[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteoarthritis-knees-both\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteoarthritis-knees-both":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100602288","treatment-of-symptomatic-bilateral-knee-osteoarthritis-intra-articular-injection-of-autologous-microfragmented-adipose-tissue-and-hyaluronic-acid-vs-intra-articular-injection-of-autologous-microfragmented-adipose-tissue-100602288",false,"NCT07121556","Treatment of Symptomatic Bilateral Knee Osteoarthritis: Intra-articular Injection of Autologous Microfragmented Adipose Tissue and Hyaluronic Acid vs Intra Articular Injection of Autologous Microfragmented Adipose Tissue","Randomized Double- Blind Study on the Treatment of Symptomatic Bilateral Knee Osteoarthritis: Intra-articular Injection of Autologous Microfragmented Adipose Tissue and Hyaluronic Acid vs Intra Articular Injection of Autologous Microfragmented Adipose Tissue. Double-Blind Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Male or female patients aged between 18 and 75;\n2. Radiographic evidence of bilateral OA of the knees graded between 2 and 4 on the Kellgren-Lawrence scale;\n3. Pain equal to or greater than 4 on the Numeric Rating Scale (NRS) for both knees;\n4. Failure, defined as persistence of symptoms after at least 6 months of conservative treatment (pharmacological, physiotherapy, or infiltration treatment);\n5. Ability and willingness to undergo the study procedures and comply with the instructions given by the study team; 6. No history of\n\n4\\. Failure, defined as persistent symptoms, after at least 6 months of conservative treatment (pharmacological, physiotherapy, or infiltration treatment); 5. Ability and consent of patients to actively participate in the rehabilitation and follow-up protocol; 6. Signature of informed consent\n\nExclusion Criteria:\n\n1. Patients incapable of understanding and willing;\n2. Diagnosis of active neoplasia;\n3. Diagnosis of rheumatoid arthritis, Reiter's syndrome, psoriatic arthritis, gout, ankylosing spondylitis, or arthritis resulting from another inflammatory disease; human immunodeficiency virus (HIV) infection, active viral hepatitis; chondrocalcinosis;\n4. Patients with uncontrolled diabetes mellitus;\n5. Patients with uncontrolled thyroid metabolic disorders;\n6. Patients who abuse alcohol, drugs, or medications;\n7. Patients with lower limb misalignment greater than 5°;\n8. Body Mass Index \\> 35 kg\u002Fm2;\n9. Pregnancy or breastfeeding, or plans to become pregnant during the study period .\n10. Patients with a history of trauma or intra-articular infiltration of therapeutic substances in the 6 months prior to screening.\n11. Patients who have undergone knee surgery in the 12 months prior to screening.\n12. Patients with insufficient abdominal adipose tissue, as assessed by the investigator.","ALL","18 Years","75 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The HYALOFAT study is a randomized controlled double-blind trial with parallel treatment arms and 1:1 allocation.\n\nBy means of a double-blind randomized controlled trial in patients with symptomatic bilateral OA of the knees, the clinical outcomes of autologous microfragmented adipose tissue injection associated with hyaluronic acid in one knee vs autologous microfragmented adipose tissue injection in the contralateral knee will be evaluated and compared. Each patient will then serve as his or her own control and not be informed of the knee assigned to the treatment group. In addition, it will be the aim of the study to evaluate the safety of the combined treatment by documenting any adverse events.",[27],"Osteoarthritis Knees Both",[29,30,31,32,33,34,35],"Osteoarthritis","Knees","HA","Micro-fragmented autologous adipose tissue","Hyaluronic acid","Intra-articular injection","Randomized double-blind study","RECRUITING","2025-12-02",{"date":39,"type":40},"2025-12-03","ACTUAL",{"date":42,"type":40},"2025-09-29",{"date":44,"type":21},"2030-09",{"name":46,"class":47},"Istituto Ortopedico Rizzoli","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":48},"100522431","effect-of-platelet-rich-plasma-prp-injection-on-knee-osteoarthritis-100522431","NCT06082531","Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis","Therapeutic Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis and Periarticular Tissue Injury","Inclusion Criteria:\n\n* The age range of the participants was 20 to 60 years old. Through a comprehensive clinical and imaging examination, it was conclusively determined that the individuals had knee osteoarthritis or experienced injuries to the cart, and meniscus surrounding the knee joint.\n* The preoperative routine tests and examinations revealed no contraindications.\n* Revised sentence: \"Informed consent of the patient\n\nExclusion Criteria:\n\n* The platelet count or function exhibits significant abnormalities、Systemic infection transmitted through the bloodstream.\n* Prolonged usage of anti-inflammatory drugs and systemic corticoid administration.\n* In injection site or damage to the skin.\n* Patients with tumors or undergoing radiotherapy and chemotherapy.\n* Pregnant or breastfeeding women.\n* Individuals with mental illnesses who are unable to cooperate with follow-up procedures.\n* Contraindications for MRI、Patients or their families do consent to participate in the study.\n* Other circumstances that render participation in the study unsuitable.","20 Years","60 Years",{"count":59,"type":21},300,[24],"To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.",[63,27,64,65],"Platelets-rich Plasma","Meniscus Disorder","Cartilage Injury",[67,29,65,68],"platelets-rich plasma","Meniscus Injury","2025-04-06",{"date":71,"type":40},"2025-04-09",{"date":73,"type":40},"2023-09-01",{"date":75,"type":21},"2025-12-31",{"name":77,"class":47},"Xijing Hospital",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":96,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":48},"100424990","prospective-functional-gait-and-outcome-comparison-study-of-medial-pivot-versus-single-radius-design-for-total-knee-arthroplasty-100424990","NCT04814082","Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty","Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot","Inclusion Criteria:\n\n* Subject is male or non-pregnant female aged between 18 and 75 years of age.\n* Subject is willing to provide informed consent to participate in the research study.\n* Subject is indicated for a primary total knee arthroplasty (TKA) based on the approved labeling of knee implant, either a medial pivot or single radius design, specifically: MicroPort Evolution Medial-Pivot Knee System, Cruciate Retaining (CS) or Stryker Triathlon Tritanium (CS)\n* Subject does not have a history of previous prosthetic replacement device on the operative knee.\n* Subject is currently ambulating and does not have a condition on the contralateral limb in the opinion of the investigator that would interfere with the gait laboratory evaluations.\n* Subject is willing and able to comply with the schedule of events for the study and is available to return to the clinic for all required follow-up visits.\n\nExclusion Criteria:\n\n* Subject has a Body Mass Index (BMI) \\>40\n* Subject has a diagnosis of avascular necrosis or inflammatory arthritis.\n* Subject has any mental or neuromuscular disorder that would create an unacceptable risk of prosthesis instability, prosthesis fixation failure, or complications in postoperative care.\n* Subject is a prisoner\n* Subject has any condition, in the opinion of the Investigator that might interfere with the evaluation of the study objectives.",{"count":20,"type":21},[24],"Patients with degenerative joint disease can effectively be treated with a primary total knee replacement to reduce pain and improve function in their daily lives. Theoretically, achievement of normal knee motion using a medial pivot design in total knee replacements can be recreated in comparison to single radius designs, which could lead to an improvement in post-surgical outcomes and satisfaction with the procedure. The aim of this study is to compare two types of implant designs (medial pivot and single radius) in a total knee replacement using clinical outcomes, patient reported outcomes, and overall function assessed by a specialized gait laboratory.",[89,90,27,91,92,93,94,95],"Osteoarthritis, Knee","Knee Osteoarthritis","Osteoarthritis Knee Left","Osteoarthritis Knee Right","Knee Pain Chronic","Knee Disease","Arthropathy of Knee Joint",[97,98],"Total Knee Arthroplasty","Total Knee Replacement","2025-01-20",{"date":101,"type":40},"2025-01-22",{"date":103,"type":40},"2021-02-01",{"date":105,"type":21},"2030-07-01",{"name":107,"class":47},"LifeBridge Health"]