[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteoarthritis-in-postmenopausal-women\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteoarthritis-in-postmenopausal-women":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100623381","phase-3-effect-of-metformin-iontophoresis-on-knee-osteoarthritis-in-postmenopausal-women-100623381",false,"NCT07395895","Effect of Metformin Iontophoresis on Knee Osteoarthritis in Postmenopausal Women","Effect of Metformin Iontophoresis Combined With Physical Therapy Rehabilitation on Knee Osteoarthritis in Postmenopausal Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial","Inclusion Criteria:\n\n* • Postmenopausal women aged 50-70 years.\n\n  * Clinical and radiographic diagnosis of knee osteoarthritis according to the American College of Rheumatology criteria.\n  * Radiographic severity classified as Kellgren-Lawrence grade II or III.\n  * Chronic knee pain for a duration of at least 3 months.\n  * Pain intensity ≥4 on the Visual Analog Scale.\n  * Ability to ambulate independently with or without assistive devices.\n  * Ability to understand and follow instructions.\n  * Willingness to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* • Severe knee osteoarthritis (Kellgren-Lawrence grade IV).\n\n  * History of knee surgery or intra-articular injections within the previous 6 months.\n  * Presence of inflammatory rheumatic diseases such as rheumatoid arthritis or gout.\n  * Neurological disorders affecting lower limb function.\n  * Uncontrolled metabolic, cardiovascular, or systemic diseases.\n  * Current or recent use of metformin or other antidiabetic medications.\n  * Skin lesions, infections, or hypersensitivity at the iontophoresis site.\n  * Contraindications to electrotherapy such as pacemakers or implanted electronic devices.\n  * Body mass index ≥35 kg\u002Fm².\n  * Participation in another clinical trial within the last 3 months.","FEMALE","50 Years","70 Years",{"count":20,"type":21},68,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","This study is designed as a randomized, double-blind, placebo-controlled clinical trial with two parallel groups. All participants will receive a standardized physical therapy rehabilitation program. Participants will be randomly allocated into either a study group receiving metformin iontophoresis or a control group receiving placebo iontophoresis. Both participants and outcome assessors will be blinded to group allocation.",[27],"Osteoarthritis in Postmenopausal Women",[29,30,31,32,33],"Metformin gel","Iontophoresis","Physical Therapy Rehabilitation","Osteoarthritis","Postmenopausal Women","NOT_YET_RECRUITING","2026-02-01",{"date":37,"type":38},"2026-02-09","ACTUAL",{"date":40,"type":21},"2026-03-01",{"date":42,"type":21},"2026-05-01",{"name":44,"class":45},"Badr University","OTHER"]