[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"other-connective-tissue-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:other-connective-tissue-disease":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100551644","neutrophil-extracellular-traps-in-different-forms-of-systemic-sclerosis-100551644",false,"NCT06462768","Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis","Neutrophil Extracellular Traps in Systemic Sclerosis","NETOSE","Inclusion Criteria:\n\n\\*For patients of group 1:\n\n* Patients with systemic sclerosis (ACR-EULAR Criteria)\n* Patients taking care of in internal medicine or in dermatology department's of the university hospital of Reims\n* Patients consenting to participate to the study\n* Patients enrolled in the national healthcare insurance program\n\nFor patients of group 2:\n\n* Patients with other connective tissue disease (ACR specific-disease criteria)\n* Patients taking care of in internal medicine or in dermatology department's of the university hospital of Reims\n* Patients consenting to participate to the study\n* Patients enrolled in the national healthcare insurance program\n\nFor patients of group 3 (healthy volunteers)\n\n* Patients eligible for blood donation (blood donation regulation criteria of January 11th 2022 decree)\n* Patients without medical history of autoimmune systemic or chronic inflammatory systemic disease,\n* Patients without current or past neoplasy disease,\n* Patients without chronic metabolic pathology\n* Patients without treatment by anti inflammatory or corticotherapy for the last 15 days,\n* Patients without infectious pathology or inflammatory acute for the last 15 days\n* Patients consenting to participate to the study\n\nExclusion Criteria for patients of all groups:\n\n* Patients\u002FHealthy volunteers under 18 years old\n* Patients\u002FHealthy volunteers protected by the law\n* Patients\u002FHealthy volunteers not consenting to participate to the study after information\n* Patients with inflammatory pathology or infectious acute intercurrent pathology in the last 15 days before inclusion\n* Pregnant or breastfeeding women",true,"ALL","18 Years",{"count":21,"type":22},260,"ESTIMATED","OBSERVATIONAL","Systemic SClerosis (SSC) is a systemic disease characterized by limited or diffuse cutaneous sclerosis, microangiopathy, overproduction of autoantibodies and variable organ damage due to vasculopathy and\u002For fibrosis. The loss of self-tolerance is believed to be caused by the dysregulation of both innate and adaptive immune systems and may involve Reactive Oxygen Species (ROS).\n\nNeutrophils are potent producers of ROS and may play a role in endothelial cells and fibrobasts dysfunction, as in autoantibodies generation. However, their role in SSC pathogenesis remains to be determined. Recent studies discovered abnormal regulation of Neutrophil Extracellular Traps (NETs) in other auto-immune diseases such as Systemic Lupus Erythematosus (SLE). NETs are web-like structures composed of chromatin backbones and granular molecules. They are released by activated neutrophils through a process called \"NETosis\". Nets were first described in 2004 as a novel host defense mechanism to trap and kill foreign pathogens. Recent evidence shows that NETs also participate in the pathogenesis of a variety of inflammatory and autoimmune diseases, including SLE.\n\nThe investigators recently highlighted this phenomenon in SSc, especially in patients with vascular complications and\u002For at a early stage of the disease. The investigators will now explore the factors implicated in this dysregulation of NETosis in SSc.",[26,27,28,29,30],"Systemic Sclerosis","Other Connective Tissue Disease","Systemic Lupus Erythematosus","Dermatomyositis","ANCA Associated Vasculitis",[32,33,34],"Systemic sclerosis","NETosis","polymorphonuclear neutrophil","RECRUITING","2024-06-12",{"date":38,"type":39},"2024-06-17","ACTUAL",{"date":41,"type":39},"2023-11-27",{"date":43,"type":22},"2029-04-27",{"name":45,"class":46},"CHU de Reims","OTHER"]