[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteoarthritis-knee-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteoarthritis-knee-pain":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,80,106],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100610336","phase-3-phase-iii-study-to-assess-the-safety-and-efficacy-of-sl1002-for-osteoarthritis-knee-pain-100610336",false,"NCT07226258","Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain","A Randomized, Double-Blind, Placebo-Controlled, Single Dose Study to Assess the Safety and Efficacy of SL1002 Injectable for the Treatment of Knee Pain in Patients With Osteoarthritis of the Knee","Inclusion Criteria includes:\n\n1. Male or female patients ≥ 40 years of age\n2. Body Mass Index (BMI) limits\n3. Chronic knee pain resulting from osteoarthritis\n4. Kellgren-Lawrence Grade 2 (mild) or Grade 3 (moderate)\n5. Baseline KOOS pain\n6. Patients taking baseline analgesics\n7. Diagnostic nerve block response\n8. Compliance with identified study requirements\n\nExclusion Criteria includes:\n\n1. Non-OA inflammatory arthritis\n2. Confounding elements\n3. Lower limb amputation.\n4. Specified alternate historic treatments\n5. Identified underlying physiologic or psychosocial conditions\n6. Patient Health Questionnaire\n7. Moderate to severe hepatic impairment\n8. Moderate to severe renal impairment\n9. Identifiable baseline medications\n10. Protocol compliance requirements\n11. Known allergies or hypersensitivity to identified agents\n12. Identified alcohol or drug abuse history\n13. Identified underlying physical exam findings: ECG abnormalities or vital sign abnormalities during study screening per investigator assessment\n14. Identified underlying abnormal laboratory results","ALL","40 Years",{"count":19,"type":20},150,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","A Randomized, Double-Blind, Placebo-Controlled, Single Dose Study to Assess the Safety and Efficacy of SL1002 for the Treatment of Knee Pain in Patients with Osteoarthritis of the Knee.",[26],"Osteoarthritis Knee Pain","RECRUITING","2026-06-22",{"date":30,"type":31},"2026-06-23","ACTUAL",{"date":33,"type":31},"2025-11-07",{"date":35,"type":20},"2027-02-28",{"name":37,"class":38},"Saol Therapeutics Inc","INDUSTRY",21,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":79},"100587902","revised-targets-for-knee-radiofrequency-ablation-100587902","NCT06934421","Revised Targets for Knee Radiofrequency Ablation","Segurança e eficácia de Nova Abordagem Ecoguiada de ablação Por radiofrequência Dos Nervos Geniculados","ReTaKRA","Inclusion Criteria:\n\n* Patients with chronic knee pain related to radiographic knee osteoarthritis, Kellgren-Lawrence (KL) grade III or IV, who are refractory to conservative treatment.\n\n(Refractoriness to conservative treatment is defined as:\n\n* Persistent pain and functional limitation after undergoing knee-targeted physiotherapy and analgesic medication in accordance with clinical guidelines for osteoarthritis \\[e.g., paracetamol, nonsteroidal anti-inflammatory drugs, and other drugs as deemed appropriate by the treating physician\\];\n* Persistent pain and functional limitation after intra-articular corticosteroid injections or limited success with such interventions.)\n\nExclusion Criteria:\n\n* Patients with previous knee arthroplasty\n* Patients who have undergone prior radiofrequency (RF) ablation\n* Significant psycho-emotional disorders\n* Addictive behaviors\n* Generalized pain\n* Nociplastic pain\n* Presence of a pacemaker\n* Presence of osteosynthesis material in the knee or adjacent anatomical regions","18 Years",{"count":50,"type":20},60,"OBSERVATIONAL","This research team is doing a study to learn more about a new way to treat long-term knee pain caused by joint damage. They are using a treatment called radiofrequency ablation (RFA). This is a procedure where doctors use heat to stop certain nerves from sending pain signals.\n\nIn this study, doctors will use ultrasound to guide a small needle to nerves around the knee, called genicular nerves. Then, they will apply heat to those nerves using radiofrequency energy to help reduce pain.\n\nThe team created this new method based on recent studies of knee anatomy. They want to find out if this method can safely reduce pain and help people with knee joint damage move better. The study includes people who have moderate to severe knee damage and still have pain after trying medicine, physical therapy, or joint injections.\n\nEach person in the study will have the treatment once. The research team will follow each person for two years. During this time, people in the study will answer simple questions about their knee pain and how it affects their daily life. The researchers will collect this information before the treatment and several times after it. One week after the procedure, the team will call each person to ask how they are feeling and check for any side effects.\n\nPossible benefits of the study include less knee pain and easier movement. Possible risks include pain during the procedure, bruising, swelling, or short-term worsening of pain. Rare risks include nerve problems, weakness, bone damage, or allergic reaction.\n\nThe study is free for participants, and there is no payment. Taking part is voluntary. Anyone can stop being in the study at any time without affecting their medical care. The research team will keep all personal information private and secure.",[26],[55,56,57,58,59,60,61,62,63,64,65,66,67,68],"Genicular nerve","Knee pain","Chronic pain","Knee osteoarthritis","Radiofrequency ablation","Ultrasound guidance","Interventional pain management","Joint degeneration","Nerve ablation","Image-guided procedures","Non-surgical treatment","Musculoskeletal intervention","Pain reduction","Functional improvement","2025-04-22",{"date":71,"type":31},"2025-04-24",{"date":73,"type":31},"2025-03-20",{"date":75,"type":20},"2031-07-30",{"name":77,"class":78},"Centro Hospitalar Universitario do Algarve","OTHER",2,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100583791","phase-2-antarctic-krill-oil-for-knee-osteoarthritis-pain-100583791","NCT06880926","Antarctic Krill Oil for Knee Osteoarthritis Pain","A Randomized, Double-Blind, Parallel-Controlled, Multicenter Clinical Trial of Antarctic Krill Oil in the Management of Knee Osteoarthritis Pain","Inclusion Criteria:\n\n* Aged 45-75 years；\n* Clinically diagnosed with knee osteoarthritis per the Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2018 edition) issued by the Chinese Medical Association, with Kellgren-Lawrence grade 1-3；\n* Knee pain Visual Analog Scale (VAS) score between 4.0 and 8.0；\n* Ability to comprehend and complete VAS and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) assessments；\n* Willingness and ability to undergo knee MRI examinations.\n\nExclusion Criteria:\n\n* Ipsilateral hip osteoarthritis;\n* Diagnosis of rheumatoid arthritis (RA), ankylosing spondylitis, sarcoidosis, amyloidosis, or any other inflammatory arthritis (e.g., gout, pseudogout);\n* Chronic pain syndromes, fibromyalgia, or comorbidities that may confound knee pain assessment;\n* Pain intensity in the lower extremities or back equal to or greater than knee pain;\n* Arthroscopic or open knee surgery within the preceding 12 months or planned during the study period;\n* Oral, intra-articular, or intramuscular corticosteroid use within 6 months prior to screening or during the study;\n* Intra-articular hyaluronic acid injection within 6 months prior to screening or during the study;\n* High-dose NSAID use (≥ maximum recommended daily dose for osteoarthritis pain relief) within 1 month prior to screening, including but not limited to: Diclofenac ≥150 mg\u002Fday; Aceclofenac ≥100 mg\u002Fday; Meloxicam ≥15 mg\u002Fday; Naproxen ≥1,000 mg\u002Fday; Piroxicam ≥20 mg\u002Fday; Ibuprofen \\>2,400 mg\u002Fday (Exempt if a ≥4-week washout period is completed prior to Day 1);\n* Bleeding disorders or anticoagulant use within 1 month (except low-dose aspirin ≤150 mg\u002Fday);\n* Regular use of glucosamine, fish oil, or other supplements unless a ≥4-week washout period (≥3 months for fish oil) is completed prior to Day 1;\n* Hypersensitivity to trial medications or seafood;\n* Administration of any medication within 6 months prior to Day 1 that may interfere with study outcomes, as judged by investigators;\n* Pregnancy (positive urine test at screening or Day 1), lactation, or inadequate contraception;\n* History of alcoholism, substance abuse, major systemic diseases (e.g., renal, cardiac, hepatic, or gastrointestinal disorders), or conditions deemed by investigators to compromise study participation or data integrity;\n* Uncontrolled hypertension (screening blood pressure ≥140\u002F90 mmHg) unless confirmed as non-hypertensive or well-controlled by a specialist;\n* Inability to provide informed consent.","45 Years","75 Years",{"count":90,"type":20},116,[92],"PHASE2","The goal of this clinical trial is to evaluate the effectiveness and safety of Antarctic Krill Oil (AKO) as a dietary supplement in managing pain associated with knee osteoarthritis (OA). The main questions it aims to answer are:\n\n①Does AKO reduce daily pain intensity in participants with moderate knee OA?\n\n②What adverse effects do participants experience when taking AKO?\n\nResearchers will conduct a randomized, double-blind study comparing AKO to a placebo (identical appearance without active components) to assess:\n\n* Changes in joint pain severity; ②Functional improvement in daily activities; ③Biochemical safety parameters,etc.",[95,26],"Osteoarthritis (OA) of the Knee","NOT_YET_RECRUITING","2025-03-16",{"date":99,"type":31},"2025-03-18",{"date":101,"type":20},"2025-04-01",{"date":103,"type":20},"2026-02-28",{"name":105,"class":78},"Qilu Hospital of Shandong University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":21,"phases":115,"briefSummary":117,"conditions":118,"keywords":127,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":4},"100570627","kinematic-alignment-in-total-knee-arthroplasty---a-double-blind-randomised-controlled-trial-between-robotic-and-caliper-based-techniques-100570627","NCT06709703","Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic and Caliper-based Techniques","L'Alignement cinématique Dans Les prothèses de Totales de Genou : un Essai randomisé contrôlé à Double Insu Comparant la Robotique Aux Instruments Traditionnels","Inclusion Criteria:\n\n* Patient aged 18 or above\n* Patient being consented for a primary total knee arthroplasty (TKA)\n* The primary TKA is planned to be done with kinematic alignment\n* All pre-operative alignments are included\n\nExclusion Criteria:\n\n* Revision TKA (including revision of unicompartimental knee arthroplasty into total knee arthroplasty with primary components). TKA being done in the setting of previous femur or tibia fracture or osteotomy are however included.\n* No available adequate pre-operative imaging\n* Patient who does want to be randomized of the two groups\n* At the discretion of the surgeon, if the patient's pathology or particular anatomy precludes the use of kinematic alignment technique, robotic surgery, or traditional instrument TKA.",{"count":114,"type":20},200,[116],"NA","Knee replacement surgery is a surgery designed to treat severe arthritis of the knee. However, as many as 20% of patients are not satisfied with the results of their surgery. To place the knee replacement in correct position, the kinematic alignment method, which tries to reproduce the patient normal anatomy, has shown promise in improving the satisfaction after knee replacement surgery. It is not known if using a robotic arm to assist in surgery is better than the traditional method when trying to recreate kinematic alignment.\n\nThe goal of this study is to learn if robotic assisted surgery is better than traditional method for knee replacement done using kinematic alignment. The main questions the study tries to answer are:\n\n1. Do the radiographs of kinematic knee replacement surgeries done with robotic assistance show better alignment than radiographs of kinematic knee replacements done with the traditional method?\n2. Does robotic assisted kinematic knee replacement give better function to patients than traditional knee replacement done with kinematic alignment?\n3. Does robotic assisted kinematic knee replacement decrease pain, improve knee movement and improve knee stability better than traditional knee replacement done with kinematic alignment?\n4. Are there more complications with robotic assisted kinematic knee replacement in comparison to traditional kinematic knee replacement?\n5. How long long does it take a surgeon to become good a performing a kinematic knee replacement using robotic assistance? Researchers will compare knee replacements done using a robotic to make the bone cuts, and compare it to the usual method using guides and manual instruments. All the knee replacements will be done using the kinematic alignment and with the same type of knee replacement prothesis.\n\nParticipants will:\n\n* Have a knee replacement done with the kinematic alignment technique by an experienced surgeon, with or without robotic assistance during the surgery.\n* Visit the clinic before surgery, six weeks after surgery, three months, six months, twelve months and twenty-four months after the surgery.\n* Fill questionnaire, have their knee examined and have radiographs of their knee done at each visit.",[119,120,121,26,122,123,124,125,126],"Arthritis","Arthritis (Knee)","Osteoarthritis","OA","OA Knee","OA Knee Pain","Osteoarthritis of Knee","Gonarthrosis; Primary",[128,129,130,131,132,133,134,135,136],"osteoarthritis","arthritis","knee osteoarthritis","knee OA","knee arthritis","total knee replacement","robotic","kinematic alignment","patient-specific surgery","2024-11-25",{"date":139,"type":31},"2024-11-29",{"date":141,"type":20},"2025-02",{"date":143,"type":20},"2028-09",{"name":145,"class":78},"Université de Sherbrooke"]