[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteoarthritis-thumb\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteoarthritis-thumb":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,41,67,111,134,161,186,210],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100414452","phase-2-pain-relief-after-trapeziectomy-ibuprofen--acetaminophen-versus-oxycodone-100414452",false,"NCT04676802","Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone","Pain Relief After Trapeziectomy Without Opioids: Ibuprofen & Acetaminophen Versus Oxycodone","Inclusion Criteria:\n\n* Undergoing trapeziectomy for thumb osteoarthritis\n\nEnglish proficient,\n\nExclusion Criteria:\n\n* Pregnancy\n\nCurrent use of opioids\n\nConcurrent surgeries (ex. trapeziectomy combined with carpal tunnel release)\n\nInability to complete study forms (education, cognitive ability, mental status, medical status)\n\nAllergy or intolerance to Ibuprofen, Acetaminophen and\u002For Oxycodone\n\nLiver or kidney dysfunction, abnormal liver enzymes restricting use of acetaminophen or ibuprofen\n\nHistory of chronic heart failure, upper gastrointestinal bleeding or coagulopathy\n\nHistory of complex regional pain syndrome","ALL","45 Years",{"count":19,"type":20},121,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the efficacy of a combination of non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen and acetaminophen, in comparison to a morphine analogue substance (oxycodone) for pain management in the first 30 days after surgery.",[26,27],"Pain, Postoperative","Osteoarthritis Thumb","RECRUITING","2026-06-08",{"date":31,"type":32},"2026-06-11","ACTUAL",{"date":34,"type":32},"2021-12-27",{"date":36,"type":20},"2027-08",{"name":38,"class":39},"Stanford University","OTHER",2,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":66},"100624157","touch-cmc-1-new-enrollment-us-study-100624157","NCT07405983","TOUCH® CMC 1 New Enrollment US Study","Effectiveness and Safety of the TOUCH® CMC 1 Prosthesis, Post-Approval Study","PAS002","Inclusion Criteria:\n\n1. Patient requiring 1st carpometacarpal (CMC) primary total joint replacement (arthroplasty) to surgically treat symptomatic Eaton-Littler Stage II or III osteoarthritis (OA)\n2. Adult (≥ 22 years of age) at the time of enrollment\n3. Willing and able to sign the study Informed Consent\n\nExclusion Criteria:\n\n1. Acute or chronic infections, local or systemic\n2. Muscular, neurological, or vascular severe deficiency affecting the joint\n3. Inadequate bone quality or quantity preventing the implant fixation\n4. Bones dimensions incompatible with implant sizes\n5. Patients who are allergic to the product's materials\n6. Any concomitant disorder that may affect the function of the implant (e.g., osteoarthritis of the wrist)\n7. Skeletally immature (i.e., pediatric population, \\\u003C22 years of age)\n8. Pregnant or nursing women\n9. Patients with contraindications to surgery in general\n10. Patients with an intellectual disability who cannot follow the instructions of their surgeon.","22 Years",{"count":51,"type":20},163,"OBSERVATIONAL","The purpose of this study is to meet a PMA (P240020) condition of approval of the TOUCH® CMC 1 Prosthesis to evaluate the effectiveness and safety of the prosthesis in the United States (US) population. The device performance in newly enrolled US patients implanted by US surgeons will be compared to device performance observed within the outside the US (OUS) premarket cohort.",[27,55],"Thumb Carpometacarpal Joint Osteoarthritis","2026-06-02",{"date":58,"type":32},"2026-06-04",{"date":60,"type":32},"2026-03-04",{"date":62,"type":20},"2030-02",{"name":64,"class":65},"Keri Medical SA","INDUSTRY",4,{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":21,"phases":79,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":110},"100522572","phase-4-intraarticular-steroids-saline-and-occupational-therapy-in-people-with-cmc1-osteoarthritis-100522572","NCT06084364","Intraarticular Steroids, Saline and Occupational Therapy in People With CMC1 Osteoarthritis","Painful Inflammatory Carpometacarpal-1 Osteoarthritis Treated With Intraarticular Steroids, Saline or an Occupational Therapy Intervention: the PICASSO Trial.","PICASSO","Inclusion Criteria:\n\n\\- Adult (40-85 years of age) men and women\n\nIn target CMC-1 joint:\n\n* OA confirmed by radiographs or ultrasound examination, and\n* Inflammation by ultrasound (grey scale synovitis grade 1-3), and\n* Pain of at least 3 on a 0-10 Numeric Rating Scale (NRS) at rest or during activities at both pre-screening and screening.\n* Patient is assessed as eligible for the proposed use of Kenacort-T\n\nExclusion Criteria:\n\n* Use of thumb orthosis on most of the days or structured hand exercises in the last 12 weeks\n* Intraarticular injections in the target CMC-1 joint in the last 12 weeks\n* More than 3 previous IACS in the target CMC-1 joint\n* Use of oral, intramuscular or intravenous steroids in the last 12 weeks\n* Previous surgery of the target CMC-1 joint\n* Planned hand surgery in the coming 24 weeks\n* Do not want to quit using oral or topical NSAIDs on the hands (such as ibuprofen, diclofenac, etoricoxib, naproxen) in the next 12 weeks\n* Systemic inflammatory joint diseases (such as rheumatoid arthritis (RA), psoriatic arthritis or gout) or other conditions that can better explain the hand pain (such as thoracic outlet syndrome, carpal tunnel disease, diabetic cheiropathy, hand injury in previous six months, or palmar tenosynovitis\u002Ftrigger finger)\n* Diagnosis of fibromyalgia\n* Diagnosis of psoriasis\n* Infection, skin disease or wounds at joint injection site\n* Serious comorbidities, cognitive dysfunction, substance\u002Falcohol abuse or any other medical condition that makes adherence to the study protocol difficult\n* Severe or uncontrolled infections\n* Known hypersensitivity to Triamcinolone acetonide (Kenacort) or any of the excipients (sodium carboxymethylcellulose, sodium chloride, polysorbate, benzyl alcohol, sodium hydroxide or hydrochloric acid)\n* Included in another clinical study\n* Use of digitalis glycosides\n* Patients vaccinated or immunized with live virus vaccines in the last 2 weeks\n* Not being able to talk or understand Norwegian\n* Known pregnancy or planned pregnancy in the next 6 months\n* Any condition that in the view of the investigator would suggest that the patient is unable to comply with the study protocol and procedures","40 Years","85 Years",{"count":78,"type":20},354,[80],"PHASE4","A placebo-controlled randomized controlled trial exploring the effect of intraarticular steroids, saline or an occupational therapy intervention in inflammatory carpometacarpal-1 osteoarthritis",[27],[84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100],"thumb","pain","inflammation","steroids","RCT","Occupational Therapy","Carpometacarpal-1","HappyHands","CMC-1","Picasso","intraarticular corticosteroid injections","IACS injections","thumb base pain","triamcinolone acetonide","Kenacort-T","osteoarthritis","OA","2026-02-06",{"date":103,"type":32},"2026-02-10",{"date":105,"type":32},"2023-11-03",{"date":107,"type":20},"2028-10",{"name":109,"class":39},"Diakonhjemmet Hospital",6,{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":118,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":40},"100544548","analysis-of-articular-biomarkers-from-osteoarthritic-thumb-basal-joints-100544548","NCT06370312","Analysis of Articular Biomarkers From Osteoarthritic Thumb Basal Joints","Analysis of Synovial Fluid, Bone and Articular Cartilage From Osteoarthritic First Carpometacarpal Joints in Relationship to Metabolic Risk Factors and Patient-reported Hand Function","Inclusion Criteria:\n\n* Men and women age ≥ 25 years\n* Radiologically confirmed and symptomatic thumb basal joint osteoarthritis (OA) planned for trapeziectomy\n\nExclusion Criteria:\n\n* Previous surgery to the affected thumb basal joint\n* Post-traumatic thumb basal joint OA\n* Rheumatoid arthritis or other chronic inflammatory arthritis, history of psoriasis affecting joints, gout or pseudogout\n* Ongoing infection in the hand or wrist\n* Inability to co-operate with the follow-up protocol or to assimilate information about the study protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction)\n* Systemic or intra-articular glucocorticoids or intraarticular platelet-rich plasma or hyaluronic acid injections in the affected joint within 3 months prior to enrollment","25 Years",{"count":120,"type":20},120,"The study project aims at examining molecular markers in synovial fluid, bone and articular cartilage from osteoarthritic thumb basal joints. The degradation of extracellular matrix (ECM) proteins in thumb basal joints will be evaluated in association to the metabolic profile of the patient, but we also aim to compare the ECM degradation and inflammatory profiles with articular cartilage degradation ECM profile from knee joints with osteoarthritis. A third aim is to evaluate associations between patient-reported hand function, pain, strength and range of thumb motion to analyses of synovial fluid.",[27,123,124],"Osteoarthritis, Knee","Metabolic Disease","2025-06-19",{"date":127,"type":32},"2025-06-25",{"date":129,"type":32},"2024-05-01",{"date":131,"type":20},"2027-04-30",{"name":133,"class":39},"Region Skane",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":21,"phases":142,"briefSummary":144,"conditions":145,"keywords":146,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":160},"100530954","a-study-on-the-effect-of-high-concentrated-platelet-rich-plasma-prp-on-osteoarthritis-in-the-thumb-base-100530954","NCT06193499","A Study on the Effect of High-concentrated Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base.","Inclusion Criteria:\n\n* Osteoarthritis in the thumb base\n* Radiological Eaton Littler class 1-3.\n* Clinical signs of thumb base osteoarthritis )pain at palpation of the CMC-1 joint and pain during provocation\u002Fgrinding test).\n\nExclusion Criteria:\n\n* Rheumatoid arthritis\n* Ongoing infection in the hand or wrist\n* History of gout or pseudogout in the hand\n* Inability to co-operate with the follow-up protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction).\n* Chronic pain syndrome \u002F centralized pain.\n* Intra-articular injection in the affected joint within 6 months.\n* Eaton Littler class 4 (symptomatic STT joint osteoarthritis).",{"count":141,"type":20},90,[143],"NA","This is a randomized double-blinded randomized comparison between injection of platelet rich plasma (PRP) and placebo for thumb basale osteoarthritis.",[27],[147,148,149,150],"CMC-1 joint","thumb basal joint","PRP","Platelet-rich plasma","2025-06-01",{"date":153,"type":32},"2025-06-03",{"date":155,"type":32},"2024-01-17",{"date":157,"type":20},"2027-06-30",{"name":159,"class":39},"Karolinska Institutet",1,{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":16,"minAge":168,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":171,"conditions":172,"keywords":173,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":160},"100397704","restoration-of-thumb-strength-and-function-in-basal-joint-arthritis-a-comparative-effectiveness-trial-restart-100397704","NCT04458584","Restoration of Thumb Strength and Function in Basal Joint Arthritis: A Comparative Effectiveness Trial (RESTART)","RESTART","Inclusion Criteria:\n\n* Males and females 21 years of age or older;\n* Undergoing elective non-prosthetic, primary basal joint arthroplasty;\n* Patient has necessary mental capacity to participate and comply with study protocol;\n* Patient is willing and able to give informed consent; and\n* Patient is willing to participate under the care of their chosen surgeon.\n\nExclusion Criteria:\n\n* Patients with a diagnosis of rheumatoid arthritis, systemic lupus erythematosis, psoriatic arthritis, or other related inflammatory arthritis;\n* Patients undergoing simultaneous bilateral hand procedures of any nature;\n* Women who are pregnant or breastfeeding;\n* Women of reproductive potential unless there is a negative urine pregnancy test on the day of surgery. Women of child bearing potential include those who are premenopausal who have not had a bilateral oophorectomy, hysterectomy or tubal ligation. Post-menopausal is defined as not having had a menstrual period for at least one calendar year.\n* Vulnerable patient populations including prisoners and institutionalized individuals.","21 Years",{"count":170,"type":20},165,"The purpose of this study is to evaluate the basis for three widely held fundamental tenets about surgical intervention for thumb basal joint arthritis;\n\n1. Trapeziectomy with ligament reconstruction and metacarpal stabilization is associated with superior functional outcomes and strength,\n2. Preservation of the arthroplasty space correlates with functional outcomes, pain relief, and restoration of strength after basal joint arthroplasty, and\n3. Mitigation of metacarpophalangeal joint (MCPJ) hyperextension optimizes postoperative strength after basal joint arthroplasty, regardless of surgical technique.\n\nIt is hypothesized that thumb basal joint arthroplasty with metacarpal stabilization, by either ligament reconstruction (I) or suture suspension (II), provides greater improvement in grip and pinch strength, and better hand function, than might be achieved following provision of pain relief alone by simple trapeziectomy (III). Preservation of the arthroplasty space will correlate positively, and MCPJ hyperextension will correlate negatively, with improved thumb function and lateral pinch strength.\n\nPrimary Aims (within 3 procedure cohorts):\n\n1. Compare pre-operative pinch and grip strength as well as patient-reported outcomes (PROs) for pain in patients before and after lidocaine injection of the trapeziometacarpal joint, prior to thumb basal joint arthroplasty;\n2. Compare post-operative pinch and grip strength and PROs for pain and function at 3 and 6 months after thumb basal joint arthroplasty with pre-operative values before and after lidocaine injection;\n3. Correlate preservation of dynamic arthroplasty space as measured on a stress radiograph with postoperative improvement in pinch and grip strength, and PROs for pain and function;\n4. Correlate dynamic MCP joint position and laxity with change in strength and patient-reported pain and function to define optimal MCPJ position.\n\nSecondary Aims (between 3 procedure cohorts):\n\n1. Compare change in pre- and post-operative pinch and grip strength and PROs for pain and function between patients having basal joint arthroplasty with and without specific metacarpal stabilization;\n2. Compare preservation of the dynamic arthroplasty space and improvement in strength and patient-reported pain and function between arthroplasty groups; and\n3. Compare changes in pinch and grip strength and PROs for pain and function with dynamic MCPJ position between arthroplasty groups.\n4. Compare postoperative neuritis and complications between surgical groups.",[27],[174,175,176],"Ligament reconstruction","Suspensionplasty","Arthroscopic Trapeziectomy","2025-04-09",{"date":179,"type":32},"2025-04-13",{"date":181,"type":32},"2020-06-29",{"date":183,"type":20},"2026-12-31",{"name":185,"class":39},"Dartmouth-Hitchcock Medical Center",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":16,"minAge":194,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":21,"phases":197,"briefSummary":198,"conditions":199,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":160},"100527751","prospective-study-of-arthrodesis-of-finger-distal-interphalangeal-joints-using-the-kerifuse-device-100527751","NCT06151834","Prospective Study of Arthrodesis of Finger Distal Interphalangeal Joints Using the Kerifuse Device","Prospective Study of Arthrodesis of Finger Distal Interphalangeal Joints Using the Kerifuse Device KF 23)","KF23","Inclusion Criteria:\n\n* Eligible patients with osteoarthritis of finger for an interphalangeal arthrodesis with KeriFuse implant\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding patient\n* Patient with an intellectual disability and who therefore cannot follow the surgeon's instructions\n* Patients with contraindications to surgery\n* Patients with acute or chronic, local or systemic infections\n* Patients with sensitivities or allergies to device components (Nickel, Titanium)","18 Years",{"count":196,"type":20},50,[143],"Arthrodesis of a distal interphalangeal joint of the finger (DIP) is mainly performed for a degenerated and painful joint. Various stabilization methods have been used to provide compression at the arthrodesis site such as pins, steel wires, compression screws, headless compression screws, bioresorbable implants and intramedullary staples.\n\nAlthough with complications such as implant fractures or dorsal cortical erosion, intramedullary arthrodesis staples provide reliable pain relief and a consistent fusion rate while inevitably scarring the finger pulp or nail dystrophy.\n\nThe aim of this study is to evaluate the bone fusion time during an arthrodesis performed with the Kerifuse shape memory implant.",[200,27],"Osteoarthritis Finger","2025-02-11",{"date":203,"type":32},"2025-02-13",{"date":205,"type":32},"2023-12-01",{"date":207,"type":20},"2026-09-01",{"name":209,"class":39},"Clinique Saint François, Nice, France",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":217,"sex":16,"minAge":194,"maxAge":4,"enrollmentInfo":218,"targetDuration":220,"studyType":52,"phases":4,"briefSummary":221,"conditions":222,"keywords":230,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":40},"100552813","embo-registry-national-registry-for-artery-embolization-100552813","NCT06477965","Embo Registry; National Registry for Artery Embolization","Multicenter National Registry for Artery Embolization (Embo Registry) for the Treatment of Osteoarthritis and Areas of Localized Pain to Assess Treatment of Artery Embolization to Determine If Subjects Have Decrease Pain, Decreased Use of Narcotics and NSAIDs, and Quality of Life Improvement Post Procedure.","Inclusion Criteria:\n\n* \\> 18 years of age undergone artery embolization interventions for the treatment of chronic pain due to osteoarthritis or other diagnoses that cause localized pain.\n\nExclusion Criteria:\n\n* None",true,{"count":219,"type":20},1000,"12 Months","Embo Registry is a retrospective and prospective observational study to evaluate real world effectiveness and the use of Artery Embolization as a treatment for chronic pain with patients that have osteoarthritis and localized pain to provide symptomatic relief. This study is to determine the efficacy and validity of procedure and that following procedure patients had decreased pain and improved quality of life.",[223,123,27,224,225,226,227,228,229],"Chronic Pain","Osteoarthritis Shoulder","Pain, Chronic","Tendonitis Elbow","Tendonitis Shoulder","Tendonitis;Achilles","Tenosynovitis",[231,232,233,234,229],"Pain","Osteoarthritis","Arthritis","Tendonitis","2024-10-24",{"date":237,"type":32},"2024-10-28",{"date":239,"type":32},"2024-07-15",{"date":241,"type":20},"2029-07-15",{"name":243,"class":39},"Vascular Solutions of North Carolina"]