[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteoarthritis-oa-of-the-knee\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteoarthritis-oa-of-the-knee":31},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,34,0,25,[9,49,82,106,128,150,169,194,215,237,267,296,328,359,372,406,431,456,483,521,544,569,603,631,656],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100053870","phase-1-contralateral-corticosteroid-injection-in-total-knee-arthroplasty-100053870",false,"NCT06809998","COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty","COSTI: COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty - A Triple Blinded, Randomized Controlled Trial Pilot Study","COSTI","Inclusion Criteria:\n\n* Patients 18 years of age and older\n* Primary osteoarthritis diagnosis with indication for primary elective unilateral TKA\n* No previous contralateral knee injections (steroids\u002Fbiologics) within one year of study\n* Not scheduled for bilateral TKA or a subsequent staged contralateral TKA within the next six months\n* No previous or active infection or trauma (osseous\u002Fligamentous\u002Fextensor mechanism) on the contralateral knee\n* Contralateral knee pain \\& symptoms - defined as a VAS of \\>4\u002F10 at initial pre-op visit\n* Contralateral knee OA quantified as: Kellgren and Lawrence grade \\>2-4\n\n  * Assessed by PI (AK) who will not be contributing any patients to the study through examination of blinded knee radiographs (3 views: AP\u002Flateral\u002FSunrise)\n* Patient is able to read and understand English and provide informed consent to participation in the study\n\nExclusion Criteria:\n\n* Other aetiologies of OA that warrants TKA (inflammatory or post traumatic arthritis)\n* Cognitive impairment (dementia, Alzheimer's, uncontrolled delirium) which will prevent patients from completing primary outcome measure or comply with follow-up requirements\n* Previous TKA or ORIF or nailing on either knee\n* Previous or active knee infection or extensor mechanism disruption\n* Previous arthroscopy on either knee\n* Medical contraindication to elective TKA surgery","ALL","18 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA. The secondary outcome was to assess the effect of contralateral corticosteroid injection on pain and functional outcomes of patients undergoing TKA.",[29,30,31,32],"Total Knee Anthroplasty","Osteoarthritis(Primary)","Osteoarthritis (OA) of the Knee","Bilateral Knee Osteoarthritis",[16,34,35],"Total Knee Arthroplasty","Corticosteroid Injection","RECRUITING","2026-07-09",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":40},"2025-01-24",{"date":44,"type":22},"2027-08-30",{"name":46,"class":47},"Unity Health Toronto","OTHER",1,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":18,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":48},"100582581","phase-4-pain-perception-during-intra-articular-knee-joint-injection-what-is-the-effect-of-needle-gauge-and-the-use-of-ethyl-chloride-100582581","NCT06865170","Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?","Inclusion Criteria:\n\n1. age ≥ 40 years\n2. fulfillment of the American College of Rheumatology criteria for knee OA\n3. confirmation of knee-related pain and\u002For functional loss by clinical examination.\n4. Patients with either\n\n   1. bilateral knee OA\u002Finjections, or\n   2. unilateral knee OA\u002Finjections.\n5. Agreed to an intra-articular knee joint injection with steroids\n6. Naive to use of ethyl chloride\n\nExclusion Criteria:\n\n1. Arthroscopy of the index knee(s) within the prior 6 months\n2. Steroid injection of the knee(s) within the prior 3 months\n3. Hyaluronic acid or platelet-rich plasma injection of the knee within the prior 6 months\n4. Patient reported prior injection of any type with ethyl chloride spray\n5. Knee effusion requiring aspiration at the time of the procedure\n6. Cognitively impaired individuals",true,"40 Years","89 Years",{"count":59,"type":22},88,[61],"PHASE4","This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence or absence of topical ethyl chloride spray. Additionally, this study will investigate the effects of other various factors on patients' pain associated with the injection. Lastly, this study aims to determine the effect of patients' subjective pain from the injection on long-term clinical outcomes.\n\nSpecific aims are as follows:\n\nAim 1): Determine the effect of needle gauge size on patient reported pain associated with an ultrasound-guided intra-articular knee injection.\n\nAim 2): Determine the effect of ethyl chloride spray on patient reported pain associated with an ultrasound-guided intra-articular knee injection.\n\nAim 3): Determine the effect of sex, age, BMI, thigh size, severity of OA, and fear of needles on patient pain associated with an ultrasound-guided intra-articular knee injection.\n\nAim 4) Determine the effect of patient pain from the procedure on longer term clinical outcomes after an ultrasound-guided intra-articular knee steroid injection.\n\nResearchers will obtain data at various time points, including pre-procedural data, immediately after the procedure, 24-48 hours after, and 6 weeks post-procedure.\n\nParticipants will:\n\nConsent to receiving an intra-articular knee joint injection with steroids if indicated.\n\nScore their \"procedural\" pain immediately following the procedure, score their post-procedural \"soreness\" 24-48 hours after via telephone call, and score their overall knee pain about 6 weeks after the procedure via telephone call.",[31,64],"Fear of Needles",[66,67,68,69,70,71],"pain perception","fear of needles","needle gauge","ethyl chloride","corticosteroid injection","25G versus 22G","NOT_YET_RECRUITING","2026-06-26",{"date":75,"type":40},"2026-06-29",{"date":77,"type":22},"2026-08",{"date":79,"type":22},"2026-12",{"name":81,"class":47},"University of California, Davis",{"id":83,"slug":84,"hasResults":12,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":48},"100568432","pharmacist-physiotherapist-collaborative-management-for-early-knee-osteoarthritis-100568432","NCT06681142","Pharmacist-physiotherapist Collaborative Management for Early Knee Osteoarthritis","PACE-OA","Inclusion Criteria:\n\n* regularly experiencing pain, aching, or stiffness in and\u002For around the knee for at least 1 month\n* complete the screening PhIT-OA questionnaire\n\nExclusion Criteria:\n\n* Prior total knee replacement or on the waitlist to have your knee replaced\n* Knee surgery within the previous 4 months\n* History of acute injury to knee within previous 6 months\n* Unable to speak and read English\n* Unwilling or unable to visit a physiotherapist at a community physiotherapy clinic (specifically the dates and times of the partnering physiotherapy clinic)\n* Previous physician-diagnosed inflammatory arthritis (including this list): Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis, Lupus, Gout\n* Physician diagnosed fibromyalgia\n* A sudden, severely painful, hot, swollen joint at any time in the past\n* History of the following medications: csDMARD or bDMARD or tsDMARD, Immunosuppressive, Allopurinol or febuxostat, Colchicine\n* Received a knee joint injection in the past 3 months or have one scheduled in the next 3 months\n* Has completed the GLA:D Hip and Knee program at all in the past","50 Years",{"count":91,"type":22},125,[93],"NA","Osteoarthritis (OA) is a slowly progressive chronic condition that is associated with aging and is characterized as joint pain. Individuals with early-stage OA usually do not seek medical attention. If and when they do, patients more often present to a pharmacy for over-the-counter medications.\n\nThe investigators want to leverage community pharmacists' accessibility and scope of practice to best support patients with early knee OA. Given there are no disease-modifying treatments for OA, treatment guidelines center on patient education, self-management, and exercise, with medications playing a supporting role. Self-management is an effective strategy that provides a solid foundation for managing this progressive chronic condition and health care professionals like physiotherapists and pharmacists can help with the development and application of these skills.",[31,96,97],"Physiotherapy","Pharmacy","2026-06-23",{"date":73,"type":40},{"date":101,"type":40},"2025-08-13",{"date":103,"type":22},"2027-09",{"name":105,"class":47},"University of Alberta",{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":55,"sex":18,"minAge":19,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":48},"100644751","enhancing-voluntary-motion-in-broad-patient-populations-with-modular-powered-orthoses-renewal-100644751","NCT07673328","Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal","Inclusion Criteria:\n\nInclusion criteria for able-bodied, young participants will be:\n\n* Aged between 18 to 65 years\n* Weigh less than 300 lbs (due to challenges in bracing heavier participants)\n* BMI \\\u003C 40 (due to challenges in bracing heavier participants)\n\nInclusion criteria for knee osteoarthritis participants will be:\n\n* Aged between 30 to 85 years\n* Medical diagnosis of patellofemoral and tibiofemoral osteoarthritis\n* Patient reported pain ≥ 4 out of 10 during activities of daily life (to avoid floor effects)\n* Weigh less than 300 lbs (due to challenges in bracing heavier participants)\n* BMI \\\u003C 40 (due to challenges in bracing heavier participants)\n* Ability to walk 6 minutes without assistance from a person (may use walking aid)\n* Ability to ascend\u002Fdescend ramps and stairs with or without the use of handrails\n\nExclusion Criteria:\n\nExclusion criteria for able-bodied, young adult participants will be:\n\n* Pregnant (self-report)\n* Any significant neuromuscular or musculoskeletal disorder that would interfere with the study\n* Unable to walk for 20 minutes\n* History of any cardiovascular, vestibular, or visual diseases and\u002For impairments that may interfere with the study\n* Cognitive deficits that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of \\\u003C22.\n* Adults with a known allergy to medical grade tape\n\nExclusion criteria for knee osteoarthritis participants will be:\n\n* Pregnant (self-report)\n* Any recent lower-extremity fracture (within 6 months)\n* Significant limitation on knee joint range of motion\n* Significant neurological (e.g., stroke) or cardiovascular disorder that may affect the ability to walk\n* Advised by a physician not to walk or exercise\n* Uncontrolled hypertension or diabetes\n* Use of opioids\n* Cognitive deficits or visual impairment that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of \\\u003C22.\n* Adults with a known allergy to medical grade tape","85 Years",{"count":114,"type":22},65,[93],"The overall goal of this project is to establish a novel design and control paradigm for modular, partial-assist powered orthoses (exoskeletons) to enhance voluntary lower-limb motion and manage pain in broad patient populations. Building upon a previous study period that addressed weakness from advanced age or muscle fatigue, this current period extends the technology to novel powered unloader orthoses designed to manage knee osteoarthritis (OA) pain. The investigators hypothesize that by providing 15-30% of biological joint torque, these motorized devices can reduce muscular contributions to painful loads on the joint's surfaces during activities of daily living (ADLs). The project aims to develop a task-agnostic, neural network-based controller and establish the feasibility of reducing knee pain and muscle effort in individuals with multi-compartment knee osteoarthritis.",[118,119,31],"Lower-limb Orthoses","Osteoarthritic Knee Pain","2026-06-22",{"date":75,"type":40},{"date":123,"type":40},"2025-07-18",{"date":125,"type":22},"2030-03-31",{"name":127,"class":47},"University of Michigan",{"id":129,"slug":130,"hasResults":12,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":23,"phases":137,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":48},"100641068","percutaneous-neurostimulation-in-knee-osteoarthritis-100641068","NCT07637682","Percutaneous Neurostimulation in Knee Osteoarthritis","Percutaneous Peripheral Temporary Neurostimulation in Moderate to Severe Knee Osteoarthritis","Inclusion Criteria:\n\n1. adults between the ages of 30 and 70 years with a clinical diagnosis of moderate to severe knee OA who suffered knee pain.\n2. Patients who cannot afford intra-articular injections or radiofrequency ablation (RFA).\n3. patients who had failed 2 different oral pain medications and 6 weeks of physical therapy.\n\nExclusion Criteria:\n\n1. Patients with OA show improvement in pain after physiotherapy.\n2. patients evaluated by an orthopaedic surgeon and deemed to be surgical candidates due to knee pathologies other than OA.\n3. pregnant patients.\n4. patients on anticoagulation therapy, who were not permitted to stop anticoagulation.\n5. patients with previous trauma, neurological or endocrine diseases like diabetes mellitus, and knee tumors; and patients with inflammatory arthritis.\n6. people who had received an intra-articular knee injection within the last 6 months.\n7. Patients with tendon tears, bursitis, or calcified tendonitis as proven by imaging.",{"count":136,"type":22},100,[93],"Peripheral nerve stimulation (PNS) is a drug-free pain management procedure that uses electrical impulses to target specific nerves and block pain signals. PNS helps decrease perception of pain, providing real answers to patients dealing with chronic knee pain. The case study discussed in this presentation is of the use of PNS targeting the superior lateral genicular nerve and the saphenous nerve for a patient with moderate to severe knee pain from osteoarthritis",[31,140],"Neuromodulation","2026-06-16",{"date":143,"type":40},"2026-06-18",{"date":145,"type":40},"2026-06-02",{"date":147,"type":22},"2026-11",{"name":149,"class":47},"Tanta University",{"id":151,"slug":152,"hasResults":12,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":23,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":167,"locationsCount":4},"100642327","the-effect-of-physical-activity-on-knee-osteoarthritis-pain-and-gait-100642327","NCT07649863","The Effect of Physical Activity on Knee Osteoarthritis, Pain and Gait","The Effect of Retro Walking on Pain and Gait Biomechanics Using Non-linear Analysis in People With Knee Osteoarthritis","Inclusion Criteria:\n\n* Male and female\n* Any ethnicity\n* Adults over 18 years old\n* Meet the UK guidelines for physical activity supported by NICE (National Institute for Health and Care Excellence) and NHS (able to exercise if it is safe with regular breaks)\n* Otherwise, adults with clinically diagnosed knee osteoarthritis according to NICE criteria or confirmed by a healthcare professional able and willing to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Any musculoskeletal injury\n* Any conditions known to affects gait (e.g. Parkinson's disease or stroke)\n* Any surgical intervention in the previous 12 months on lower limbs\n* Surgical replacement of hip or knee joints\n* BMI (body mass index) over 35\n* Athletes or take part in significant recreational activity\n* Takes any medication known to affect the gait and ability to walk\n* Received an intra-articular injection in the last 3 months\n* Have been told by medical professionals that they should not take part in any intensity exercise\u002Fphysical activity",{"count":158,"type":22},44,[93],"Knee osteoarthritis, a chronic musculoskeletal disease, is the most prevalent type of osteoarthritis and the leading cause of disability and major healthcare costs worldwide. The pathogenesis of the disease is not fully understood and there are few non-invasive disease-modifying therapies available to patients. Therefore, there is a critical need to enhance therapeutic interventions, which requires improvement of our understanding of knee osteoarthritis pathogenesis.\n\nIncreasing evidence suggests that physical activity and exercise training are cost-effective and widely available interventions for the treatment of knee osteoarthritis, however, consideration of type of physical activity and optimal exercise modality are needed to reduce pain, improve gait, knee joint function, stiffness, and muscle weakness in individuals with knee osteoarthritis.\n\nThe aim of this pilot clinical trial is to compare individuals with knee osteoarthritis who have not exercised with individuals that have performed retro walking exercise chosen from the systematic review and survey we have conducted previously to reduce pain and improve gait.\n\nNon-linear analyses will be performed to determine the effects of exercise intervention on gait biomechanics and stability of movement in these patients. These findings may form a basis for recommendations of exercise\u002Fphysical activity interventions for the benefits of patients with knee osteoarthritis including pain reduction, mobility improvement and gait modification.",[31],"2026-06-11",{"date":141,"type":40},{"date":165,"type":22},"2026-07",{"date":79,"type":22},{"name":168,"class":47},"Anglia Ruskin University",{"id":170,"slug":171,"hasResults":12,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":23,"phases":179,"briefSummary":181,"conditions":182,"keywords":183,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":48},"100617832","early-phase-1-long-term-effects-of-mobithron-advance-on-knee-osteoarthritis-aims-to-investigate-the-effects-of-mobithron-advance-on-oa-progression-100617832","NCT07323745","Long-Term Effects of Mobithron Advance on Knee Osteoarthritis Aims to Investigate the Effects of Mobithron Advance on OA Progression","Long-Term Effects of Mobithron Advance on Knee Osteoarthritis","mobithron adv","Inclusion Criteria:\n\n* Males and female patients above 50 years old at the time of recruitment.\n* OA Diagnosis: Patients with one or both knee osteoarthritis according to clinical and radiological criteria of the American College of Rheumatology (ACR).\n* OA Grade: Kellgren Lawrence grade 1-3\n\nExclusion Criteria:\n\n* Secondary arthritis (e.g., rheumatoid arthritis, psoriatic arthritis).\n* History of joint surgery.\n* Patients who received steroid injection treatment within the last 3 months or hyaluronic acid injection treatment within the last 6 months.\n* Contraindications to Mobithron Advance (e.g., known allergies, severe liver or kidney disease).\n* Patients planning for knee surgery within the research period.\n* Patients on pharmacological treatment for osteoarthritis, other than rescue analgesic agent, e.g: glucosamine, chondroitin, oral steroid",{"count":178,"type":22},84,[180],"EARLY_PHASE1","The goal of this clinical trial is to learn if the Mobithron Advance drug works to treat and slow the progression of osteoarthritis (OA) in patients. It will also learn about the safety and long-term effects of this drug. The main questions it aims to answer are:\n\n* Does long-term administration of Mobithron Advance can modify the progression of knee osteoarthritis with Kellgren-Lawrence grade 1 to 3 in HUSM patients?\n* Does long term usage of Mobithron Advance has safety profile? Researchers will compare the Mobithron Advance drug to a placebo (a look-alike substance that contains no drug) to see if said drug works to treat OA.\n\nParticipants will:\n\n* Undergo pre-study assessment (baseline assessments) during first visit\n* Take oral Mobithron Advance daily for 1 year\n* Visit the clinic once at 3 months, 6 months and 12 months intervals from the initial visit for follow up assessments",[31],[184],"Mobithron Advance","2026-06-09",{"date":187,"type":40},"2026-06-12",{"date":189,"type":40},"2026-05-03",{"date":191,"type":22},"2027-10-31",{"name":193,"class":47},"Universiti Sains Malaysia",{"id":195,"slug":196,"hasResults":12,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":202,"phases":4,"briefSummary":203,"conditions":204,"keywords":205,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":210,"completionDateStruct":211,"leadSponsor":213,"locationsCount":48},"100642796","evaluating-the-effectiveness-of-mobithron-xtra-in-patients-with-primary-knee-osteoarthritis-over-a-3-month-period-100642796","NCT07643662","Evaluating the Effectiveness of Mobithron Xtra in Patients With Primary Knee Osteoarthritis Over a 3-month Period","Observational Study to Evaluate the Effectiveness of Mobithron Xtra in Patients With Primary Knee Osteoarthritis Over a 3-month Period","Inclusion Criteria:\n\n* Adults ≥40 years with primary knee osteoarthritis (OA)\n* Radiographic diagnosis of primary knee OA (Grade 2 or 3 on Kellgren-Lawrence scale)\n* Stable physiotherapy regimen for ≥3 months (if applicable).\n* Baseline VAS score ≥ 5\n* No prior surgical intervention for the affected knee\n\nExclusion Criteria:\n\n* Secondary OA (such as post-traumatic and inflammatory arthritis)\n* Grade IV Primary OA\n* Patients on analgesia (e.g., paracetamol, NSAIDs)\n* Patients on Mobithron (P\u002FAdvance\u002FXtra) or glucosamine products\n* Recent intra-articular injections within 6 months\n* Recent\u002Fplanned knee surgery within 3 months\n* Severe comorbidities or cognitive impairment",{"count":136,"type":22},"OBSERVATIONAL","Knee osteoarthritis is a common condition that causes knee pain, stiffness, reduced mobility, and difficulty performing daily activities. Many patients seek non-surgical treatment options to help manage their symptoms and improve their quality of life.\n\nThis study aims to evaluate the effectiveness and safety of Mobithron® Xtra, an oral health supplement containing hyaluronic acid, undenatured type II collagen, and Boswellia serrata extract, in adults with primary knee osteoarthritis. Participants will take Mobithron® Xtra once daily for 3 months as part of their routine care.\n\nThe study will observe changes in knee pain, stiffness, physical function, treatment satisfaction, and overall perception of improvement using validated patient-reported outcome measures, including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS), Treatment Satisfaction Questionnaire for Medication (TSQM), and Patient Global Impression of Change (PGIC).\n\nThis is a prospective, multicentre observational study involving patients receiving treatment in participating general practitioner clinics throughout Malaysia. No experimental procedures will be performed, and participants will continue to receive standard clinical care. Safety will be monitored throughout the study by documenting any adverse events reported by participants.\n\nThe findings from this study may provide valuable real-world evidence regarding the role of Mobithron® Xtra in improving symptoms and quality of life among patients with primary knee osteoarthritis.",[31],[206,207],"knee osteoarthritis","mobitron","2026-06-08",{"date":162,"type":40},{"date":165,"type":22},{"date":212,"type":22},"2027-12",{"name":214,"class":47},"University of Malaya",{"id":216,"slug":217,"hasResults":12,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":222,"enrollmentInfo":223,"targetDuration":225,"studyType":202,"phases":4,"briefSummary":226,"conditions":227,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":4},"100639885","cohort-of-lower-extremity-sports-injuries-and-degenerationyongjiang-cohort-100639885","NCT07592871","Cohort of Lower-Extremity Sports Injuries and Degeneration(Yongjiang Cohort)","Bidirectional Cohort of Lower-Extremity Sports Injuries and Degeneration (Yongjiang Cohort)","Inclusion Criteria:\n\n* Patients who plan to receive relevant clinical evaluation or treatment at Ningbo No. 2 Hospital and are able to complete baseline assessment.\n* Patients with a clinical diagnosis of knee-related injury or degenerative knee disease.\n* Patients who are willing to provide informed consent and participate in follow-up.\n\nExclusion Criteria:\n\n* Patients who are unable to complete the core baseline assessments or have substantial missing key clinical information.\n* Patients with severe comorbid conditions or cognitive impairment that may affect assessment of the main outcomes or prevent participation in follow-up.\n* Patients who are considered by the investigator to be unsuitable for inclusion in this cohort.","90 Years",{"count":224,"type":22},500,"2 Years","This is an observational cohort study conducted at Ningbo No. 2 Hospital. The study will include patients with knee-related sports injuries or degenerative knee conditions who receive routine clinical care. The purpose is to build a standardized real-world clinical cohort and evaluate knee injury, degeneration, recovery, and long-term outcomes.\n\nAfter informed consent, participants will undergo baseline data collection, including medical history, laboratory tests, questionnaires, X-ray and MRI imaging, and functional assessments. Patients younger than 50 years will mainly be assessed for sports injury and functional recovery, while patients aged 50 years or older will receive additional sarcopenia-related assessments such as grip strength, DXA testing, and gait evaluation.\n\nNo experimental treatment, randomization, or intervention will be assigned. Participants will be followed at about 6, 12, and 24 months after treatment or surgery to assess knee function, imaging changes, reinjury, reoperation, pain, quality of life, falls, and functional decline. The study plans to enroll about 500 participants.",[31],"2026-05-19",{"date":230,"type":40},"2026-05-22",{"date":232,"type":22},"2026-06-01",{"date":234,"type":22},"2028-05-31",{"name":236,"class":47},"Ningbo No.2 Hospital",{"id":238,"slug":239,"hasResults":12,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":245,"enrollmentInfo":246,"targetDuration":4,"studyType":23,"phases":248,"briefSummary":249,"conditions":250,"keywords":252,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":262,"leadSponsor":264,"locationsCount":48},"100638168","genicular-nerve-block-in-knee-arthroplasty-100638168","NCT07589127","GENicular Nerve Block in KNEE Arthroplasty","GENicular Nerve Block in KNEE Arthroplasty - The GENKNEE Trial","GENKNEE","Inclusion Criteria:\n\n* Symptomatic knee OA grade II-IV according to the Kellgren-Lawrence classification system scheduled for primary total knee arthroplasty\n* American Society of Anesthesiologists (ASA) Physical Status grade I-III\n* Able to provide written informed consent\n* Able to undergo surgery under spinal anesthesia\n\nExclusion Criteria:\n\n* Younger than 18 or older than 80 years\n* ASA physical status IV\n* Allergy to local anesthetics\n* Revision surgery\n* Chronic opioid use (\\> 3 months)\n* Coagulopathy\n* Cognitive impairment\n* Inability to comply with study procedures\n* Patients scheduled for day care surgery.","80 Years",{"count":247,"type":22},70,[93],"The goal of this clinical trial is to learn whether a preoperative genicular nerve block (GNB) can reduce pain after knee replacement surgery in adults with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA). It will also assess whether this treatment can reduce opioid use and improve recovery.\n\nThe main questions it aims to answer are:\n\n* Does a preoperative GNB reduce pain during movement 24 hours after surgery compared with placebo?\n* Does it reduce opioid consumption and improve physical activity and functional outcomes after surgery?\n\nResearchers will compare patients receiving a GNB to patients receiving a placebo injection to see if the nerve block improves postoperative pain and recovery.\n\nParticipants will:\n\n* Be randomly assigned to receive either a GNB or a placebo injection before surgery\n* Undergo standard knee replacement surgery and postoperative care\n* Report pain levels at regular intervals after surgery\n* Complete questionnaires on function, quality of life, and recovery\n* Wear an activity monitor to measure physical activity after surgery\n* Attend follow-up assessments at 1 week, 1 month, and 3 months",[31,34,251],"Genicular Nerve Block",[253,254,255,256,257],"Osteoarthritis","Knee","Knee osteoarthritis","Total knee arthroplasty","Genicular nerve block","2026-05-11",{"date":260,"type":40},"2026-05-15",{"date":232,"type":22},{"date":263,"type":22},"2029-06-01",{"name":265,"class":266},"Helse Møre og Romsdal HF","OTHER_GOV",{"id":268,"slug":269,"hasResults":12,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":273,"eligibilityCriteria":274,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":275,"enrollmentInfo":276,"targetDuration":4,"studyType":23,"phases":278,"briefSummary":279,"conditions":280,"keywords":282,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":48},"100637221","effect-of-high-intensity-laser-therapy-on-femoral-cartilage-in-knee-osteoarthritis-100637221","NCT07584603","Effect of High-Intensity Laser Therapy on Femoral Cartilage in Knee Osteoarthritis","The Role of High-intensity Laser Therapy on Femoral Cartilage Thickness in Patients With Knee Osteoarthritis","HILT-KOA","Inclusion Criteria:\n\n* Male and female participants aged 40-60 years.\n* Diagnosed with knee osteoarthritis (Kellgren-Lawrence grade II or III).\n* Knee pain for at least 3 months.\n* Visual Analogue Scale (VAS) score ≥ 3.\n* Willing to provide written informed consent and comply with treatment and follow-up schedule.\n\nExclusion Criteria:\n\n* History of knee surgery or traumatic knee injury.\n* Inflammatory arthritis (e.g., gout, psoriatic arthritis).\n* History of cancer or psychiatric illness.\n* Cognitive disorders (e.g., Parkinson's disease, Alzheimer's disease).\n* Severe comorbidities limiting exercise (e.g., severe COPD, heart failure, cerebrovascular event).\n* Hip or ankle joint disability.\n* Intra-articular knee injection within the past 3 months.","60 Years",{"count":277,"type":22},58,[93],"This clinical trial will evaluate the effects of High-Intensity Laser Therapy (HILT) on femoral cartilage thickness and other clinical outcomes in people with knee osteoarthritis. Participants aged 40 to 60 years with grade II or III knee osteoarthritis will be randomly assigned to receive either HILT plus conventional physiotherapy or conventional physiotherapy alone. Both groups will receive 12 treatment sessions on alternate days for 4 weeks. The study will assess changes in cartilage thickness using ultrasound, as well as improvements in pain, knee movement, muscle strength, and daily function. Findings from this research may help improve physiotherapy treatment strategies for patients with knee osteoarthritis.",[31,281],"Osteoarthitis",[283,284,285,286,253],"High Intensity Laser Therapy","Knee Osteoarthritis","Femoral Cartilage Thickness","High Level Laser Therapy","2026-05-07",{"date":289,"type":40},"2026-05-13",{"date":291,"type":22},"2026-07-01",{"date":293,"type":22},"2027-05-10",{"name":295,"class":47},"University of Lahore",{"id":297,"slug":298,"hasResults":12,"nctId":299,"briefTitle":300,"officialTitle":300,"acronym":301,"eligibilityCriteria":302,"healthyVolunteers":55,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":23,"phases":305,"briefSummary":306,"conditions":307,"keywords":316,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":48},"100610737","platelet-rich-plasma-for-musculoskeletal-conditions-100610737","NCT07231471","Platelet Rich Plasma for Musculoskeletal Conditions","PRP for MSK","Inclusion Criteria:\n\n* 18+ years old\n* Musculoskeletal pathology that may benefit from a PRP injection\n* Failed other conservative treatments\n\nExclusion Criteria:\n\n* No active malignancy\n* No active infection in the area of injection\n* No platelet disorder\n* No active systemic infections\n* No patients currently undergoing dialysis",{"count":304,"type":22},10000,[93],"The primary purpose of this study is to follow patients with various musculoskeletal (MSK) conditions over a one-year follow-up period after receiving a platelet rich plasma (PRP) injection, assessing changes in their pain levels, functional abilities, and overall patient satisfaction.\n\nThis will develop a robust registry of patients treated with PRP for a range of MSK conditions. These conditions include, but are not limited to, osteoarthritis (OA) of the knee, hip, glenohumeral joint, elbow, ankle, and sacroiliac joint, as well as rotator cuff tendinopathy, lateral and medial epicondylitis, plantar fasciitis, patellar tendinopathy, Achilles tendinopathy, and proximal hamstring tendinopathy.",[308,31,309,310,311,312,313,314,315],"Osteoarthritis (OA)","Osteoarthritis (OA) of the Hip","Osteoarthritis (OA) of the Shoulder","Osteoarthritis Ankle","Elbow Osteoarthritis","Epicondylitis of the Elbow","Plantar Fasciitis of Both Feet","Tendinopathy",[317,318,253,315],"PRP","Platelet Rich Plasma","2026-05-05",{"date":321,"type":40},"2026-05-06",{"date":323,"type":40},"2025-12-29",{"date":325,"type":22},"2035-01-01",{"name":327,"class":47},"University of Utah",{"id":329,"slug":330,"hasResults":12,"nctId":331,"briefTitle":332,"officialTitle":332,"acronym":333,"eligibilityCriteria":334,"healthyVolunteers":12,"sex":18,"minAge":335,"maxAge":336,"enrollmentInfo":337,"targetDuration":4,"studyType":23,"phases":339,"briefSummary":340,"conditions":341,"keywords":346,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":355,"leadSponsor":357,"locationsCount":48},"100625073","ketogenic-diet-to-reduce-osteoarthritis-pain-in-mci-100625073","NCT07417891","Ketogenic Diet to Reduce Osteoarthritis Pain in MCI","KDROP-MCI","Inclusion Criteria:\n\n* English speaking\n* Diagnosis of major joint osteoarthritis\n* Diagnosis of mild cognitive impairment\n\nExclusion Criteria:\n\n* Diabetes that requires insulin\n* Cancer requiring chemo- or radiation therapy in the last 2 years\n* Cardiac event within 1 year\n* Recent history of renal stones\n* Diagnosis of fibromyalgia\n* Already following a ketogenic diet\n* Following a dietary pattern that does not allow for a ketogenic approach\n* Unable to control one's diet","55 Years","75 Years",{"count":338,"type":22},10,[93],"Osteoarthritis and mild cognitive impairment are common conditions that share underlying biological processes related to metabolism and inflammation. This study will examine whether a well-formulated ketogenic diet influences pain, physical function, and cognitive outcomes in adults with osteoarthritis and mild cognitive impairment. Participants will follow a supervised ketogenic dietary intervention, with assessments conducted before and after the intervention to evaluate changes in symptoms and related biological markers. The goal of this study is to better understand shared mechanisms between joint pain and cognitive health and to explore whether a ketogenic dietary approach may support symptom management in these populations.",[309,31,310,253,342,343,344,345],"Mild Cognitive Impairment","MCI","Mild Cognitive Impairment (MCI)","Dementia",[347,348,349,350],"ketogenic diet","chronic pain","osteoarthritis","mild cognitive impairment","2026-04-30",{"date":353,"type":40},"2026-05-04",{"date":232,"type":22},{"date":356,"type":22},"2027-06-01",{"name":358,"class":47},"University of Kansas Medical Center",{"id":360,"slug":4,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":23,"phases":362,"briefSummary":27,"conditions":363,"keywords":364,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":369,"leadSponsor":371,"locationsCount":48},"100578338",{"count":21,"type":22},[25,26],[29,30,31,32],[16,34,35],"2026-04-29",{"date":367,"type":40},"2026-05-01",{"date":42,"type":40},{"date":370,"type":22},"2027-07-30",{"name":46,"class":47},{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":378,"eligibilityCriteria":379,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":380,"enrollmentInfo":381,"targetDuration":4,"studyType":23,"phases":383,"briefSummary":384,"conditions":385,"keywords":389,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":48},"100584741","impact-of-bone-marrow-aspirate-injections-in-knee-arthroscopy-100584741","NCT06893302","Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy","Bone Marrow Aspirate Injections in Knee Arthroscopy: A Randomized, Single-Blind, Controlled Trial","BMA","Inclusion Criteria:\n\n1. Require a primary knee arthroscopy for a meniscal injury or focal chondral defect (knee debridement or meniscectomy)\n2. Have Kellgren-Lawrence grade 0 arthritis\n3. Have Outerbridge cartilage grade 2 or lower\n4. Ages 18-64\n\nExclusion Criteria:\n\n1. Have previously undergone ipsilateral knee surgery\n2. Have Kellegren-Lawrence grade 3 or greater\n3. Have received other OrthoBiologics within 3 mo of surgery\n4. Have ligament deficiencies\n5. Need meniscal repair\n6. Need a concomitant osteotomy or other realignment surgery\n7. Have used DMARDs within the last three months\n8. Have a hx of anemia, bleeding disorders, or inflammatory joint disease (rheumatoid arthritis, infectious arthritis, hemophilic arthropathy, Charcot's knee)\n9. Have a hx of metabolic bone disease (osteoporosis, osteomalacia, rickets, osteitis fibrosa cystica, Paget's disease of bone)\n10. Patients who are currently pregnant","64 Years",{"count":382,"type":22},50,[93],"This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or cartilage damage. Like flipping a coin, patients will be randomly assigned to one of two groups of 25 patients each. One group will receive standard arthroscopic surgery plus an injection of bone marrow aspirate, while the other group will receive standard surgery plus a saline (salt water) injection. During surgery, for patients in the treatment group, approximately 4mL (less than one teaspoon) of bone marrow will be taken from their hip bone using a special needle system. A small amount (1mL) will be sent to the laboratory for testing. Patients will be followed for 12 months after surgery and will complete questionnaires about their pain levels and knee function at several time points: before surgery, 2 weeks, 6 weeks, 3 months, 6 months, and 12 months after surgery. These questionnaires will ask about pain, daily activities, and overall improvement.",[386,387,388,31],"Chondral Lesion of the Knee","Meniscal Injuries","Cartilage Defects of the Knee",[390,391,392,393,349,394,395,396,378],"knee arthroscopy","meniscal injury","knee debridement","meniscectomy","cartilage defect","chondral lesion","bone marrow aspirate","2026-04-23",{"date":399,"type":40},"2026-04-27",{"date":401,"type":22},"2026-06",{"date":403,"type":22},"2029-04",{"name":405,"class":47},"Hospital for Special Surgery, New York",{"id":407,"slug":408,"hasResults":12,"nctId":409,"briefTitle":410,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":12,"sex":18,"minAge":412,"maxAge":112,"enrollmentInfo":413,"targetDuration":4,"studyType":23,"phases":415,"briefSummary":416,"conditions":417,"keywords":418,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":422,"lastUpdatePostDateStruct":423,"startDateStruct":425,"completionDateStruct":427,"leadSponsor":429,"locationsCount":48},"100570038","the-efficacy-of-transcutaneous-pulsed-radiofrequency-acupuncture-for-knee-osteoarthritis-100570038","NCT06702046","The Efficacy of Transcutaneous Pulsed Radiofrequency Acupuncture for Knee Osteoarthritis","Inclusion Criteria:\n\n* Age from 45 to 85 year-old with knee pain for more than six months\n* Fulfill the combined clinical and radiographic criteria of knee OA established by the American College of Rheumatology with a Kellgren and Lawrence score of 2 or greater\n* Pain score above 3 (range 0-10 on the visual analog scale; higher scores indicate greater pain\n* Could participate in 4 weeks of treatment and 3 months of follow-up\n\nExclusion Criteria:\n\n* Knee OA combined with any infection, inflammation, autoimmune disease, or fracture\n* History or underlying disease that would affect posture and balance, such as malignancy, dizziness, vertigo, or stroke\n* Ever underwent any type of knee operation or internal fixation\n* Pregnant or planning to become pregnant\n* Receiving other treatment for knee OA in previous 3 months\n* History of epilepsy, electronic devices implanted in the body\n* Active infection at the stimulator contact site\n* Lack of informed consent\n* Any other reason thought likely to result in inability to complete the trial","45 Years",{"count":414,"type":22},90,[93],"Efficacy of transcutaneous acupoint pulsed radiofrequency with rehabilitation for knee osteoarthritis.",[31],[206,419,420,421],"transcutaneous pulsed radiofrequency","acupuncture","acupoints","2026-04-21",{"date":424,"type":40},"2026-04-24",{"date":426,"type":40},"2025-02-24",{"date":428,"type":22},"2028-06-30",{"name":430,"class":47},"Shin Kong Wu Ho-Su Memorial Hospital",{"id":432,"slug":433,"hasResults":12,"nctId":434,"briefTitle":435,"officialTitle":435,"acronym":436,"eligibilityCriteria":437,"healthyVolunteers":55,"sex":18,"minAge":438,"maxAge":4,"enrollmentInfo":439,"targetDuration":4,"studyType":23,"phases":441,"briefSummary":442,"conditions":443,"keywords":444,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":454,"locationsCount":48},"100633607","the-gorun-study-gradual-onset-of-running-and-knee-joint-health-in-novice-runners-100633607","NCT07528885","The GORUN Study: Gradual Onset of RUNning and Knee Joint Health in Novice Runners","GORUN","Inclusion criteria (all):\n\n* have been running consistently for no more than six months at time of enrolment, with a cumulative weekly volume of less than 5 kilometres OR have yet to take up recreational running consistently\n* are comfortable running and walking on a treadmill for at least 30 minutes\n\nInclusion criteria (knee osteoarthritis (OA) group):\n\n* have definitive knee OA as diagnosed using x-rays\n* report having experienced frequent knee pain over the past 3 months\n\nInclusion criteria (Control group):\n\n* have no evidence of knee OA based on x-rays\n* have had pain-free knees for at least the past 3 months\n\nExclusion Criteria (all):\n\n* have an inflammatory arthritic condition (e.g. gout or rheumatoid arthritis)\n* have a presence of any health condition (other than OA in the knee OA group) affecting normal movement or that precludes engaging in moderate to high impact activities such as running\n\nAdditionally, exclusion criteria based on MRI safety:\n\n* cannot safely fit into the MRI scanner\n* presence of metallic implants (including pace makers, brain aneurysm clips, stents, cochlear implants, artificial heart valves, and prostheses)\n* recent surgery or tattoos within the past 6 weeks\n* current or possible pregnancy\n* electrical stimulator for nerves or bones\n* infusion pumps\n* shrapnel or other metallic fragments\n* non-removable metallic jewellry","35 Years",{"count":440,"type":22},80,[93],"Knee osteoarthritis (OA) is a debilitating disease affecting millions worldwide. Exercise is a core treatment for knee OA, and is advocated by all clinical guidelines. Running is a common exercise that is accessible and evokes a number of positive physical and psychological benefits. However, the appropriateness of recreational running in the presence of knee OA is unclear.\n\nA growing literature base appears to suggest that running may not be deleterious to the health - especially at the knee joint - of people with knee OA. Our recent research has focused on examining a number of health outcomes relevant to knee OA in older individuals with knee OA, but has been limited to experienced runners. This study will address that limitation by focusing on how novice (new) runners respond to a new running program.",[31],[445,446],"running","exercise","2026-04-07",{"date":449,"type":40},"2026-04-14",{"date":451,"type":22},"2026-05",{"date":453,"type":22},"2030-12-31",{"name":455,"class":47},"University of British Columbia",{"id":457,"slug":458,"hasResults":12,"nctId":459,"briefTitle":460,"officialTitle":461,"acronym":4,"eligibilityCriteria":462,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":463,"targetDuration":4,"studyType":23,"phases":465,"briefSummary":466,"conditions":467,"keywords":471,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":476,"startDateStruct":478,"completionDateStruct":479,"leadSponsor":481,"locationsCount":48},"100633115","imageless-navigation-versus-image-based-navigation-in-robotic-assisted-total-knee-arthroplasty-for-knee-osteoarthritis-100633115","NCT07522489","Imageless Navigation Versus Image-Based Navigation in Robotic-Assisted Total Knee Arthroplasty for Knee Osteoarthritis","Outcomes of Robotic-Assisted Total Knee Arthroplasty With Imageless Navigation Versus Image-Based Navigation: A Randomised, Single-Blinded, Non-Inferiority Trial","Inclusion Criteria:\n\n1. Symptomatic, radiologically confirmed advanced osteoarthritis of the knee.\n2. Patients referred for primary robotic-assisted total knee arthroplasty.\n3. Patients in whom a correctly performed radiograph with designated sensors has confirmed the possibility of performing robotic-assisted total knee arthroplasty with image-based navigation.\n4. Patients capable of giving informed consent to participate in the study and willing to attend all follow-up visits.\n\nExclusion Criteria:\n\n1. No informed consent for the surgery.\n2. No informed consent for taking part in the study.\n3. Pregnancy.\n4. Active infections.\n5. Diagnosed comorbidities: autoimmune arthritis, malignant tumors, serious neurological disorders affecting a reliable functional outcome measurement (e.g., severe stroke, severe Parkinson's disease).",{"count":464,"type":22},146,[93],"The goal of this clinical trial is to learn if imageless navigation is not inferior to image-based navigation in robotic-assisted total knee arthroplasty (RA-TKA) for treating patients with knee osteoarthritis.\n\nThe main questions the study aims to answer are:\n\n1. Does imageless procedure provide functional results comparable to those of image-based navigation?\n2. Are there differences in postoperative complications patients may experience after RA-TKA with imageless and image-based navigation? Researchers will compare imageless navigation with image-based navigation used in total knee arthroplasty to assess whether imageless navigation is comparable for the treatment of knee osteoarthritis.\n\nParticipants will:\n\n1. Answer survey questions about knee pain and function before RA-TKA.\n2. Undergo RA-TKA with imageless navigation or image-based navigation.\n3. Visit the Clinic after 6 months and 12 months after surgery for checkups and to answer the same survey questions about postoperative knee pain and function.",[31,468,469,470],"Knee Pain Arthritis","Total Knee Arthroplasty (TKA)","Robotic Assisted Arthroplasty",[284,472,473,474,475],"Robotic-Assisted Total Knee Arthroplasty","Patient Reported Outcome Measures","Imageless Navigation","Image-based Navigation",{"date":477,"type":40},"2026-04-13",{"date":451,"type":22},{"date":480,"type":22},"2029-01",{"name":482,"class":47},"Medical University of Warsaw",{"id":484,"slug":485,"hasResults":12,"nctId":486,"briefTitle":487,"officialTitle":488,"acronym":489,"eligibilityCriteria":490,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":4,"enrollmentInfo":491,"targetDuration":4,"studyType":23,"phases":492,"briefSummary":493,"conditions":494,"keywords":503,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":514,"startDateStruct":516,"completionDateStruct":518,"leadSponsor":520,"locationsCount":48},"100598260","feasibility-of-choose-to-move-replacement-ready-100598260","NCT07069179","Feasibility of Choose to Move Replacement Ready","Choose to Move Replacement Ready: A Feasibility Trial of a Virtual Health-promoting Intervention for People Awaiting Total Hip or Knee Replacement Surgery","CTM-RR","Inclusion Criteria:\n\n1. Activity coach hired by the Active Aging Society (activity coaches must speak English to participate in the evaluation);\n2. English-speaking older adults (aged \\>=50 years) who participate in CTM-RR will be invited to participate in the evaluation\n3. Referral partner (People who work in a healthcare setting who refer patients into the program)\n\nExclusion Criteria:\n\n1. non-English speaking activity coach\n2. non-English speaking referral partner",{"count":21,"type":22},[93],"Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada. Recently, the investigators adapted CTM for the \\>14000 people in BC who are on surgical waitlists for total knee replacement or total hip replacement (TKR\u002FTHR) for osteoarthritis (OA). The primary goal of this observational study is to learn if the adapted program, Choose to Move Replacement Ready (CTM-RR), is feasible to deliver to people with hip and\u002For knee osteoarthritis who are on surgical waitlists for TKR\u002FTHR.\n\nParticipants who enrol in CTM-RR will answer online survey questions about the program and about their physical activity, mobility, pain, function, quality of life, willingness to undergo surgery, overall perception of their joint condition, psychosocial health, self-efficacy, social isolation, loneliness, and sedentary time. CTM-RR activity coaches will also answer online survey questions about the program. CTM-RR participants, activity coaches, and referral partners will also participate in interviews about the program.",[253,31,495,496,497,498,499,500,501,502],"Osteoarthritis, Hip","Total Knee Arthroplasty; Total Hip Arthroplasty","Mobility Limitation","Social Isolation or Loneliness","Pain","Implementation Science","Physical Inactivity","Sedentary Behaviors",[253,504,505,506,507,508,499,509,510,511,512],"Implementation science","Social isolation","Physical activity","Mobility","Loneliness","Joint replacement","Feasibility","Acceptability","Fidelity","2026-03-10",{"date":515,"type":40},"2026-03-12",{"date":517,"type":40},"2025-07-14",{"date":519,"type":22},"2028-03",{"name":455,"class":47},{"id":522,"slug":523,"hasResults":12,"nctId":524,"briefTitle":525,"officialTitle":526,"acronym":527,"eligibilityCriteria":528,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":89,"enrollmentInfo":529,"targetDuration":4,"studyType":23,"phases":530,"briefSummary":531,"conditions":532,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":541,"locationsCount":543},"100561950","personalized-digital-training-intervention-to-reduce-inflammation-by-correcting-pathological-movement-patterns-in-pre-stage-knee-osteoarthritis-after-anterior-cruciate-ligament-reconstruction-100561950","NCT06596824","Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction","Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis (OA)","PROTO-WP4","Inclusion Criteria:\n\n* Signed written informed consent\n* Adult subjects between 18 to 50 years old at the time of screening\n* Primary ACL reconstruction within a maximum of 6 months after a unilateral ACL injury\n* Complete baseline assessment between 8 and 12 weeks after ACL reconstruction\n\nExclusion Criteria:\n\n* Significant trauma to a weight-bearing joint within 12 months prior to study initiation (excluding the ACL injury)\n* Previous surgeries on the study knee (except for the ACL reconstruction)\n* Signs of knee OA as defined by the OARSI-Joint Space Narrowing (JSN) Score of two or more (standing AP x-ray)\n* Physical activity level: Tegner activity score before injury of 0-2 (very low activity) or 8-10 (very high activity)\n* Body mass index ≥ 30 kg\u002Fm2;\n* Inflammatory arthropathies;\n* Immunosuppression due to illness or medication;\n* Sepsis or hemostasis disorders;\n* Severe uncontrolled inflammatory disease or autoimmune disease (e.g., ulcerative colitis, Crohn's disease, etc.);\n* Having malignancy and undergoing treatment including chemotherapy, radiotherapy, or immunotherapy;\n* Contraindications for MRI, including pacemakers, defibrillators, metal implants, pregnancy, sensorineural hearing loss above 30 dB, tinnitus and claustrophobia\n* Unable to freely give their informed consent (e.g., individuals under legal guardianship).\n* Currently enrolled in or has not yet completed a period of at least 5 times as the half-life time of the drug used in the previous trial since ending other investigational device or drug trial(s)\n* Patients who are dependent on the sponsor, investigator, or study site;\n* Pregnant or breast-feeding women or women of childbearing potential not protected by an effective contraceptive method of birth control (defined as pearl index \\\u003C 1);\n* Any form of substance abuse, psychiatric disorder, or other condition that, in the opinion of the Investigator, may invalidate communication with the Investigator and\u002For designated study personnel;\n* Patients who are committed to an institution by virtue of an order issued by either the judicial or the administrative authorities;",{"count":21,"type":22},[93],"Osteoarthritis (OA) is a condition that causes pain and stiffness in the joints, often due to injuries like torn ligaments. Even after surgery, these injuries can lead to long-term joint problems. Current treatments don\\'t fully prevent OA from developing. This study is testing a new 12-week exercise program designed to improve how the knee moves, using a special sensor-based system. The goal is to reduce joint inflammation and prevent the development of OA in patients who have had knee surgery.",[31,533],"ACL Reconstruction","2026-02-27",{"date":536,"type":40},"2026-03-02",{"date":538,"type":40},"2024-09-01",{"date":540,"type":22},"2027-12-31",{"name":542,"class":47},"Charite University, Berlin, Germany",2,{"id":545,"slug":546,"hasResults":12,"nctId":547,"briefTitle":548,"officialTitle":549,"acronym":4,"eligibilityCriteria":550,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":57,"enrollmentInfo":551,"targetDuration":4,"studyType":23,"phases":553,"briefSummary":554,"conditions":555,"keywords":559,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":561,"lastUpdatePostDateStruct":562,"startDateStruct":563,"completionDateStruct":565,"leadSponsor":567,"locationsCount":4},"100626011","phase-4-post-operative-pain-relief-zynrelef-or-periarticular-injections-in-ratka-100626011","NCT07430085","Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA","Postoperative Pain Outcomes After Use of Bupivacaine-Meloxicam Extended-Release Solution in Robot Assisted Total Knee Arthroplasty: A Prospective Study","Inclusion Criteria:\n\nMales or females aged 18-89 years\n\nDiagnosed with knee osteoarthritis requiring surgical intervention\n\nIndicated for unilateral RATKA\n\nExclusion Criteria:\n\nPediatric, pregnant, or incarcerated patients\n\nBMI of more than 45 kg\u002Fm2\n\nProlonged opioid use history of \\>5 mg\u002Fday for \\>1 month\n\nHistory of contralateral TKA \\\u003C2 years prior to the index TKA\n\nType 1 Hypersensitivity to NSAIDs or local anesthetics\n\nDiagnosis of severe renal disease",{"count":552,"type":22},150,[61],"Prospective Cohort of patients who are scheduled for a Robot Assisted Total Knee Arthroplasty (RATKA). A prospective survey of patient reported outcome measures (Numeric Rating Scale) will be obtained postoperatively of 72 hours, as well as at the postoperative opioid consumption after 72 hours.",[556,308,31,557,558],"Periarticular Block","Pain After Surgery","Knee Arthroplasty, Total",[560],"Zynrelef","2026-02-24",{"date":534,"type":40},{"date":564,"type":22},"2026-01-31",{"date":566,"type":22},"2028-02-28",{"name":568,"class":47},"Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)",{"id":570,"slug":571,"hasResults":12,"nctId":572,"briefTitle":573,"officialTitle":574,"acronym":4,"eligibilityCriteria":575,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":576,"targetDuration":4,"studyType":23,"phases":578,"briefSummary":579,"conditions":580,"keywords":583,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":594,"lastUpdatePostDateStruct":595,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":601,"locationsCount":48},"100587552","mako-cementless-tka-vs-mako-cemented-tka-100587552","NCT06929871","Mako Cementless TKA vs Mako Cemented TKA","A Prospective Randomised Controlled Trial Comparing Cementless Mako Robotic-arm Assisted Total Knee Arthroplasty Versus Cemented Mako Robotic-arm Assisted Total Knee Arthroplasty.","Inclusion Criteria:\n\n1. Patient has symptomatic knee osteoarthritis requiring primary TKA\n2. Patient and surgeon are in agreement that TKA is the most appropriate treatment\n3. Patient is fit for surgical intervention following review by surgeon and anaesthetist\n4. Patient is over 18 years old at time of surgery\n5. Gender: male and female\n6. Patient must be capable of giving informed consent and agree to comply with the postoperative review program\n7. Patient must have sufficient postoperative mobility to attend follow-up clinics and allow for radiographs to be taken\n\nExclusion Criteria:\n\n1. Patient is not suitable for routine primary TKA e.g. patient has ligament deficiency that requires a constrained prosthesis\n2. Patient has bone loss that requires augmentation\n3. Patient is not medically fit for surgical intervention\n4. Patient requires revision surgery following previously failed correctional osteotomy or ipsilateral TKA\n5. Patient has a DEXA scan with T-score \\\u003C -2.5 at any point\n6. Patient is immobile or has another neurological condition affecting musculoskeletal function\n7. Patient is less than 18 years at time of surgery\n8. Patient is unable or unwilling to sign the informed consent form specific to this study\n9. Patient is unable to attend the follow-up programme\n10. Previous pathological fracture",{"count":577,"type":22},120,[93],"The overall aims of this prospective, randomised, single-blinded controlled trial are to compare functional, radiological and clinical outcomes in Mako robotic-arm assisted cementless Total Knee Arthroplasty (TKA) versus Mako robotic-arm assisted cemented TKA.",[581,582,34,31],"Total Knee Replacement","Total Knee Replacement Surgery",[584,585,586,587,588,589,590,591,592,593],"robotic surgery","cemented implants","uncemented implants","makoplasty","functional outcomes","clinical outcomes","radiological outcomes","inflammatory marker","radiostereometric analysis","RSA","2026-02-17",{"date":596,"type":40},"2026-02-20",{"date":598,"type":40},"2025-09-29",{"date":600,"type":22},"2031-08-01",{"name":602,"class":47},"University College, London",{"id":604,"slug":605,"hasResults":12,"nctId":606,"briefTitle":607,"officialTitle":608,"acronym":4,"eligibilityCriteria":609,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":610,"targetDuration":4,"studyType":23,"phases":612,"briefSummary":613,"conditions":614,"keywords":615,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":623,"startDateStruct":625,"completionDateStruct":627,"leadSponsor":629,"locationsCount":48},"100617909","the-effectiveness-of-a-herbal-supplement-in-osteoarthritis-100617909","NCT07324746","The Effectiveness of a Herbal Supplement in Osteoarthritis.","Effectiveness of a Herbal Supplement Containing Boswellia Serrata, Curcuma Longa, and Vitis Vinifera in Patients With Osteoarthritis.","Inclusion Criteria:\n\n* Aged ≥ 18\n* Diagnosis of osteoarthritis in knee or hip\n* Numerical Rating Scale (NRS) ≥ 4 during the most painful movement in the last 24 hours\n* Lequesne's Functional Index (LFI) score ≥ 7\n* Ambulant patient\n\nExclusion Criteria:\n\n* Pregnant and breastfeeding\n* Autoimmune disease such as rheumatoid arthritis, gout, lupus\n* Joint trauma, joint injury, joint infection, meniscus tear, complete loss of articular cartilage\n* Expectation of surgery\n* History of the viscous or corticosteroids injections into affected joints or oral corticosteroids within last 12 months\n* Allergy to one of the intervention's ingredients or NSAIDs\n* Peptic ulceration and upper gastrointestinal haemorrhage\n* High alcohol intake, inability to abstain from alcohol, substance abuse, history of addiction\n* Tumor, cancer\n* Abnormal renal or\u002Fand hepatic functions or altered blood chemistry\n* Use of concomitant medication able to interfere with the interventions",{"count":611,"type":22},30,[93],"This study aims to evaluate the effectiveness and safety of a combined herbal supplement containing Boswellia serrata, Curcuma longa, and Vitis vinifera in adults with clinically diagnosed knee or hip osteoarthritis.\n\nThe primary objective is to determine whether the supplement improves osteoarthritis-related symptoms.\n\nThe supplement will be compared with a placebo.\n\nParticipants will:\n\n* take the supplement and placebo for 4 weeks each, one at a time;\n* complete validated questionnaires (6 times online)\n* perform three performance-based physical tests (6 times online)\n* provide a urine sample",[308,309,31,253],[616,617,618,619,253,620,255,621],"Boswellia serrata","Curcuma longa","Curcumin","Turmeric","Grape extract","Hip osteoarthritis","2026-01-27",{"date":624,"type":40},"2026-01-29",{"date":626,"type":40},"2025-12-05",{"date":628,"type":22},"2026-09",{"name":630,"class":47},"Middlesex University",{"id":632,"slug":633,"hasResults":12,"nctId":634,"briefTitle":635,"officialTitle":636,"acronym":4,"eligibilityCriteria":637,"healthyVolunteers":55,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":638,"targetDuration":4,"studyType":23,"phases":640,"briefSummary":641,"conditions":642,"keywords":643,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":647,"lastUpdatePostDateStruct":648,"startDateStruct":650,"completionDateStruct":652,"leadSponsor":654,"locationsCount":48},"100620201","effects-of-different-relaxation-therapies-on-pain-and-sleep-in-hip-and-knee-arthroplasty-patients-100620201","NCT07354542","Effects of Different Relaxation Therapies on Pain and Sleep in Hip and Knee Arthroplasty Patients","Comparison of the Effects of Virtual Reality-based and Traditional Relaxation Therapy on Postoperative Pain and Sleep Quality in Patients Undergoing Hip and Knee Replacement Surgery","Inclusion Criteria:\n\n* Those who volunteered to participate in the research,\n* 18 years and older,\n* No diagnosed mental or sleep problems, epilepsy, or depression,\n* No vision, hearing, or speech problems,\n* Those who speak Turkish,\n* Knee and hip replacement surgery ,\n* No active nausea or vomiting prior to the virtual reality application,\n* According to the Numerical Rating Scale, the patient reports pain.\n* Those receiving analgesia treatment according to clinical protocol,\n* Anyone who owns a mobile phone or tablet capable of playing videos, using any brand of internet provider,\n* Patients who had not previously practiced breathing exercises were included .\n\nExclusion Criteria:\n\n* Having a problem that prevents communication,\n* Being admitted to the ward where the surgery and study were performed at another center,\n\n  . Complications develop after knee and hip replacement surgery,\n* Nausea and vomiting may occur during the procedure.\n* Wanting to withdraw from the research,\n* Experiencing chronic pain.",{"count":639,"type":22},82,[93],"Hip and knee replacement surgery is commonly performed in older adults. After surgery, many patients experience pain, limited movement, and sleep problems. These difficulties can make daily activities such as walking or climbing stairs more challenging and may reduce quality of life during recovery.\n\nRelaxation exercises are often used to help reduce pain and improve sleep after surgery. Virtual reality (VR) is a technology that provides a multisensory experience and may help people relax by shifting their attention away from pain and discomfort.\n\nThis study is designed to compare two different relaxation approaches used after hip and knee replacement surgery. One group of patients will perform relaxation exercises using virtual reality, while another group will perform traditional relaxation exercises. The study will examine pain levels and sleep quality in both groups.\n\nThe results of this study may help to better understand whether virtual reality-based relaxation can be used as an alternative or supportive method for managing pain and sleep problems after joint replacement surgery.",[309,31],[644,645,646],"Postoperative Pain","Sleep Quality","Virtual Reality","2026-01-22",{"date":649,"type":40},"2026-01-23",{"date":651,"type":40},"2024-11-01",{"date":653,"type":22},"2026-01-30",{"name":655,"class":47},"Bartın Unıversity",{"id":657,"slug":658,"hasResults":12,"nctId":659,"briefTitle":660,"officialTitle":661,"acronym":4,"eligibilityCriteria":662,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":663,"targetDuration":4,"studyType":23,"phases":664,"briefSummary":665,"conditions":666,"keywords":668,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":672,"lastUpdatePostDateStruct":673,"startDateStruct":675,"completionDateStruct":677,"leadSponsor":678,"locationsCount":48},"100606699","neurolysis-for-the-treatment-of-medial-chronic-knee-pain-due-to-osteoarthritis-100606699","NCT07178951","Neurolysis for the Treatment of Medial Chronic Knee Pain Due to Osteoarthritis","Safety and Feasibility of the Neurolyser XR Device for the Treatment of Predominantly Medial Chronic Knee Pain Due to Osteoarthritis","Inclusion Criteria:\n\n1. Moderate to severe, predominantly medial chronic knee pain\n2. Age adult \\>18 years old\n3. WOMAC Score of 30 or higher\n4. NRS\\>6 with ambulation\n5. Radiological confirmation of knee osteoarthritis (Kellgren-Lawrence Scale: 2-4)\n6. Participants in whom the measured skin to bone depth is 2-6 cm using imaging ultrasound and ultrasound gel pad in the upper medial and lower medial joint capsule targets.\n\nExclusion Criteria:\n\n1. Individuals meeting any of the following criteria are not eligible for participation in this study:\n2. Individuals after any surgery associated with altered integrity of bone structure\n3. Individuals with severe pain in the second knee\n4. Individuals unable to understand and complete the research questionnaires in the official language\n5. Individuals presenting with any severe medical condition preventing the participant from safely and effectively being treated in the study or reporting study outcomes, per PI decision\n6. Individuals with extensive scarring of the skin and tissue overlying the treatment area\n7. Individuals enrolled in or planned to be enrolled in another clinical trial during the duration of this research project\n8. Individuals with active inflammatory (e.g., rheumatoid) arthritis\n9. Individuals with concomitant mental health disorders, excluding compensated mood disorders\n10. Individuals with altered perception and processing of pain: Average NRS \\> 9, PCS\\>30, SSS-8 \\> 11, CSI\\>40 \\[46\\], \\[47\\], \\[48\\]\n11. Individuals with a first-degree family member already enrolled in this study\n12. Individuals who are scheduled for any interventional\u002Fsurgical procedure within 3 months from the screening date, excluding trivial surgeries (e.g., cataract, skin tumors)\n13. Inability to attend follow-up visits and physiotherapy due to travel distance or other restrictions\n14. Symptomatic multifocal nociplastic chronic pain (e.g., fibromyalgia, generalized osteoarthritis) or any other chronic pain condition that could influence symptoms.\n15. Participants who have undergone radiofrequency ablation of the genicular nerves in the planned treatment limb within the preceding 6 months.",{"count":338,"type":22},[93],"This study involves the use of sound waves to block pain signals caused by osteoarthritis of the knee. The sound waves are tightly focused on a specific area of the nerve. The sound waves cause a break in the nerve which carries pain signals. Sound waves transmit through the skin so there is no need for needles. The procedure takes approximately one hour. The device has been approved in Health Canada and Europe for the treatment of lower back pain. This study is to evaluate the use of the same device for people in Canada who have knee pain related to osteoarthritis.",[31,468,667],"Chronic Knee Pain",[349,669,670,671],"knee pain","focused ultrasound","nerve ablation","2026-01-05",{"date":674,"type":40},"2026-01-07",{"date":676,"type":22},"2026-01",{"date":79,"type":22},{"name":679,"class":680},"FUSMobile Inc.","INDUSTRY"]