[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteopathic-manipulative-treatment-omt-effects-on-cerebrospinal-fluid-csf-dynamics\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteopathic-manipulative-treatment-omt-effects-on-cerebrospinal-fluid-csf-dynamics":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100639618","exploring-how-osteopathic-manipulative-treatment-may-affect-spinal-fluid-flow-an-mri-study-100639618",false,"NCT07629765","Exploring How Osteopathic Manipulative Treatment May Affect Spinal Fluid Flow: An MRI Study","Exploring the Impact of Osteopathic Manipulative Treatment on CSF Dynamics: A Mechanistic MRI-Based Investigation","Inclusion Criteria:\n\n* Healthy adults between 18 and 80 years of age\n* Able and willing to provide informed consent\n* Able to safely undergo MRI procedures\n* Able to participate in osteopathic manipulative treatment (OMT)\n\nExclusion Criteria:\n\n* History of severe traumatic brain injury\n* Fibromyalgia\n* Epilepsy\n* Severe neurodegenerative disorders\n* Brain tumor or brain metastasis\n* Stroke or cerebrovascular disease\n* Hydrocephalus\n* Brain malformations\n* Demyelinating disorders\n* Congenital abnormalities affecting cerebrospinal fluid (CSF) flow\n* Spinal stenosis\n* Prior brain surgery\n* Chiari malformation\n* Syringomyelia\n* Other spinal conditions that may disrupt CSF flow\n* Manual therapy within the previous 2 weeks\n* Use of medications that affect CSF flow and\u002For production (including carbonic anhydrase inhibitors, furosemide, thiopental, desflurane, halothane, ketamine, etc.)\n* Uncontrolled hypertension\n* Uncontrolled diabetes\n* MRI contraindications, including implanted metallic\u002Felectronic devices or -severe claustrophobia\n* Pregnancy",true,"ALL","18 Years","80 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","his study aims to investigate whether Osteopathic Manipulative Treatment (OMT) affects cerebrospinal fluid (CSF) flow and glymphatic clearance in the human brain. CSF plays an important role in brain health by supporting nutrient delivery, waste removal, and pressure regulation. Aging and certain neurological conditions are associated with reduced CSF circulation and impaired brain waste clearance.\n\nParticipants will undergo magnetic resonance imaging (MRI) scans before and after a 30-minute OMT session to evaluate changes in CSF flow dynamics and brain physiology. The study will also examine whether age, cognition, sleep quality, physical function, anxiety, and depression are associated with changes in CSF flow following OMT.\n\nThe study will enroll healthy adults between 18 and 80 years of age. Data collected from MRI imaging and questionnaires may help improve understanding of the physiological effects of OMT and its potential role in supporting brain health",[28],"Osteopathic Manipulative Treatment (OMT) Effects on Cerebrospinal Fluid (CSF) Dynamics",[30,31,32,33,34,35,36,37],"Osteopathic Manipulative Treatment","Cerebrospinal Fluid","CSF Dynamics","Brain MRI","Glymphatic System","Aging Brain","Healthy Adults","Manual Therapy","NOT_YET_RECRUITING","2026-06-01",{"date":41,"type":42},"2026-06-05","ACTUAL",{"date":44,"type":22},"2026-06",{"date":46,"type":22},"2027-08",{"name":48,"class":49},"Edward Via Virginia College of Osteopathic Medicine","OTHER"]