[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteochondritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteochondritis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100489352","study-comparing-two-methods-for-the-treatment-of-large-chondral-and-osteochondral-defects-of-the-knee-100489352",false,"NCT05651997","Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee","Randomized Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee: Augmented Microfracture Technique vs. 3rd Generation of ACI","Inclusion Criteria:\n\n* Patients aged between 15-50 years\n* Symptomatic chondral and osteochondral defect, grade III and IV according to the ICRS classification, and size between 2.5 and 15 cm2\n* Failure of a conservative treatment\n* Patient in good general condition, documented by an ASA score ≤ 2 (American Society of Anesthesiologists)\n* Patient considered compliant and able to participate in rehabilitation and pre- and post-operative follow-up\n* Consent to participate in the study\n\nExclusion Criteria:\n\n* All inflammatory and synovial pathologies\n* Diffuse or mirror lesions\n* An unfavorable biomechanical environment\n* Obesity grade II or higher, with a BMI\\>35 kg\u002Fm2\n* Active smoking\u002F active drug dependency (hard drugs)\n* Poor compliance\n* The patient is already part of another clinical trial that may compromise the present study\n* Vulnerable populations (except minors aged 15-18 years)\n* Presence of open growth plate (15-18 years)\n* Pregnancy or planned pregnancy during the study (MRI-related contra-indication)\n* Proven allergy to penicillin and gentamicin (for MACT group) and porcine collagen (for both groups)\n\nFor final inclusion, an additional exclusion criteria will be assessed after randomization:\n\n\\- Positive to HIV, HBV, HCV, syphilis.","ALL","15 Years","50 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","The major objective of this study is to evaluate the efficacy of the MACT versus the AMT for the treatment of large cartilage defects in patellofemoral and femorotibial injuries.",[27,28,29],"Articular Cartilage Defect","Chondral Defect","Osteochondritis",[31,32],"Cellular therapy","Human articular chondrocytes","NOT_YET_RECRUITING","2026-03-10",{"date":36,"type":37},"2026-03-12","ACTUAL",{"date":39,"type":21},"2026-12",{"date":41,"type":21},"2032-06-01",{"name":43,"class":44},"Centre Hospitalier Universitaire Vaudois","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100385267","introduction-of-aci-for-cartilage-repair-100385267","NCT04296487","Introduction of ACI for Cartilage Repair","Introduction of Autologous Chondrocyte Implantation Procedure for the Treatment of Chondral Defect in the Knee","Inclusion Criteria:\n\n1. Age between 15 and 50.\n2. Lesions classified as ICRS Grade III or IV and smaller than 15 cm2\n3. Lesions that have failed prior therapy (conservative or surgical treatment ≥ six months)\n4. Subjects who understand and sign the consent form for this study\n\nExclusion Criteria:\n\n1. Body mass index (BMI) of 35 or more\n2. Osteoarthritis or rheumatoid arthritis\n3. Diffuse lesion\n4. Uncorrected mal-alignment, ligamentous instability, or meniscal tear\n5. Presence of growth cartilage (15-18 years old)\n6. Active smoking or drug consumption\n7. Women who are pregnant\n8. Positive serology for HIV-1 or HIV-2, Hepatitis B and C and syphilis\n9. Proven allergy to porcine collagen, penicillin and gentamicin\n10. Poor compliance",{"count":53,"type":21},218,[24],"This study was aimed to evaluate effectiveness and safety of autologous chondrocyte suspension for treatment of knee articular cartilage defects.",[27,28,29],"RECRUITING",{"date":59,"type":37},"2026-03-11",{"date":61,"type":37},"2017-09-01",{"date":63,"type":21},"2030-09",{"name":43,"class":44},1]