[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteoporosis-senile\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteoporosis-senile":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100599517","phase-1-a-clinical-study-evaluating-the-dermal-safety-of-soluble-denosumab-microneedle-patches-100599517",false,"NCT07085520","A Clinical Study Evaluating the Dermal Safety of Soluble Denosumab Microneedle Patches","CSEDSSDMP","Inclusion Criteria:\n\n1. Signed and dated informed consent.\n2. Commitment to comply with the study protocol and cooperate throughout the study.\n3. Age 18-70, healthy or adult male or female with osteoarthritis combined with osteoporosis.\n4. No history of skin diseases or other underlying conditions.\n5. No antihistamines, vasodilators, vasoconstrictors, anticoagulants, hormones, or immunosuppressants within the past month.\n6. If of childbearing age, women must have used contraception for at least one month before screening and commit to using contraception throughout the study period and for a specified time after the study ends.\n\nExclusion Criteria:\n\n1. Pregnant or breastfeeding women.\n2. Smoking \\>10 cigarettes per day or smoking history \\>20 years.\n3. Presence of conditions that may interfere with the study results (e.g., severe diseases, infectious diseases, allergies, etc.) or relevant medical history.\n4. Individuals receiving systemic or local treatments that affect skin homeostasis.\n5. Allergic or intolerant to polyvinylpyrrolidone (PVP) or polyvinyl alcohol (PVA).\n6. Contraindications for denosumab (e.g., hypocalcemia).",true,"ALL","18 Years","70 Years",{"count":21,"type":22},12,"ESTIMATED","INTERVENTIONAL",[25],"PHASE1","The goal of this clinical trial is to evaluate the skin safety of a soluble denosumab microneedle patch in participants with osteoporosis and osteoarthritis. The main questions it aims to answer are:\n\n* Is the soluble denosumab microneedle patch safe for use on the skin?\n* What are the potential skin reactions to the patch?\n\nResearchers will compare different doses of the microneedle patch to assess its safety.\n\nParticipants will:\n\n* Apply the microneedle patch to four different areas around their knee\n* Undergo skin assessments at various time points after application\n* Be monitored for any adverse skin reactions\n\nThe study will take place at a single center and involve a small number of participants to provide preliminary data on the safety of this novel drug delivery system.",[28,29,30,31,32],"Osteoarthritis","Osteoarthritis (OA) of the Knee","Osteoporosis","Osteoporosis (Senile)","Healthy","NOT_YET_RECRUITING","2025-07-17",{"date":36,"type":37},"2025-07-25","ACTUAL",{"date":39,"type":22},"2025-07-31",{"date":41,"type":22},"2026-05-31",{"name":43,"class":44},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":45},"100586481","epidemiological-study-of-osteoporosis-in-the-elderly-population-of-shandong-province-100586481","NCT06915935","Epidemiological Study of Osteoporosis in the Elderly Population of Shandong Province","Study on the Epidemiological Characteristics of Osteoporosis and the Diagnostic Significance of Bone Metabolic Biochemical Markers in the Elderly Population of Shandong Province","Inclusion Criteria:\n\n* Residents ≥65 years of age who had lived in the area for more than 6 months in the past 1 year\n\nExclusion Criteria:\n\n* People with cognitive impairment or mental illness","65 Years",{"count":55,"type":22},2000,"OBSERVATIONAL","At present, there is little epidemiological information on osteoporosis in the elderly population of Shandong Province, especially the lack of systematic research on the role of bone metabolism and biochemical indicators in the diagnosis and prognosis of osteoporosis in the elderly population of Shandong Province. The group intends to conduct a study on the epidemiological characteristics of osteoporosis patients and the significance of bone metabolism biochemical indexes in the diagnosis and prognosis of osteoporosis in elderly people in Shandong Province, which includes 1) assessing the prevalence of osteoporosis and the risk factors associated with osteoporosis in the community population, and 2) exploring the role of bone metabolism biochemical indexes in the diagnosis and prognosis of osteoporosis in the hospitalised population. Expected outcomes include the establishment of a database of community and inpatient populations in Shandong Province, publication of research papers, and participation in academic conferences at home and abroad. The database will collect and organise data on osteoporosis in the community and inpatient osteoporosis in Shandong Province, and provide support for subsequent data analysis and research.",[30,31],[60,61,62,63],"osteoporosis","epidemiology","elderly","Biochemical indexes of bone metabolism","RECRUITING","2025-04-04",{"date":67,"type":37},"2025-04-08",{"date":69,"type":37},"2023-08-01",{"date":71,"type":22},"2026-01-31",{"name":73,"class":44},"The Second Hospital of Shandong University"]