[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteoarthritis-of-knee\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteoarthritis-of-knee":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,45,76,104,132,162,185,208,239,260,289,310],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100583599","cannabinoids-for-osteoarthritis-pain-effectiveness-trial-100583599",false,"NCT06878417","Cannabinoids for Osteoarthritis Pain Effectiveness Trial","The Effectiveness of Oral Cannabis Extracts for Osteoarthritic Pain: an Internal Pilot, Placebo Controlled, Blinded Randomized Trial","COPE","Inclusion Criteria:\n\n1. Age 40-80 years\n2. Diagnosed with hip and\u002For knee osteoarthritis as per the American College of Rheumatology criteria\n3. Experiencing moderate to severe pain interference as indicated by a PROMIS-PI SF-6a T-score ≥ 60\n4. Have not initiated any new analgesics or osteoarthritis treatments in the previous 4 weeks\n5. Able to self-report, understand and read English or French\n\nExclusion Criteria:\n\n1. Hip or knee surgery planned in the coming 4 months,\n2. Injection into the affected joint(s) within the past 3 months (e.g., cortisone, plasma-rich protein, etc.),\n3. Planned injection into the affected joint(s) during trial period,\n4. Inflammatory arthritis (e.g., rheumatoid arthritis, Psoriatic arthritis, gout, etc.),\n5. Contraindications to taking cannabis\u002Fcannabinoids,\n6. Used nabilone or nabiximols in the last 30 days,\n7. Used cannabis (medical or recreational) in the last 30 days (to allow sufficient washout),\n8. A history of diagnosed cannabis use disorder or dependence,\n9. Active substance use disorder,\n10. Current DSM-V diagnosis of bipolar disorder, major depression, or psychosis,\n11. An uncontrolled medical or major psychiatric disorder,\n12. Currently on warfarin,\n13. Known pregnancy or currently breastfeeding,\n14. Men and women planning a pregnancy during the study or in the 12 weeks after stopping IPs\n15. No fixed address or a plan to change addresses in the coming 4 months,\n16. Known or suspected allergy to palm\u002Fcoconut oil","ALL","40 Years","80 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to investigate whether oral cannabis extracts can effectively manage pain caused by osteoarthritis (OA), a common joint condition affecting one in seven Canadians. Current OA treatments often have limited effectiveness and may cause side effects. As a result, many individuals with OA turn to medical cannabis for pain relief, despite limited scientific evidence supporting its efficacy.\n\nThe goal of this study is to assess the feasibility of a larger trial evaluating the effects of two cannabis compounds-CBD and THC-compared to a placebo (a look-alike substance containing no active drug) on pain interference in patients with hip and\u002For knee osteoarthritis.\n\nParticipants will:\n\n* Take either CBD, THC, or a placebo capsule daily for 8 weeks\n* Complete follow-ups remotely, with no in-person clinic visits required\n* Maintain a diary tracking their study drug usage and any additional pain medications",[28,29],"Osteoarthritis of Knee","Osteoarthritis Hip",[31],"Medical Cannabis","RECRUITING","2026-06-17",{"date":35,"type":36},"2026-06-22","ACTUAL",{"date":38,"type":36},"2026-01-29",{"date":40,"type":22},"2027-02-28",{"name":42,"class":43},"University Health Network, Toronto","OTHER",3,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100594027","robot-aided-off-axis-neuromuscular-training-for-knee-oa-100594027","NCT07014098","Robot-Aided Off-Axis Neuromuscular Training for Knee OA","Effectiveness of Robot-Aided Off-Axis Neuromuscular Training for Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 45 - 85 years.\n* Meets the ACR classification criteria for knee OA (clinical + radiographic criteria); Kellgren-Lawrence grade I-III.\n* Persistent knee pain ≥ 3 months.\n* Able to independently complete elliptical training (6 minutes without interruption).\n\nExclusion Criteria:\n\n* Other inflammatory joint diseases (e.g., rheumatoid arthritis).\n* Knee trauma, surgery, or intra-articular injections within the past year.\n* History of knee or hip replacement.\n* Cardiovascular disease or uncontrolled hypertension contradict to exercises.\n* Cognitive impairment (Montreal cognitive assessment \\\u003C 22).\n* Currently participating in another interventional study for the lower limb.\n* Neurological impairment (e.g., stroke, Parkinson's disease, radicular pain).","45 Years","85 Years",{"count":55,"type":22},36,[25],"Although the primary knee motion occurs in flexion\u002Fextension, the frontal and transverse (off-axis) knee motions are smaller but crucial for maintaining joint stability and normal knee loading. Altered kinematics and neuromuscular control in off-axis knee motions have been reported in patients with knee osteoarthritis (OA), which are associated with excessive knee loading and the progression of knee OA. However, traditional rehabilitative treatments for people with knee OA and existing exercise equipment often focus on sagittal plane movement. Probably due to the technical limitations, there is a lack of convenient and effective equipment\u002Fmethod to train patients with knee OA in off-axis (frontal and transverse) planes.\n\nThe purpose of this study is to use a robot-aided elliptical training device to measure knee neuromechanical properties and to improve neuromuscular control in off-axis knee motions, aiming for joint de-loading and pain reduction for individuals with knee OA.",[28],[60,61,62,63,64,65],"knee osteoarthritis","robot-assisted","neuromuscular training","knee biomechanics","knee symptoms","evaluation-based training strategy","NOT_YET_RECRUITING","2026-04-17",{"date":69,"type":36},"2026-04-21",{"date":71,"type":22},"2026-05-01",{"date":73,"type":22},"2030-01",{"name":75,"class":43},"University of Maryland, Baltimore",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":53,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100576225","phase-4-knee-injections-for-obese-patients-with-knee-arthritis-100576225","NCT06782529","Knee Injections for Obese Patients With Knee Arthritis","Comparison of Varying Doses of Steroid for Intra-articular Knee Injections","Inclusion Criteria:\n\n• Patients with BMI ≥30 kg\u002Fm2 and radiograph-proven knee osteoarthritis who are interested in receiving a steroid injection for knee arthritis.\n\nExclusion Criteria:\n\n* BMI \\\u003C 30 kg\u002Fm2\n* Uncontrolled diabetics with a hemoglobin A1c \\> 8%\n* No other treatment within the time frame of the study.\n* Patients that are undergoing physical therapy at the time of the study.","55 Years",{"count":85,"type":22},40,[87],"PHASE4","The purpose of this study is to assess obese patients with knee arthritis and determine the non-inferiority of a low dose steroid treatment vs. standard dose steroid treatment for two knee outcome measures: pain and function.",[28],[91,92,93],"Knee Osteoarthritis","Corticosteroid Injection","Obesity","2026-03-06",{"date":96,"type":36},"2026-03-10",{"date":98,"type":36},"2025-01-24",{"date":100,"type":22},"2027-01-24",{"name":102,"class":43},"Mayo Clinic",1,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100588078","phase-4-perioperative-colchicine-for-tka-100588078","NCT06936709","Perioperative Colchicine for TKA","Effect of Colchicine in the Perioperative Period on Reducing Post-Operative Pain in Total Knee Arthroplasty","Inclusion Criteria:\n\n* Patients 18 years or older undergoing elective total knee arthroplasty for osteoarthritis.\n\nExclusion Criteria:\n\n* Subject has impaired hepatic function (Child-Pugh Class \\>B)\n* Subject has impaired renal function (GFR \\\u003C 60 ml\u002Fmin\u002F1.73 m2)\n* Subject has known adverse reaction to colchicine\n* Subject has chronic opioid use (Filled opioid medication twice within 6 months of surgical date)\n* Subject is pregnant or expecting to become pregnant during the time of the study associated with colchicine exposure (postoperative days 0-3)\n* Subject is unable to provide informed consent\n* Subject is actively prescribed medication that interact with colchicine in a manner that would increase the risk of colchicine toxicity, i.e.:\n* Antifungals: Ketoconazole, itraconazole, fluconazole, etc…\n* Macrolides : Clarithromycin, erythromycin\n* HIV protease : Ritonavir, Atazanavir, saquinavir, etc...\n* Ca2+: Verapamil and Diltiazem\n* Cyclosporine\n* Danazol\n* Amiodorone\n* Quinidine\n* Anti-hepaciviral combinations\n* Grapefruit juice\n* Statins: atorvastatin, lovastatin, simvastatin, etc…\n* Gemfibrozil and other fibrates\n* Digoxin","18 Years",{"count":113,"type":22},75,[87],"This study is a prospective, randomized, double-blinded, placebo-controlled study of the drug colchicine in the acute postoperative period for patients who are undergoing a total knee arthroplasty (TKA). Patients aged 18 years or older who are undergoing TKA will be invited to participate in the study. The primary endpoint of this study is to determine if colchicine, an anti-inflammatory medication commonly used for gout attacks, will decrease the postoperative pain of patients undergoing elective TKA.",[28,117,118],"Recovery Following Primary Total Knee Arthroplasty","Perioperative Pain Control",[120,121,122],"Total Knee Arthroplasty","Colchicine","Postoperative Pain","2025-08-15",{"date":125,"type":36},"2025-08-17",{"date":127,"type":22},"2025-12-01",{"date":129,"type":22},"2026-03-01",{"name":131,"class":43},"Geisinger Clinic",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":139,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":142,"phases":4,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":161},"100599035","surgical-outcome-after-displaced-bucket-handle-meniscal-lesions---repair-versus-partial-meniscectomy-100599035","NCT07079254","Surgical Outcome After Displaced Bucket-handle Meniscal Lesions - Repair Versus Partial Meniscectomy","Surgical Outcome After Displaced Bucket-handle Meniscal Lesions - Repair Versus Partial Meniscectomy: A 10-year Observational Study","Inclusion Criteria:\n\n* 15 years or above.\n* Displaced longitudinal bucket-handle tear including the posterior horn on MRI and a knee extension deficit.\n\nExclusion Criteria:\n\n* Patient younger than 15 years.\n* Insufficient knowledge of the Swedish language.\n* Per-operative findings including a bucket-handle rupture in combination with a complete radial rupture","15 Years",{"count":141,"type":22},300,"OBSERVATIONAL","The menisci of the knee joint are structures composed of cartilage and connective tissue, whose primary functions are to stabilize the joint and distribute weight across joint surfaces. In doing so, it helps protect the joint from osteoarthritis - a form of joint failure commonly referred to as \"joint wear\". Meniscal surgeries are among the most common orthopaedic procedures performed both in Sweden and globally. Historically, damaged menisci were treated by removing the injured part. However, this approach is linked to early-onset osteoarthritis. Osteoarthritis affects approximately one-third of individuals over the age of 45 and ranks among the ten most common diagnoses in Europe based on years lived with disability. The knee is the most frequently affected joint, and the importance of the menisci in preserving knee function has become increasingly recognized.\n\nIn recent years, advances in surgical techniques have led to a shift towards meniscus-preserving procedures. A typical injury is the displaced meniscus, in which a large portion of the meniscus becomes detached from the joint capsule and wedges itself inside the joint, causing mechanical locking and preventing full extension. A displaced meniscus often loses its blood supply and suffers mechanical damage from being compressed between the joint surfaces. To preserve the meniscus and prevent irreversible damage, early surgical intervention is required. If the injury is too old or the tissue too damaged, the injured part of the meniscus must be removed, which significantly increases the risk of developing early knee osteoarthritis.\n\nIt remains unclear how soon surgery must be performed to successfully preserve the meniscus, and this likely depends on various other factors, including patient age, presence of additional joint injuries, and surgical technique. There is currently no reliable data on the proportion of displaced menisci that heal after meniscus-preserving surgery. However, studies suggest that 20-30% of repaired menisci require reoperation due to failed healing.\n\nGiven that displaced menisci are considered surgical emergencies, they pose a significant burden on healthcare systems already strained by limited access to urgent surgery. Meanwhile, ongoing development of surgical techniques raise ethical and logistical questions for health providers - especially as the scientific evidence for the benefits of some advanced treatments remains inconclusive.\n\nTherefore, more research is needed to guide the optimal management of displaced bucket-handle lesions across a diverse patient population, taking into account age, activity level, and concurrent injuries. A key priority is to identify predictors of healing potential, particularly the time window during which surgical repair remains a viable option. With better knowledge, more menisci could potentially be preserved - reducing both the number of unnecessary re-operations and the long-term incidence of knee osteoarthritis.",[145,146,28],"Meniscus Rupture","Meniscus Injury",[148,149,150,151],"Meniscus","Re-operation","Bucket-handle","Osteoarthritis","2025-07-22",{"date":154,"type":36},"2025-07-25",{"date":156,"type":36},"2023-10-07",{"date":158,"type":22},"2045-12",{"name":160,"class":43},"Region Skane",2,{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":170,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":23,"phases":173,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":4},"100593630","the-effect-of-balneotherapy-on-knee-osteoarthritis-100593630","NCT07008937","The Effect of Balneotherapy on Knee Osteoarthritis","The Effect of Balneotherapy on the Inflammatory Process and Quality of Life in Patients With Knee Osteoarthritis","Balneotherapy","Inclusion Criteria:\n\n* Being over 50 years old\n* Patients diagnosed with knee OA\n* At stages 2-to-4 according to the Kellgren- Lawrence classification\n* Patients who agree to receive balneotherapy treatment\n\nExclusion Criteria:\n\n* Neoplasia\n* Infections\n* Uncompensated cardiac or pulmonary problems\n* Total knee arthroplasty\n* Inflammatory joint diseases (e.g., RA, AS)\n* Intra-articular injections in the past 6 months\n* Corticosteroids or anti-cytokine therapy\n* Patients with a BMI over 30 kg\u002Fm2","50 Years",{"count":172,"type":22},50,[25],"Osteoarthritis (OA) is a chronic degenerative disease characterized by the breakdown and repair processes of the cartilage structure in synovial joints. Balneotherapy is one of the most commonly applied treatment methods in patients with OA. It is used to reduce pain and stiffness, improve joint mobility and quality of life, and prevent disease progression. Hyperthermia caused by balneotherapy activates the sympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis. After heat stress, HSp levels in the blood increase, triggering the HSp-cytokine-HPA-cortisol anti-inflammatory feedback mechanism, resulting in an anti-inflammatory effect and neuroendocrine immune regulation.\n\nIn various pathologies associated with low-grade inflammation-especially rheumatic diseases-balneotherapy and mud therapy have been reported to decrease serum concentrations of pro-inflammatory cytokines such as TNF-α and IL-1β. Serum COMP levels are elevated in OA patients. There is evidence that measuring COMP levels could serve as a prognostic marker for the development of OA in patients with chronic knee pain. It is evaluated not only as a cartilage marker but also as an indicator of synovial inflammation.\n\nThe aim of this study is to evaluate the response to inflammation and stress in patients with knee OA by examining the levels of CRP, IL-1 beta, COMP, and HSp following balneotherapy treatment. Additionally, changes in patients' quality of life and functional status after balneotherapy will also be evaluated.Fifty patients with primary osteoarthritis who meet the inclusion criteria and are receiving inpatient or outpatient treatment in the Physical Medicine and Rehabilitation clinic will be included in the study. It is planned to include 30 patients in the treatment group and 20 patients in the control group. Pain will be assessed using VAS, physical function and stiffness using WOMAC, and quality of life using the SF-36 scale. To determine the serum levels of COMP, IL-1 beta, CRP, and HSp70, blood samples will be collected under standard conditions from patients in a fasting state between 8:00-9:00 AM. Biochemical markers will be evaluated using ELISA kits.\n\nFor balneotherapy, patients will be treated in a thermal pool for 15-20 minutes daily, with full-body immersion, for a total of 15 days.",[28],"2025-06-05",{"date":178,"type":36},"2025-06-06",{"date":180,"type":22},"2025-07",{"date":182,"type":22},"2025-12",{"name":184,"class":43},"Ahi Evran University Education and Research Hospital",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":23,"phases":196,"briefSummary":197,"conditions":198,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":4},"100591706","preoperative-rehabilitation-training-and-total-knee-arthroplasty-outcomes-100591706","NCT06983912","Preoperative Rehabilitation Training and Total Knee Arthroplasty Outcomes","The Effect of Preoperative Rehabilitation on Functional Recovery After Total Knee Arthroplasty: A Randomized Controlled Trial","PRTKAO","Inclusion Criteria:\n\n1. Clinical diagnosis is osteoarthritis and Scheduled for joint replacement surgery.\n2. Age ≥18 years old and ≤90 years old, with no gender restrictions.\n3. Patients voluntarily participate in the study and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Severe cardiopulmonary insufficiency, unable to tolerate rehabilitation training.\n2. Neurological disorders leading to motor dysfunction.\n3. Mental illnesses that prevent cooperation with rehabilitation training.\n4. Severe joint deformities or muscle atrophy present before surgery, affecting the implementation of rehabilitation training.","90 Years",{"count":195,"type":22},500,[25],"Joint replacement surgery is an effective treatment for severe joint diseases, but the postoperative recovery process is complex and lengthy. Preoperative rehabilitation training, as an important part of preoperative preparation, has been proven to significantly improve postoperative recovery outcomes. However, there is currently a lack of systematic research on the optimal protocols and duration of preoperative rehabilitation training and their specific impacts on postoperative recovery. This study aims to evaluate the effects of preoperative rehabilitation training on postoperative recovery after joint replacement through a randomized controlled trial, providing scientific evidence for clinical practice.",[28],"2025-05-14",{"date":201,"type":36},"2025-05-21",{"date":203,"type":22},"2025-08-01",{"date":205,"type":22},"2028-08-31",{"name":207,"class":43},"Fuzhou University Affiliated Provincial Hospital",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":216,"sex":217,"minAge":52,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":23,"phases":221,"briefSummary":222,"conditions":223,"keywords":227,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":237,"locationsCount":4},"100590804","proprioceptive-fatigue-adaptation-in-osteoarthritis-100590804","NCT06972186","Proprioceptive Fatigue Adaptation in Osteoarthritis","Neuromotor Adaptation to Fatigue: Changes in Lower Extremity Proprioception in Patients With Osteoarthritis","PROFA-OA","Inclusion Criteria:\n\n* Female, aged 50-65\n* Postmenopausal\n* Grade 2-3 knee osteoarthritis (Kellgren-Lawrence Scale) for OA group\n* No lower extremity surgery in the last 6 months\n* No neuromuscular or orthopedic condition affecting the lower extremities\n\nExclusion Criteria:\n\n* Severe balance disorders or vestibular disease\n* Bilateral knee prosthesis or severe osteoporosis\n* Lower extremity musculoskeletal injury in the last 6 months",true,"FEMALE","65 Years",{"count":220,"type":22},20,[25],"This study aims to investigate the effects of fatigue induced by isokinetic exercise on passive and active joint position sense in postmenopausal women diagnosed with knee osteoarthritis (gonarthrosis). A healthy control group matched for age and sex will also be included for comparative analysis. Participants will undergo proprioceptive assessments before and after an isokinetic fatigue protocol. We hypothesize that (1) fatigue will impair both passive and active joint position sense in patients with gonarthrosis, (2) active joint position sense will be more affected than passive sense, and (3) the deterioration in proprioception will be greater in the gonarthrosis group compared to healthy controls.",[28,224,225,226],"Proprioception","Isokinetic Test","Gonarthritis",[228,229,230,231],"osteoarthritis of knee","propripception","isokinetic test","gonarthritis","2025-05-06",{"date":199,"type":36},{"date":235,"type":22},"2025-06-01",{"date":127,"type":22},{"name":238,"class":43},"Kocaeli Sağlık ve Teknoloji Üniversitesi",{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":17,"minAge":245,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":23,"phases":248,"briefSummary":249,"conditions":250,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":103},"100566175","ultra-sound-guided-genicular-nerves-cooled-radiofrequency-ablation-in-total-knee-replacement-surgeries-100566175","NCT06651762","Ultra Sound Guided Genicular Nerves Cooled Radiofrequency Ablation in Total Knee Replacement Surgeries","Inclusion Criteria:• Undergoing a scheduled unilateral total knee replacement surgery\n\n\\-\n\nExclusion Criteria:\n\n* • Allergy to any of the drugs used in the study\n\n  * Alcohol or drug abuse\n  * Psychiatric disease","21 Years",{"count":247,"type":22},66,[25],"Total Knee Replacement surgery is common procedure that is usually done for patients suffering from persistent pain with limitation of movement. Unfortunately, they do suffer after the operation as it is associated still with significant pain that affect the rehabilitation plan, hospital length of stay, life style and patient satisfaction. New approaches are rising every day to add to the multimodal management plan. Genicular nerves cooled radiofrequency ablation is a new approach that can be simply done U.S. guided with little side effects, if any, and great results.",[28],"2025-02-21",{"date":253,"type":36},"2025-02-24",{"date":255,"type":36},"2024-10-14",{"date":257,"type":22},"2025-06-13",{"name":259,"class":43},"Ain Shams University",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":218,"enrollmentInfo":267,"targetDuration":4,"studyType":23,"phases":269,"briefSummary":270,"conditions":271,"keywords":274,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":161},"100575092","morbid-obesity-and-severe-knee-osteoarthritis---which-should-be-treated-first-100575092","NCT06767787","Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?","Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First? A Randomized Cross-over Study","Inclusion Criteria:\n\n* BMI \\> or = 35, on surgical waitlist for a total knee arthroplasty and laparoscopic sleeve gastrectomy\n\nExclusion Criteria:\n\n* a history of revision surgery, surgery for neoplastic disease, significant mental illness, ASA class \\> 3 denoting absence of significant impact of comorbidities, and previous esophagogastric surgery.",{"count":268,"type":22},142,[25],"The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery. Our secondary goal is to compare complication rates between these groups to determine if there is a difference based on the order of the two procedures.\n\nParticipants will be randomly placed in one of two groups, with each undergoing both procedures but in opposite order. Quality of life will be assessed via questionnaires before and between each procedure, and rates of complications will also be documented to compare their rates between groups.",[28,272,273],"Arthroplasties, Knee Replacement","Sleeve Gastrectomy",[60,275,276,277,278,279],"bariatric surgery","laparoscopic sleeve gastrectomy","knee replacement","knee arthroplasty","obesity","2025-01-28",{"date":282,"type":36},"2025-01-30",{"date":284,"type":22},"2025-02",{"date":286,"type":22},"2027-01",{"name":288,"class":43},"Memorial University of Newfoundland",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":17,"minAge":170,"maxAge":193,"enrollmentInfo":296,"targetDuration":4,"studyType":23,"phases":297,"briefSummary":298,"conditions":299,"keywords":301,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":306,"leadSponsor":308,"locationsCount":103},"100575545","evaluating-the-effectiveness-of-using-a-home-laser-device-to-treat-patients-with-knee-osteoarthritis-100575545","NCT06773676","Evaluating the Effectiveness of Using a Home Laser Device to Treat Patients With Knee Osteoarthritis","Evaluation of the Efficacy of a Home-Use Photobiomodulation Device for the Treatment of Patients With Knee Osteoarthritis: A Double-Blind, Randomized, Sham-Controlled Clinical Study","Inclusion Criteria:\n\n1. Diagnoses of knee osteoarthritis by American College of Rheumatology (ACR)\n2. Kellgren \\& Lawrence classification 1-3\n3. Knee pain on movement 40 to 90 mm Visual Analog Scale\n4. Knee pain and related functional reduction for at least 1 month\n\nExclusion Criteria:\n\n1. Pregnant or nursing, or with the ability to become pregnant and not using an accepted form of birth control\n2. Other causes of knee-related pain (e.g. hip OA, arterial insufficiency, radiculopathy etc) have been ruled out by physical examinations.\n3. Knee surgery for KOA\n4. Intra-articular steroid injection and\u002For oral steroid treatment within the last six months\n5. Rheumatoid arthritis\n6. Symptomatic OA in other joints (i.e. hip, hand)\n7. Use of narcotics on the day of evaluation\n8. Active malignancy\n9. Uncontrolled diabetes mellitus\n10. Neurological conditions: sciatica, neuropathy, multiple sclerosis\n11. Other chronic pain conditions that may affect results: Fibromyalgia, back pain, hip pain\n12. Has any photobiomodulation (low level laser) device at home or has previously used photobiomodulation for knee pain\n13. Has known dermatological sensitivity to light\n14. Enrolled in any other clinical trial within the last 6 weeks or enrollment in another clinical trial during participation in this trial.",{"count":172,"type":22},[25],"Osteoarthritis is a degenerative disease affecting joint cartilage and its surrounding tissue. It is the leading cause of disability in the elderly. Photobiomodulation (PBM), has been used widely for alleviation of pain, reduction of inflammation, and acceleration of wound healing, and particularly to treat knee osteoarthritis (KOA). The purpose of the current study is to determine if a near-infrared PBM device (B-Cure Laser), applied at home, by the patient or personal caregiver in a real-life situation, can reduce pain and improve functionality in patients with KOA.",[300],"Osteoarthritis Of Knee",[151,91],"2025-01-13",{"date":304,"type":36},"2025-01-14",{"date":304,"type":22},{"date":307,"type":22},"2027-01-31",{"name":309,"class":43},"Barzilai Medical Center",{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":4,"enrollmentInfo":317,"targetDuration":4,"studyType":23,"phases":319,"briefSummary":320,"conditions":321,"keywords":329,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":342,"leadSponsor":344,"locationsCount":4},"100570627","kinematic-alignment-in-total-knee-arthroplasty---a-double-blind-randomised-controlled-trial-between-robotic-and-caliper-based-techniques-100570627","NCT06709703","Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic and Caliper-based Techniques","L'Alignement cinématique Dans Les prothèses de Totales de Genou : un Essai randomisé contrôlé à Double Insu Comparant la Robotique Aux Instruments Traditionnels","Inclusion Criteria:\n\n* Patient aged 18 or above\n* Patient being consented for a primary total knee arthroplasty (TKA)\n* The primary TKA is planned to be done with kinematic alignment\n* All pre-operative alignments are included\n\nExclusion Criteria:\n\n* Revision TKA (including revision of unicompartimental knee arthroplasty into total knee arthroplasty with primary components). TKA being done in the setting of previous femur or tibia fracture or osteotomy are however included.\n* No available adequate pre-operative imaging\n* Patient who does want to be randomized of the two groups\n* At the discretion of the surgeon, if the patient's pathology or particular anatomy precludes the use of kinematic alignment technique, robotic surgery, or traditional instrument TKA.",{"count":318,"type":22},200,[25],"Knee replacement surgery is a surgery designed to treat severe arthritis of the knee. However, as many as 20% of patients are not satisfied with the results of their surgery. To place the knee replacement in correct position, the kinematic alignment method, which tries to reproduce the patient normal anatomy, has shown promise in improving the satisfaction after knee replacement surgery. It is not known if using a robotic arm to assist in surgery is better than the traditional method when trying to recreate kinematic alignment.\n\nThe goal of this study is to learn if robotic assisted surgery is better than traditional method for knee replacement done using kinematic alignment. The main questions the study tries to answer are:\n\n1. Do the radiographs of kinematic knee replacement surgeries done with robotic assistance show better alignment than radiographs of kinematic knee replacements done with the traditional method?\n2. Does robotic assisted kinematic knee replacement give better function to patients than traditional knee replacement done with kinematic alignment?\n3. Does robotic assisted kinematic knee replacement decrease pain, improve knee movement and improve knee stability better than traditional knee replacement done with kinematic alignment?\n4. Are there more complications with robotic assisted kinematic knee replacement in comparison to traditional kinematic knee replacement?\n5. How long long does it take a surgeon to become good a performing a kinematic knee replacement using robotic assistance? Researchers will compare knee replacements done using a robotic to make the bone cuts, and compare it to the usual method using guides and manual instruments. All the knee replacements will be done using the kinematic alignment and with the same type of knee replacement prothesis.\n\nParticipants will:\n\n* Have a knee replacement done with the kinematic alignment technique by an experienced surgeon, with or without robotic assistance during the surgery.\n* Visit the clinic before surgery, six weeks after surgery, three months, six months, twelve months and twenty-four months after the surgery.\n* Fill questionnaire, have their knee examined and have radiographs of their knee done at each visit.",[322,323,151,324,325,326,327,28,328],"Arthritis","Arthritis (Knee)","Osteoarthritis Knee Pain","OA","OA Knee","OA Knee Pain","Gonarthrosis; Primary",[330,331,60,332,333,334,335,336,337],"osteoarthritis","arthritis","knee OA","knee arthritis","total knee replacement","robotic","kinematic alignment","patient-specific surgery","2024-11-25",{"date":340,"type":36},"2024-11-29",{"date":284,"type":22},{"date":343,"type":22},"2028-09",{"name":345,"class":43},"Université de Sherbrooke"]