[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteoarthritic-knee-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteoarthritic-knee-pain":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100644751","enhancing-voluntary-motion-in-broad-patient-populations-with-modular-powered-orthoses-renewal-100644751",false,"NCT07673328","Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal","Inclusion Criteria:\n\nInclusion criteria for able-bodied, young participants will be:\n\n* Aged between 18 to 65 years\n* Weigh less than 300 lbs (due to challenges in bracing heavier participants)\n* BMI \\\u003C 40 (due to challenges in bracing heavier participants)\n\nInclusion criteria for knee osteoarthritis participants will be:\n\n* Aged between 30 to 85 years\n* Medical diagnosis of patellofemoral and tibiofemoral osteoarthritis\n* Patient reported pain ≥ 4 out of 10 during activities of daily life (to avoid floor effects)\n* Weigh less than 300 lbs (due to challenges in bracing heavier participants)\n* BMI \\\u003C 40 (due to challenges in bracing heavier participants)\n* Ability to walk 6 minutes without assistance from a person (may use walking aid)\n* Ability to ascend\u002Fdescend ramps and stairs with or without the use of handrails\n\nExclusion Criteria:\n\nExclusion criteria for able-bodied, young adult participants will be:\n\n* Pregnant (self-report)\n* Any significant neuromuscular or musculoskeletal disorder that would interfere with the study\n* Unable to walk for 20 minutes\n* History of any cardiovascular, vestibular, or visual diseases and\u002For impairments that may interfere with the study\n* Cognitive deficits that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of \\\u003C22.\n* Adults with a known allergy to medical grade tape\n\nExclusion criteria for knee osteoarthritis participants will be:\n\n* Pregnant (self-report)\n* Any recent lower-extremity fracture (within 6 months)\n* Significant limitation on knee joint range of motion\n* Significant neurological (e.g., stroke) or cardiovascular disorder that may affect the ability to walk\n* Advised by a physician not to walk or exercise\n* Uncontrolled hypertension or diabetes\n* Use of opioids\n* Cognitive deficits or visual impairment that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of \\\u003C22.\n* Adults with a known allergy to medical grade tape",true,"ALL","18 Years","85 Years",{"count":20,"type":21},65,"ESTIMATED","INTERVENTIONAL",[24],"NA","The overall goal of this project is to establish a novel design and control paradigm for modular, partial-assist powered orthoses (exoskeletons) to enhance voluntary lower-limb motion and manage pain in broad patient populations. Building upon a previous study period that addressed weakness from advanced age or muscle fatigue, this current period extends the technology to novel powered unloader orthoses designed to manage knee osteoarthritis (OA) pain. The investigators hypothesize that by providing 15-30% of biological joint torque, these motorized devices can reduce muscular contributions to painful loads on the joint's surfaces during activities of daily living (ADLs). The project aims to develop a task-agnostic, neural network-based controller and establish the feasibility of reducing knee pain and muscle effort in individuals with multi-compartment knee osteoarthritis.",[27,28,29],"Lower-limb Orthoses","Osteoarthritic Knee Pain","Osteoarthritis (OA) of the Knee","RECRUITING","2026-06-22",{"date":33,"type":34},"2026-06-29","ACTUAL",{"date":36,"type":34},"2025-07-18",{"date":38,"type":21},"2030-03-31",{"name":40,"class":41},"University of Michigan","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":66,"leadSponsor":68,"locationsCount":42},"100620713","percutaneous-transcatheter-genicular-embolization-in-osteoarthritis-100620713","NCT07361198","Percutaneous Transcatheter Genicular Embolization in Osteoarthritis","Inclusion Criteria:\n\n* Adults aged 40 to 80 years\n* Clinical symptoms consistent with chronic knee pain\n* Radiographically confirmed knee osteoarthritis of Kellgren-Lawrence grade II-IV or persistent knee pain following total knee arthroplasty\n* Insufficient pain relief after standard conservative treatment (e.g., pharmacological therapy, physical therapy, or injections)\n* Ability to understand the study procedures and provide written informed consent \\_ Willingness and ability to comply with the study procedures and follow-up schedule\n\nExclusion Criteria:\n\n* Active local or systemic infection\n* Known coagulation disorders or ongoing anticoagulation that cannot be safely interrupted\n* Significant peripheral arterial disease affecting the lower limbs\n* Known allergy or contraindication to iodinated contrast agents\n* Severe renal impairment\n* History of fibromyalgia or other generalized chronic pain syndromes that may confound pain assessment\n* Pregnancy or breastfeeding","40 Years","80 Years",{"count":52,"type":21},20,[24],"This clinical study investigates a minimally invasive treatment called percutaneous transcatheter embolization of knee arteries for patients with chronic knee pain caused by advanced knee osteoarthritis or persistent pain after total knee replacement. Osteoarthritis of the knee is a common degenerative condition that can lead to long-term pain, reduced mobility, and decreased quality of life, and some patients do not achieve sufficient relief with standard treatments.\n\nThe study is based on the hypothesis that targeted embolization of small arteries supplying the inflamed tissues of the knee can safely reduce abnormal blood flow associated with inflammation, leading to pain relief and improved knee function. During the procedure, a thin catheter is guided through the blood vessels to the affected area of the knee, where a temporary embolic agent is administered to reduce pathological blood supply.\n\nThe aim of the study is to evaluate the safety and effectiveness of this procedure by assessing changes in pain intensity, knee function, and quality of life over a follow-up period of up to 24 months. The results of this study may help determine whether this minimally invasive approach can offer a new treatment option for patients who have limited alternatives for managing chronic knee pain",[28,56,57],"Osteo Arthritis of the Knee","Osteoarthitis",[59,60,61],"genicular artery embolisation","osteoarthritis","MSK embolisation","2026-02-02",{"date":64,"type":34},"2026-02-04",{"date":62,"type":34},{"date":67,"type":21},"2029-12-01",{"name":69,"class":41},"Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":82,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":102},"100353113","freedom-1-study-for-chronic-knee-pain-100353113","NCT03877653","Freedom-1 Study for Chronic Knee Pain","Double-Blinded Randomized Control Trial of Knee Pain Utilizing Sub-Threshold Peripheral Nerve Stimulation","Inclusion Criteria:\n\ni. Subject is over 18 years of age; ii. Subjects with a history of chronic, function-limiting (m-MPS \\>6\u002F10) knee pain from osteoarthritis of at least three months in duration with or without prior surgeries; iii. Subject has been diagnosed with Kellgren-Lawrence Grade II or III knee osteoarthritis, confirmed by X-ray studies conducted in the last year; iv. Subject has been examined and has been deemed to be an appropriate candidate for the procedure, including chronic knee pain in patients post total knee replacement (TKR); v. Subjects who are able to understand this investigation, and give voluntary, written informed consent to participate in this study; vi. Subjects who are able to co-operate with the study procedures and are willing to return to the center for all the required post-operative follow-ups; vii. Documented failure of at least two less invasive treatment modalities including physical therapy, intra-articular steroids and\u002For oral NSAIDS; viii. Subject has not had recent invasive surgical procedures of the knee within the following intervals in relation to the time of signing Informed Consent:- 2 weeks for steroid injection - 4 weeks for radiofrequency, cryoablation or hyaluronic acid (HA) injection ix. Subject noted good (\\> 75%) but only temporary relief for at least 2 hours from an infrapatellar saphenous nerve injection with local anesthetic; x. Subject is deemed to be neuro-psycho-socially appropriate for implantation therapies based of assessment of a Clinical Psychologist.\n\nExclusion Criteria:\n\nxi. Significant contralateral knee pain that would influence their level of activity greater to 6 on the modified-Mankosky Pain Scale; xii. Hip or foot pain greater than knee pain; xiii. Neurogenic or vascular claudication; xiv. Subject has been diagnosed with Kellgren-Lawrence Grade IV knee osteoarthritis, confirmed by X-ray studies conducted in the last year; xv. Uncontrolled major depression or uncontrolled psychiatric disorders; xvi. Uncontrolled or acute medical illnesses including coagulopathy, renal insufficiency, chronic liver dysfunction, progressive neurological deficit, infection, unstable angina, and severe chronic obstructive pulmonary disease; xvii. Chronic severe conditions that could interfere with the interpretations of the outcome assessments for pain and bodily function (eg. Rheumatoid arthritis, severe spinal stenosis, activity-limiting cardiac disease); xviii. Women who are pregnant or planning to become pregnant, lactating; xix. Body mass index (BMI) greater than 40 (morbid obesity); xx. Subjects with multiple complaints involving concomitant knee, foot, or ankle pathology or radiculopathy, that will not be amenable to study due to the overlap of pain complaints; xxi. Subject has been examined and has been deemed to be inappropriate for the procedure based on anatomical restrictions; xxii. Lymphedema or stasis ulcers or other conditions that would compromise the surgical site; xxiii. History of adverse reaction to local anesthetic drugs; xxiv. Worker's compensation claimants; xxv. Incarcerated or has an ankle position locator; xxvi. Documented allergy to device material components; xxvii. Known or suspected substance abuse within the last 2 years; xxviii. Pacemaker or implanted defibrillator; xxix. Participation in another clinical study that could confound the results of this study; xxx. Based on the opinion of the investigator any legal or medical concerns that would preclude his\u002Fher enrollment in the study or potentially confound the results; xxxi. Any other implanted active medical devices in the same site.",{"count":78,"type":21},100,[24],"To demonstrate the potential benefits and risk of active sub-threshold stimulation in the treatment of chronic knee pain as compared to subjects that did not have active stimulation. Improvement will be assessed in relation to the clinical outcome measures of pain, with primary endpoint; Pain relief rate as measured by the number of subjects with greater or equal to a 50% decrease in pain on the visual analog scale, comparing baseline to the 1-month follow-up.",[28],[83,84,85,86,87,88,89,90,91],"PNS","Chronic","Pain","Wireless","Neuromodulation","knee","osteoarthritic","peripheral nerve stimulation","infra patellar saphenous","2025-02-11",{"date":94,"type":34},"2025-02-13",{"date":96,"type":34},"2021-09-01",{"date":98,"type":21},"2027-06",{"name":100,"class":101},"Curonix LLC","INDUSTRY",13]