[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"out-of-hospital-cardiac-arrest\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:out-of-hospital-cardiac-arrest":246},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,34,0,25,[9,47,75,103,131,156,180,203,234,261,285,309,340,359,383,409,434,460,482,505,524,543,561,586,612],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100552447","neuroprotective-effect-of-remote-ischemic-post-conditioning-in-out-of-hospital-cardiac-arrest-100552447",false,"NCT06473207","Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest","Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest : a Randomized Open Label Controlled Trial","RIPOST-CA","Inclusion Criteria:\n\n* Out-of-hospital cardiac arrest with stable return of spontaneous circulation (ROSC \\> 20 minutes)\n* Patient receiving invasive mechanical ventilation for coma (Glasgow score \\\u003C 8)\n* Availability of a lower limb without intravenous infusion or tension cuff positioned on it\n* Randomization and application of the first session of the tested procedure within 4 hours after ROSC\n* Consent of a next-of-kin or inclusion in emergency procedure\n\nExclusion criteria :\n\n* Age \\\u003C 18 y.o or pregnancy\n* Patient unable to walk without assistance, unable to support himself properly without assistance, bedridden, incontinent and requiring nursing constant attention and care (corresponding to a mRS equal to 4 or 5)\n* Interval between cardiac arrest and ROSC (no flow + low flow) estimated \\> 60 minutes\n* Unwitnessed cardiac arrest with asystole as first rhythm\n* In-hospital cardiac arrest\n* Refractory cardiac arrest (no ROSC considered as stable)\n* Cardiac arrest from traumatic, hemorrhage, stroke or hanging supposed origin\n* Mean arterial pressure \\\u003C 65mmHg persisting despite appropriate vascular filling and vasopressor and\u002For inotropic support\n* Active uncontrolled bleeding\n* Contraindication or not possible to use a pneumatic tourniquet on none of the two lower limbs (amputations, intravenous infusion positioned on both lower limbs, tourniquet size incompatible with patient morphology)\n* Implementation of extracorporeal arteriovenous circulation for refractory cardiac arrest or refractory cardiogenic shock before inclusion\n* Patient already included in this study\n* Inclusion in another interventional study which purpose is to improve prognosis after a cardiac arrest\n* Judicial protection measure\n* Patient without French social security","ALL","18 Years",{"count":21,"type":22},48,"ESTIMATED","INTERVENTIONAL",[25],"NA","Patients admitted to intensive care unit (ICU) following an out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality rate, primarily due to ischemia-reperfusion (I\u002FR) syndrome leading to anoxic-ischemic brain injury. Despite current recommended advanced life support therapies, no specific treatment or procedure has yet been shown to improve the neurological outcome of such patients.\n\nRemote ischemic post-conditioning (RIPOST) which usually consists of applying brief and repeated cycles of ischemia alternating with reperfusion by inflating and deflating a blood pressure cuff or a pneumatic tourniquet placed around a limb, is a promising strategy to protect organs against I\u002FR injury, including brain. Regarding cardiac arrest, pre-clinical studies have demonstrated an improvement in neurological outcome in animal subjects treated with RIPOST after cardiopulmonary resuscitation.\n\nThe aim of our study is to demonstrate the benefit of early RIPOST in OHCA patients in reducing neurological injury and organ failure related to I\u002FR syndrome.",[28],"Out-Of-Hospital Cardiac Arrest",[30,31,32,33],"Remote ischemic conditioning","Out-of-hospital cardiac arrest","Neuroprotection","Cardiac arrest","RECRUITING","2026-06-15",{"date":37,"type":38},"2026-06-16","ACTUAL",{"date":40,"type":38},"2025-01-11",{"date":42,"type":22},"2028-04",{"name":44,"class":45},"Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer","OTHER",1,{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100361050","compression-only-cpr-versus-standard-cpr-in-out-of-hospital-cardiac-arrest---a-randomized-survival-study-100361050","NCT03981107","Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival Study","A Randomized Trial Comparing Survival After of a Simplified Form of Cardiopulmonary Resuscitation (CPR) Consisting of Compressions Only Compared to CPR With Compressions and Rescue Breaths","TANGO2","Inclusion Criteria:\n\n* Unconsciousness with no, abnormal or agonal breathing (suspected OHCA)\n* The suspected OHCA is witnessed (seen or heard)\n* Any Bystander at the scene has previous training in CPR\n\nExclusion Criteria:\n\n* Age below 18 years\n* Collapse is not witnessed\n* Bystander has no prior CPR training\n* Obvious asphyxia (i.e. hanging, foreign body, suffocation, strangulation)\n* Obvious drug overdose \u002F intoxication\n* Pregnancy\n* Trauma (penetrating, blunt, burn injury)\n\nPost randomisation exclusion Criteria from data analysis:\n\n* Not EMS-verified cardiac arrest\n* Previous do not resuscitate (DNR) decision",{"count":56,"type":22},3260,[25],"Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of mortality in the industrialized world. Bystander CPR before arrival of the Emergency Medical Service (EMS) is associated with an increased chance of survival.\n\nDuring the last decade, the best form of bystander CPR has been debated. Chest Compression Only CPR (CO-CPR) has been advocated as a preferable method in situations where the bystander has no previous knowledge in CPR, both because its believed to be equally efficient but also a simplified form of CPR that could lead to a higher incidence of bystander-CPR.\n\nIn an initiative to increase CPR rates the American Heart Association has launched public campaigns such as the \"hands-only CPR\" promoting CO-CPR as an option to S-CPR for adult non-asphyxic cardiac arrest. In the 2015 updates of the European resuscitation council guidelines it states that the confidence in the equivalence between the two methods is not sufficient to change current practice.\n\nWhether CO-CPR leads to a survival rate no worse than, or even superior to standard CPR in situations where the bystander has previous CPR training remains unclear. This clinical question remains unanswered while millions of people are trained in CPR worldwide each year.\n\nTo investigate whether CO-CPR is non-inferior to standard CPR (S-CPR) when performed by a bystander with previous CPR training in witnessed, non-asphyxic cases of OHCA. Superiority testing will also be performed for the purpose of demonstrating a possible increase in survival with CO-CPR.",[28,60,61],"Cardiac Arrest","Cardiopulmonary Resuscitation",[61,63,64,60],"Chest compressions only CPR","Dispatcher assisted CPR","2026-05-04",{"date":67,"type":38},"2026-05-08",{"date":69,"type":38},"2017-01-01",{"date":71,"type":22},"2028-12-31",{"name":73,"class":45},"Karolinska Institutet",2,{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":18,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":46},"100625380","pre-hospital-cooling-to-improve-cardiac-arrest-neurological-outcomes-precedence-100625380","NCT07421882","PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)","PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE): a Pilot Feasibility Study","PRECEDENCE","Inclusion Criteria:\n\n1. Out-of-hospital cardiac arrest (OHCA) of any rhythm attended by Singapore Civil Defence Force (SCDF) paramedics.\n2. Return of spontaneous circulation (ROSC) achieved in the pre-hospital setting.\n3. Age ≥16 years and ≤80 years.\n4. Patient remains comatose after ROSC, with Glasgow Coma Scale (GCS) ≤8.\n\nExclusion Criteria:\n\n1. Age \\>80 years.\n2. Traumatic cause of cardiac arrest.\n3. Tympanic temperature \\\u003C34°C at time of assessment.\n4. Pregnant females.\n5. Termination of resuscitation in the Emergency Department.\n6. Withdrawal of life support within 24 hours of Coronary Care Unit (CCU) admission.","16 Years","80 Years",{"count":86,"type":22},50,[25],"The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface cooling device (CarbonCool® vest) in adult out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC). The study aims to assess feasibility, fidelity, acceptability, and safety of initiating cooling in the field by emergency medical services (EMS) prior to hospital arrival. Results will inform the design of a larger definitive trial to determine the clinical effectiveness of early pre-hospital TTM in improving neurological outcomes.",[28,61,90,91],"Death, Sudden, Cardiac","Therapeutic Hypothermia",[93],"Return of Spontaneous Circulation","2026-04-23",{"date":96,"type":38},"2026-04-29",{"date":98,"type":38},"2026-02-01",{"date":100,"type":22},"2027-03",{"name":102,"class":45},"Singapore General Hospital",{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":111,"sex":18,"minAge":112,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":118,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":130,"locationsCount":46},"100556847","enhanced-community-first-responder-system-evaluation-in-singapore-100556847","NCT06530433","Enhanced Community First Responder System Evaluation in Singapore","Evaluation of an Enhanced Community First Responder Support System to Improve Bystander Cardiopulmonary Resuscitation Quality for Patients Experiencing Out-of-hospital Cardiac Arrest","TCPR-Link","Inclusion Criteria:\n\n* 18 years old and above\n* SCDF registered CFRs\n* Trial dispatchers with an active account of myResponder® app on their mobile phones\n\nExclusion Criteria:\n\n* The CFRs who are pregnant\n* Experiencing any serious physical Conditions\n* Mental Health Conditions",true,"21 Years",{"count":114,"type":22},165,[25],"The rise in out-of-hospital cardiac arrest (OHCA) cases in Singapore highlights the need for effective bystander cardiopulmonary resuscitation (BCPR). Despite many lay responders performing CPR, survival rates with good neurological outcomes have not significantly improved, prompting research into the quality of CPR as a critical factor. The study by Gallagher EJ et al. showed a significant survival improvement with high-quality CPR.\n\nTo address this, the Unit of Pre-hospital and Emergency Research (UPEC) trained thousands of community first responders (CFRs) in simplified CPR techniques using hands-only and DA-CPR methods. A significant innovation is the CPRcard®, developed by Laerdal in Norway, which offers real-time feedback on the quality of chest compressions. However, only 36% of CFRs using the CPRcard® achieved the desired compression standards, indicating room for improvement.\n\nThe study proposes enhancing CFR support with information communication technology (ICT), enabling two-way audio and one-way video communication between CFRs and dispatchers. This aims to reduce stress among responders, increase their willingness to engage with OHCA alerts, and improve CPR quality.\n\nThe clinical trial in Singapore will compare the current system against the enhanced CFR support system (eCSS), focusing on the real-time relay of CPR performance data, communication ease, and implementation factors. The high-quality CFR and OHCA registries in Singapore provide a robust setting for this research, aiming to enhance CPR delivery and improve OHCA outcomes through technology and real-time support.",[28],[119,120,121,122,123],"cardiopulmonary resuscitation","Bystander CPR","Community first responder","CPRCard","TCPR Link","2026-04-08",{"date":126,"type":38},"2026-04-13",{"date":128,"type":38},"2024-08-01",{"date":71,"type":22},{"name":102,"class":45},{"id":132,"slug":133,"hasResults":12,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":84,"enrollmentInfo":138,"targetDuration":4,"studyType":23,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":46},"100521616","emergency-resuscitative-endovascular-balloon-occlusion-of-the-aorta-in-out-of-hospital-cardiac-arrest-100521616","NCT06071910","Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest","ERICA-ARREST","Inclusion criteria\n\n* Non-Traumatic OHCA in patients within the East of England area AND with a East Anglian Air Ambulance (EAAA) REBOA team in attendance\n* Patients below or equal to 80yrs of age and above or equal to 18yrs of age, according to available information\u002Festimate at scene\n* No flow \\\u003C10 mins from data available (i.e. total period in OHCA with no CPR)\n* In cardiac arrest (with no sustained ROSC) on arrival of the EAAA REBOA team\n\nExclusion criteria\n\n* Patients aged less than 18 or above 80 years\n* Known terminal illness\n* Multiple severe co-morbidities\n* Traumatic Cardiac Arrest (TCA)\n* Inability to deploy mechanical CPR (e.g. LUCAS Device)\n* Pregnancy, obvious or suspected",{"count":139,"type":22},40,[25],"This study will assess the feasibility of performing pre-hospital resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct to conventional Advanced Life Support (ALS) in patients suffering from non-traumatic out of hospital cardiac arrest (OHCA). As well as providing valuable insights into the technical feasibility of performing this procedure as part of a resuscitation attempt, the study will also document the beneficial physiological effects of REBOA in this group of patients.",[28,60,143,144,145,146],"Cardiac Arrhythmia","Ventricular Fibrillation","Ventricular Arrythmia","Pulseless Electrical Activity","2026-02-26",{"date":149,"type":38},"2026-03-02",{"date":151,"type":38},"2024-06-04",{"date":153,"type":22},"2026-12-31",{"name":155,"class":45},"Queen Mary University of London",{"id":157,"slug":158,"hasResults":12,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":163,"targetDuration":165,"studyType":166,"phases":4,"briefSummary":167,"conditions":168,"keywords":169,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":46},"100481144","the-validation-and-development-of-termination-of-resuscitation-tor-rules-in-ohca-patients-in-asia-countries-100481144","NCT05545176","The Validation and Development of Termination-of-Resuscitation (TOR) Rules in OHCA Patients in Asia Countries","The Validation and Development of Termination-of-Resuscitation (TOR) Rules in Patients Following Out-of-Hospital Cardiac Arrest (OHCA) in Asia Countries","Inclusion Criteria:\n\n* out of hospital cardiac arrest (OHCA) patients\n\nExclusion Criteria:\n\n* age \\\u003C18 years\n* non-EMS transport to the emergency department\n* obvious signs of death (e.g. decapitation, rigor mortis, lividity, and decapitation) or having do-not-resuscitate (DNR) orders\n* missing data despite meeting the inclusion criteria.",{"count":164,"type":22},140000,"20 Years","OBSERVATIONAL","Objectives\u002FHypotheses\n\n1. Prehospital termination-of-resuscitation (TOR) rules were developed in North American and European sites. Whether they remained valid in different geographic, ethnic, and cultural background areas is still under debate.\n2. Differences in characteristics of out-of-hospital cardiac arrests (OHCAs) and configurations of emergency medical service (EMS) between the Western and Asian countries, including relatively lower rate of presenting shockable rhythm (i.e. ventricular fibrillation \u002F ventricular tachycardia; VF\u002FVT), lower rates of bystander CPR, less advanced life support (ALS) implementation, and less public access defibrillators, might create potential threats to the prediction accuracy of TOR rules.\n3. We aim to conduct a study to validate the performance of ever published TOR rules in Asian OHCA population, including non-traumatic, traumatic, and pediatric OHCA patients. Furthermore, assess the possible variables that may impact the performance of TOR rules.\n4. We also aim to develop new TOR rules based on PAROS registry for Asia population, focusing on non-traumatic, traumatic, and pediatric OHCA patients, respectively.",[28],[28,170],"OHCA","2026-02-23",{"date":173,"type":38},"2026-02-25",{"date":175,"type":38},"2007-01-01",{"date":177,"type":22},"2032-12-31",{"name":179,"class":45},"National Taiwan University Hospital",{"id":181,"slug":182,"hasResults":12,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":185,"eligibilityCriteria":186,"healthyVolunteers":111,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":187,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":189,"conditions":190,"keywords":192,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":46},"100626067","drone-delivery-of-automated-external-defibrillators-to-lay-users-daedalus-a-proof-of-concept-study-100626067","NCT07430813","Drone Delivery of Automated External Defibrillators to Lay Users (DAEDALUS): A Proof of Concept Study","DAEDALUS","Inclusion Criteria:\n\n* Work Package 1\n\n  * Adults aged 18 years and older\n  * Able to understand verbal explanations given in English\n  * Physically able to perform CPR and apply a defibrillator to a training manikin\n* Work Package 2\n\n  * Purposeful sampling will recruit participants from diverse backgrounds, including those with and without OHCA experience.\n  * Able to understand verbal explanations or written information given in English\n\nExclusion Criteria:\n\n* Work Package 1\n\n  * Under 18 years of age\n  * Unable to perform CPR\n  * Severe cognitive impairments\n  * Pregnant individuals\n  * Healthcare professionals\n  * Unable to understand verbal English sufficiently\n* Work Package 2\n\n  * Individuals under 18.\n  * Unable to provide informed consent.\n  * Experiencing severe psychological distress triggered by events surrounding cardiac arrest\n  * Unable to understand or speak verbal or written information given in English",{"count":188,"type":22},36,"Summary in non-technical language\n\nAim(s) of the research\n\nWe are working on a way to use drones to deliver Automated External Defibrillators (AEDs) - devices that help restart a person's heart by giving it an electric shock. These drones will bring AEDs to people helping someone having a cardiac arrest outside of a hospital setting. Our goal is to make sure everything works smoothly, from the time the emergency call is made to when the AED helps the patient. This research is important because it will help us find out the best process to deliver AEDs by drone and what challenges might come up.\n\nBackground to the research\n\nA cardiac arrest happens when a person's heart suddenly stops, which stops blood from getting to their organs. Acting fast is very important. In the UK, less than 10% of people survive cardiac arrests because it often takes too long to get them the help they need. AEDs can save lives by restarting the heart, but they need to get to the patient quickly.\n\nDesign and methods used\n\nThis project has two main parts:\n\n1. Creating the drone delivery process:\n\n   We will develop a system to get an AED to someone in need, from the moment someone calls 999 to when the AED reaches the patient. This involves working with emergency services, Air Traffic Control, and drone operators. We will test how this works using testing sessions with training manikins at Redhill Aerodrome over four days. We will measure how long things take and gather feedback to improve the process after each session.\n2. Interviews:\n\nWe will talk to people who have been involved in a cardiac arrest, like patients, family members, carers, or members of the public who have helped someone having a cardiac arrest. We will also speak to people who have no experience of cardiac arrests, to understand how they feel about drones delivering AEDs. We want to know if people think this is a good idea and what challenges or concerns they might have.\n\nPatient and Public Involvement\n\nA group of patients, family members\u002Fcarers, and members of the public will help us check that our plans are practical and clear and will provide feedback throughout the study. They will also help review the results and create materials to share with the public. We will provide training, so everyone feels comfortable contributing.\n\nDissemination\n\nWe will keep everyone updated through a newsletter on our website and social media. The public involvement group will review and contribute to these updates. We will also hold public events and share our findings in reports, journal articles, conferences and webinars, so a wide range of people can access the results.",[191],"Out of Hospital Cardiac Arrest",[193],"Drone Delivery of Automated External Defibrillators to Lay Users","2026-02-17",{"date":196,"type":38},"2026-02-24",{"date":198,"type":38},"2025-11-03",{"date":200,"type":22},"2027-02-27",{"name":202,"class":45},"University of Surrey",{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":209,"eligibilityCriteria":210,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":211,"targetDuration":4,"studyType":23,"phases":213,"briefSummary":216,"conditions":217,"keywords":222,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":233},"100606394","phase-2-early-double-sequential-defibrillation-in-out-of-hospital-cardiac-arrest-100606394","NCT07174986","Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest","\"A Randomized Trial Assessing the Effect of Early Double Sequential Defibrillation With Anterior-posterior and Anterior Lateral Pad Placement and Sequential Defibrillation Compared to Standard Pad Placement and Single Defibrillation in Patients With Out of Hospital Cardiac Arrest With Initial Shockable Rhythm and at Least One Failed Standard Defibrillation\"","DOUBLE D","Inclusion Criteria:\n\n* OHCA patients with VT\u002FVF at first rhythm analysis and at least one defibrillation performed in standard (A-L) position\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Obvious pregnancy\n* Known preexisting Do Not Attempt Resuscitation order",{"count":212,"type":22},916,[214,215],"PHASE2","PHASE3","Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)\u002Fventricular tachycardia (VT) do not respond to initial defibrillation. The survival decreases with number of defibrillations required to terminate VF\u002FVT. In 2022, one prospective cluster randomized trial showed increased survival among (OHCA) patients in refractory VF using Double Sequential Defibrillation (DSD). If DSD can increase survival among all patients in VF that dont respond to one defibrillation, i.e. before it has become refractory is not known.\n\nThe aim of this trial is to assess survival with a double defibrillation strategy initiated as soon as possible among patients with Out of Hospital Cardiac Arrest with initial shockable rhythm and at least one failed standard defibrillation, compared with continued resuscitation using standard defibrillation.",[191,144,218,219,220,221],"Defibrillation","CPR","ACLS","Sudden Death",[223,224,220],"Double sequential defibrillation","Double sequential external defibrillation","2026-02-12",{"date":194,"type":38},{"date":228,"type":38},"2025-09-08",{"date":230,"type":22},"2029-12",{"name":232,"class":45},"Gabriel Riva",14,{"id":235,"slug":236,"hasResults":12,"nctId":237,"briefTitle":238,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":241,"targetDuration":243,"studyType":166,"phases":4,"briefSummary":244,"conditions":245,"keywords":247,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":7},"100450179","german-cardiac-arrest-registry-100450179","NCT05142124","German Cardiac Arrest Registry","G-CAR","Inclusion Criteria:\n\n* patients with out-of-hospital cardiac arrest with assumed cardiovascular cause\n\nExclusion Criteria:\n\n* rejection of register participation by patient or legal representative",{"count":242,"type":22},400,"12 Months","In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes. Despite the medical progress over the last decades, rates of survival with good neurological outcome remain low. For many below-mentioned issues, no adequate evidence from randomized trials is available. Therefore, a systematic and standardized recording of the pre-clinical, clinical and post-clinical treatment course and of the clinical outcomes of OHCA patients is essential to improve patient care. Aim of the German Cardiac Arrest Registry (G-CAR) is to achieve a better understanding of the disease entity, leading to an optimized treatment of OHCA patients. The recorded data include information on demographic and psychosocial aspects, course of the disease, clinical, laboratory and other examinations as well as treatment modalities in patients with OHCA due to a cardiac cause.",[246],"Out-of-hospital Cardiac Arrest",[246,170,248,249,250,251,252],"resuscitation","cardiac arrest center","acute care medicine","intensive care","post-resuscitation care","2026-02-10",{"date":225,"type":38},{"date":256,"type":38},"2021-07-21",{"date":258,"type":22},"2027-06-30",{"name":260,"class":45},"Leipzig Heart Science gGmbH",{"id":262,"slug":263,"hasResults":12,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":12,"sex":18,"minAge":165,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":270,"conditions":271,"keywords":273,"overallStatus":277,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":284,"locationsCount":4},"100588094","timing-for-computed-tomography-and-post-resuscitation-care-on-short-term-outcomes-in-out-of-hospital-cardiac-arrest-100588094","NCT06936917","Timing for Computed Tomography and Post-Resuscitation Care on Short-Term Outcomes in Out-of-Hospital Cardiac Arrest","Impact of Timing for Computed Tomography and Post-Resuscitation Care Sequence on Short-Term Outcomes in Out-of-Hospital Cardiac Arrest","Inclusion Criteria:\n\n1. Adults aged 20 years or older.\n2. Patients who experienced out-of-hospital cardiac arrest (OHCA), received resuscitative efforts in the emergency department, achieved return of spontaneous circulation (ROSC), and subsequently underwent computed tomography (CT) imaging (regardless of the anatomical region scanned).\n\nExclusion Criteria:\n\n1. Patients with cardiac arrest due to traumatic causes (traumatic OHCA).\n2. Patients who were transferred to non-NTUH-affiliated hospitals for post-resuscitation care.\n3. Patients whose prognosis could not be determined from medical records.\n4. Patients with incomplete, missing, or otherwise restricted medical records that limited data accessibility or review.",{"count":269,"type":22},5000,"This retrospective multicenter study investigates the association between the timing of computed tomography (CT) scans and short-term outcomes in adult non-traumatic out-of-hospital cardiac arrest (OHCA) patients who achieved return of spontaneous circulation (ROSC). The study includes cases from January 1, 2016, to August 31, 2024, across six branches of National Taiwan University Hospital. Data collected include demographics, Utstein variables, emergency department (ED) interventions and their timing. Primary outcomes are survival to admission, and 1-day, 3-day, and 7-day survival. Secondary outcomes focus on the timing and sequence of CT imaging and other interventions in relation to short-term prognosis and ED length of stay. The study aims to explore whether earlier CT utilization can improve outcomes in the post-resuscitation phase of care.",[191,272],"Computed Tomography",[31,274,275,276,119],"Computed tomography","short-term outcome","resuscitation management","NOT_YET_RECRUITING","2025-11-17",{"date":280,"type":38},"2025-11-19",{"date":282,"type":22},"2027-12-31",{"date":282,"type":22},{"name":179,"class":45},{"id":286,"slug":287,"hasResults":12,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":293,"targetDuration":4,"studyType":23,"phases":295,"briefSummary":296,"conditions":297,"keywords":299,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":308,"locationsCount":46},"100531749","the-effect-of-prehospital-combination-of-epinephrine-vasopressin-and-steroid-in-ohca-100531749","NCT06203847","The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA","A Randomized Clinical Trial of Patient Outcomes Following Out-of-Hospital Cardiac Arrest Receiving Epinephrine Versus In-together Vasopressin, Epinephrine, and Steroid. (OHCA REVIVES Trial)","REVIVES","Inclusion Criteria:\n\n* Adult patients (aged \\>= 18 )\n* Out-of-hospital cardiac arrest in the studied regions\n* Treated by paramedics authorized and capable of giving prehospital medication\n\nExclusion Criteria:\n\n* OHCA with traumatic etiology\n* Obvious signs of death like decapitation, rigor mortis, livor mortis, decomposition, etc.\n* DNR (Do Not Resuscitation) or termination of resuscitation requested by the family\n* Patients with known or suspected pregnancy\n* No vascular access was established before hospital arrival\n* ROSC before the administrated medication\n* No patient contact (cancelled ambulance call or the patient was transported to the hospital before the arrival of trial-trained paramedics)\n* Received epinephrine prior to the arrival of trial-trained paramedics",{"count":294,"type":22},1344,[25],"This project is a randomized controlled clinical research design, The hypothesis P-I-C-O of the study is: For adult patients in the Taipei City and New Taipei City communities who have suffered sudden non-traumatic death and have been resuscitated by advanced paramedics, the intervention group that receives combined drug treatment (epinephrine, vasopressin, methylprednisolone) has a better rate of sustained recovery of spontaneous circulation (ROSC) (primary outcome) and long-term survival status (secondary outcomes) compared to the control group that receives single drug treatment (epinephrine).",[60,28,298],"Emergency Medical Services",[28,298,300,301,302],"Corticosteroid","Epinephrine","Vasopressin","2025-11-16",{"date":280,"type":38},{"date":306,"type":38},"2024-07-16",{"date":153,"type":22},{"name":179,"class":45},{"id":310,"slug":311,"hasResults":12,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":317,"enrollmentInfo":318,"targetDuration":4,"studyType":23,"phases":320,"briefSummary":321,"conditions":322,"keywords":324,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":339},"100518021","prehospital-resuscitation-intranasal-cooling-effectiveness-survival-study-2-100518021","NCT06025123","Prehospital Resuscitation Intranasal Cooling Effectiveness Survival Study 2","Prehospital Resuscitation Intranasal Cooling Effectiveness Survival Study 2 (PRINCESS2)","PRINCESS2","INCLUSION CRITERIA:\n\nPatients ≥18 years that meet all of the following inclusion criteria:\n\n1. Adult out-of-hospital cardiac arrest patients with initial shockable rhythm\n2. Unconsciousness defined as Glasgow Coma Scale \\\u003C 8\n3. Inclusion within 20 minutes from EMS arrival\n\nEXCLUSION CRITERIA:\n\nPatients are not eligible if they meet one or more of the following criteria:\n\n1. Age ≥ 80 years\n2. Obvious non-cardiac causes to cardiac arrest\n3. Obvious already hypothermic\n4. Obvious barrier to placing intra nasal catheters\n5. Have a known Do Not Attempt to Resuscitate (DNAR) order or other limitations in care\n6. Have a known terminal disease\n7. Known or clinically apparent pregnancy","79 Years",{"count":319,"type":22},1022,[25],"The aim of this clinical trial is to study the impact of ultra-early transnasal evaporative cooling after cardiac arrest and subsequent hypothermia at hospital, on survival with complete neurologic recovery, compared to currently recommended normothermia. The study population will consist of patients 18-79 years old, with out-of-hospital cardiac arrest with initial shockable rhythm.\n\nThe main research question it aims to answer is whether there is a difference in survival with complete neurologic recovery at 90 days after cardiac arrest between the group of patients that received ultra-early cooling, compared to the group that was treated with normothermia.\n\nParticipants will be randomized to two groups. One group (the intervention group) will receive ultra-early trans-nasal evaporative cooling initiated by EMS personnel at the scene of the cardiac arrest, and subsequent systemic hypothermia for 24 hours at hospital arrival. The other group (the control group), will receive standard of care (advanced cardiac life support and normal body temperature (normothermia)).",[28,323,144],"Hypothermia",[325,326,327,328,329,330],"Therapeutic hypothermia","transnasal cooling","neurologic outcome","ultrafast hypothermia","prehospital","ECPR","2025-09-19",{"date":333,"type":38},"2025-09-25",{"date":335,"type":38},"2024-03-27",{"date":337,"type":22},"2028-05",{"name":73,"class":45},11,{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":111,"sex":18,"minAge":19,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":350,"conditions":351,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":358,"locationsCount":46},"100559728","the-development-of-the-simulation-curriculum-and-ai-incorporated-assessment-tool-for-transesophageal-echocardiography-100559728","NCT06567912","The Development of the Simulation Curriculum and AI-incorporated Assessment Tool for Transesophageal Echocardiography","The Development of the Simulation Curriculum and Artificial Intelligence-incorporated Assessment Tools for Transesophageal Echocardiography in Patients With Cardiac Arrest","Inclusion Criteria:\n\nEmergency physicians interested in TEE learning.\n\nExclusion Criteria:\n\nEmergency physicians are not interested in TEE learning.","99 Years",{"count":349,"type":22},100,"This study aims to establish a novel transesophageal echocardiography (TEE) simulation curriculum based on previous research results and suggestions from the American College of Emergency Physicians. To better evaluate the efficacy of the curriculum, an evaluation model utilizing artificial intelligence (AI) would be introduced. The study population is at least 60 junior physicians in the emergency department or other departments interested in TEE. After the curriculum, junior physicians could utilize TEE on cardiac arrest patients and improve diagnostic accuracy and patient outcomes.",[28],"2025-09-16",{"date":354,"type":38},"2025-09-22",{"date":356,"type":38},"2023-08-01",{"date":153,"type":22},{"name":179,"class":45},{"id":360,"slug":361,"hasResults":12,"nctId":362,"briefTitle":363,"officialTitle":364,"acronym":365,"eligibilityCriteria":366,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":367,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":369,"conditions":370,"keywords":373,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":381,"locationsCount":46},"100546628","refractory-cardiac-arrest-treated-on-field-by-ecmo-100546628","NCT06397417","Refractory Cardiac Arrest Treated On Field By ECMO","Prognosis of Refractory Out-of-hospital Cardiac Arrests Treated With Extracorporeal Cardiopulmonary Resuscitation (ECMO) by the Urgent Medical Aid Service (SAMU) of Paris","ReCATOBE","Inclusion Criteria:\n\n* All patients who have benefited from an installation or attempted installation of an extracorporeal membrane oxygenation (ECMO) device following a non-traumatic refractory cardiac arrest as part of the ECMO TEAM of the Samu de Paris during the time of the study.\n* Obtaining non-opposition from the patient or a relative in the event of the patient's death or a lasting state of health preventing them from becoming aware of the study.\n\nExclusion Criteria:\n\n\\- Minor patients",{"count":368,"type":22},840,"Out-of-hospital cardiac arrest without resumption of spontaneous circulatory activity despite advanced medical resuscitation is considered refractory. Under certain well-defined conditions, today in many cities around the world and particularly in Paris, it benefits from resuscitation called ECPR (extracorporeal cardiopulmonary resuscitation). This technique consists of the installation of an extracorporeal membrane oxygenation (ECMO) device allowing organ perfusion while waiting for a resumption of cardiac activity. Since 2011, the Paris SAMU (SAMU 75) has set up a team capable of implementing ECPR for refractory out-of-hospital cardiac arrests. This team based within the SAMU of Paris at the Necker hospital (ECMO team) composed of an emergency doctor or anesthesiologist-resuscitator, a nurse anesthetist and an ambulance driver intervenes in Paris and its nearby region at the request of medical regulation. Given the growing development of this activity, it is essential to measure its effectiveness in real-life conditions.",[371,372],"Out-of-Hospital Cardiac Arrest","Extracorporeal Cardiopulmonary Resuscitation",[371,372],"2025-09-05",{"date":376,"type":38},"2025-09-12",{"date":378,"type":38},"2025-03-05",{"date":380,"type":22},"2046-03",{"name":382,"class":45},"Assistance Publique - Hôpitaux de Paris",{"id":384,"slug":385,"hasResults":12,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":389,"eligibilityCriteria":390,"healthyVolunteers":111,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":393,"conditions":394,"keywords":395,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":406,"locationsCount":408},"100557441","technological-and-patient-tailored-innovations-for-maximizing-effectiveness-of-cardiac-arrest-resuscitation-100557441","NCT06538155","Technological and Patient-tailored Innovations for Maximizing Effectiveness of Cardiac Arrest Resuscitation","Technological and Patient-tailored Innovations for Maximizing Effectiveness of Cardiac Arrest Resuscitation: the TIME-CARE Project","TIME-CARE","AIM 1: PREDICTION AND RECOGNITION OF CARDIAC ARREST AIM 1.1: PREDICT A MAJOR CARDIOVASCULAR EVENT\n\nInclusion criteria:\n\n* Age 18-70 years;\n* Being a healthy volunteer (i.e., an individual with no history of cardiovascular events willing to contribute to the project) or a patient (survivors and non-survivors) who experienced major cardiovascular events (i.e., myocardial infarction or cardiac arrest);\n* Users of a smartwatch or smartphone that continuously and automatically collect health data;\n* Informed consent.\n\nExclusion criteria:\n\n* Impossibility to access\u002Fexport data;\n* User did not wear the wearable device for periods longer than 24 hours;\n* User did not wear the wearable device in the 4 weeks preceding the event.\n\nAIM 1.2 CARDIAC ARREST DETECTION FROM VIDEOS No patient involved.\n\nAIM 2: TECHNOLOGIES TO INCREASE CPR AND DEFIBRILLATION USE BEFORE AMBULANCE ARRIVAL No patient involved.\n\nAIM 3: PATIENT-TAILORED RESUSCITATION AIM 3.1: CLINICAL STUDY IN PATIENTS WHO RECEIVED CPR\n\nInclusion criteria:\n\n* Adults (≥ 18 years);\n* Patients suffering a non-traumatic cardiac arrest treated with chest compressions (both survivors and non-survivors);\n* Received a TEE, chest x-ray, or chest CT scan as the standard clinical assessment following cardiac arrest;\n* Informed consent.\n\nExclusion criteria:\n\n\\- Patients with severe thorax\u002Fmediastinal deformity.\n\nAIM 3.2 CLINICAL STUDY IN PATIENTS WHO RECEIVED A CHEST CT SCAN\n\nInclusion criteria:\n\n* Adults (≥ 18 years);\n* Received a chest CT scan for any reasons;\n* Informed consent.\n\nExclusion criteria:\n\n\\- Patients with severe thorax\u002Fmediastinal deformity.\n\nAIM 3.3 MACHINE LEARNING (ML) ALGORITHM No patient involved.",{"count":392,"type":22},500,"Out-of-hospital cardiac arrest (OHCA) affects 275,000 people in Europe every year. In Italy alone, 50,000 people experience OHCA annually, with only 9% surviving. Half of the survivors suffer severe brain damage. Immediate CPR and defibrillation by bystanders before the ambulance arrives can save lives, but often, CPR starts only when the ambulance gets there. Additionally, half of all OHCAs occur when the person is alone, causing delays in recognizing the emergency, calling for help, and starting lifesaving actions. Effective chest compressions and defibrillation are crucial but are often not done correctly or are not customized for each patient. Current guidelines recommend the same approach for everyone, which doesn't consider individual needs.\n\nTo tackle these issues, we plan to develop artificial intelligence (AI) algorithms, smartphone apps, and new devices. Our main goal is to create tools and technologies to improve the recognition of OHCA and provide timely and effective interventions, ultimately reducing the impact of OHCA and improving survival rates.\n\nFirst, we aim to create an AI algorithm that can predict major cardiovascular events like heart attacks or cardiac arrests minutes, hours, or days before they happen. We will collect data from wearable devices to train and validate this algorithm, helping us identify individuals at risk. By alerting these individuals, they can seek emergency care and receive treatment before a cardiac arrest occurs. We will also work on recognizing OHCA cases from surveillance camera footage when they happen to people who are alone.\n\nSecond, to increase the rate of CPR and defibrillation before ambulances arrive, we will develop a smartphone app that geolocates and alerts nearby citizens to act as first responders. The app will guide them on how to quickly find a defibrillator and use it.\n\nThird, to find the best spots on the chest for compressions and defibrillation, we will study chest scans from CTs and echocardiograms in both elective patients and cardiac arrest victims. This will help us understand the effects of compressing different heart structures and develop a sensor to determine the optimal positions for compressions and defibrillator pads.\n\nOur multidisciplinary team of clinicians, researchers, and engineers will conduct experimental, simulation, and observational studies to develop these technologies, evaluate their potential for patents, design a plan for their use, and test their effectiveness in preventing and recognizing OHCA. We believe that by improving each step in the chain of survival-preventing cardiac events, early recognition, timely CPR and defibrillation, and high-quality advanced resuscitation-we can significantly improve treatment times and reduce the global death and disability rates caused by OHCA.",[28,60],[396,397,119,398],"out-of-hospital cardiac arrest","cardiac arrest","extracorporeal cardiopulmonary resuscitation","2025-08-05",{"date":401,"type":38},"2025-08-06",{"date":403,"type":38},"2025-01-27",{"date":405,"type":22},"2026-08-31",{"name":407,"class":45},"Università Vita-Salute San Raffaele",3,{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":415,"eligibilityCriteria":416,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":417,"targetDuration":4,"studyType":23,"phases":419,"briefSummary":420,"conditions":421,"keywords":422,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":46},"100567743","initial-double-sequential-external-defibrillation-in-out-of-hospital-cardiac-arrest-100567743","NCT06672159","Initial Double Sequential External Defibrillation in Out of Hospital Cardiac Arrest","A Randomized Controlled Trial on Early Double External Sequential Defibrillation in Out of Hospital Cardiac Arrest","DUALDEFIB","Inclusion Criteria:\n\n* Patients with out of hospital cardiac arrest presenting with a shockable rhythm\n\nExclusion Criteria:\n\n* Age below 18 years\n* Obvious or suspected pregnancy\n* Incarcerated patients\n* Preexisting do-not-resuscitate order",{"count":418,"type":22},356,[25],"Double Sequential External Defibrillation (DSED) represents an alternative treatment of refractory ventricular fibrillation (rVF) in out-of-hospital cardiac arrest (OHCA). The procedure consists of two defibrillators that administer shocks at the same time.\n\nCurrently, the procedure is not initiated before at least three failed attempts with one defibrillator. This can delay the potential benefits of establishing DSED earlier in the treatment. Studies have shown that early defibrillation is crucial for survival in OHCA patients, and in 2022, a clinical trial showed that survival in patients treated with DSED was higher compared to standard treatment.\n\nThe effect of initiating OHCA treatment is unknown. The DUALDEFIB trial seeks to investigate if treating OHCA patients with DSED as an initial treatment will increase survival and provide improved neurological outcome.",[60,28,144],[423,424],"Double defibrillation","Cardiopulmonary resuscitation","2025-06-04",{"date":427,"type":38},"2025-06-05",{"date":429,"type":38},"2025-04-28",{"date":431,"type":22},"2028-10",{"name":433,"class":45},"St. Olavs Hospital",{"id":435,"slug":436,"hasResults":12,"nctId":437,"briefTitle":438,"officialTitle":439,"acronym":4,"eligibilityCriteria":440,"healthyVolunteers":111,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":441,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":443,"conditions":444,"keywords":445,"overallStatus":277,"whyStopped":4,"lastUpdateSubmitDate":451,"lastUpdatePostDateStruct":452,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":458,"locationsCount":46},"100586948","ambulance-clinicians-experiences-of-attending-ohca-in-children-100586948","NCT06922019","Ambulance Clinicians' Experiences of Attending OHCA in Children","Exploring UK Ambulance Clinicians' Experiences of Attending Out of Hospital Cardiac Arrest (OHCA) Incidents Involving Children: A Mixed Methods Study","Out of hospital cardiac arrest patients\n\nInclusion Criteria:\n\n* Patients attended by London Ambulance Service NHS Trust (LAS)\n* Incidents occurring between January 2021 and December 2024\n* Out of Hospital Cardiac Arrest recognised by LAS clinicians\n* Aged under 18 years at the time the incident occurred\n\nExclusion Criteria:\n\n* New born patients who had not taken their first spontaneous breath before cardiac arrest was recognised\n* Incidents occurring outside of LAS' operational area (Greater London, UK)\n* Patients who have registered an NHS National Data Opt-Out\n\nSurvey participants\n\nInclusion Criteria:\n\n* Ambulance clinician (including registered healthcare professionals and non-registered ambulance clinicians)\n* Currently responds to 999 calls (face to face) as part of their role\n* Would be expected to attend a paediatric OHCA incident as part of their role\n* Consents to participate in study\n\nExclusion Criteria:\n\n* Non-clinical ambulance service employee\n* Not employed by an NHS Ambulance Service in the UK\n\nInterview participants (recent exposure)\n\nInclusion Criteria:\n\n* Ambulance clinician (including registered healthcare professionals and non-registered ambulance clinicians)\n* Employed by a participating NHS Ambulance Service Site\n* Attended an out of hospital cardiac arrest incident involving a child (\\>1 day old, \\\u003C 18 years old) in the 12 months prior to the proposed interview date\n* Consents to participation in the study\n\nExclusion Criteria:\n\n* Previously participated in an interview or focus group discussion as part of this study\n* Employed in a specialist critical care role (e.g. Critical Care Paramedic)\n* Attended an out of hospital cardiac arrest incident involving a child (\\>1 day old, \\\u003C18 years old) within two weeks of the proposed interview date\n\nInterview participants (historic exposure)\n\nInclusion Criteria:\n\n* Ambulance clinician (including registered healthcare professionals and non-registered ambulance clinicians)\n* Employed by a participating NHS Ambulance Service Site\n* Attended an out of hospital cardiac arrest incident involving a child (\\>1 day old, \\\u003C 18 years old) more than 12 months prior to the proposed interview date\n* Consents to participation in the study\n\nExclusion Criteria:\n\n* Previously participated in an interview or focus group discussion as part of this study\n* Attended an out of hospital cardiac arrest incident involving a child (\\>1 day old, \\\u003C 18 years old) within 12 months of the proposed interview date\n* Employed in a specialist critical care role (e.g. Critical Care Paramedic)\n\nFocus group participants\n\nInclusion Criteria:\n\n* Ambulance clinician employed in a specialist critical care role (e.g. Critical Care Paramedic)\n* Employed by a participating NHS Ambulance Service Site\n* Consents to participation in the study\n\nExclusion Criteria:\n\n* Previously participated in an interview or focus group discussion as part of this study\n* Has not attended an out of hospital cardiac arrest incident involving a child (\\>1 day old, \\\u003C18 years old) whilst working in a specialist critical care role (e.g. Critical Care Paramedic)",{"count":442,"type":22},2137,"This research will explore ambulance clinicians' experiences of attending out of hospital cardiac arrest (OHCA) incidents involving children.\n\nOHCA occurs when the heart stops beating. This is a time critical emergency that requires immediate treatment to maximise the changes of survival. OHCA affecting children is rare, but when it happens it is vital that paramedics and other ambulance clinicians can respond and deliver high quality care.\n\nBecause OHCA in children is rare, ambulance clinicians attend these incidents infrequently. Some clinicians may only ever attend this type of incident once in their career. These incidents are technically challenging for ambulance clinicians, and highly stressful. Evidence from other setting suggests that clinicians may be ill-prepared to manage these events.\n\nThis research aims to understand how OHCA incidents involving children are currently managed, and to explore the views and experiences of ambulance clinicians with respect to attending OHCA incidents involving children.\n\nBy learning from what is currently being done, and from clinicians' experiences, the research team aims to develop recommendations for how the response to these patients, and the support provided to ambulance clinicians, could be improved.\n\nThe research team will review the records of patients under the age of 18 who have been treated for OHCA by one ambulance service over a four-year period. Data will be collected from these records to allow the care delivered to be compared to international guidelines, and to explore what factors might influence the delivery of this care.\n\nThe research will also involve a survey of ambulance clinicians working across the UK to understand their experiences, and how prepared they feel to attend these incidents. Finally, the research team will undertake interviews with clinicians who have been involved in the management of a child with OHCA and focus group discussions with specialist clinicians to allow us to learn from their experiences.",[191],[446,447,448,449,450],"out of hospital cardiac arrest","paediatric","children","ambulance","emergency medical service","2025-04-08",{"date":453,"type":38},"2025-04-10",{"date":455,"type":22},"2025-05-01",{"date":457,"type":22},"2027-01",{"name":459,"class":45},"University of Warwick",{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":464,"acronym":4,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":466,"targetDuration":4,"studyType":23,"phases":468,"briefSummary":469,"conditions":470,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":477,"leadSponsor":479,"locationsCount":46},"100509542","impact-of-early-antibiotics-on-non-traumatic-out-of-hospital-cardiac-arrest-ohca-100509542","NCT05914779","Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest (OHCA)","Inclusion Criteria:\n\n* ● Adults aged \\>18 years, presenting to HGH ED after out-of-hospital cardiac arrest\n\n  * Patients with low likelihood of infection as per the definitions provided above\n  * Ability to obtain informed consent from the subjects or their next of kin\u002Ffamily member\u002Flegal surrogate in case of incapacitation due to sedation, mechanical ventilation, etc. In case the next of kin is not available, an independent physician who is not a part of the investigative team will complete and sign the checklist as per HMC Policy \"RES 11026\\_Appendix 6.5\". (see section 4.1.3 for details) A member of the investigative team and a witness will also sign this form before the potential subject is enrolled in the study.\n\nExclusion Criteria:\n\n* Patients who have clear evidence of infection, as defined by criteria for the study.\n\n  * Patients who have received antibiotics within the last 1 week prior to admission.\n  * Patients with malignancy, except those who have been cured or in complete remission.\n  * Females with known pregnancy.\n  * Known immunocompromised states (including HIV\u002FAIDS, transplant recipients on immunosuppressant drugs, long-term \\[\\> 3 weeks of prednisone \\>5mg\u002Fday equivalent\\] steroid therapy).\n  * Patients on immunologic disease modifying agents (commonly known as \"biologics\")\n  * Patients considered \"brain-dead\" or \"vegetative state\"\n  * Patients transferred from another hospital, long term care facility or institution\n  * Neutropenia (total WBC \\\u003C1,500\u002Fmm3 or absolute neutrophil count of \\\u003C1,000\u002Fmm3)",{"count":467,"type":22},1000,[25],"Specific Aim : The specific aim is to conduct a randomized prospective clinical trial to determine whether no antibiotics in OHCA patients in the ED with very low likelihood of infection is non-inferior to early antibiotic treatment. Hypothesis a: 28-day all-cause mortality will be non-inferior in OHCA patients with very low likelihood of infection who do not receive antibiotic therapy compared with those who receive early antibiotic therapy Hypothesis b: There will be no difference in subsequent incidence of proven infections in the no antibiotics vs, early antibiotics groups Hypothesis c: There will be no difference in the length of ICU stay and overall hospital stay in the early antibiotics vs. no antibiotics groups",[471,28],"Infection, Bacterial","2025-04-01",{"date":474,"type":38},"2025-04-03",{"date":476,"type":38},"2023-03-01",{"date":478,"type":22},"2025-12-31",{"name":480,"class":481},"Hamad Medical Corporation","INDUSTRY",{"id":483,"slug":484,"hasResults":12,"nctId":485,"briefTitle":486,"officialTitle":486,"acronym":487,"eligibilityCriteria":488,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":489,"enrollmentInfo":490,"targetDuration":491,"studyType":166,"phases":4,"briefSummary":492,"conditions":493,"keywords":494,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":46},"100449431","wroclaw-out-of-hospital-cardiac-arrest-registry-100449431","NCT05132387","Wroclaw Out-Of-Hospital Cardiac Arrest Registry","WOHCA","Inclusion Criteria:\n\n* Age \\\u003C 60 years\n* witnessed sudden cardiac arrest with immediate CPR\n* supposed cardiac cause of the event\n* ventricular fibrillation (VF) or pulseless ventricular tachycardia (VT) at first medical contact with 3 unsuccessful defibrillations (no ROSC)\n* CPR conducted with Lund University Cardiopulmonary Assist System (LUCAS™)\n* Estimated transfer time from the scene to the Emergency Department \\\u003C 30 minutes.\n* End tidal carbon dioxide (ETCO2) \\> 10 mmHg\n\nExclusion Criteria:\n\n* Total presumed time from 112 call to ECMO implantation longer than 60 minutes\n* Age \\\u003C 18 years old or \\> 60 years old;\n* Non-shockable initial rhythm\n* Unavailability of the automated CPR device\n* Unavailability of the catheterisation laboratory\n* Severe concomitant illness with decreased life expectancy\n* Severe body injury\n* Severe active bleeding\n* Drowning\n* Terminal cancer","60 Years",{"count":86,"type":22},"1 Month","The purpose of this study is to assess the efficacy of institutionalized care program of patients with out-of-hospital cardiac arrest.",[28],[495],"Cardiac arrest, ECMO, ECMO-CPR","2025-03-26",{"date":498,"type":38},"2025-03-30",{"date":500,"type":38},"2021-10-25",{"date":502,"type":22},"2028-01-01",{"name":504,"class":45},"Wroclaw Medical University",{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":4,"eligibilityCriteria":511,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":512,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":514,"conditions":515,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":519,"completionDateStruct":521,"leadSponsor":522,"locationsCount":46},"100456031","nfl-dynamics-as-a-predictor-factor-in-patients-with-out-of-hospital-cardiac-arrest-100456031","NCT05218278","NFL Dynamics as a Predictor Factor in Patients With Out of Hospital Cardiac Arrest","Dynamics of Light Chain of NFL as a Predictor Factor of Neurological Outcome in Patients With Out of Hospital Cardiac Arrest","Inclusion Criteria:\n\n* out-of-hospital cardiac arrest successfully resuscitated and admitted to the ICU\n\nExclusion Criteria:\n\n* trauma, drowning, electrocution, less than 18 years of age,",{"count":513,"type":22},60,"To investigate the pharmacodynamics of light chain of NFL in patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable neurological outcome compared to those with non-favorable neurological outcome.",[28,516],"Neurological Injury","2025-03-25",{"date":498,"type":38},{"date":520,"type":38},"2022-01-01",{"date":153,"type":22},{"name":523,"class":45},"University Medical Centre Maribor",{"id":525,"slug":526,"hasResults":12,"nctId":527,"briefTitle":528,"officialTitle":528,"acronym":4,"eligibilityCriteria":529,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":530,"targetDuration":532,"studyType":166,"phases":4,"briefSummary":533,"conditions":534,"keywords":535,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":542,"locationsCount":46},"100302887","korean-cardiac-arrest-research-consortium-100302887","NCT03222999","Korean Cardiac Arrest Research Consortium","Inclusion Criteria:\n\n* OHCA patients who were transported to participating emergency department (ED) by emergency medical service with resuscitation efforts and whose arrest was identified as a presumed cardiac etiology by emergency physicians in ED.\n\nExclusion Criteria:\n\n* OHCA with terminal illness documented by medical record, under hospice care, with pregnancy, with pre-documented 'Do Not Resuscitate' card\n* OHCA of definite non-cardiac etiology, including trauma, drowning, poisoning, burn, asphyxia, or hanging",{"count":531,"type":22},30000,"6 Months","This study will evaluated the epidemiology and the outcomes of patients suffering out-of-hospital cardiac arrest with presumed cardiac etiology in Korea.",[371],[371],"2025-03-04",{"date":538,"type":38},"2025-03-06",{"date":540,"type":38},"2015-10-01",{"date":71,"type":22},{"name":528,"class":45},{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":547,"acronym":4,"eligibilityCriteria":548,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":489,"enrollmentInfo":549,"targetDuration":551,"studyType":166,"phases":4,"briefSummary":552,"conditions":553,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":554,"lastUpdatePostDateStruct":555,"startDateStruct":557,"completionDateStruct":559,"leadSponsor":560,"locationsCount":46},"100525484","systemic-evaluation-of-the-etiologies-of-young-adults-with-non-traumatic-out-of-hospital-cardiac-arrest-100525484","NCT06122337","Systemic Evaluation of the Etiologies of Young Adults With Non-traumatic Out-of-hospital Cardiac Arrest","Inclusion Criteria:\n\n* non-traumatic out-of-hospital cardiac arrest\n\nExclusion Criteria:\n\n* traumatic cardiac arrest\n* pregnancy",{"count":550,"type":22},300,"1 Year","The goal of this observational study is to establish the protocol of systemic analysis of the causes of non-traumatic cardiac arrest in young patients. The main questions it aims to answer are:\n\n* Whether the protocolized classification of cardiac arrest minimizes the proportion of unknown causes and mis-classification in young cardiac arrest patients?\n* Whether the incorporation of genetic tests in the identification protocol of arrest cause helps the recognition of sudden arrhythmic death syndrome in young cardiac arrest patients?\n\nParticipants will be asked to received serial examinations including genetic analysis to explore the cause of cardiac arrest.",[28],"2025-02-17",{"date":556,"type":38},"2025-02-19",{"date":558,"type":38},"2023-10-31",{"date":153,"type":22},{"name":179,"class":45},{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":567,"eligibilityCriteria":568,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":569,"enrollmentInfo":570,"targetDuration":4,"studyType":23,"phases":572,"briefSummary":573,"conditions":574,"keywords":575,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":578,"lastUpdatePostDateStruct":579,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":584,"locationsCount":46},"100576798","rapid-prehospital-access-to-ecpr-in-prague-100576798","NCT06789978","Rapid Prehospital ACcess to ECPR in Prague","Prehospital Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study in Prague","RACE","Inclusion Criteria:\n\n* Estimated age 18-70 years\n* Refractory out-of-hospital cardiac arrest (3 unsuccessful defibrillations and\u002For at least 10 minutes of resuscitation in case of pulseless electrical activity)\n* Witnessed cardiac arrest\n* ECPR team available\n* ECPR team alert within 20 minutes from the emergency call\n\nExclusion Criteria:\n\n* Unwitnessed cardiac arrest\n* Asystole\n* ETCO2 less than 10 mmHg upon ECPR team arrival\n* Known limitations of intensive care (Do Not Resuscitate - DNR status)\n* Known severe neurological impairment prior to cardiac arrest (mRS 4-6)\n* Suspected or known pregnancy","70 Years",{"count":571,"type":22},20,[25],"A prospective pilot feasibility study of prehospital ECPR in patients with refractory OHCA",[191,372],[33,330,576,577],"ECMO","Prehospital","2025-02-12",{"date":580,"type":38},"2025-02-14",{"date":582,"type":38},"2025-01-20",{"date":37,"type":22},{"name":585,"class":45},"General University Hospital, Prague",{"id":587,"slug":588,"hasResults":12,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":592,"eligibilityCriteria":593,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":84,"enrollmentInfo":594,"targetDuration":4,"studyType":23,"phases":596,"briefSummary":597,"conditions":598,"keywords":599,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":604,"lastUpdatePostDateStruct":605,"startDateStruct":606,"completionDateStruct":608,"leadSponsor":610,"locationsCount":233},"100539652","remote-conditioning-in-out-of-hospital-cardiac-arrest-100539652","NCT06306625","REmote COnditioning in Out-of-Hospital Cardiac Arrest","REmote Ischemic COnditioning in Out-of-Hospital Cardiac Arrest: The RECO-OHCA Study","RECO-OHCA","Inclusion Criteria:\n\n* Age between 18 and 80 years old\n* Out-of-hospital cardiac arrest, whatever the initial cardiac rhythm (shockable or non-shockable) or the duration of no-flow and low-flow,\n* Presence of a witness who may or may not have started cardiopulmonary resuscitation, or patient seen alive in the 30 minutes prior to the cardiac arrest,\n* Hospitalisation in critical care (intensive care unit or cardiac intensive care unit) for less than 3 hours,\n* Informed consent obtained from a close relative (exceptionally from the patient himself if his condition permits) or, failing this, use of the emergency procedure by the investigator.\n\nExclusion Criteria:\n\n* Traumatic cardiac arrest\n* Patient on extracorporeal circulatory assistance\n* Cardiac arrest for which continuation of resuscitation does not appear justified (unavoidable death, terminal stage of an irreversible disease, etc.)\n* Contraindication of the use of brachial cuff on both arms (arteriovenous fistula, lymphoedema or severe peripheral vascular pathology, unstable humeral fracture, continuous infusion into an upper limb vein of an essential drug such as a catecholamine, radial arterial catheter for continuous invasive measurement of blood pressure)\n* Pregnant, parturient, or breast-feeding women\n* Patients deprived of their liberty by a judicial or administrative decision,\n* Patients under legal protection (guardianship, curatorship),\n* Patient not affiliated to a social security scheme or beneficiary of a similar scheme,\n* Previous inclusion in the study,\n* Subject participating in other interventional research that may interfere with the present study according to the investigator's judgement or that includes an exclusion period still in progress at inclusion",{"count":595,"type":22},220,[25],"Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia. The pathophysiology of organ dysfunction after resuscitated out-of-hospital cardiac arrest involves ischemia-reperfusion processes. Remote ischemic conditioning is a therapeutic strategy used to protect organs against the detrimental effects of ischemia-reperfusion injury.\n\nThe objective of the present trial is to determine whether remote ischemic conditioning performed early after out-of-hospital cardiac arrest can decrease mortality, or multiple organ failure and\u002For severe neurological failure.",[28],[31,600,601,602,603],"remote conditioning","ischemic conditioning","ischemia-reperfusion","intensive care unit","2025-02-11",{"date":578,"type":38},{"date":607,"type":38},"2024-06-21",{"date":609,"type":22},"2026-10-05",{"name":611,"class":45},"Hospices Civils de Lyon",{"id":613,"slug":614,"hasResults":12,"nctId":615,"briefTitle":616,"officialTitle":617,"acronym":618,"eligibilityCriteria":619,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":569,"enrollmentInfo":620,"targetDuration":4,"studyType":23,"phases":622,"briefSummary":623,"conditions":624,"keywords":627,"overallStatus":277,"whyStopped":4,"lastUpdateSubmitDate":629,"lastUpdatePostDateStruct":630,"startDateStruct":632,"completionDateStruct":634,"leadSponsor":636,"locationsCount":4},"100577980","the-osiris-ecpr-trial-100577980","NCT06805344","The OSIRIS ECPR Trial","Out-of-hospital Refractory Cardiac Arrest Treated with Extracorporeal Cardiopulmonary Resuscitation","OSIRIS","Inclusion Criteria:\n\n1. Age ≥18 and ≤ 70 years presumed or known\n2. Witnessed OHCA\n3. Bystander CPR provided\n4. Presumed cardiac or unknown cause\n5. An initial documented shockable rhythm of VF (ventricular fibrillation) or pulseless VT (ventricular tachycardia)\n6. Minimum of ≥ 10 min of ACLS without ROSC or at least ≥ 3 defibrillations in ongoing VF\u002Fpulseless VT\n7. Body morphology able to accommodate a mechanical chest compression device\n8. ECPR team and intensive care unit (ICU) capacity in the receiving center available\n9. Estimated transfer time from the scene to the hospital ≤ 30 minutes or to the scene ≤ 30 minutes\n10. Eligible for intensive care without restrictions or limitations\n\nExclusion Criteria:\n\n1. ACLS ≥ 30 minutes before randomization\n2. Known limitations in care or a Do Not Attempt to Resuscitate (DNAR) order\n3. Known severe disease making 90-day survival unlikely\n4. Known bleeding diathesis or acute or recent intracranial bleeding\n5. Known, obvious or suspected pregnancy\n6. Known pre-arrest severe cognitive dysfunction (mRS ≥ 4)\n7. Known hypothermia as a cause of cardiac arrest",{"count":621,"type":22},686,[25],"The OSIRIS trial is an investigator-initiated, multicenter, multinational, open-label, randomized controlled trial with a 2:1 concealed allocation of refractory out-of-hospital cardiac arrest (OHCA) patients to the extracorporeal cardiopulmonary resuscitation (ECPR) based approach versus the conventional cardiopulmonary resuscitation (CCPR) approach.",[60,144,28,625,372,626],"Sudden Cardiac Arrest","Extracorporeal Membrane Oxygenation",[397,398,628,396],"extracorporeal membrane oxygenation","2025-01-30",{"date":631,"type":38},"2025-02-03",{"date":633,"type":22},"2025-02",{"date":635,"type":22},"2030-06",{"name":585,"class":45}]