[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteomyelitis-of-lower-extremities\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteomyelitis-of-lower-extremities":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100613450","phase-4-comparison-of-oral-antibiotics-for-bone-infections-of-the-leg-and-foot-100613450",false,"NCT07266753","Comparison of Oral Antibiotics For Bone Infections of the Leg and Foot","Oral Beta-lactams Versus Non-beta-lactamS for Treatment of Lower Extremity Osteomyelitis","OSTEO","Inclusion Criteria:\n\n1. Adult (\\> 18 years old)\n2. OM of the lower extremity (below the knee) as determined by the treating healthcare provider (clinically and\u002For radiographically)\n3. Expected duration of treatment at least 28 additional days of antibiotic therapy for the infection episode, from the time of enrolment\n4. Treating health care team has already transitioned or is willing to transition to oral antibiotic therapy for the remainder of the treatment duration\n\nExclusion Criteria:\n\n1. Prior enrolment in the OSTEO trial\n2. Already received more than 14 days of uninterrupted antibiotic treatment for this episode of OM\n3. No beta-lactam or non-beta-lactam option due to any of:\n\n   1. Allergy\n   2. Suspected or confirmed antimicrobial resistance\n   3. Medical contraindications\n   4. Non-modifiable drug-drug interaction risk\n4. Need to receive combination antibiotic therapy with both beta-lactam and non-beta-lactam, with the exception of metronidazole and rifampin\n5. Prior antibiotic treatment for the same infection in the past 6 months\n6. Known pregnancy, planning to become pregnant during the study period, or breastfeeding","ALL","18 Years",{"count":20,"type":21},1418,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this clinical trial is to compare different classes of oral antibiotics (beta-lactam and non-beta-lactam antibiotics) for the treatment of bone infections of the leg and foot. The hypothesis is that oral beta-lactam antibiotics work as well as oral non-beta-lactam antibiotics to treat these infections. The first step is to assess whether it is possible to perform the trial by determining whether participants can be recruited and followed successfully. If the trial is proven to be possible, it will be expanded to ensure an answer to whether the two antibiotic classes work as well for the treatment of bone infections of the leg and foot.",[27,28,29],"Osteomyelitis of Lower Extremities","Osteomyelitis - Foot","Osteomyelitis of the Foot",[31,32,33,34],"Osteomyelitis","Bone Infection","Lower Extremity","Oral beta-lactams versus non-beta-lactams","RECRUITING","2026-03-23",{"date":38,"type":39},"2026-03-27","ACTUAL",{"date":41,"type":39},"2026-02-26",{"date":43,"type":21},"2033-12-31",{"name":45,"class":46},"Michael Garron Hospital","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":57,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100612268","osteomyelitis-multi-center-prospective-cohort-study-100612268","NCT07251374","Osteomyelitis Multi-center Prospective Cohort Study","Construction of a Multicenter Disease-Specific Database and Prospective Cohort for Osteomyelitis","Inclusion Criteria:\n\n1. Signed informed consent provided.\n2. Diagnosis of osteomyelitis confirmed by the site per guidelines (including definitive\u002Fsuggestive criteria).\n\nExclusion Criteria:\n\n1. Patients who, in the opinion of the investigator, are unable to comply with the entire study procedure (including postoperative management and regular follow-up) due to psychiatric, cognitive, or behavioral disorders, or other objective reasons.\n2. Any other condition that, in the opinion of the investigator, would make the patient unsuitable for participation in the study.","65 Years",{"count":56,"type":21},2000,"1 Year","OBSERVATIONAL","To establish a prospective, multicenter, real-world cohort of patients with osteomyelitis, by systematically collecting and analyzing detailed treatment and follow-up data, in order to provide clinical evidence for the standardization of its treatment",[27],[31,62,63,64],"Multi-center","Prospective","Disease-Specific Database","NOT_YET_RECRUITING","2025-11-24",{"date":68,"type":39},"2025-11-26",{"date":70,"type":21},"2025-12-10",{"date":72,"type":21},"2028-09-30",{"name":74,"class":46},"Southwest Hospital, China",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":4},"100598548","phase-4-antibiotic-impregnated-beads-in-osteomyelitis-100598548","NCT07072923","Antibiotic Impregnated Beads in Osteomyelitis","Utility of Antibiotic Impregnated Beads in Lower Extremity Osteomyelitis","Inclusion Criteria:\n\n* patients with lower extremity osteoarticular infections with or without hardware\n\nExclusion Criteria:\n\n* patients who are hemodynamically unstable or have altered mental status and cannot give consent\n* patient per investigators discretion are excluded",{"count":84,"type":21},100,[24],"Lower extremity bone infections, such as osteomyelitis, often occur after bone fractures, surgery, or when prosthetic joints or hardware become infected. Treatment usually includes antibiotics, chosen based on the infection's specifics. Options include intravenous (IV) or oral antibiotics, and sometimes local treatment with antibiotic-loaded beads placed directly at the infection site. Traditionally, these beads are made of non-absorbable materials, requiring a second surgery to remove them. However, a newer approach uses absorbable calcium sulfate beads, which can deliver higher antibiotic doses and don't need removal. This study will compare the use of IV and\u002For antibiotics in combination with absorbable antibiotic calcium sulfate beads with IV and\u002For oral antibiotics without absorbable beads, which serves as the current standard of care.",[29,88,27],"Antibiotic Impregnated Beads",[90],"osteomyelitis, lower extremity, foot, calcium sulfate beads","2025-07-09",{"date":93,"type":39},"2025-07-18",{"date":95,"type":21},"2025-09-01",{"date":97,"type":21},"2027-09-30",{"name":99,"class":46},"University of Arizona"]