[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osseointegration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osseointegration":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,50,72,105,126,155],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100640017","autologous-demineralized-dentin-graft-with-or-without-melatonin-for-immediate-implant-osseointegration-100640017",false,"NCT07610876","Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration","Effect of Autologous Demineralized Dentin Graft With or Without Melatonin Gel on the Osseo Integration of Immediately Placed Implants: A Randomized Clinical Study","Inclusion Criteria:\n\n* Age above 20 years\n* Non-restorable maxillary premolar teeth\n* Candidates for immediate implant placement\n* Intact socket walls\n* Jumping gap \\>2 mm\n* Non-smokers or light smokers\n* No acute infection\n* Adequate bone for primary stability\n\nExclusion Criteria:\n\n* Heavy smokers\n* Bruxism or clenching\n* Uncontrolled systemic disease\n* Chemotherapy\u002Fradiotherapy\n* Immunocompromised patients",true,"ALL","20 Years",{"count":20,"type":21},16,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar region. Sixteen patients requiring extraction and immediate implant placement will be randomly allocated into two groups. Clinical and radiographic outcomes including implant stability, peri-implant probing depth, modified bleeding index, marginal bone loss, buccal bone thickness, and bone density will be evaluated over a 9-month follow-up period.",[27,28,29],"Dental Implants","Immediate Implant Placement","Osseointegration",[31,32,33,34,29,35,36],"Melatonin","Dentin graft","Immediate implant","ADDG","CBCT","Dental implant stability","RECRUITING","2026-05-20",{"date":40,"type":41},"2026-05-28","ACTUAL",{"date":43,"type":41},"2025-08-11",{"date":45,"type":21},"2026-11-10",{"name":47,"class":48},"Suez Canal University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":49},"100567227","erythropoietin-gel-effect-on-dental-implant-stability-100567227","NCT06665451","Erythropoietin Gel Effect on Dental Implant Stability","Evaluation of Erythropoietin Gel Effect on Stability of Immediate Implant ( Clinical and Radiographical Study )","Inclusion Criteria:\n\n* All patients Should have nonrestorable teeth in the anterior maxilla indicated for extraction and seeking implant placement.\n* Good general periodontal health and maintenance.\n\nExclusion Criteria:\n\n* Heavy smokers who smoke more than ten cigarettes per day\n* Acute infected socket\n* Ant socket with wall defect.\n* Pregnency\n* Local or systemic conditions that will interfere with bone healing (uncontrolled diabetes mellitus or human immune deficiency virus infections, resonance therapy), bone disorders (hyperparathyroidism, osteoporosis, or Paget's disease.\n* Patients who had subjected to intravenous and\u002For oral bisphosphonate therapy.","50 Years",{"count":59,"type":21},24,[24],"* Achieving and maintaining long-term osseointegration for dental implants is a key objective in the field of dentistry. The success of osseointegration is influenced by the surface treatment applied to dental implants. Numerous coating techniques have been developed to improve and speed up osseointegration.\n* The aim of the current study is to assess immediate dental implant stability coated with erythropoietin gel, both clinically and radiographically.\n* Materials and Methods: We conducted a randomized controlled clinical trial.The sample will include patients demanding immediate implant treatment in the anterior maxilla . Patients will be randomly allocated into the two groups of the study. The group A will be treated with erythropoietin gel coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla . Group B will be treated with non coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla .\n* The primary outcome variable will be implant stability and the secondary outcome will be crestal marginal bone level and bone density around implants. It will be measured at time of implant placement and reevaluated after 6-months .",[29],"2026-05-15",{"date":65,"type":41},"2026-05-18",{"date":67,"type":41},"2025-03-15",{"date":69,"type":21},"2026-07",{"name":71,"class":48},"Al-Azhar University",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":49},"100613235","phase-1-influence-of-prosthetic-foot-stiffness-on-transtibial-osseointegrated-bone-anchored-limb-outcomes-100613235","NCT07263945","Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes","TBAL","Inclusion Criteria:\n\n* Unilateral transtibial amputation due to traumatic, congenital, or cancer-related causes\n* \\> 12-months bone-anchored limb implantation surgery (Bone Anchored Limb group)\n* \\> 12-months limb amputation (Socket Control group)\n* Non-vascular amputation etiology\n* Low profile prosthetic foot (nominal)\n* Can walk unassisted for 5-minutes\n* \\> 18 years old\n\nExclusion Criteria:\n\n* Major amputation on contralateral limb\n* Vascular amputation etiology\n* Neurologic pathology that impairs coordination\u002Fbalance\n* Regular assistive device use required for community ambulation\n* Inflammatory diseases or diabetes\n* Pregnancy or breastfeeding","18 Years",{"count":81,"type":21},60,[83],"PHASE1","A clinical trial utilizing cross-over study design in which individuals with transtibial amputation using either a bone-anchored limb or standard socket prosthesis will perform activities of daily living with varying prosthetic foot stiffness categories to complete the following 4 Specific Aims: 1) Determine the influence of prosthetic foot stiffness on dynamic bone-implant loading, 2) Determine how prosthetic foot stiffness influences function, pain, and multi-joint biomechanics outcomes, 3) Establish how prosthetic foot stiffness influences osseoperception and fall risk, and 4) Establish target ranges of optimal foot stiffness based on the sensitivity biomechanical outcomes to variability in foot stiffness.",[86,87,88,29],"Amputation","Transtibial Amputation - Unilateral","Bone Anchored Devices",[90,91,92,93,94,95],"amputation","bone anchored limb","osseointegration","transtibial amputation","below knee amputation","prosthetics","2026-04-20",{"date":98,"type":41},"2026-04-21",{"date":100,"type":41},"2025-11-25",{"date":102,"type":21},"2030-05-31",{"name":104,"class":48},"University of Colorado, Denver",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":113,"phases":4,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":4},"100575840","advancing-antimicrobial-photodynamic-therapy-to-prevent-infection-in-osseointegrated-prosthesis-patients-100575840","NCT06777511","Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients","Inclusion Criteria:\n\n* All patients with osseointegrated prostheses 18 years of age or older\n\nExclusion Criteria:\n\n* Ongoing infection\n* Pregnant\n* Anticipated issues with compliance or follow-up",{"count":112,"type":21},10,"OBSERVATIONAL","This will be a prospective observational trial enrolling 20 patients with osseointegrated prostheses. Participants will be recruited from the orthopaedic outpatient clinic at Walter Reed National Military Medical Center in Bethesda, MD.\n\nAll eligible consenting patients will undergo daily stoma management per standard of care.\n\nPatients will integrate antimicrobial photodynamic therapy into their stoma management program. The first treatment will take place in the orthopaedic clinic. All others will take place at home. Topical 5-ALA will be applied to the metal at the penetration site. After 2 hours, the light delivery device will be utilized and light will be administered for 15 minutes.\n\nData collection: After obtaining informed consent, study personnel will record injury-specific variables, surgery-specific variables, other variables related to their hospital course, demographic variables as well as comorbidities on the study case report forms (CRFs). They will obtain this information directly from the participant, from the participant's medical record, and the participant's treating orthopaedic surgeon or other health care providers. Baseline data collection points include participant characteristics and amputation details such as age, sex, comorbidities, highest education level achieved, social support, initial reason for amputation, type of amputation and all surgical dates. Study participants will be followed at 1 and 2 weeks after initiation of PDT treatment. To ensure research participant safety, serious adverse events (SAEs) will be documented and promptly submitted to the local IRB as per the required reporting processes.\n\nFollow-up: Study participants will be followed at 1 week and 2 weeks.",[86,29],"NOT_YET_RECRUITING","2026-02-03",{"date":119,"type":41},"2026-02-04",{"date":121,"type":21},"2026-03-01",{"date":123,"type":21},"2027-03-28",{"name":125,"class":48},"Dartmouth-Hitchcock Medical Center",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":113,"phases":4,"briefSummary":136,"conditions":137,"keywords":138,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":154},"100615787","movement-of-dental-implants-during-osseointegration-100615787","NCT07297147","Movement of Dental Implants During Osseointegration","Do Dental Implants Move During Osseointegration? A Prospective Multicenter Clinical Study Using Intraoral Scan Superimposition and Stability Analysis.","MOVs-OI","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Indication for a single implant-supported restoration.\n* Good general health and absence of active periodontal disease.\n* Willingness to provide written informed consent and to undergo two intraoral scans (immediately after implant placement - T0 - and before prosthetic loading - T1).\n\nExclusion Criteria:\n\n* Uncontrolled systemic disease or any medical condition contraindicating implant surgery.\n* High-risk antiresorptive therapy (e.g., intravenous bisphosphonates or denosumab).\n* Pregnancy or breastfeeding, if applicable to local policy.\n* Inability to attend the T1 follow-up visit or contraindication to intraoral scanning (e.g., limited mouth opening, severe gag reflex).",{"count":135,"type":21},100,"Prospective multicenter observational study assessing whether dental implants undergo three-dimensional positional change between placement (T0) and pre-loading after osseointegration (T1). Two intraoral scans (STL) will be superimposed to quantify linear (mm) and angular (degrees) displacement. Clinical variables include insertion torque, primary and secondary ISQ, anatomical site, placement timing, operator-perceived bone density (Lekholm \\& Zarb), bruxism, and night guard use. The primary endpoint is the 3D displacement at \\~3-4 months. Multivariable analyses will explore associated factors.",[27,29],[139,29,140,141,142,143,144],"Dental implants","Intraoral scan","Micromotion","ISQ","Insertion torque","Bruxism","2025-12-09",{"date":147,"type":41},"2025-12-22",{"date":149,"type":21},"2026-01-01",{"date":151,"type":21},"2027-10-01",{"name":153,"class":48},"Aula Dental Avanzada",3,{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":22,"phases":165,"briefSummary":166,"conditions":167,"keywords":169,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":49},"100550616","the-application-of-root-analogy-implant-in-immediate-implantation-100550616","NCT06449391","The Application of Root Analogy Implant in Immediate Implantation","A Clinical Exploratory Study of Root Analogy Implant","RAI","Inclusion Criteria:\n\n* Age:20-60 years old, gender unlimited\n* Good oral hygiene\n* No systemic diseases\n* There are irreparable residual roots, no obvious apical periodontitis, no looseness greater than degree II, and the tooth position includes four quadrant anterior teeth and premolars\n* Root length greater than 10 mm, and no significant bone resorption at the alveolar crest\n* There is no significant displacement of adjacent teeth and no significant elongation of opposing teeth\n* The bone density of the target implant area is Class II and Class III\n* The lateral bone wall of the lips (cheeks), palate (tongue) is intact and larger than 1mm\n* The subjects are able to understand the purpose of the experiment, willing to -cooperate with surgical treatment and follow-up, voluntarily participate in the experiment, and sign an informed consent form.\n\nExclusion Criteria:\n\n* Patients with moderate to severe periodontitis\n* Missing proximal and distal adjacent teeth in the target residual root\n* Residual roots with root adhesion\n* The target implant area has a bone density of Class I or IV\n* Acute infectious disease or metabolic bone disease activity period\n* Patients with diabetes history and poor blood glucose control (fasting blood glucose ≥ 8.8 mmol\u002FL L)\n* Patients with liver and kidney dysfunction (AST, ALT ≥ 1.5 times ULNULN, creatinine ≥ 1.5 times ULNULN)\n* Individuals with a history of osteoporosis\n* Individuals with a history of malignant tumors or other serious illnesses who are not suitable for surgery\n* Individuals with mental disorders and lack of autonomous behavior ability Pregnant women, lactating or menstruating women, and women with pregnancy plans within six months\n* Various possible causes of imaging artifacts in the surgical area\n* Receiving medication that may affect bone metabolism (such as bisphosphonates) within the past 3 months\n* The researchers estimate poor compliance or other factors that are not suitable for conducting this experiment.","60 Years",{"count":112,"type":21},[24],"The current clinical implant techniques used include immediate implantation, early implantation, and delayed implantation. With the acceleration of the current pace of life, immediate implantation is increasingly favored by patients due to its advantages such as fewer surgeries, shorter waiting times, and less impact on aesthetics. The research group has shown that the mismatch between traditional implants and extraction sockets in immediate implantation surgery has caused some complications. Therefore, it is believed that 3D printed personalized root shaped implants with certain roughness are more suitable for use in immediate implantation surgery.",[168,27,29],"Dental Implantation",[170,171],"root analogy implant","Immediate implantation","2024-06-06",{"date":174,"type":41},"2024-06-10",{"date":176,"type":41},"2024-04-01",{"date":178,"type":21},"2026-06-30",{"name":180,"class":48},"The Dental Hospital of Zhejiang University School of Medicine"]