[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteomyelitis-tibia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteomyelitis-tibia":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100471658","phase-4-prophylactic-antibiotic-coated-nail-to-prevent-infection-a-clinical-trial-100471658",false,"NCT05421741","Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial","Inclusion Criteria:\n\n* Patients 18 years or older\n* Gustilo Type II or III open tibia fracture requiring definitive fixation with intramedullary nail\n\nExclusion Criteria:\n\n* Less than 18 years of age\n* Allergy to vancomycin or gentamicin\n* Unable to speak English or Spanish\n* Pregnant and lactating women\n* Prisoner\n* Unable to follow up for 12 months","ALL","18 Years",{"count":18,"type":19},484,"ESTIMATED","INTERVENTIONAL",[22],"PHASE4","This prospective randomized clinical trial will compare outcomes between patients treated primarily with a prophylactic antibiotic coated nail and those treated with traditional standard of care intramedullary (IM) nailing.",[25,26,27],"Osteomyelitis Tibia","Tibial Fractures","Open Tibia Fracture",[29],"Antibiotic-coated nail","RECRUITING","2026-05-21",{"date":33,"type":34},"2026-05-26","ACTUAL",{"date":36,"type":34},"2023-05-15",{"date":38,"type":19},"2027-12",{"name":40,"class":41},"Wake Forest University Health Sciences","OTHER",14,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":20,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},"100498162","phase-3-intramedullary-calcium-sulfate-antibiotic-depot-100498162","NCT05766670","Intramedullary Calcium Sulfate Antibiotic Depot","Intramedullary Calcium Sulfate Antibiotic Depot for Prevention of Open Fracture Related Infection: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients 18 years and older\n* Type II or III open tibia fracture requiring definitive fixation with intramedullary nail\n\nExclusion Criteria:\n\n* Less than 18 years of age\n* Allergy to vancomycin or tobramycin\n* Hypercalcemia\n* Unable to speak English or Spanish\n* No email, phone, or other point of contact\n* Pregnant and lactating women\n* Prisoner",{"count":51,"type":19},497,[53],"PHASE3","The goal of this randomized clinical trial is to study the best treatment for open lower leg fractures to prevent infection. The main questions it aims to answer is if treating tibia fracture patients with a calcium sulfate antibiotic depot is better at preventing infection that the standard of care.",[56,25,26],"Open tíbia Fracture",[58],"antibiotic depot","2025-12-11",{"date":61,"type":34},"2025-12-15",{"date":63,"type":34},"2024-04-08",{"date":65,"type":19},"2028-01",{"name":40,"class":41},10]