination status in order to take part in the study.","6 Years",{"count":103,"type":20},30,[23],"The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint. We will record cardiovascular responses to maneuvers of exaggerated sway, leg crossing, crouching, and gluteal muscle tensing in children who faint (N=20), as well as their height, weight, muscularity, and pubertal (Tanner) stage. Autonomic cardiovascular control will be measured using a Valsalva manoeuvre (expiration against a closed airway for 20 seconds) and a supine-stand test. The primary outcomes are noninvasive measures of cardiovascular responses to the maneuvers (blood pressure, cerebral blood flow, and stroke volume (volume of blood pumped per heartbeat). Comparisons will be made across levels of sex, diagnosis, Tanner stage, muscularity, height, and degree of autonomic control.",[107,108,27],"Syncope, Vasovagal","Postural Orthostatic Tachycardia Syndrome","2026-04-22",{"date":111,"type":37},"2026-04-23",{"date":113,"type":37},"2023-04-17",{"date":115,"type":20},"2027-06",{"name":117,"class":44},"Simon Fraser University",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":15,"minAge":101,"maxAge":16,"enrollmentInfo":126,"targetDuration":4,"studyType":21,"phases":128,"briefSummary":129,"conditions":130,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":45},"100481957","paediatric-syncope-in-the-emergency-department-100481957","NCT05555771","Paediatric Syncope in the Emergency Department","Determining the Effectiveness of Counterpressure Maneuvers in Pediatric Patients Presenting With Syncope to the Emergency Department","DETECT-ED","Inclusion Criteria:\n\n1. Those between the ages of 6-18 years (inclusive)\n2. Presenting to the ED daily 1000-2200 with resolved transient loss of consciousness that has occurred within the last week\n3. Able to complete the survey in English\n4. Willing and able to provide consent and assent\n\nExclusion Criteria:\n\n1. Those with a known history of any of the following:\n\n   * Suspected or confirmed cardiac arrhythmia diagnosis (e.g., Wolff-Parkinson-White, long QT)\n   * Traumatic head injury\n   * New presentation of seizure disorder\n   * Epilepsy recurrence\n   * Overdose, intoxication\n   * Structural heart disease\n2. Patients with hypoglycaemia and who are psychogenic with vasovagal syncope who do not present with prodromal symptoms\n3. Previously enrolled in this study",{"count":127,"type":20},300,[23],"The investigators will assess the efficacy of clinically recommended counterpressure maneuvers (CPM) in preventing syncope for paediatric patients. Participants presenting to the emergency department (ED) will first provide written informed consent. In stage I, they will be asked to complete a brief survey documenting the presentation of their syncopal episode, and any prodromal symptoms they experienced. Participants that consent to the second stage of the study will either receive usual care (control arm) or training in counter pressure maneuvers alongside usual care (intervention arm; leg crossing, bending, arm tensing). These patients will be followed for one years time, and will be asked to complete monthly surveys detailing their syncopal and presyncopal recurrence. Medical records will be accessed over the duration of the study to identify any changes in medical diagnosis.",[107,108,27],{"date":111,"type":37},{"date":133,"type":37},"2022-09-03",{"date":135,"type":20},"2027-09-30",{"name":137,"class":44},"Dr. Victoria Claydon",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":76,"phases":4,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":4},"100514349","continuous-and-non-invasive-measurements-by-task-force-corecardio-in-autonomic-function-testing-aft-100514349","NCT05977335","Continuous and Non-invasive Measurements by Task Force® CORE\u002FCARDIO in Autonomic Function Testing (AFT)","Inclusion Criteria:\n\n* Adult patients (patients aged ≥ 18 years)\n* Patients giving written informed consent to participate in the study.\n* Patients with intact perfusion of both hands evidenced by a positive Allen's test.\n* Patients with orthostatic intolerance will be included\n\nExclusion Criteria:\n\n* Patients with vascular implants at the sites of non-invasive BP measurement (fingers or upper arms)\n* Very low perfusion in the periphery\n* Arterial vascular diseases (arteriosclerosis, Raynaud's syndrome, endarteritis obliterans, collagenosis, severely advanced vascular diseases (PAOD))\n* Patients with significant edema in the fingers\n* Patients with atrial fibrillation\n* Patients with valvular disease of grade 2 or above\n* Patients with ventricular assist devices\n* Subjects not passing the Allen's test for both hands.\n* Patients with a large lateral difference in BP (\\> 15 mmHg for systolic BP and\u002For \\>10 mmHg for diastolic BP) or with same arm measurement differences \\> 10 mmHg in systolic or diastolic BP during assessment of lateral differences",{"count":145,"type":20},75,"Background: The investigational device, \"Task Force® CORE\" (TFC, CNSystems Medizintechnik GmbH, Graz, Austria) together with the \"Task Force® CARDIO\" (TFCARDIO, CNSystems Medizintechnik GmbH, Graz, Austria) medical device software, is a new CE-marked medical device for continuous non-invasive determination of blood pressure (BP), cardiac output (CO) and derived parameters based on the well established CNAP® (continuous non-invasive arterial pressure) technology by CNSystems.\n\nAim: The primary aim of this prospective, method comparison, open study is data acquisition for the performance evaluation of the TFC during autonomic function testing in comparison with an clinically accepted reference method. Setting: The setting of the clinical investigation will be the autonomic function testing laboratory at the Department of Neurology, the University Hospital Center Zagreb.\n\nInclusion criteria: Patients who are over 18 years and who provide written informed consent.\n\nSample size: The study has an calculated sample size of 70 patients. Considering a drop-out rate of 5%, a total of 75 patients will be included.\n\nStatistics: Descriptive statistics, values for the percentage error and correlation estimates will be derived. Furthermore, scatterplot, Bland-Altman analysis, concordance analysis of parameter changes and further comparative statistics will be performed.",[148,27],"Autonomic Dysfunction",[150,151,152,153,154],"Blood Pressure","Hemodynamics","Non-invasive","Continuous","Autonomic Function Testing","2026-03-16",{"date":157,"type":37},"2026-03-18",{"date":159,"type":20},"2026-11-01",{"date":161,"type":20},"2027-12-01",{"name":163,"class":164},"CNSystems Medizintechnik GmbH","INDUSTRY",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":21,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":45},"100608003","the-stand-up-study-100608003","NCT07195903","The STAND-UP Study","Evaluation of Supracardiac Venous Angioplasty and Stenting on Ortho- Static Intolerance and Orthostatic Hypotension - The STANDUP Study","Inclusion criteria :\n\n1. Age 18 years\n2. Diagnosed orthostatic intolerance or orthostatic hypotension not responding to standard medical management or complicated by supine hypertension\n3. Able to provide informed consent • Exclusion criteria:\n\n1\\. Pregnancy or breastfeeding 2. Active infection 3. Coagulopathy or contraindication to anticoagulation therapy",{"count":173,"type":20},100,[23],"Orthostatic hypotension (OH) and orthostatic intolerance (OI) are common conditions where blood pressure drops when standing up, causing dizziness, fainting, or fatigue. These affect up to 30% of adults over 65 and raise risks for heart disease, stroke, kidney problems, and more. Current medications often don't fully help and can cause side effects like high blood pressure when lying down.\n\nThe STANDUP study tests a new approach: using a minimally invasive procedure to open narrowed veins above the heart (supracardiac veins) that may block blood flow back to the heart. We believe fixing these blockages could improve blood pressure control and reduce symptoms. This is a 2-year study enrolling 100 adults (age 18+) with OH or OI that hasn't improved with standard treatments or is worsened by lying-down high blood pressure.\n\nWhat happens in the study? Participants get imaging (like X-rays and ultrasound) to check for vein narrowing. If needed, doctors use a thin tube (catheter) through a small skin puncture to inflate a tiny balloon (angioplasty) or place a small mesh tube (stent) to widen the veins. The procedure takes a few hours under local anesthesia, with monitoring for safety. Follow-up visits check symptoms, blood pressure, and quality of life at 2-4 weeks, 3 months, 6 months, 1 year, and 2 years.\n\nWho can join?\n\nAdults 18+ with diagnosed OH\u002FOI not helped by meds. Must give informed consent. Not eligible if: Pregnant, breastfeeding, actively infected, or unable to take blood thinners.\n\nPossible benefits: Better standing tolerance, fewer symptoms, improved daily life, less need for meds, and new knowledge on vein issues in OH\u002FOI.\n\nRisks: Rare but include bleeding, infection, stroke, vein clots, stent issues, radiation from imaging, or temporary symptom worsening. We'll monitor closely and report any problems.\n\nThis single-arm trial (no placebo group) will compare before-and-after results to see if the procedure helps. No study drug costs; covered by insurance or clinic. Led by Dr. Karthikeyan Arcot at St. Francis Hospital, Roslyn, NY. Contact for details.",[177,27],"Orthostatic Hypotension, Dysautonomic","2025-09-19",{"date":180,"type":37},"2025-09-29",{"date":182,"type":37},"2025-01-23",{"date":184,"type":20},"2030-01-01",{"name":186,"class":44},"St. Francis Hospital, New York",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":76,"phases":4,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":5},"100538329","autonomic-dysfunction-in-patients-following-bariatric-surgery-the-adipose-study-100538329","NCT06289413","Autonomic Dysfunction in Patients Following Bariatric Surgery: The ADiPOSE Study","Inclusion Criteria:\n\n* Between the age of 18 - 85 years\n* Can provide consent\n* Negative urine B-hCG\n* Continued follow-up with the bariatric surgery team.\n* BS includes one of the following: gastric bypass, sleeve gastrectomy, and biliopancreatic diversion with duodenal switch.\n* Phase I: Underwent BS within the last 3 years\n* Phase II: Will undergo BS within the next 3 months or underwent BS in the last 30 days\n\nExclusion Criteria:\n\n* Unable to provide consent\n* Pregnant or breastfeeding\n* BMI \\\u003C 35\n* Revision surgery of one of the following BS from above\n* Prior history of autonomic dysfunction prior to BS\n* Developed AD 72 months post-procedure\n* No evidence of AD\u002FOI","85 Years",{"count":195,"type":20},400,"Observational two phase, retrospective and prospective registry study to assess the prevalence of and characterize outcomes of autonomic dysfunction (AD) in patients who undergo bariatric surgery (BS) and to better define the underlying pathophysiology of AD following BS.",[148,27],"2025-08-27",{"date":200,"type":37},"2025-08-28",{"date":202,"type":37},"2024-02-12",{"date":204,"type":20},"2025-12",{"name":206,"class":44},"Kansas City Heart Rhythm Research Foundation"]