[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteochondral-lesion-of-talus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteochondral-lesion-of-talus":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100556621","autologous-osteoperiosteal-transplantation-for-the-treatment-of-severe-osteochondral-lesions-of-the-talus-100556621",false,"NCT06527482","Autologous Osteoperiosteal Transplantation for the Treatment of Severe Osteochondral Lesions of the Talus","A Multicenter Prospective Cohort Study of Autologous Osteoperiosteal Transplantation for the Treatment of Severe Osteochondral Lesions of the Talus","Inclusion Criteria:\n\n* Chronic ankle pain, diagnosed as Osteochondral Lesions of the Talus (OLT);\n* Hepple V OLT on the medial side of the talus or the diameter of the lesion ≥ 8 mm;\n* Conservative treatment of at least 3 months fails to relieve symptoms;\n* Willingness to voluntarily participate in the trial and to sign informed consent.\n\nExclusion Criteria:\n\n* Varus or valgus deformity of the ankle of more than 5 degrees;\n* Grade III injury of the lateral collateral ligament of ankle;\n* Chronic synovitis (rheumatoid arthritis, pigmented villous nodular synovitis, etc.);\n* Joint fibrosis, stiffness, and significantly restricted range of motion;\n* Evidence of moderate to severe knee osteoarthritis on plain radiographs;\n* Failure to complete the rehabilitation protocol as required;\n* Patient medically not fit for surgery, radiographs or MRI;\n* For women, pregnant, planning to be pregnant or lactating.","ALL","18 Years","60 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","The goal of this clinical trial is to establish a multicenter prospective cohort of patients with severe osteochondral lesion of the talus (OLT), evaluate the clinical efficacy of autologous osteoperiosteal transplantation and the incidence of postoperative donor-site morbidity. The main questions it aims to answer are:\n\nDoes autologous osteoperiosteal transplantation have good clinical outcomes in the treatment of severe OLT? Does autologous osteoperiosteal transplantation treat severe OLT with fewer postoperative complications?\n\nParticipants will:\n\nUndergo autologous osteoperiosteal transplantation for OLT Receive clinical follow-up 3, 6, 12, and 24 months after surgery and answer scales of ankle function assessment Take CT and MRI preoperatively and 12 and 24 months after surgery",[25,26],"Osteochondral Lesion of Talus","Autologous Osteoperiosteal Transplantation",[25,26,28,29],"Arthroscopic Techniques","Clinical Efficacy","RECRUITING","2024-08-04",{"date":33,"type":34},"2024-08-06","ACTUAL",{"date":36,"type":34},"2023-09-01",{"date":38,"type":21},"2026-09-01",{"name":40,"class":41},"Peking University Third Hospital","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":42},"100543664","microfracture-with-platelet-rich-plasma-gel-injection-for-osteochondral-lesion-of-the-talus-100543664","NCT06358807","Microfracture With Platelet Rich Plasma Gel Injection for Osteochondral Lesion of the Talus","Clinical Efficacy of Arthroscopic Microfracture Combined With Local Injection of Platelet Rich Plasma Gel in Treatment of Osteochondral Lesion of the Talus: A Randomized Control Trial","Inclusion Criteria:\n\n* Chronic ankle pain, diagnosed as osteochondral lesion of the talus;\n* Lesion size ≤ 1.5 cm2 or the diameter of the lesion ≤ 1.5 cm;\n* Conservative treatment of at least 3 months fails to relieve symptoms;\n* Willingness to voluntarily participate in the trial and to sign informed consent.\n\nExclusion Criteria:\n\n* Varus or valgus deformity of the ankle of more than 5 degrees;\n* Grade III injury of the lateral collateral ligament of ankle;\n* Chronic synovitis (rheumatoid arthritis, pigmented villous nodular synovitis, etc.);\n* Joint fibrosis, stiffness, and significantly restricted range of motion;\n* Evidence of moderate to severe knee osteoarthritis on plain radiographs;\n* Failure to complete the rehabilitation protocol as required;\n* Patient medically not fit for surgery, radiographs or MRI;\n* For women, pregnant, planning to be pregnant or lactating.",{"count":51,"type":21},70,"INTERVENTIONAL",[54],"NA","The goal of this clinical trial is to learn if combined local injection of platelet rich plasma (PRP) gel adds clinical efficacy to isolated arthroscopic microfracture in treatment of osteochondral lesion of the talus (OLT). The interface integration of the injured area will also be assessed via radiographic follow-up. The main questions it aims to answer are:\n\n* Does arthroscopic microfracture combined with PRP gel injection improve ankle function of participants based on American Orthopedic Foot and Ankle Society (AOFAS) Score?\n* Does arthroscopic microfracture combined with PRP gel injection improve interface integration of the injured cartilage on magnetic resonance imaging (MRI)? Researchers will compare arthroscopic microfracture with concomitant local injection of PRP gel to isolated microfracture to see if intraoperative PRP gel injection adds clinical efficacy to isolated arthroscopic microfracture in treatment of OLT.\n\nParticipants will:\n\n* Undergo either isolated arthroscopic microfracture or microfracture with intraoperative injection of PRP gel\n* Receive clinical follow-up 3, 6, 12, and 24 months after surgery and answer scales of ankle function assessment\n* Take MRI preoperatively and 6, 12 and 24 months after surgery",[25,57,58],"Microfractures","Platelet Rich Plasma",[25,57,58,28,29],"2024-05-17",{"date":62,"type":34},"2024-05-20",{"date":64,"type":34},"2024-01-01",{"date":66,"type":21},"2026-12-31",{"name":40,"class":41}]