[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteo-arthritis-knee-and-hip\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteo-arthritis-knee-and-hip":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,57,89,121],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":5},"100633852","comparative-effectiveness-of-exercise-cognitive-behavioural-therapy-and-their-combination-for-people-with-chronic-musculoskeletal-pain-and-poor-sleep-sleepfit-trial-100633852",false,"NCT07532070","COMPARATIVE EFFECTIVENESS OF EXERCISE, COGNITIVE BEHAVIOURAL THERAPY, AND THEIR COMBINATION FOR PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN AND POOR SLEEP: SLEEPFIT TRIAL","SLEEPFIT","INCLUSION CRITERIA Participants will be included if they have persistent LBP defined as i) age ≥18 years; ii) sought or seriously considered care from a primary care clinician or specialist for their LBP within the past 6 weeks; iii) have at least moderate LBP-related interference with normal work or daily activity (including both work outside the home and housework), as assessed by item 8 of the 36-item Short Form Health Survey OR hip or knee OA defined by the National Institute for Health and Care Excellence as: i) age ≥45 years; ii) activity-related hip or knee joint pain; and iii) no morning hip or knee stiffness, or morning stiffness ≤30 minutes)\n\n* An average pain of ≥4 on an 11-point numerical rating scale (NRS); 0 equals no pain, 10 equals worst pain possible over the last week\n* ≥11 on the Insomnia Severity Index\n* Access to a computer\u002Flaptop\u002Ftablet with internet availability for videoconferencing consultations\n* Willing and able to participate in video consultations\n* Verification that participants recruited in the US are beneficiaries of the Military Health System.\n\nEXCLUSION CRITERIA\n\n* Self-report engagement in \\>120 minute per week of at least moderate intensity physical activity within the past 6 months\n* Current or previous engagement in CBT-I in the past 6 months\n* Cognitive impairment (based on ≥7 on the Short Orientation Memory Concentration Test\n* Received an injection of any substance into the study pain site in the previous 3 months\n* Waiting or planning to receive an injection in the study pain site in the next 12 months\n* Had within the past 12 months, or waiting or planning surgery in the next 12 months\n* Neurological or systemic conditions that may affect physical function (e.g. Parkinson's, Active cancers, multiple sclerosis, rheumatoid arthritis, ankylosing spondylitis)\n* Failing the American College of Sports Medicine pre-participation Health Screening Questionnaire without medical clearance to participate\n* Unable to give informed consent and\u002For participate in the intervention and assessment procedures.\n* Unable to speak or read English.","ALL","18 Years",{"count":19,"type":20},384,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to find out which lifestyle approach works best for people with chronic musculoskeletal pain (such as low back pain or hip\u002Fknee osteoarthritis) who also have poor sleep. Participants will be randomly assigned to one of three 12-month home-based programs: exercise, cognitive behavioral therapy for insomnia (CBT-I), or a combination of both. Each program includes up to 10 online sessions with a physiotherapist and guidance on managing pain, sleep, and physical activity. We will measure changes in pain, sleep quality, and overall health using questionnaires, wearable devices, sensory tests, and blood samples. The goal is to improve understanding of non-medication treatments for pain and sleep problems.",[26,27,28],"Osteo Arthritis Knee and Hip","Low Back Pain","Insomnia",[30,31,32,33,34,28,35,36,37,38,39,40,41,42,43,44],"Chronic musculoskeletal pain","Low back pain","Hip osteoarthritis","Knee osteoarthritis","Poor sleep","Cognitive Behavioral Therapy for Insomnia (CBT-I)","Exercise therapy","Lifestyle intervention","Non-pharmacological treatment","Randomized controlled trial","Sleep quality","Pain management","Physiotherapy","Wearable activity monitor","Sleep EEG","RECRUITING","2026-05-04",{"date":48,"type":49},"2026-05-05","ACTUAL",{"date":51,"type":20},"2026-04",{"date":53,"type":20},"2029-04",{"name":55,"class":56},"University of Sydney","OTHER",{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":16,"minAge":65,"maxAge":4,"enrollmentInfo":66,"targetDuration":4,"studyType":21,"phases":68,"briefSummary":69,"conditions":70,"keywords":71,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100625532","predicting-the-right-advice-at-the-right-time-in-patients-with-hip-and-knee-osteoarthritis-the-e-coach-cross-over-100625532","NCT07423858","Predicting The Right Advice at The Right Time in Patients With Hip and Knee OsteoArthritis: the e-cOAch Cross-over.","Developing Data Driven Algorithms for Predicting The Right Advice at The Right Time in Patients With Hip and Knee OsteoArthritis: The e-cOAch Cross-over Study","e-cOAch","Inclusion Criteria:\n\n1. Have a hip or knee joint that, self-administered through a questionnaire, meets the National\n\n   Institute for Health and Care Excellence clinical criteria for osteoarthritis:\n   1. Aged 45 years or over and;\n   2. Activity-related pain at the joint and;\n   3. Joint morning stiffness that lasts no longer than 30 minutes or no morning stiffness at the joint;\n2. History of pain at the joint for at least 3 months;\n3. Have access to a smartphone with internet connection and an email address;\n4. Able to give informed consent and willing to commit to all study evaluation and assessment procedures\n5. Able to read and understand texts in Dutch at B1 level.\n\nExclusion Criteria:\n\n1. Self-reported systemic arthritis (e.g., rheumatoid arthritis, gout) avoid confounding due to overlapping symptoms;\n2. Scheduled for lower limb joint surgery within the next year or underwent lower limb joint surgery (total hip, total knee) the last year as surgical interventions could affect outcomes and confound the assessment of treatment effects.","45 Years",{"count":67,"type":20},600,[23],"This study aims to learn how symptoms and daily functioning change over time in people with hip or knee osteoarthritis (OA). The goal is to use this information to build computer models that can predict these changes. In the future, these models may help give people with OA the right self-care advice at the right time through a web application called ArtroseCoach.\n\nPeople with OA will take part in this study for one year. Every two weeks, they will fill in online questionnaires covering various aspects of their health and daily functioning, such as pain, daily activities, and participation in life. During the year, participants will be randomly assigned to one of several self-care programs in the ArtroseCoach web app. These programs focus on physical activity, weight management, or sleep. Each program lasts 12 weeks. At four points during the year (weeks 3, 15, 27, and 39), participants will receive one of these programs or no program at all. No one will receive the same program twice.\n\nThe ArtroseCoach web app provides education about OA, lifestyle advice, and tips to support behavior change. The study will help researchers understand which factors are linked to changes in pain and physical functioning over time. This knowledge will be used to improve the ArtroseCoach and other future tools that support people with OA in managing their condition on their own.",[26],[72,73,74,75,76,77,78],"Stepped care","Self-management","Lifestyle behaviours","Movement behaviour","Sleep behaviour","Weight management","Hip and knee osteoarthritis","2026-02-17",{"date":81,"type":49},"2026-02-20",{"date":83,"type":49},"2025-09-01",{"date":85,"type":20},"2027-02",{"name":87,"class":56},"UMC Utrecht",1,{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":16,"minAge":96,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":21,"phases":99,"briefSummary":100,"conditions":101,"keywords":102,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100622447","test-retest-reliability-of-a-submaximal-exercise-test-in-patients-with-hip-and-knee-osteoarthritis-100622447","NCT07383740","Test-Retest Reliability of a Submaximal Exercise Test in Patients With Hip and Knee Osteoarthritis","Test-Retest Reliability of a Submaximal Exercise Test in Patients With Hip- and\u002For Knee Osteoarthritis","Inclusion Criteria:\n\n* Currently listed on the waiting list for an osteoarthritis rehabilitation program due to clinically diagnosed hip and\u002For knee osteoarthritis.\n\nExclusion Criteria:\n\n* Another primary cause of symptoms or disability, such as inflammatory joint disease or fracture.\n* Another condition currently causing more symptoms than osteoarthritis, for example fibromyalgia.\n* Insufficient understanding of written and spoken Swedish.\n* Medication that affects heart rate.\n* Contraindications for a submaximal ergometer bicycle test according to the screening protocol, such as heart disease.","30 Years",{"count":98,"type":20},40,[23],"The aim is to evaluate the test-retest reliability of the primary care-adapted Ekblom-Bak submaximal ergometer bicycle test in patients with hip- and\u002For knee osteoarthritis (OA).\n\nForty patients with hip- and\u002For knee OA eligible for the Swedish national OA treatment program in primary care are to be recruited. After screening for contraindications, participants will perform the aEB-test twice within 1-2 weeks.\n\nThe investigators hypothezise that the test will demonstrate acceptable test-retest reliability in patients with hip- and\u002For knee OA.\n\nTo establish reliability is essential for future studies using this test in this population and may support its integration into routine clinical assessment.",[26],[103,104,105,106,107,108,109],"Osteoarthritis","knee osteoarthritis","hip osteoarthritis","exercise test","reliability","cardiorespiratory fitness","test-retest","NOT_YET_RECRUITING","2026-02-03",{"date":113,"type":49},"2026-02-06",{"date":115,"type":20},"2026-03",{"date":117,"type":20},"2027-10",{"name":119,"class":120},"Vastra Gotaland Region","OTHER_GOV",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":21,"phases":130,"briefSummary":132,"conditions":133,"keywords":136,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":4},"100618631","phase-4-general-anaesthesia-vs-spinal-anaesthesia-patient-outcomes-and-success-in-outpatient-primary-total-knee-and-hip-arthroplasty-100618631","NCT07334132","General Anaesthesia vs Spinal Anaesthesia: Patient Outcomes and Success in Outpatient Primary Total Knee and Hip Arthroplasty","GASPS","Inclusion Criteria:\n\n1. The participant has given their written consent to participate in the trial.\n2. Planned for primary TKA or THA.\n3. Adults aged 18 to 80 years at time of written consent.\n4. ASA (American Society of Anaesthesiologists) classification 1 or 2, or 3 without significant functional impairment.\n5. Scheduled start of surgery before 13:00.\n6. Ability to communicate in Swedish, ensuring understanding of informed consent and follow-up procedures.\n\nExclusion Criteria:\n\n1. Indication for surgery other than degenerative or inflammatory joint diseases (e.g. fracture).\n2. Body mass index (BMI) \\> 35 kg\u002Fm.\n3. Preoperative opioid use exceeding 20 mg oral morphine equivalents daily.\n4. Haemoglobin \\\u003C 120 g\u002FL (sample no older than 3 months).\n5. Known bleeding disorders, including coagulopathies.\n6. Known allergies to investigational anaesthetic drugs (e.g., bupivacaine, remifentanil, or propofol).\n7. Neurological conditions with persistent motor or sensory deficits.\n8. Localised infections at the spinal injection site.\n9. Determined by the surgical or anaesthesia team to be unsuitable for trial participation and\u002For outpatient surgery.\n10. Women of childbearing potential (i.e., those who are fertile, following menarche and until becoming post-menopausal, unless permanently sterile)\n\n    1. Who are not willing to use a highly effective method of contraception judged by the investigator, from the time of signing the informed consent, OR\n    2. Who has a positive pregnancy test at enrolment","80 Years",{"count":67,"type":20},[131],"PHASE4","Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are common operations used to treat severe joint disease, most often caused by osteoarthritis. An increasing number of these procedures are now performed as outpatient surgery, meaning that patients can go home on the same day as the operation. This can be beneficial for both patients and healthcare systems, but it requires safe and efficient anaesthetic care.\n\nTwo different types of anaesthesia are commonly used for these operations: general anaesthesia (where the patient is asleep) and spinal anaesthesia (where the lower part of the body is numbed). Both methods are well established and widely used. Previous studies suggest that the choice of anaesthesia may affect how quickly patients recover, how comfortable they feel after surgery, and whether they can be safely discharged on the day of surgery. However, most existing studies are based on retrospective data, and there is limited randomized evidence comparing these anaesthetic techniques in the outpatient setting.\n\nThe GASPS trial is a multicentre, randomized, phase IV clinical study that compares general anaesthesia and spinal anaesthesia in adults undergoing outpatient primary total knee or hip arthroplasty. A total of 600 participants will be included and randomly assigned to receive one of the two anaesthetic methods on the day of surgery. All participants will receive standard surgical and perioperative care, and both anaesthetic techniques are part of routine clinical practice.\n\nThe main aim of the study is to investigate whether the type of anaesthesia influences the chance of successful same-day discharge, defined as going home on the day of surgery without needing to be readmitted within 48 hours. The study will also examine recovery time, pain, nausea and vomiting, use of pain medication, complications, patient-reported recovery and function, and healthcare costs. In addition, patient experiences of anaesthesia and postoperative recovery will be explored through interviews in a smaller group of participants.\n\nParticipants will be followed using questionnaires and medical records from the day of surgery up to 12 months after the operation. The results of this study are expected to provide clear and reliable information to help guide anaesthetic care for patients undergoing outpatient hip and knee replacement surgery.",[26,134,135],"Osteo Arthritis","Inflammatory Joint Disease (IJD)",[137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155],"Total Knee Arthroplasty","Total Hip Arthroplasty","Outpatient Surgery","Same-Day Discharge","Ambulatory Arthroplasty","General Anaesthesia","Spinal Anaesthesia","Neuraxial Anaesthesia","Total Intravenous Anaesthesia","Postoperative Recovery","Quality of Recovery","QoR-15","Postoperative Pain","Postoperative Nausea and Vomiting","PONV","Patient-Reported Outcomes","Health Economic Evaluation","Cost-Effectiveness","Randomized Clinical Trial","2026-01-02",{"date":158,"type":49},"2026-01-12",{"date":160,"type":20},"2026-04-01",{"date":162,"type":20},"2029-12-31",{"name":164,"class":56},"Region Örebro County"]