[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"out-of-hospital-cardiac-arrest-ohca\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:out-of-hospital-cardiac-arrest-ohca":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,38,81,114,141,169,197,224,252,276,307,330,354,384,405,428,456,480],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100640807","out-of-hospital-cardiac-arrest-epidemiology-and-outcomes-in-western-lithuania-2022-2028-100640807",false,"NCT07622082","Out-of-hospital Cardiac Arrest Epidemiology and Outcomes in Western Lithuania 2022-2028","Prehospital Processess Optimization and Emergency Medical Services' Dispatcher's Actions Modeling Impact on Quality of Cardiopulmonary Resuscitation After Sudden Cardiac Arrest","Inclusion Criteria:\n\n* people experiencing out-of-hospital cardiac arrest\n\nExclusion Criteria:\n\n* all others","ALL","18 Years",{"count":19,"type":20},4000,"ESTIMATED","1 Year","OBSERVATIONAL","Out-of-hospital cardiac arrest rate is common problem, because of high mortality rate. It is not clear incidence rate, epidemiology and outcomes in Lithuania",[25],"Out-of-hospital Cardiac Arrest (OHCA)","NOT_YET_RECRUITING","2026-05-27",{"date":29,"type":30},"2026-06-02","ACTUAL",{"date":32,"type":20},"2026-09-01",{"date":34,"type":20},"2030-01-01",{"name":36,"class":37},"Lithuanian University of Health Sciences","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":45,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100640694","femart-1-pilot-study-100640694","NCT07596446","FEMART-1 Pilot Study","FEMART-1","Inclusion Criteria:\n\n\\* Non-traumatic out-of-hospital cardiac arrest (OHCA).\n\nPatients meeting criteria for one of the following clinical scenarios:\n\nGroup A - ECPR-like group:\n\n* Refractory cardiac arrest, including cardiac arrest occurring in the presence of the EMS crew.\n* Age 18-70 years.\n* Effective bystander cardiopulmonary resuscitation.\n* Initial rhythm of ventricular fibrillation (VF), pulseless ventricular tachycardia (pVT), or pulseless electrical activity (PEA).\n\nGroup B - post-ROSC group:\n\n* Return of spontaneous circulation (ROSC) after non-traumatic OHCA.\n* Age 18-70 years.\n\nExclusion Criteria:\n\n* Trauma as the probable primary cause of cardiac arrest.\n* Known severe comorbidity, including:\n\n  * terminal stage of incurable disease (advanced malignancy, advanced dementia, terminal pulmonary disease, terminal heart failure, or palliative care status),\n  * established do-not-resuscitate (DNR) status,\n  * severe pre-existing neurological disability (CPC 3 or CPC 4),\n  * known severe peripheral arterial disease or known occlusion of lower limb arteries,\n  * suspected pulmonary embolism with indication for thrombolytic therapy,\n  * known severe hematological disease associated with severe thrombocytopenia,\n  * morbid obesity.\n* Known or suspected pregnancy.","70 Years",{"count":47,"type":20},60,"INTERVENTIONAL",[50],"NA","The FEMART-1 Pilot Study is focused on evaluating the feasibility, safety, and procedural timing of prehospital femoral arterial sheath placement in patients with non-traumatic out-of-hospital cardiac arrest (OHCA), both during ongoing cardiopulmonary resuscitation and after return of spontaneous circulation (ROSC).\n\nThe primary objective of the study is to enable invasive arterial blood pressure monitoring for targeted and continuous hemodynamic management using vasopressor therapy in the prehospital setting. The study evaluates the feasibility, safety, and procedural performance of invasive arterial monitoring with the aim of improving assessment of the patient's hemodynamic status and enabling more accurate titration of vasopressor support. This approach may reduce episodes of hypotension and decrease the risk of recurrent cardiac arrest while allowing safer transport to specialized cardiac arrest centers.\n\nFemoral arterial access enables more precise monitoring of perfusion pressure, targeted vasopressor titration, and early recognition of impending circulatory collapse. The intervention may contribute to improved early organ perfusion and could be associated with more favorable neurological and overall clinical outcomes after cardiac arrest. In accordance with the ERC Guidelines 2025, which emphasize active hemodynamic optimization after ROSC and acknowledge the potential role of invasive arterial pressure monitoring during ongoing resuscitation, the study evaluates not only feasibility, safety, and procedural timing, but also the potential clinical benefit of continuous hemodynamic-guided management in the prehospital phase, including (1) early identification of hypotension, (2) targeted vasopressor administration, and (3) prevention of re-arrest.\n\nThe study is conducted by the Prague Air Rescue Service Kryštof 01 (Prague Emergency Medical Services) in collaboration with the Central Bohemian Emergency Medical Service, the Second Department of Internal Medicine - Cardiology and Angiology of the General University Hospital in Prague and First Faculty of Medicine, Charles University, and the Department of Anesthesiology, Resuscitation and Intensive Care Medicine of the General University Hospital in Prague and First Faculty of Medicine, Charles University.\n\nFEMART-1 is designed as a prospective pilot study without external funding.",[53,25,54],"Sudden Cardiac Arrest","Cardiogenic Shock Acute",[56,57,58,59,60,61,62,63,64,65,66,67,68],"ECPR","Femoral Arterial Sheath","Femoral Cannulation","Invasive Blood Pressure Monitoring","Prehospital Care","Emergency Medical Services","Resuscitation","Ultrasound-Guided Vascular Access","OHCA","ROSC","Hemodynamic Monitoring","Refractory Cardiac Arrest","ALS","RECRUITING","2026-05-18",{"date":72,"type":30},"2026-05-20",{"date":74,"type":20},"2026-05-11",{"date":76,"type":20},"2027-03-30",{"name":78,"class":79},"Emergency Medical Service, Prague","OTHER_GOV",1,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":89,"targetDuration":91,"studyType":22,"phases":4,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":113},"100636368","pain-after-cardiac-arrest-and-resuscitation-paincare-100636368","NCT07564778","Pain After Cardiac Arrest and Resuscitation (PAINCARE)","Characterizing and Quantifying Pain After Cardiac Arrest and Resuscitation: Insights From the PAINCARE Substudy of the STEPCARE Trial","PAINCARE","Inclusion Criteria:\n\n* Out-of-hospital cardiac arrest\n* Adult, age 18 years or older\n* Spontaneous circulation without chest compressions for at least 20 minutes\n* Comatose, defined as not obeying verbal commands\n* Enrolled within 4 hours after return of spontaneous circulation\n\nExclusion Criteria:\n\n* Restrictions or limitations of care\n* On extracorporeal membrane oxygenation before randomization\n* Pregnancy\n* Previously randomized in the STEPCARE trial\n* Trauma or hemorrhage as the presumed cause of arrest\n* Suspected or confirmed intracranial hemorrhage",{"count":90,"type":20},300,"6 Months","The PAINCARE substudy is an observational cohort substudy nested within the international STEPCARE trial, which evaluates sedation, temperature, and mean arterial pressure strategies after out-of-hospital cardiac arrest. PAINCARE aims to describe the burden of pain during early intensive care after cardiac arrest and to evaluate associations between early pain burden and selected ICU and patient-reported outcomes. Pain is common in critically ill patients but may be difficult to assess in patients who are unconscious, sedated, mechanically ventilated, or unable to self-report. PAINCARE collects structured pain assessments during the first 168 hours after randomization using validated self-report or behavioral pain instruments and relates early pain burden to outcomes including delirium burden, ventilator-free time, ICU-free time, and follow-up pain outcomes. All analyses are observational; PAINCARE is not designed to determine whether modifying pain burden improves outcomes.",[94,25],"Pain",[96,97,98,99,100,101,102,103,104],"Chest compressions","delirium","quality of life","Cardiopulmonary resuscitation","Mechanical ventilation","ICU length of stay","critical care","cardiac arrest survivors","pain assessment",{"date":106,"type":30},"2026-05-14",{"date":108,"type":30},"2023-10-15",{"date":110,"type":20},"2028-10-31",{"name":112,"class":37},"Region Skane",3,{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":48,"phases":125,"briefSummary":126,"conditions":127,"keywords":128,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":80},"100620060","ventilation-performance-and-feedback-simulation-trial-100620060","NCT07352709","Ventilation Performance and Feedback Simulation Trial","Understanding the Effect of Feedback on Ventilation Performance of Rescuers in a Simulation Trial","VENT-SIM","Inclusion Criteria:\n\n* Age \\>= 18 years\n* Credentialed EMS\n\nExclusion Criteria:\n\n* EMS Instructor\n* Inactive EMS role","60 Years",{"count":124,"type":20},80,[50],"The study \"Understanding the Effect of Feedback on Ventilation Performance of Rescuers in a Simulation Trial\" will address treatments administered by Emergency Medical Services (EMS) during cardiopulmonary resuscitation (CPR) in simulated out-of-hospital cardiac arrest (OHCA). The investigators propose a randomized controlled trial among EMS responders to compare quality of rescue breathing performance with and without real-time feedback, along with evaluating CPR strategies (providing rescue breathing during pauses interrupting chest compression vs rescue breathing during uninterrupted chest compressions). The goal of this trial is to learn if visual feedback improves the ability of rescuers to deliver a specified amount of air. The main questions the study aims to answer are:\n\n* Does real-time visual feedback improve ventilation performance and the ability of rescuers to provide a specified amount of air?\n* Will different CPR strategies change the effect of feedback on performance? Researchers will compare real-time feedback to no feedback (not showing the visual feedback) to see if real-time feedback works to improve performance.\n\nRescuers will:\n\n* Deliver assisted ventilation breaths to a mannequin with and without feedback with two different CPR strategies in one session.\n* Fill out a survey about the experience level.",[25],[129,130,131],"ventilation during resuscitation","CPR","emergency medical services","2026-05-01",{"date":134,"type":30},"2026-05-04",{"date":136,"type":20},"2026-06-01",{"date":138,"type":20},"2031-09-30",{"name":140,"class":37},"University of Texas Southwestern Medical Center",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":48,"phases":150,"briefSummary":151,"conditions":152,"keywords":157,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":80},"100637044","abdominal-aortic-tourniquet-application-for-non-traumatic-out-of-hospital-cardiac-arrest-100637044","NCT07573566","Abdominal Aortic Tourniquet Application for Non-Traumatic Out-of-Hospital Cardiac Arrest","ATTICA","Inclusion Criteria:\n\n* Cardiac arrest with indication for initiation of resuscitation\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Pregnancy (suspected or confirmed)\n* Age \\\u003C 18 years\n* Abdominal circumference does not allow application of the AAJT\n* Traumatic etiology\n* Planned eCPR or other intervention in which study inclusion would delay the standard of care\n* Known abdominal aortic aneurysm",{"count":149,"type":20},5,[50],"The aim of the study is to investigate whether occluding the abdominal aorta with an external device could be a potential therapeutic option in cases of non-traumatic cardiac arrest occurring outside of a hospital.\n\nIn cardiac arrest, the heart suddenly stops beating, causing the circulation of blood to collapse. In this situation, vital organs-especially the brain and the heart itself-are no longer adequately supplied with oxygen. Without immediate treatment, severe damage or death occurs within minutes.\n\nThe study therefore examines a specific intervention: the temporary occlusion of the abdominal aorta, which carries blood to the lower regions of the body. If this artery is blocked for a short period, the available blood can be redirected more effectively to the upper parts of the body. In theory, this could improve the oxygen supply to these organs and increase the likelihood that the heart will resume beating or that neurological damage can be reduced.",[153,25,154,155,156],"Cardiac Arrest (CA)","Asystole","Pulseless Electrical Activity","Ventricular Fibrillation",[158,64,159],"AAJT","Aortic occlusion","2026-04-30",{"date":162,"type":30},"2026-05-07",{"date":164,"type":20},"2026-08",{"date":166,"type":20},"2027-09",{"name":168,"class":37},"Klinikum Klagenfurt am Wörthersee",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":176,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":48,"phases":180,"briefSummary":181,"conditions":182,"keywords":183,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":193,"leadSponsor":195,"locationsCount":4},"100596177","trial-of-mobile-external-defibrillator-for-out-of-hospital-cardiac-arrest-in-singapore-100596177","NCT07042061","Trial of Mobile External Defibrillator for Out-of-hospital Cardiac Arrest in Singapore.","Out-of-Hospital Cardiac Arrest Care Through Empowered and Equipped Community First Responders: Mobile External Defibrillation Investigation for Cardiac Arrest in Singapore (MEDICS).","1.1. Inclusion Criteria\n\nStudy participants must meet all the inclusion criteria to participate in this study:\n\n1. Must be proficient in English. Able to read and understand English fluently.\n2. Be aged 21-74 years of age at point of recruitment.\n3. Willing and able to move rapidly to a scene that can be 400 meters away from their location.\n4. Be a registered CFR with SCDF.\n5. Must be active myResponder® mobile phone app user so they can receive alerts about nearby OHCA cases.\n\n1.2. Exclusion Criteria All subjects meeting any of the following exclusion criteria will be excluded from participation in this study.\n\n1. Not proficient in English. Cannot read and understand English.\n2. Aged less than 21 and over 74 years of age.\n3. Not willing to be a myResponder app user.\n4. Not able to move rapidly to a scene that can be 400 meters away from their location.\n5. Given the short duration of the trial, those who are pregnant will be ineligible.\n6. Those experiencing any serious physical injury or handicap and those with obvious mental handicap.","21 Years","74 Years",{"count":179,"type":20},1000,[50],"The goal of this clinical trial is to learn the feasibility of equipping the volunteer community responders (VCR) with the mobile external automated defibrillators (mAEDs) for the management of adults experiencing out-of-hospital cardiac arrest (OHCA) patients. It will also provide early signals if this enhanced system can help increase the frequency of defibrillation and doing it earlier. The main questions it aims to answer are:\n\n* Can equipped VCRs apply mAEDs more frequently and earlier to potentially get more patients successfully resuscitated?\n* Is this system enhancement is feasible in the long run.\n\nParticipants, the VCRs, will:\n\n* Carry a 450 gm mAED with them all the time for up to an year and use it on an OHCA patient if and when alerted to help.\n* They will hand over this single-use battery-operated device to the EMS crew for data retrieval and potential replacement\n* They will be interviewed for their experience of being equipped and use of the mAED.",[25],[184,185,186,187,188],"Out-of-hospital","Cardiac arrest","Automated external defibrillator","AED","Community volunteers","2026-04-23",{"date":191,"type":30},"2026-04-27",{"date":132,"type":20},{"date":194,"type":20},"2027-01-31",{"name":196,"class":37},"Singapore General Hospital",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":201,"acronym":202,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":48,"phases":206,"briefSummary":209,"conditions":210,"keywords":211,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":80},"100611386","phase-2-resuscitation-enhancement-to-avoid-rearrest-through-evidence-based-strategies-in-prehospital-post-resuscitation-care-100611386","NCT07239908","Resuscitation Enhancement to Avoid Rearrest Through Evidence-based Strategies in Prehospital Post-resuscitation Care","RE-ARREST","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Patients with out-of-hospital cardiac arrest (OHCA) who received resuscitative care from the Siriraj Emergency Medical Services Center (SiEMS).\n\nPatients who achieved return of spontaneous circulation (ROSC) prior to hospital arrival.\n\n\\- Patients subsequently transported to the Emergency Department of Siriraj Hospital for further treatment.\n\nExclusion Criteria:\n\n* Suspected traumatic cardiac arrest.\n* ROSC patients whose legally authorized representative declined vasopressor administration, despite clinical indication according to the prehospital post-resuscitation care protocol.\n* ROSC patients who had not undergone endotracheal intubation, and whose legally authorized representative declined endotracheal intubation, despite protocol-based indication.\n* ROSC patients without rearrest whose legally authorized representative declined further blood investigations or additional procedures after arrival at the Emergency Department.\n* Patients whose legally authorized representative declined participation in the study.\n* Patients without an available legally authorized representative to provide consent for study participation.",{"count":205,"type":20},318,[207,208],"PHASE2","PHASE3","Out-of-hospital cardiac arrest (OHCA) remains a leading global emergency condition with low survival to hospital discharge despite advances in cardiopulmonary resuscitation. Return of spontaneous circulation (ROSC) rates have improved; however, 30-50% of patients experience rearrest after ROSC, which is associated with significantly reduced survival. Preventable physiologic factors related to prehospital care - including hypoxia, hypotension, and hyperventilation - are frequently identified prior to rearrest. Evidence-based post-ROSC clinical bundles exist mainly for in-hospital settings, while structured prehospital post-resuscitation care protocols are limited, particularly in resource-constrained environments.\n\nThe RE-ARREST project aims to develop, implement, and evaluate an evidence-based prehospital post-resuscitation care protocol designed for paramedic-led Emergency Medical Services. The intervention includes structured monitoring, tailored oxygenation and ventilation targets, vasopressor use criteria (norepinephrine), fluid management decision support, teamwork communication, and operational training workshops using simulation.\n\nThis is a quasi-experimental pre-post interventional study conducted at the Siriraj Emergency Medical Service (SiEMS), Thailand. The study compares outcomes from retrospective pre-implementation cases with prospective post-implementation cases, including both patient-centered outcomes and provider compliance. Adult OHCA patients with ROSC achieved prehospital and transported to Siriraj Hospital are eligible. The estimated sample size is 318 participants (pre-intervention 212; post-intervention 106) over two years.\n\nThe primary outcome is the incidence of rearrest within 1 hour after ROSC during prehospital care and initial emergency department management. Secondary outcomes include protocol compliance, survival-to-admission, and survival-to-hospital-discharge. The protocol emphasizes feasibility, safety, and replicability to inform scalable EMS clinical practice guidelines.\n\nThis research is expected to provide novel evidence on targeted prehospital post-ROSC care and has the potential to reduce rearrest, improve neurologically favorable survival, and strengthen EMS system quality improvement efforts in Thailand and other low-to-middle-resource settings.",[25],[212,213,214],"Post cardiac arrest care","Out-of-hospital cardiac arrest","Prehospital care","2026-04-16",{"date":217,"type":30},"2026-04-21",{"date":219,"type":30},"2025-12-01",{"date":221,"type":20},"2028-12-01",{"name":223,"class":37},"Siriraj Hospital",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":232,"targetDuration":4,"studyType":48,"phases":234,"briefSummary":235,"conditions":236,"keywords":237,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":251},"100626933","phase-3-impact-of-low-dose-epinephrine-in-the-management-of-out-of-hospital-cardiac-arrest-on-neurological-outcome-100626933","NCT07442071","Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological Outcome","Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological Outcome: A Multicenter Randomized and Double-blind Trial.","Low-EPI","Inclusion Criteria:\n\nMale or female, aged ≥18 years. Out-of-hospital cardiac arrest for which resuscitation is decided by the SMUR team.\n\nMedical Out-of-hospital cardiac arrest. Affiliated with or beneficiary of a social security plan\n\nExclusion Criteria:\n\n* Non-medical Out-of-hospital cardiac arrest (traumatic, drownings, electrocution, asphyxia, overdose, unknown cause).\n* Out-of-hospital cardiac arrest without advanced life support (Do Not Attempt Resuscitation order, body finding, the decision not to attempt advanced life support is at the physician's discretion).\n\n  * Pregnant women, birthing or breastfeeding mothers\n  * Adults under legal protection measure (such as guardianship, conservatorship)\n  * Individuals deprived of liberty due to judicial or administrative decision",{"count":233,"type":20},4336,[208],"This study will test whether a lower dose of epinephrine (0.5 mg) given during emergency treatment for out-of-hospital cardiac arrest helps more patients survive with good brain function, compared to the standard dose (1 mg). Adults who experience cardiac arrest outside the hospital and are treated by emergency medical teams will be randomly assigned to receive either the low dose or the standard dose of epinephrine. The study will compare survival and neurological outcomes between the two groups over 28 days.",[25],[238,239,240,241],"Epinephrine,","Cardiac Arrest","Neurological Outcome","Emergency Medicine","2026-02-26",{"date":244,"type":30},"2026-03-02",{"date":246,"type":20},"2026-06",{"date":248,"type":20},"2030-07",{"name":250,"class":37},"Central Hospital, Nancy, France",26,{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":261,"conditions":262,"keywords":264,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":80},"100626692","measurement-of-airway-opening-index-during-out-of-hospital-cardiac-arrest-the-lazarus-aoi-trial-100626692","NCT07438938","Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.","Lazarus-AOI","Inclusion Criteria:\n\n* Adult (over 18 years old) patients with out-of-hospital cardiac arrest.\n* Patients undergoing cardiopulmonary resuscitation (CPR).\n* Patients who were intubated and had available capnogram recordings immediately after intubation.\n\nExclusion Criteria:\n\n* Patients that were not intubated\n* Patients that did not receive CPR following intubation\n* Cases with a technical challenge with the ETCO₂ measurement (i.e., issues with waveform data of the capnogram.",{"count":260,"type":20},150,"Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Despite constantly improving resuscitation techniques, the chances of survival remain limited. During cardiopulmonary resuscitation (CPR), a closure of the airway may occur, impeding ventilation. This phenomenon also complicates the interpretation of the end-tidal CO2 (ETCO2) in the capnogram. The extent to which airway closure occurs is quantified by the Airway Opening Index (AOI). This can be calculated from the capnogram and is seen as a measure of the quality of CPR applied as well as a possible indicator to predict the outcome of CPR.\n\nIn this study, we analyse capnogram data from approximately 150 cases, collected during interventions for OHCA and logged in the Lazarus database (UZ Gent and AZORG) to answer three research questions below:\n\n1. What is the prevalence of AOI during CPR?\n2. Is there a correlation between AOI and return of spontaneous circulation (ROSC)?\n3. Does the application of positive end-expiratory pressure (PEEP) affect the AOI and ROSC?\n\nA mathematical model for calculating AOI, based on a method from previous work by Bandhari et al. \\[1\\] will be developed. Using this model, the AOI will be calculated from the individual capnograms for all cases in the Lazarus database.\n\nIn addition, a multivariable regression model will be used to analyse whether AOI can be used to predict ROSC. Corrections will be made for relevant confounders such as age, gender, witnessed arrest and rhythm pattern.\n\nFinally, it is investigated whether PEEP has a positive influence on AOI. This study aims to contribute to better insights into airway dynamics during CPR and the optimization of ventilation in OHCA.",[153,25,263],"Resuscitated Sudden Cardiac Death",[265,266],"capnography","airway closure","2026-02-23",{"date":269,"type":30},"2026-02-27",{"date":271,"type":30},"2022-10-01",{"date":273,"type":20},"2027-01-01",{"name":275,"class":37},"University Hospital, Ghent",{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":282,"eligibilityCriteria":283,"healthyVolunteers":11,"sex":16,"minAge":284,"maxAge":4,"enrollmentInfo":285,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":287,"conditions":288,"keywords":292,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":80},"100626136","the-air-cpr-study-ai-guided-chest-compressions-100626136","NCT07431710","The AIR-CPR Study: AI-Guided Chest Compressions","Utilizing Artificial Intelligence to Optimize Chest Compression Region During Cardio-pulmonary Resuscitation for Patients With Out-of-hospital Cardiac Arrest.","AIR-CPR","Inclusion Criteria:\n\n1. Adults aged 20 years or older.\n2. Patients with out-of-hospital cardiac arrest (OHCA) undergoing 3.cardiopulmonary resuscitation (CPR) in the emergency department.\n\nCardiac arrest caused by non-traumatic factors.\n\nExclusion Criteria:\n\n1. Pregnant patients.\n2. Patients with obvious signs of death.\n3. Patients with a signed \"Do Not Resuscitate\" (DNR) order.\n4. Patients requiring extracorporeal cardio-pulmonary resuscitation (ECPR).\n5. Patients requiring Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA).\n6. Cardiac arrest caused by massive hemorrhage, aortic emergencies, tension pneumothorax, cardiac tamponade, or pulmonary embolism.\n7. History of severe aortic valve disease or previous aortic valve surgery.\n8. Patients for whom TEE or femoral arterial catheterization is contraindicated.\n9. Situations where the medical team is unable to perform TEE or femoral arterial catheterization during CPR.","20 Years",{"count":286,"type":20},255,"The AIR-CPR project aims to improve survival rates for patients with Out-of-Hospital Cardiac Arrest (OHCA) by utilizing Artificial Intelligence (AI) to optimize chest compression locations. Current guidelines recommend a standardized compression point (the lower half of the sternum), yet recent research indicates that this position can compress the aortic valve in approximately 48.7% of patients, significantly reducing the chances of successful resuscitation.\n\nThis study will develop a deep learning model based on YOLO v8 to analyze real-time arterial pressure waveforms to identify proper aortic valve opening and closing. By identifying specific waveform features that humans cannot easily distinguish, the AI will guide rescuers to adjust the compression site-typically toward the left ventricle-to ensure optimal blood output. The project seeks to transform CPR from a standardized \"one-size-fits-all\" approach into a personalized, precision medicine intervention.",[25,289,290,291],"Cardiopulmonary Resuscitation (CPR)","Aortic Valve Compression","Precision Resuscitation",[293,294,295,296,297,66],"Artificial Intelligence","Transesophageal Echocardiography","Arterial Pressure Waveform","Chest Compression Location","Personalized Resuscitation","2026-02-19",{"date":300,"type":30},"2026-02-24",{"date":302,"type":30},"2025-01-06",{"date":304,"type":20},"2027-12-31",{"name":306,"class":37},"Far Eastern Memorial Hospital",{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":314,"targetDuration":4,"studyType":48,"phases":316,"briefSummary":317,"conditions":318,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":329},"100588279","phase-3-the-application-of-positive-end-expiratory-pressure-in-out-of-hospital-cardiac-arrest-the-lazarus-peep-trial-100588279","NCT06939335","The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.","Lazarus-PEEP","Inclusion Criteria:\n\n1. Age: Adults aged 18 years and older.\n2. Type of Cardiac Arrest: Patients who have experienced a non-traumatic out-of-hospital cardiac arrest.\n3. CPR Administration: Patients receiving cardiopulmonary resuscitation from an advanced life support (ALS) team.\n4. Intubation and Ventilation: Patients who are intubated and ventilated during resuscitation efforts.\n\nExclusion Criteria:\n\n1. Cardiac arrest in patient younger than 18 years of age.\n2. Traumatic cardiac arrest, including drowning, penetrating or blunt injury, and burns.\n3. Immediate Return of Spontaneous Circulation (ROSC): Patients who achieve ROSC before intubation and initiation of intubation.\n4. Pregnancy.\n5. Mechanical ventilation during arrest: patients already receiving mechanical ventilation at the moment of cardiac arrest, due to reasons other than their arrest, will be excluded.\n6. Do Not Resuscitate (DNR) Orders: Patients with existing DNR orders or any advanced directive indicating that CPR should not be performed.\n7. Failure to intubate: if intubation is unsuccessful, ventilation by any means (MBV, SGA) should take priority over the study protocol, and the patient is excluded.\n8. Enrolment in Other Studies: Patients currently enrolled in another interventional clinical trial that could interfere with the outcomes of this study.",{"count":315,"type":20},132,[208],"The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition where the heart suddenly stops beating. PEEP is used during ventilation, which may enhance oxygen levels by keeping the airways open throughout CPR.\n\nThis study aims to determine if using PEEP during CPR helps restart the heart more effectively, improves survival rates, and enhances survival with good neurologic outcomes after a cardiac arrest compared to standard CPR without PEEP.\n\nResearchers will randomly assign participants to one of two groups: one receiving CPR with PEEP set at 5 cm of water pressure and the other receiving standard CPR without PEEP. Participants will be treated by emergency medical teams trained in advanced life support, and specialised sensors will measure airflow and airway pressure during resuscitation.\n\nAdditionally, the study will evaluate potential side effects associated with PEEP, such as increased pressure within the chest or lung injuries. Findings from this trial will guide recommendations on the usage of PEEP in standard CPR practices to potentially improve patient outcomes.",[153,25,319,320],"Positive End-expiratory Pressure (PEEP)","Ventilation During Resuscitation","2026-01-20",{"date":323,"type":30},"2026-01-21",{"date":325,"type":30},"2025-04-25",{"date":327,"type":20},"2027-02-01",{"name":275,"class":37},7,{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":338,"enrollmentInfo":339,"targetDuration":4,"studyType":48,"phases":341,"briefSummary":342,"conditions":343,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":4},"100612841","the-effectiveness-of-continuous-compression-synchronous-ventilation-bio-cpr-100612841","NCT07258823","the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR)","Study on the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR) in the ACLS Stage of Cardiopulmonary Resuscitation (ACLS) Based on the Bionic Concept to Explore the Best Mechanical Ventilation Strategy","Bio-CPR","Inclusion Criteria:\n\n1. 18-65 years old; 2. Cardiac arrest with witnesses; 3. Onset - compression start time\\\u003C5 minutes; 4. Initial ventricular fibrillation rhythm; 5. Endotracheal intubation and use of a mechanical chest CPR device; Patients with OHCA who meet the above conditions\n\nExclusion Criteria:\n\n* 1\\. OHCA patients who are not suitable for mechanical compression ventilation; 2. The participant or his\u002Fher legally authorized representative (LAR) is unable or unwilling to provide written informed consent.","75 Years",{"count":340,"type":20},408,[50],"Bio-CPR is an innovative new mechanical resuscitation model proposed by our research group. A multi-center RCT study was established to comprehensively evaluate the efficacy of this model and the current standard CPR protocol, verify its safety and efficacy, and provide high-quality clinical evidence support.",[25,153,130,344],"ACLS","2025-11-21",{"date":347,"type":30},"2025-12-02",{"date":349,"type":20},"2026-02-01",{"date":351,"type":20},"2027-08-31",{"name":353,"class":37},"Guangdong Provincial People's Hospital",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":338,"enrollmentInfo":362,"targetDuration":4,"studyType":48,"phases":364,"briefSummary":365,"conditions":366,"keywords":370,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":379,"leadSponsor":381,"locationsCount":383},"100575766","hypothermia-versus-normothermia-after-extracorporeal-cardiopulmonary-resuscitation-for-out-of-hospital-cardiac-arrest-100575766","NCT06776549","Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest","Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest: A Cluster Randomized Trial (SAVE-J NEUROTHERM Trial)","J-NEURO","Inclusion Criteria:\n\n* OHCA\n* Age of 18-75 years, known or estimated\n* An initial cardiac arrest rhythm of ventricular fibrillation\u002Fpulseless ventricular tachycardia or pulseless electrical activity\n\nExclusion Criteria:\n\n* ECMO initiated after sustained return of spontaneous circulation (ROSC) and patients with sustained ROSC before ECMO initiation\n* OHCA of presumed non-cardiac etiology\n* Time from emergency call or witnessed arrest to hospital arrival of \\>60 min\n* Time from hospital arrival to ECMO initiation of \\>60 min\n* Pre-hospital ECPR\n* Unavailability of the ECMO heat exchanger for temperature control\n* Glasgow Coma Scale score before temperature control of \\>8\n* Core body temperature upon hospital arrival of ≤32ºC\n* Surgical intervention before temperature control (e.g., surgical intervention for the primary disease or complications related to resuscitation\u002FECMO procedures)\n* Do Not Attempt Resuscitation) order confirmed prior to temperature control\n* Limitations in intensive care before temperature control\n* Known cerebral performance category (CPC) of 3-4 before cardiac arrest\n* Known chronic obstructive pulmonary disease with home oxygen therapy\n* Known or suspected pregnancy\n* Concomitant illness, such as malignancy, shortens life expectancy (180-day survival unlikely)\n* Consent not obtained or withdrawn by the participant or surrogate\n* Other reasons, physician's decision not to enroll the patient",{"count":363,"type":20},468,[50],"The SAVE-J NEUROTHERM trial is a cluster randomized trial that evaluated and compared the mortality risk, neurological outcomes, and adverse events between patients who underwent hypothermia and those who underwent normothermia after extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest.",[25,367,368,369],"ECMO Treatment","Temperature","Post Cardiac Arrest Syndrome",[185,371,372,373,374],"Out-of-hospital cardiac arrest (OHCA)","Extracorporeal cardiopulmonary resuscitation (ECPR)","Temperature control","Post cardiac arrest syndrome (PCAS)","2025-06-26",{"date":377,"type":30},"2025-06-27",{"date":302,"type":30},{"date":380,"type":20},"2028-12-31",{"name":382,"class":37},"Kagawa University",28,{"id":385,"slug":386,"hasResults":11,"nctId":387,"briefTitle":388,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":11,"sex":16,"minAge":176,"maxAge":390,"enrollmentInfo":391,"targetDuration":4,"studyType":48,"phases":393,"briefSummary":394,"conditions":395,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":403,"locationsCount":80},"100491485","neuroprotection-via-optimizing-cerebral-blood-flow-after-cardiac-arrest-neuro-intact-study-100491485","NCT05679739","NEUROprotection Via optimizINg Cerebral Blood Flow afTer cArdiaC arresT (NEURO-INTACT) Study","Inclusion Criteria:\n\n1. At least 21 years of age\n2. Comatose defined as not being able to obey verbal commands and no verbal response to pain after sustained ROSC.\n\nExclusion Criteria:\n\n1. ≥ 80 years old at time of enrolment\n2. Pregnant patients\n3. Limitations of care or life support therapy withdrawn within 24 hours of admission","79 Years",{"count":392,"type":20},49,[50],"This single-center proof of concept study aims to assess the efficacy of a blood pressure strategy targeting person- and time-specific cerebral blood flow compared with standard-of-care using neuron-specific enolase as a quantitative biomarker of brain injury. Our central hypothesis is that an individualized blood pressure strategy targeting cerebral perfusion will reduce the extent of brain injury as indicated by changes in levels of neuron-specific enolase from baseline at 72 hours. To test this hypothesis, we will recruit 49 patients to an individualized blood pressure management strategy targeting cerebral blood flow, where optimal blood pressure will be serially calculated by the ICM+ brain monitoring software (Cambridge, UK) using inputs from transcranial Doppler ultrasound and near-infrared spectroscopy.",[396],"Out-Of-Hospital Cardiac Arrest (OHCA)","2025-05-13",{"date":399,"type":30},"2025-05-16",{"date":401,"type":30},"2023-08-29",{"date":164,"type":20},{"name":404,"class":37},"National University Hospital, Singapore",{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":409,"acronym":410,"eligibilityCriteria":411,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":412,"targetDuration":4,"studyType":48,"phases":414,"briefSummary":415,"conditions":416,"keywords":417,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":419,"lastUpdatePostDateStruct":420,"startDateStruct":422,"completionDateStruct":424,"leadSponsor":426,"locationsCount":427},"100590815","cerebral-near-infrared-spectroscopy-in-out-of-hospital-cardiac-arrest-and-neurological-prognosis-100590815","NCT06972329","Cerebral Near Infrared Spectroscopy in Out-of-Hospital Cardiac Arrest and Neurological Prognosis","NISOHCA","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Non-traumatic out-of-hospital cardiac arrest witnessed and managed by the mobile emergency unit (SMUR).\n\nExclusion Criteria:\n\n* Scalp\u002Fcranial or facial injury preventing the placement of electrodes for NIRS measurement.\n* Spontaneous cardiac activity upon the arrival of the SMUR.\n* Decision by the SMUR physician not to initiate specialized resuscitation.",{"count":413,"type":20},542,[50],"Out-of-hospital cardiac arrest (OHCA) prognosis remains poor : 7% of patients surviving without neurological impairment.\n\n65% of patients dying after hospital admission were neurologically impaired. When treating a patient with CA, neurological outcome remains extremely difficult to predict, especially in the pre-hospital setting. Practitioners have very little objective information to help them with neuropronostication.\n\nAlthough an EtCO2 level of \\\u003C 10 mmHg is associated with a poor neurological prognosis, European recommendations point out that this data alone is not currently sufficient to predict a patient's prognosis or to make a decision to stop resuscitation. Current recommendations do not suggest any other objective parameter during resuscitation for neuropronostication of patients with out-of-hospital cardiac arrest.\n\nCerebral tissue oxygen saturation (rSO2) is measured using the near infrared spectrometry (NIRS) technique. Cerebral NIRS (cNIRS) enables non-invasive measurement of changes in cerebral oximetry during the management of a cardiac arrest (CA).\n\nVarious clinical studies conducted over the last ten years have demonstrated that there is a probable link between cNIRS levels during resuscitation and return of spontaneous circulation (ROSC), but a clear threshold value has not been defined.\n\nThe aim of the NISOHCA study is to confirm that a 40% threshold of cNIRS in the pre-hospital setting for OHCA can specifically predict survival with good neurological outcome at D90 .",[25],[213,418],"Cerebral Near infrared spectroscopy (NIRSc)","2025-05-12",{"date":421,"type":30},"2025-05-15",{"date":423,"type":20},"2025-11",{"date":425,"type":20},"2028-02",{"name":250,"class":37},6,{"id":429,"slug":430,"hasResults":11,"nctId":431,"briefTitle":432,"officialTitle":433,"acronym":434,"eligibilityCriteria":435,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":436,"targetDuration":4,"studyType":48,"phases":438,"briefSummary":439,"conditions":440,"keywords":441,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":455},"100476664","mean-arterial-pressure-after-out-of-hospital-cardiac-arrest-100476664","NCT05486884","Mean Arterial Pressure After Out-of-hospital Cardiac Arrest","Mean Arterial Pressure After Out-of-hospital Cardiac Arrest: the METAPHORE Randomized Trial","METAPHORE","Inclusion Criteria:\n\n* Admission to ICU following an out-of-hospital cardiac arrest with an initially shockable or non-shockable rhythm ;\n* Sustained ROSC defined as 20 minutes with signs of circulation without the need for chest compressions;\n* Under invasive mechanical ventilation for coma, defined as a Glasgow score ≤ 8\u002F15;\n* Consent from a relative or of a procedure for emergency inclusion.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years ;\n* In-hospital cardiac arrest (first cardiac arrest);\n* Unwitnessed CA with initial rhythm of asystole\n* Delay between ROSC and attempting randomisation \\> 6 hours ;\n* Cardiac arrest in a context of multiple trauma ;\n* Cardiac arrest in a context of hemorrhagic shock or severe hemorrhage necessitating hemostasis (surgery or radiological or endoscopic hemostasis) ;\n* Cardiac arrest secondary to an acute brain disease (ischemic or hemorrhagic stroke, subarachnoid hemorrhage, severe traumatic brain injury) ;\n* Refractory shock :\n\nDefined as a MAP \\\u003C 65 mmHg for more than one hour on norepinephrine or epinephrine at a dose \\> 1 µg\u002Fkg\u002Fmin despite adequate fluid resuscitation ;\n\n* Extracorporeal circulatory support prior to inclusion;\n* Known allergy to norepinephrine or to any of its excipients;\n* Decision to limit care before inclusion ;\n* Modified Rankin score of 4 or 5 before cardiac arrest ;\n* Inclusion in another interventional study in which the principal endpoint is neurological prognosis ;\n* Pregnancy or breast feeding ;\n* Adult patient deprived of freedom or under legal protection (patients under guardianship or curatorship) (article L1121-6 of the French Health Code) ;\n* Non-French speaking;\n* Patient already included in this trial ;\n* Absence of social security cover.",{"count":437,"type":20},1380,[50],"Out-of-hospital cardiac arrest is a public health problem for which overall survival is below 10%. Post-cardiac arrest syndrome is the principal cause of death in intensive care units (ICU), due to refractory shock or brain injuries secondary to anoxia. Brain anoxia is responsible for severe neurological sequelae that may be aggravated by cerebral hypoperfusion during the first few hours after the return of spontaneous circulation. Current recommendations are to ensure that arterial blood pressure is sufficient for the perfusion of organs, but no minimum threshold mean arterial pressure (MAP) has been defined. In practice, most teams target a MAP of at least 65 mmHg. Several observational studies have shown a correlation between MAP and neurological prognosis, patients with a higher initial MAP having a better outcome. Recent pilot studies have demonstrated the feasibility of increasing the target MAP after cardiac arrest, but conflicting results have been obtained concerning patient prognosis. These findings may be explained by changes to the autoregulation of the brain after cardiac arrest, with a shift of the curve towards the right, or its abolition. Cerebral blood flow is dependent on MAP, and a target MAP of 65 mmHg for these patients may result in insufficient brain perfusion. Conversely, a too high MAP might cause brain lesions due to vasogenic edema, hemorrhagic complications or excess perfusion in conditions of diminished brain metabolism. An interventional study is required to evaluate the effect of increasing MAP on neurofunctional outcome after cardiac arrest. Given the data available for brain autoregulation, the correlation between MAP and prognosis, and the risks theoretically associated with a higher MAP, investigator plans to compare a standard threshold of MAP (≥ 65 mmHg) with a high threshold of MAP (≥ 90 mmHg). Investigator hypothesizes that a high MAP within the first 24 hours after cardiac arrest will improve neurofunctional outcome.",[239,25],[442,443,444,445],"cardiac arrest","outcome","cerebral blood flow","mean arterial pressure","2025-03-21",{"date":448,"type":30},"2025-03-26",{"date":450,"type":30},"2024-09-28",{"date":452,"type":20},"2028-03-28",{"name":454,"class":37},"Centre Hospitalier le Mans",27,{"id":457,"slug":458,"hasResults":11,"nctId":459,"briefTitle":460,"officialTitle":461,"acronym":462,"eligibilityCriteria":463,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":464,"targetDuration":4,"studyType":48,"phases":465,"briefSummary":466,"conditions":467,"keywords":468,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":477,"leadSponsor":478,"locationsCount":80},"100567755","application-of-transesophageal-echocardiography-in-pre-hospital-cardiac-arrest-patients-100567755","NCT06672315","Application of Transesophageal Echocardiography in Pre-hospital Cardiac Arrest Patients","Transesophageal Echocardiography in Pre-hospital Cardiac Arrest Patients; TAPCAP","TAPCAP","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Patients with out-of-hospital cardiac arrest (OHCA)\n3. Non-traumatic cause of cardiac arrest\n\nExclusion Criteria:\n\n1. Presence of obvious signs of death, such as decapitation, rigor mortis, livor mortis, or decomposition.\n2. Family explicitly expresses a Do Not Attempt Resuscitation (DNR) order, or the patient has a documented refusal of resuscitation.\n3. Any condition that contraindicates the use of transesophageal echocardiography (TEE), such as esophageal tumors, preventing probe insertion.\n4. Patients eligible for ECPR (Extracorporeal Cardiopulmonary Resuscitation) treatment.\n5. Spontaneous circulation has already been stabilized before performing TEE.",{"count":47,"type":20},[50],"The Use of Point-of-Care Ultrasound (POCUS), Transthoracic Echocardiography (TTE), and Transesophageal Echocardiography (TEE) in Cardiac Arrest and Acute Coronary Syndrome Patients\n\nStudies have shown that POCUS can rapidly change the management in nearly 80% of cases in emergency settings, particularly in environments such as war zones and disaster relief. TTE is highly sensitive in diagnosing acute coronary syndromes and can effectively rule out myocardial infarction. In cardiac arrest patients, TTE assists in determining cardiac activity and identifying reversible causes, such as pericardial tamponade and pneumothorax. However, TTE can be affected by suboptimal image quality due to factors like chest compression in out-of-hospital cardiac arrest (OHCA) patients.\n\nIn Taiwan's emergency medical system, EMT-Ps (paramedics) undergo approximately one year of training, which enables them to provide emergency care, including ultrasound examinations, before hospital arrival. Research on pre-hospital cardiac arrest has shown that most ultrasound applications can be completed within 3 minutes and do not significantly increase on-scene time.\n\nTEE, though advantageous for its high-quality imaging and ability to reduce interruptions during chest compressions, faces challenges in pre-hospital emergency applications due to specialized training and equipment requirements. However, a study in Vienna, Austria, demonstrated that TEE could be performed and yield high-quality images in most pre-hospital cases, with an average examination time of 5.1 minutes.\n\nSeveral hospitals in Taiwan have begun training personnel in TEE, emphasizing the importance of establishing TEE image registries for large-scale, effective research analysis. However, these efforts also face challenges related to resources and collaboration. The research team has over three years of experience using TEE in the emergency department to examine OHCA patients, and a three-year study will be conducted to validate the efficacy of pre-hospital TEE in cardiac arrest patients.",[25],[469,294,470,471,64],"Left Ventricular Outflow Tract","TEE","LVOT","2025-03-03",{"date":474,"type":30},"2025-03-05",{"date":476,"type":30},"2024-12-30",{"date":351,"type":20},{"name":479,"class":37},"Jen-Tang Sun",{"id":481,"slug":482,"hasResults":11,"nctId":483,"briefTitle":484,"officialTitle":485,"acronym":486,"eligibilityCriteria":487,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":488,"targetDuration":4,"studyType":48,"phases":490,"briefSummary":491,"conditions":492,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":493,"lastUpdatePostDateStruct":494,"startDateStruct":496,"completionDateStruct":498,"leadSponsor":500,"locationsCount":502},"100573290","phase-2-ketamine-sedation-as-neuroprotective-agent-following-out-of-hospital-cardiac-arrest-100573290","NCT06744361","Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest","KETamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest (OHCA) - the KETOHCA Trial","KETOHCA","Inclusion Criteria:\n\n* Adults (age ≥18 years) AND\n* resuscitated OHCA of presumed cardiac cause with a shockable first recorded heart rhythm AND\n* mean arterial pressure (MAP) \\>40 mmHg AND\n* a decision to perform prehospital intubation.\n\nExclusion Criteria:\n\n* Advanced life support termination-of-resuscitation (TOR) criteria met\n* Systolic blood pressure \\>190 mmHg\n* Known allergy to ketamine or propofol\n* Chronic diseases making 180-day survival unlikely\n* Body temperature \\\u003C30° C.",{"count":489,"type":20},282,[207],"OHCA is a critical medical emergency with significant mortality and morbidity primarily due to hypoxic-ischemic brain injury (HIBI). Despite advances in resuscitation techniques, the neurological outcomes for survivors remain poor. Current post-resuscitation practices lack specific neuroprotective strategies. Ketamine, an N-Methyl-D-Aspartate (NMDA) receptor antagonist, has shown potential neuroprotective properties in preclinical and clinical studies due to its ability to inhibit excitotoxicity and reduce neuronal apoptosis. This trial hypothesizes that ketamine, when used for sedation in OHCA patients, may offer superior neuroprotective benefits compared to the commonly used sedative propofol. By comparing the effects of ketamine and propofol on neuronal damage markers and long-term neurological outcomes, this study aims to identify a potentially effective intervention to improve the prognosis of OHCA patients.",[25],"2024-12-19",{"date":495,"type":30},"2024-12-20",{"date":497,"type":30},"2024-12-12",{"date":499,"type":20},"2027-09-01",{"name":501,"class":37},"Christian Hassager",2]