[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteonecrosis-of-the-jaw\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteonecrosis-of-the-jaw":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,77,100],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100639753","bone-quality-evolution-in-medication-related-osteonecrosis-of-the-jaw-assessed-by-cbct-b-onj-evol-100639753",false,"NCT07588269","Bone Quality Evolution in Medication-Related Osteonecrosis of the Jaw Assessed by CBCT (B-ONJ EVOL)","Evolution of Bone Quality in Medication-Related Osteonecrosis of the Jaw: A Retrospective Multicenter Study Using Cone Beam Computed Tomography (CBCT)","B-ONJ EVOL","Inclusion Criteria:\n\n* Adult patient aged 18 years or older\n* Diagnosis of medication-related osteonecrosis of the jaw (MRONJ), stage 0, 1, or 2\n* Available diagnostic CBCT and at least 2 follow-up cone beam computed tomography (CBCT) examinations\n* Able to understand the study information and not opposed to participation\n\nExclusion Criteria:\n\n* Other jaw bone disease\n* History of cervicofacial irradiation\n* Stage 3 medication-related osteonecrosis of the jaw\n* Fewer than 2 follow-up cone beam computed tomography (CBCT) examinations","ALL","18 Years",{"count":20,"type":21},25,"ESTIMATED","OBSERVATIONAL","Medication-related osteonecrosis of the jaw (MRONJ) is a known complication of antiresorptive therapies such as bisphosphonates and denosumab. It can lead to bone damage in the jaw, with variable clinical outcomes depending on disease stage and management.\n\nCone Beam Computed Tomography (CBCT) is currently recommended for diagnosis and follow-up of MRONJ. However, most studies rely on qualitative or descriptive imaging findings, and little is known about how bone quality evolves over time using quantitative imaging parameters.\n\nThis retrospective multicenter study aims to describe the evolution of bone quality in patients with MRONJ using CBCT imaging. Bone parameters such as bone mineral density and trabecular structure will be measured at diagnosis and during follow-up.\n\nThe study will help improve understanding of bone changes over time in MRONJ and may contribute to better assessment and management of the disease.",[25,26],"Medication-related Osteonecrosis of the Jaw","Osteonecrosis of the Jaw",[28,29,30,31,32,33],"Medication-related osteonecrosis of the jaw","Cone beam computed tomography","Bone mineral density","Bone morphometry","Trabecular bone","Antiresorptive agents","NOT_YET_RECRUITING","2026-05-11",{"date":37,"type":38},"2026-05-14","ACTUAL",{"date":40,"type":21},"2027-01",{"date":42,"type":21},"2027-04",{"name":44,"class":45},"Nantes University Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100563919","piezoeletric-surgery-vs-conventional-surgery-for-treatment-of-mronj-100563919","NCT06622421","Piezoeletric Surgery vs Conventional Surgery for Treatment of MRONJ","Piezoeletric Surgery vs Conventional Surgery for Treatment of Medication-related Osteonecrosis of the Jaws: a Randomized Clinical Trial","PIEZOPZ-1","Inclusion Criteria:\n\n* Ability to understand the information provided and to give free consent;\n* Age greater than 18 years at the time of diagnosis;\n* Diagnosis of stage 1 or stage 2 MRONJ, according to the SICMF-SIPMO classification \\[1\\];\n* Need for surgical treatment of MRONJ.\n\nExclusion Criteria:\n\n* Patients with a previous history of radiotherapy in the head and neck area;\n* Patients with psychiatric disorders;\n* Women of childbearing age\n* Patients in stages of MRONJ other than stage 1 and 2;\n* Patients undergoing retreatment of MRONJ;\n* Patients with general medical contraindications for oral surgery procedures;\n* Patients unable to attend the outpatient visits required by the protocol.",{"count":55,"type":21},34,"INTERVENTIONAL",[58],"NA","To date, surgical therapy of MRONJ remains the therapy of choice while still in association with a medical approach. Surgical intervention aims to stop the progression of the pathology through the removal of the tissue macroscopically affected (resective surgery,sequestrectomy, debridement).\n\nThese surgical procedures are classically performed by the use of handpiece burs, but due to the advent of piezoelectric surgery in dentistry, a comparison of the two techniques is required\n\nAt present there are no randomized clinical trials designed to compare the postoperative discomfort of the two previously described techniques in the treatment of MRONJ. Therefore, the aim of this study is to evaluate the postoperative discomfort in a group of patients undergoing surgical therapy for MRONJ with piezoelectric instruments compared to a control group undergoing MRONJ surgical therapy with traditional rotary instruments.\n\nMETHODS This is a randomized clinical trial conducted in patients diagnosed with MRONJ who require surgical therapy.\n\nPatients will be recruited and evaluated for a period of 24 months. Follow-up of patients enrolled in the study will last 12 months. Specifically, once patients diagnosed with MRONJ requiring surgical therapy are identified, surgery will be scheduled within 1 month, then follow-up visits will be conducted at 1, 2, 3 weeks and 3, 6, 12 months after surgery.\n\nPatients enrolled and randomized into one of the two groups will all undergo necrotic bone removal surgery by the same operator with decades of experience in treating MRONJs. Marginal bone resection surgery will be performed using rotary or piezoelectric instruments. Both surgical procedures involve wound closure by first intention healing using sutures. Each bone block removed will undergo histologic examination for diagnostic confirmation of osteonecrosis. Postoperative instructions will be explained to patients, and sutures will be removed at 7 or 14 days after surgery.\n\nEach patient will be asked for a 3D radiologic exam (CT or CBCT) at least 12 months after surgery in order to asses the",[61,26,62],"Bisphosphonate-Associated Osteonecrosis of the Jaw","Osteonecrosis Due to Drug",[64,65,66],"MEDICATION RELATED OSTEONECROSIS OF THE JAW","SURGICAL TREATMENT OF MRONJ","MRONJ","2025-09-17",{"date":69,"type":38},"2025-09-22",{"date":71,"type":21},"2025-12-01",{"date":73,"type":21},"2027-09-01",{"name":75,"class":45},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":76},"100551260","medication-related-osteonecrosis-of-the-jaws-mronj-in-a-cohort-of-patients-treated-by-antiresorptive-drugs-100551260","NCT06457776","Medication Related Osteonecrosis of the Jaws (MRONJ) in a Cohort of Patients Treated by Antiresorptive Drugs","Medication Related Osteonecrosis of the Jaws (MRONJ) in a Cohort of Patients Treated by Antiresorptive Drugs: a Cohort Prospective Study","Inclusion Criteria:\n\n* Patients with specific prescription to initiate therapy with antiresorptive drugs\n\nExclusion Criteria:\n\n* Previous Head and Neck Radiotherapy",{"count":85,"type":21},126,"The objective of this prospective observational study is to investigate the incidence of Medication Related Osteonecrosis of the Jaws (MRONJ) in patients receiving antiresorptive drugs for oncohematologic reasons during a 5-year follow-up. Secondary objectives are to compare the different antiresorptive drugs in relation to the incidence of MRONJ and to identify any systemic as well as local risk factors.",[26,88,62,89,61],"Osteonecrosis Due to Drugs, Jaw","Bisphosphonate-Associated Osteonecrosis","RECRUITING","2024-06-17",{"date":93,"type":38},"2024-06-20",{"date":95,"type":38},"2021-01-01",{"date":97,"type":21},"2028-01-01",{"name":99,"class":45},"Catholic University of the Sacred Heart",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":56,"phases":110,"briefSummary":111,"conditions":112,"keywords":113,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":128},"100548285","leukocyte--and-platelet-rich-fibrin-in-the-surgical-treatment-of-medication-related-osteonecrosis-of-the-jaw-100548285","NCT06419010","Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw","Use of Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw: a Randomized Controlled Trial","PeRFOrMand","Inclusion Criteria:\n\n* MRONJ requiring surgical treatment according to AAOMS criteria (stage 2 or 3; failure of first-line treatments; sequestration of a necrotic bone block), the resection of which needs general anesthesia;\n* Affiliates or beneficiaries of a social security scheme.\n* Having given free and informed written consent.\n\nExclusion Criteria:\n\n* Presence of a maxillo-mandibular neoplastic lesion;\n* Presence of several MRONJ lesions;\n* History of cervico-facial radiotherapy;\n* Contraindication to general anesthesia;\n* Reduced life expectancy (estimated at less than 6 months).",{"count":109,"type":21},150,[58],"Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious side-effect of antiresorptive therapies used in the management of bone diseases, such as osteoporosis or bone metastases. A surgical management can lead to a resolution of the disease, but with perfectible results. For this purpose, the use of autologous platelet concentrates (APC) can be useful. With this study, researchers aim to demonstrate the efficacy of L-PRF (Leukocyte- and Platelet-Rich Fibrin) as an adjunct to the surgical treatment of MRONJ in terms of wound healing.",[26],[114,115,116,117,118],"therapeutics","surgical","autologous platelet concentrates","Platelet-Rich Fibrin","PRF","2024-05-16",{"date":121,"type":38},"2024-05-17",{"date":123,"type":21},"2024-05",{"date":125,"type":21},"2027-05",{"name":127,"class":45},"University Hospital, Toulouse",7]