[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteochondral-defect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteochondral-defect":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,39,66,89,122,147],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100355514","descriptive-study-of-the-reconstruction-of-osteochondral-lesions-of-the-knee-clinical-and-imaging-results-100355514",false,"NCT03908931","Descriptive Study of the Reconstruction of Osteochondral Lesions of the Knee: Clinical and Imaging Results","Inclusion Criteria:\n\n* cartilaginous reconstruction by autologous transplant or collagenous chondro-inducing knee matrix\n* \\> 18 years\n\nExclusion Criteria:\n\n* Other cartilaginous reconstruction techniques,\n* other than knee joint","ALL","18 Years",{"count":18,"type":19},130,"ESTIMATED","INTERVENTIONAL",[22],"NA","The purpose of this study is to evaluate the clinical results and MRI imaging of autologous cartilage reconstructions or collagen matrix of the knee.\n\nThere is currently little data in the literature on clinical outcomes and imaging of this type of lesion.",[25],"Osteochondral Defect","RECRUITING","2026-03-16",{"date":29,"type":30},"2026-03-17","ACTUAL",{"date":32,"type":30},"2019-04-01",{"date":34,"type":19},"2035-06-01",{"name":36,"class":37},"Versailles Hospital","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":15,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":50,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":38},"100551588","evaluation-of-clinical-and-radiological-outcomes-in-patients-undergoing-fixation-of-osteochondral-fragments-with-reasorbable-screws-in-the-knee-joint-100551588","NCT06462040","Evaluation of Clinical and Radiological Outcomes in Patients Undergoing Fixation of Osteochondral Fragments With Reasorbable Screws in the Knee Joint","OC-FIX","Inclusion Criteria:\n\n1. Patients undergoing surgical fixation of osteochondral fragment using resorbable screw technique, either arthroscopically or via mini-open procedure depending on the lesion's location, from 01\u002F01\u002F2017, and all new patients eligible for this type of intervention until 31\u002F12\u002F2025.\n2. Patients aged between 12 and 35 years at the time of the surgical intervention.\n3. Patients with the presence of osteochondral fragments confirmed by magnetic resonance imaging.\n4. Patients with osteochondral lesions observed on imaging and symptoms attributable to the presence of osteochondral fragments.\n5. Patients diagnosed with osteochondritis dissecans or recent contusion\u002Fsprain trauma.\n\nExclusion Criteria:\n\n1. Patients with concomitant complex ligamentous injuries or fractures at the time of the intervention;\n2. Patients who are no longer reachable;\n3. Women of childbearing age who cannot exclude pregnancy;\n4. Patients who are unable to provide informed consent or patients who are unwilling to sign the informed consent form.","12 Years","35 Years",{"count":49,"type":19},100,"2 Years","OBSERVATIONAL","Various techniques for the fixation of unstable osteochondral fragments have been used over the years, each with associated advantages and disadvantages, and differing clinical outcomes. However, the literature on the treatment of this type of injury in the adolescent and young adult population is scarce and involves small case series. Failure to treat these injuries can lead to serious consequences such as chronic pain, residual joint stiffness, and the development of early osteoarthritis, necessitating more invasive and burdensome interventions for the national health system, such as prosthetic replacements or osteotomies.\n\nDue to the lack of real consensus within the scientific community regarding the ideal treatment for these patients and the insufficient medium\u002Flong-term follow-up data on the effects of these injuries on articular cartilage in young patients, this study aims to evaluate the clinical and radiological conditions of patients undergoing osteochondral fragment fixation using the same surgical technique (fixation with resorbable screws performed arthroscopically or via open surgery depending on the lesion's location) in order to clarify preventive measures against cartilage degeneration following these injuries, which are very common in adolescence.",[25,54,55,56],"Osteochondritis Dissecans","Osteochondral Fracture","Osteochondral Fracture of Patella","2026-01-29",{"date":59,"type":30},"2026-01-30",{"date":61,"type":30},"2024-09-25",{"date":63,"type":19},"2028-06",{"name":65,"class":37},"Istituto Ortopedico Rizzoli",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":15,"minAge":46,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":20,"phases":76,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":5},"100532741","evaluating-cryopreserved-osteochondral-allograft-cores-for-the-treatment-of-osteochondral-lesions-in-the-knee-100532741","NCT06216756","Evaluating Cryopreserved Osteochondral Allograft Cores for the Treatment of Osteochondral Lesions in the Knee","A Prospective, Open Label, Single-Arm, Multi-Center Study Evaluating Cryopreserved Osteochondral Allograft Cores for the Treatment of Osteochondral Lesions in the Knee","Inclusion Criteria:\n\n* Patients are ≥12 years and ≤ 60 years of age at the time of surgery.\n* Symptomatic patient presenting with moderate to severe pain in the index knee - unresponsive to conservative treatment (i.e., medication, bracing, physical therapy) and\u002For previous surgical intervention OR unsalvageable lesion that requires transplantation at the discretion of the treating physician.\n* Radiographically diagnosed, by MRI or CT scans, or through arthroscopy, to have a cartilage defect on the femoral condyle between 0.9-8.0 cm2 in size.\n* Will be having an osteochondral transplant procedure.\n* Has a mechanically stable knee or can be mechanically stabilized in the same procedure.\n* Has a normally aligned knee as confirmed by anatomic comparison to contralateral limb, or \\\u003C5° varus or valgus malalignment that has been corrected or will be corrected in same procedure.\n* Ipsilateral knee compartment has intact menisci or requires partial meniscectomy ≤ 50% resulting in stable menisci.\n* Confirmation MRI, CT scan, or arthroscopy obtained pre-operatively within 90 days of surgery\n* Willingness to follow standardized rehabilitation procedures.\n* Has the ability to understand the requirements of the study, to provide written informed consent, and to comply with the study protocol.\n\nExclusion Criteria:\n\n* Bipolar articular cartilage involvement (kissing lesions) of the ipsilateral compartment (i.e., \\> than ICRS Grade 2 on the opposing articular surface).\n* Has had a prior osteochondral allograft transplant procedure in the same knee.\n* Will be receiving a meniscus allograft transplantation in the same procedure.\n* Body Mass Index (BMI)of ≥ 35 kg\u002Fm2.\n* Active malignancy: undergoing treatment for tumor or boney traumatic injury or a history of any invasive malignancy (except non-melanoma skin cancer) unless the patient has been treated with curative intent and there have been no clinical signs or symptoms of the malignancy for at least 5 years.\n* Clinical and\u002For radiographic disease in the affected joint that includes generalized osteoarthritis, gout or a history of gout or pseudo-gout.\n* Active local microbial infection or a systemic infection, including HIV, syphilis, Hepatitis B or Hepatitis C.\n* Currently immunologically suppressed or immunocompromised, or a medical condition requiring radiation and\u002For chemotherapy.\n* Unstable cardiovascular, renal, hepatic, endocrine and\u002For pulmonary disease, cancer, or uncontrolled diabetes.\n* Has a history of any inflammatory joint arthropathy.\n* Currently using\u002Fchronic on oral corticosteroids.\n* Received interarticular corticosteroid injection ≤ 90 days prior to surgery.\n* Received hyaluronic acid injections into the joint space ≤ 45 days prior to surgery.\n* Is a female patient who is pregnant.\n* Physically or mentally compromised (i.e., being currently treated for a psychiatric disorder, senile dementia, Alzheimer's disease) in a manner that would compromise his\u002Fher ability to participate in the clinical study.\n* Has a history of substance abuse- (including but not limited to recreational drugs, alcohol) or has been treated in the last 6 months before enrollment for alcohol and\u002For drug abuse in an in-patient substance abuse program.\n* Patients who, in the opinion of the Investigator, would not be able or willing to comply with the protocol.\n* Is currently involved in a study of another investigational product for similar purpose or has been in the previous 90 days.\n* Has any contraindications for MRI.\n* Is having the procedure as part of a Worker's Compensation claim.\n* Is a ward of the state, prisoner, or transient.","60 Years",{"count":75,"type":19},68,[22],"The primary objective of this study is to obtain evidence of the effectiveness of Cryopreserved Osteochondral Allograft Core in the treatment of osteochondral lesions on the femoral condyle.",[25],"2025-11-20",{"date":81,"type":30},"2025-11-25",{"date":83,"type":30},"2024-12-01",{"date":85,"type":19},"2031-03",{"name":87,"class":88},"AlloSource","INDUSTRY",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":15,"minAge":16,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":20,"phases":100,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":4},"100584940","phase-1-eb-oc-for-the-treatment-of-focal-chondralosteochondral-defects-in-the-knee-100584940","NCT06895889","EB-OC for the Treatment of Focal Chondral\u002FOsteochondral Defects in the Knee","A Prospective, Randomized, Controlled, Open-label, First-in-human Phase I\u002FIIb Study to Evaluate the Safety and Efficacy of the EB-OC Graft in the Repair of Full Thickness Chondral\u002Fosteochondral Defects of the Knee","Inclusion Criteria:\n\n1. Subject is male or female, between 18 and 65 years of age\n2. Subject's body mass index (BMI) is ≤ 35 kg\u002Fm2.\n3. Subject has up to two symptomatic, full-thickness cartilage defects of the knee femoral condyle with or without bone involvement that are:\n\n   1. Located on the femoral condyles or femoral trochlea\n   2. Each between 0.75 and 3 cm2 in area on screening images as confirmed by an independent radiologist\n   3. Classified as International Cartilage Repair Society (ICRS) grade 3 or 4.\n   4. Has baseline Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain \\\u003C65 and KOOS Activities of Daily Life \\\u003C70.\n4. Subject is willing and able to provide informed consent and comply with study requirements.\n5. Subject agrees to actively participate in a strict rehabilitation protocol and follow-up program.\n6. For women of childbearing potential, subject must have a negative pregnancy test at Screening, cannot be lactating and must be willing to use adequate contraception throughout study participation.\n\n   Note: Adequate contraception methods will include the following: Abstinence, Oral Contraceptives, Barrier Methods (Condoms, IUD's), or surgical sterilization.\n7. Subject is willing to give up the use of narcotics for 6 months post-surgery and use and record alternative pain medications (e.g., acetaminophen, or narcotic analgesics, if prescribed).\n\nNote: Post-surgical use of aspirin for clot prevention and narcotics for immediate post-surgical pain are acceptable.\n\nExclusion Criteria:\n\n1. Lesions on the opposing surface of the tibia that are classified as ICRS grade 3 or 4.\n2. Lesions on the opposing surface of the patella that are classified as ICRS grade 3 or 4 if a trochlear defect is being treated.\n3. Any existing prosthetic implants in the index knee.\n4. History of knee surgery in the index knee within 6 months prior to screening.\n5. Has osteoarthritis of Kellgren-Lawrence Grade ≥3 as diagnosed on standing radiographs in the index knee.\n6. Known history of hypersensitivity to gentamicin, other aminoglycosides, or products of bovine origin.\n7. Inflammatory arthritis, inflammatory joint disease, or uncorrected congenital blood coagulation disorders.\n8. Current infection or history of infection in the index knee joint.\n9. Current skin infection of the index knee joint or skin infection of the index knee joint within the past 3 months.\n10. Osteochondral defect greater than 7 mm in depth.\n11. Avascular necrosis (AVN) or osteonecrosis (ON).\n12. Meniscus tears or defects that require concomitant or prior removal of \\>50% of meniscus in the index knee.\n13. Varus or valgus malalignment exceeding 5° in either knee.\n14. Need for corrective concomitant osteotomy (tibio-femoral or patellofemoral).\n15. Symptomatic musculoskeletal condition in the lower limbs that could impede efficacy measures in the target knee.\n16. Diagnosed musculoskeletal cancer or any diagnosed cancer, other than musculoskeletal if not on long term remission (e.g., at least 5 years or negative biopsy at last exam), except basal cell carcinoma.\n17. Clinically significant abnormalities in vital signs at the time of screening defined by\n\n    * Systolic BP \\>140 or \\\u003C90 mmHg or diastolic BP \\>90 or \\\u003C60 mmHg\n    * Pulse \\\u003C60 or \\>100 bpm\n    * Respiratory Rate \\\u003C9 or \\>20\n    * Temperature \\>99 °F\n18. Hemoglobin, platelet, white blood cell count, creatinine, aspartate aminotransferase (AST), and alanine aminotransferase (ALT), prothrombin time (PT), and partial thromboplastin time (PTT) below the lower limit of normal or above the upper limit of normal.\n19. Active infection (e.g., HIV, viral hepatitis, syphilis, cellulitis, respiratory infection, etc.).\n20. Alcohol and drug (including medication) abuse.\n21. Subjects with any contraindications to MR imaging.\n22. Participation in concurrent trials or in previous trial within 90 days of signing informed consent.\n\nIntra-Operative Exclusion Criteria\n\n1. Greater than 2 defects requiring treatment\n2. A symptomatic defect with greater than 5 mm of bone loss",true,"65 Years",{"count":99,"type":19},36,[101,102],"PHASE1","PHASE2","EB-OC is a tissue engineered osteochondral tissue graft comprising of a living tissue engineered cartilage layer attaching to a bone scaffold. The goal of this clinical trial is to learn about in the safety and efficacy of the EB-OC graft in participants who require repair of chondral\u002Fosteochondral defects of the knee. The main question it aims to answer is if the EB-OC graft works to regenerate osteochondral tissue comprising of native hyaline cartilage anchors to the regenerated bone. Participants will receive treatment of either the EB-OC Graft implantation in an arthrotomy procedure or abrasion chondroplasty. Researchers will compare results from the EB-OC graft to abrasion chondroplasty to assess overall safety and effectiveness.",[105,25],"Chondral Defect",[107,108,109,110,111],"Abrasion Chondroplasty","Focal Chondra","Osteochondral Defects","Orthobiologics","Cartilage regeneration","NOT_YET_RECRUITING","2025-03-19",{"date":115,"type":30},"2025-03-26",{"date":117,"type":19},"2026-01-01",{"date":119,"type":19},"2028-12-31",{"name":121,"class":88},"Epibone, Inc.",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":129,"targetDuration":131,"studyType":51,"phases":4,"briefSummary":132,"conditions":133,"keywords":136,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":38},"100390469","knee-registry-knieregister-100390469","NCT04364334","Knee Registry (Knieregister)","Collecting Diagnostic, Treatment and Follow-up Data on Knee Treatments.","Inclusion Criteria:\n\n* Receives orthopaedic knee surgery or conservative knee treatment (advice, physiotherapy, injections etc) at the UMC Utrecht;\n* Able to read and understand Dutch language;\n* Is able and willing to signs the broad consent form.\n\nExclusion Criteria:\n\n* Receives no treatment (refusal of surgery or treatment);\n* Receives treatment elsewhere.",{"count":130,"type":19},1000000,"20 Years","Rationale: In view of patient care, patient characteristics and treatment parameters are registered for all patients visiting the Mobility Clinic of the University Medical Center Utrecht for orthopaedic knee treatment. Patients also fill out questionnaires for function, pain and mobility of the knee, before and after treatment.\n\nObjective: The main objective of this registry is to collect patient characteristics and treatment parameters together with data from the questionnaires in a database. This knee registry can be used for future research questions.\n\nStudy design: This is a longitudinal observational registry.\n\nStudy population: All patients that visit the Mobility Clinic will be asked to participate in the knee registry. Patients that meet one or more of the following criteria will be excluded: are below the age of 16, not able or willing to sign the broad consent form, not being able to read and understand Dutch language, or receiving medical treatment for their knee elsewhere.\n\nMain study parameters\u002Fendpoints: Data will be collected for future research for which the purpose is not known at this time. When new research will be conducted, study parameters will be set. A study application has to be submitted to the institutional ethical review board of the University Medical Center Utrecht. Patients do not need to be asked permission for the use of their data for each study individually. Only when additional information is needed.\n\nNature and extent of the burden and risks associated with participation, benefit and group relatedness: The burden for patients to participate in this registry is minimal and consists of time. Any future results may be beneficial for patients. Participation or refusal to participate in the registry has no consequences for their treatment.",[134,135,54,105,25],"Knee Pathology","Osteoarthritis, Knee",[137],"Knee","2023-11-28",{"date":140,"type":30},"2023-12-05",{"date":142,"type":30},"2017-01",{"date":144,"type":19},"2100-01",{"name":146,"class":37},"UMC Utrecht",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":15,"minAge":154,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":158,"conditions":159,"keywords":160,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":38},"100380661","study-protocol-to-evaluate-clinical-and-imaging-results-of-knee-fresh-osteochondral-allografts-100380661","NCT04236492","Study Protocol to Evaluate Clinical and Imaging Results of Knee Fresh Osteochondral Allografts","Study Protocol for a Prospective Observational Study to Evaluate the Clinical and Imaging Results of the Fresh Osteochondral Allograft Transplantation for Osteochondral Knee Lesions","Inclusion Criteria:\n\nPatients undergoing cartilage repair with fresh osteochondral allograft transplantation for large focal full-thickness chondral and osteochondral defects (\\>2 cm2) on the tibial plateau, femoral condyles, trochlea and\u002For patella Bipolar lesions are included.\n\nExclusion Criteria:\n\n* BMI\\> 30 kg \u002F m2\n* Systemic inflammatory diseases\n* Inflammatory arthritis\n* Advanced osteoarthritis\n* Tricompartmental degenerative process\n* Active infection\n* Patients who are unable to provide written informed consent.","15 Years","50 Years",{"count":157,"type":19},40,"The main objective of this study is to assess the clinical and radiological results after carrying out a transplant of fresh osteochondral allograft in the knee.",[25],[161,162,163,164,165],"fresh osteochondral allografts","integration","osteochondral defect","knee","chondral lesion","2023-03-15",{"date":168,"type":30},"2023-03-16",{"date":170,"type":30},"2018-06-06",{"date":172,"type":19},"2026-11-10",{"name":174,"class":37},"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau"]