[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteearthritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteearthritis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,71,103,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100638081","effects-of-mobilized-balance-platform-exercises-on-balance-parameters-in-patients-with-knee-osteoarthritis-100638081",false,"NCT07575425","Effects of Mobilized Balance Platform Exercises on Balance Parameters in Patients With Knee Osteoarthritis","Effects of Mobilized Balance Platform Exercises on Balance Parameters, Functional Status, and Pain in Patients With Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged between 45 and 65 years\n* Diagnosis of knee osteoarthritis classified as Kellgren-Lawrence grade 2 or 3\n* Willingness to participate voluntarily in the study\n\nExclusion Criteria:\n\n* Presence of orthopedic knee implants\n* Kellgren-Lawrence grade 1 or grade 4 knee osteoarthritis\n* Sensory impairment\n* Diagnosis of malignancy\n* Unhealed fractures\n* Circulatory disorders\n* Infection around the knee joint\n* Severe hearing loss or visual impairment\n* Cognitive impairment\n* Uncontrolled hypertension or diabetes mellitus\n* Vestibular disorders causing balance problems, such as vertigo\n* Use of walking assistive devices such as canes or walkers","ALL","45 Years","65 Years",{"count":20,"type":21},36,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective single-blind randomized controlled study aims to investigate the effects of mobilized balance platform exercises on balance parameters, pain, functional status, fear of falling, and kinesiophobia in patients with knee osteoarthritis. A total of 36 patients diagnosed with knee osteoarthritis will be recruited from the outpatient clinic of Gaziler Physical Medicine and Rehabilitation Training and Research Hospital.\n\nParticipants will be randomly assigned to one of two groups. The control group will receive conventional physical therapy including transcutaneous electrical nerve stimulation (TENS) and a home exercise program consisting of knee strengthening, balance, range of motion, proprioceptive, and stretching exercises. The intervention group will receive the same conventional treatment in addition to mobilized balance platform exercises using the Huber 360 system.\n\nPain severity, functional status, balance parameters, fear of falling, and kinesiophobia will be evaluated before and after treatment by an assessor blinded to treatment allocation.",[27,28],"Osteearthritis","Knee Arthritis, Osteoarthritis","RECRUITING","2026-05-03",{"date":32,"type":33},"2026-05-08","ACTUAL",{"date":35,"type":33},"2026-05-04",{"date":37,"type":21},"2026-10-30",{"name":39,"class":40},"Gaziler Physical Medicine and Rehabilitation Education and Research Hospital","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":41},"100626650","tecar-therapy-in-chronic-knee-osteoarthritis-100626650","NCT07438392","Tecar Therapy in Chronic Knee Osteoarthritis","Effects of Tecar Therapy (Targeted Radiofrequency Therapy) on Pain, Physical Function, and Physical Capacity in Patients With Chronic Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients with Kellgren-Lawrence stage 2 or 3 knee osteoarthritis\n* Patients with bilateral knee pain for at least 6 weeks\n* Male and female patients aged 40-75\n* Patients who accept and sign the informed consent form\n\nExclusion Criteria:\n\n* Those who have received physical therapy for knee pain in the last 6 months\n* Those who have received intraarticular injection treatments such as hyaluronic acid, PRP, or steroids for knee pain in the last 6 months\n* Those who have undergone knee surgery for any reason\n* Those with inflammatory arthritis\n* Those with existing neurological, cognitive, or psychiatric disorders\n* Those with pacemakers\n* Those with a history of malignancy\n* Those with local vascular or sensory impairment\n* Those with local or systemic infections\n* Those with open wounds on the skin\n* Pregnant or breastfeeding","40 Years","75 Years",{"count":52,"type":21},60,[24],"This study aimed to investigate the effects of Tecar therapy on pain, physical function, and physical capacity in patients with chronic knee osteoarthritis.",[27],[57,58,59,60],"osteoarthritis","Radiofrequency Therapy","Pain","Physical Functional Performance","NOT_YET_RECRUITING","2026-02-27",{"date":64,"type":33},"2026-03-02",{"date":66,"type":21},"2026-04-01",{"date":68,"type":21},"2026-08-01",{"name":70,"class":40},"Kirsehir Ahi Evran Universitesi",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":98,"leadSponsor":100,"locationsCount":102},"100623407","effects-of-diagonal-proprioceptive-neuromuscular-facilitation-patterns-on-pain-and-functional-outcomes-in-patients-with-knee-osteoarthritis-100623407","NCT07396233","Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Both male and females with an age range between 40-60 years.\n* Patients diagnosed with unilateral or bilateral Knee OA.\n* Grade-II or grade-III on kellgren and Lawrence classification.\n* Patients having pain intensity more than 3.4 cm on VAS as minimum cut off value.\n* Duration of knee OA more than 3 months (chronic).\n\nExclusion Criteria:\n\n* Patients with any neurological disorder.\n* History of lower limb arthroplasty or any other knee surgery.\n* Septic knee arthritis.\n* Inflammatory rheumatic disease such as rheumatoid arthritis and gout.\n* Cancer or any other malignancy such as bone tumor.\n* Knee deformities such as contracture, genu valgum and genu varum.\n* History of ligamentous injury and meniscal tear.","60 Years",{"count":79,"type":21},150,[24],"A randomized controlled trial will be conducted at the Department of Physiotherapy, Dr. Ziauddin Hospital and Al-Rayaz Hospital, Karachi, Pakistan. A total of 150 patients diagnosed with knee osteoarthritis, aged between 40-60 years, will be recruited through a non-probability purposive sampling technique. Written informed consent will be obtained from all eligible participants prior to enrollment. The participants will be randomly allocated by the help of computer generated randomization sheet, into two groups i.e. experimental and the control group, with 75 participants in each group. Group A (experimental group) will receive diagonal proprioceptive neuromuscular facilitation (PNF) pattern exercises, while Group B (control group) will receive conventional strength training exercises. Heat therapy will be administered to both groups. All participants will be assessed using a standardized assessment form. Outcome measures will include pain intensity, knee range of motion, functional disability, hamstring flexibility, dynamic balance, and fatigue level. A single blinded assessor will assess all participants at baseline and at post intervention. Treatment sessions will be given thrice a week on alternate days for 6 weeks.",[83,27,84],"Knee Osteoarthristis","Knee Pain Arthritis",[86,87,88,89,90,91,92,93],"Knee Osteoarthritis","Functional Disability","Knee Pain","Conventional Training","Osteoarthritis","Arthritis","Musculoskeletal Disease","Joint Disease","2026-02-07",{"date":96,"type":33},"2026-02-11",{"date":94,"type":33},{"date":99,"type":21},"2027-02-22",{"name":101,"class":40},"University of Karachi",2,{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":111,"sex":16,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100617256","value-of-adding-t2-mapping-routine-mri-in-assessment-of-knee-articular-cartilage-early-osteoarthritis-100617256","NCT07316257","Value of Adding T2 Mapping Routine MRI in Assessment of Knee Articular Cartilage Early Osteoarthritis","Value of Adding T2mapping Sequence to Routine MRI Protocol in Assessment of Knee Articular Cartilage in Early Osteoarthritis","T2 mapping OS","Inclusion Criteria:\n\n* patients with clinical evidence of osteoarthritis\n\nExclusion Criteria:\n\n* • contraindications for MRI such as claustrophobia, heart pacemaker and ferromagnetic implants\n\n  * patients in which the misaligned images or distortions due to motion artifacts made the interpretation of the MRI unreliable.\n  * Patients with previous knee operation",true,"20 Years","50 Years",{"count":115,"type":21},70,"OBSERVATIONAL","This work aims at elucidating the role of MRI complementary T2 mapping in assessment of the articular knee cartilage for improving sensitivity of detection of early stage of osteoarthritis",[27,119,120],"OA","OA Knee","2025-12-30",{"date":123,"type":33},"2026-01-05",{"date":125,"type":21},"2026-01-01",{"date":127,"type":21},"2027-02-01",{"name":129,"class":40},"Assiut University",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":147,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":41},"100617459","effect-of-agarcollagen-based-compounds-on-osteoarticular-pain-randomized-triple-blind-clinical-trial-100617459","NCT07318896","Effect of Agar\u002FCollagen-based Compounds on Osteoarticular Pain: Randomized Triple-blind Clinical Trial","Evaluation of the Effect of Agar and\u002For Collagen Based Compounds on Osteoarticular Pain. A Randomized, Parallel, Placebo Controlled, Triple Blind Clinical Trial (AGARTROSIS)","AGARTROSIS","Inclusion Criteria:\n\n* Men and women between 40 and 70 years of age.\n* Submit a score of 6 to 10 out of 20 on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) knee pain questionnaire.\n* Sign the informed consent form.\n* Know how to read, write, and speak Spanish and\u002For Catalan.\n\nExclusion Criteria:\n\n* Present body mass index (BMI) values \\\u003C18.5 kg\u002Fm\\^2 or ≥30 kg\u002Fm\\^2.\n* Present intolerances or allergies related to Agar-Agar, or any of the components of the products being evaluated, such as collagen or maltodextrin.\n* Take or have taken medications that may affect the study results. This is especially true for those who have been treated with oral or intra-articular corticosteroids within the 4 and 12 weeks prior to screening, respectively, or medications for osteoarthritis at the time of screening.\n* Patients who depend on prescription medications for pain control.\n* Take multivitamin or mineral supplements, collagen derivatives, or supplements containing bioactive compounds that may exert an anti-inflammatory effect, such as turmeric, ginger, omega-3, or polyphenol supplements.\n\n(Individuals who consume multivitamin, mineral, or collagen-derived supplements or supplements will be eligible to participate in the study, provided they are willing to discontinue their intake for at least two weeks prior to the start of the study and throughout the entire study period).\n\n* Be an active smoker or have been one for less than 6 months.\n* Alcohol consumption:\n\n  * Men: Consume 4 or more Standard Drink Units (SDU) daily or SDUs weekly.\n  * Women: Consume 2 or more Standard Drink Units (SDU)\\* daily or SDUs weekly.\n* Have a diagnosis of osteoarthritis, active rheumatoid arthritis, and any inflammatory arthritic condition such as secondary inflammatory arthritis, gout, pseudogout, knee infection, marked angular deformities, or significant injury to the target joint within the 6 months prior to the start of the trial; arthroplasty and joint surgery of the target knee within the 2 years prior to the start of the study.\n* Have any gastrointestinal disease that affects the absorption of the compound and\u002For the study results, such as celiac disease, Crohn's disease, active cancer of any organ of the digestive or renal system, or hepatitis.\n* Be ineligible to participate in the study, according to the pre-screening evaluator's criteria.\n* Have lost 3 kg or more in the last 3 months.\n* Be pregnant or intend to become pregnant.\n* Be breastfeeding.\n* Be unable to follow the study guidelines.\n* Be participating or have participated in a clinical trial involving drug intervention or nutritional intervention within the last 30 days prior to inclusion in the study.","70 Years",{"count":140,"type":21},80,[24],"Joints-comprising bone, cartilage, ligaments, and synovial fluid-enable stable daily movement but may deteriorate with age, excess body weight, overuse, injury, or disease. Such degeneration, common from age 40 onward, underlies joint disorders like osteoarthritis, particularly in the knees, hips, hands, and spine, and is a major cause of chronic pain and disability. While antiinflammatory analgesics remain the standard approach to symptom control, they neither cure disease nor regenerate cartilage and can produce significant long-term adverse effects (gastrointestinal, hepatic, renal, and cardiovascular). These limitations motivate interest in natural or complementary strategies with safer profiles.\n\nWithin this context, marine algae, especially agar derived from red seaweed, have attracted attention for potential intestinal, metabolic, and joint benefits, aided by their fiber content. Another promising option is undenatured type II collagen (UC-II), the principal structural component of articular cartilage, whose endogenous production declines with age; clinical studies indicate that a daily intake of 40 mg UC-II can improve mobility, reduce pain, and enhance quality of life in individuals with osteoarthritis or exercise-related joint discomfort. Based on these considerations, an agar-agar supplement has been developed to relieve knee joint symptoms.",[27,144,145,146],"Joint Damage","Inflammation","Cartilage Damage",[148,149,150,151],"Agar-Agar","undenatured collagen type II","Joint pain","knee pain","2025-12-19",{"date":154,"type":33},"2026-01-06",{"date":156,"type":33},"2025-11-10",{"date":158,"type":21},"2027-02",{"name":160,"class":40},"Fundació Eurecat"]