[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"outcome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:outcome":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,75,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100593956","wise-choices-in-the-intensive-care-unit-100593956",false,"NCT07013175","Wise Choices in the Intensive Care Unit","WIse CHoices in the Intensive Care Unit, a Cluster Randomized Registry Based Clinical Trial","WICH-ICU","Inclusion Criteria:\n\n* Patients 18 years or older, treated in Swedish ICU's\n\nExclusion Criteria:\n\n* Patients under the age of 18 years","ALL","18 Years",{"count":20,"type":21},10000,"ESTIMATED","INTERVENTIONAL",[24],"NA","Aim: to evaluate if the Choosing Wisely campaign can be introduced without harming critically ill patients.\n\nBackground: Each year, around 45,000 patients are admitted to Sweden's 81 ICUs (intensive care units), costing 6-7 billion SEK (6% of total healthcare expenditure). The high costs of health care are partly attributable to overuse of diagnostic tests. Up to 30% of these tests lead to treatments that provide no benefit for patients, some of them may even be harmful(1-3). To improve quality of care while combating this problem of cost, the American Board of Internal Medicine Foundation developed the Choosing Wisely Campaign, tasking professional societies to develop lists of top five medical services patients and physicians should question. Patients in the ICU, can especially benefit from this paradigm shift. They are subjected to multiple testing on a daily - sometimes hourly - basis, therefore this field of medicine responded to the campaign quickly. Two sets of top-five-lists of tests and interventions that can be questioned have been published(4 5).\n\nIn multiple countries, including Sweden, the Choosing Wisely campaign is gathering traction among critical care physicians and is on the verge of being introduced. It is both common-sensical and will save money, so health care leaders are positive. However, the investigators have an opportunity, and a duty, to assess the evidence; can the Choosing Wisely campaign be introduced without harming ICU patients?\n\nThe present study thus aims to evaluate the introduction of the Choosing Wisely campaign in the context of the ICU. Is this change of care strategy associated with changes in 30-day-mortality? Secondary outcomes include ICU length of stay, use of non-invasive- or invasive mechanical ventilation and continuous renal replacement therapy. This is a registry-based cluster randomized controlled study (R-RCT), targeting Swedish ICU's across multiple regions. Primary and secondary outcomes will be retrieved from the Swedish Intensive care Register (SIR), making ICU participation easier and less costly.",[27,28,29,30,31],"Critical Illness","Ventilation","Outcome","Dialysis","Acute Kidney Injury",[33,34],"critical illness","choosing wisely","RECRUITING","2025-11-24",{"date":38,"type":39},"2025-12-02","ACTUAL",{"date":41,"type":39},"2025-11-03",{"date":43,"type":21},"2027-12-31",{"name":45,"class":46},"Karolinska Institutet","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100528769","the-association-between-post-resuscitation-time-series-management-in-the-emergency-department-and-short-term-outcomes-for-out-of-hospital-cardiac-arrest-patients-100528769","NCT06165081","The Association Between Post-resuscitation Time Series Management in the Emergency Department and Short-term Outcomes for Out-of-hospital Cardiac Arrest Patients","Inclusion Criteria:\n\n* Adults over the age of 20 who have experienced cardiac arrest prior to arrival and have been resuscitated to regain spontaneous heartbeat in the emergency department\n\nExclusion Criteria:\n\n* Traumatic mechanism, Loss of medical record","20 Years",{"count":56,"type":21},6000,"OBSERVATIONAL","This study examines the impact of emergency department (ED) management on short-term outcomes of nontraumatic adult out-of-hospital cardiac arrest (OHCA) patients. Conducted by a research team at National Taiwan University Hospital and its affiliated hospitals, including branches in Hsinchu and Yunlin, the study spans from January 2016 to August 2023. It focuses on a sequential population of patients, analyzing data like age, gender, medical history, prehospital care details (e.g., witnessed collapse, bystander CPR), and specifics of ED management.\n\nOHCA, with an incidence rate of 50-100 per 100,000 people, presents high mortality and severe complications, leading to significant healthcare expenditures. After resuscitation in the ED, only about one-fifth of patients achieve return of spontaneous circulation (ROSC). The prognosis for these patients remains grim, with a mere 5% experiencing favorable neurological outcomes. Understanding the mechanisms of OHCA, identifying risk factors, effective interventions, and the timing of ED treatments like vasopressors and electrocardiography are crucial.\n\nPatients post-OHCA often undergo a postcardiac arrest syndrome (PCAS), marked by cellular hypoxia and a consequential inflammatory response. Stability of vital signs and rapid ED interventions, including identifying OHCA causes and coordinating with specialists, are vital for short-term recovery. This study aims to determine if ED management and time-related factors from ROSC to various interventions (e.g., ECG, CT scans) affect short-term survival rates, including survival to hospital admission and survival after 1, 3, and 7 days.\n\nBy retrospectively analyzing patient data, including Utstein Style prehospital cardiac arrest registry variables and emergency department management details, the study seeks to shed light on the crucial phase of post-resuscitation care. The ultimate goal is to improve survival rates and neurological outcomes in OHCA patients, emphasizing the need for more comprehensive research in this area",[60,61,29],"Resuscitation","Emergency Department",[63,64],"Out-of-hostpital cardiac arrest","Short-term outcome","2025-11-17",{"date":67,"type":39},"2025-11-18",{"date":69,"type":39},"2024-01-01",{"date":71,"type":21},"2026-12-31",{"name":73,"class":46},"National Taiwan University Hospital",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":85,"studyType":57,"phases":4,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":74},"100580391","effect-of-the-new-definition-of-epilepsies-of-the-ilae-of-2014-on-the-diagnosis-after-the-first-seizure-100580391","NCT06836687","Effect of the New Definition of Epilepsies of the ILAE of 2014 on the Diagnosis After the First Seizure","Monocentric Study to Investigate the Effect of the New Definition of Epilepsies of the International League Against Epilepsy of 2014 on the Diagnosis After the First Seizure, on Patient Satisfaction, Cognition and Health Economic Factors","EFS-ILAE2014","Inclusion Criteria:\n\n* Completion of the 18th year of life\n* first epileptic seizure\n* Ability to understand the patient information and to give written consent\n* Written consent for voluntary participation in the study\n\nExclusion Criteria:\n\n* Chronic drug or alcohol abuse in the last two years",{"count":84,"type":21},1000,"10 Years","The present study is a prospective study on the development of seizure frequency, medication adherence, quality of life and cognitive performance after a first epileptic seizure using the new diagnostic criteria for epilepsy of the International League Against Epilepsy of 2014 at the time of diagnosis.",[88,89,29],"Seizure, Epileptic","Neuropsychology",[91,92,89,93],"First epileptic seizure","Definition of epilepsy","outcome","2025-02-18",{"date":96,"type":39},"2025-02-20",{"date":98,"type":39},"2018-03-01",{"date":100,"type":21},"2038-08-01",{"name":102,"class":46},"University Hospital Marburg",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":74},"100433041","phase-2-factors-influencing-the-prognosis-of-olfactory-dysfunction-after-upper-sensation-100433041","NCT04918953","Factors Influencing the Prognosis of Olfactory Dysfunction After Upper Sensation","Second Affiliated Hospital, College of Medicine, Zhejiang University","Inclusion Criteria:\n\n* The history of upper respiratory tract infection was confirmed, and the previous sense of smell was normal.\n\nExclusion Criteria:\n\n* Other causes of olfactory disorder suggested by the history","70 Years",{"count":112,"type":21},90,[114],"PHASE2","Objective: This study aimed to analyze the outcomes of post-infectious olfactory dysfunction treated with different doses of corticosteroids and specify factors related to the curative effect. Methods: The medical records of patients diagnosed with post-infectious olfactory dysfunction from January 2020 to december 2025 were reviewed. All patients were treated with different doses of oral corticosteroids for 12 days or they inhaled corticosteroids for 1 month.",[29],[118],"Corticosteroid, olfactory dysfunction, Smell.","NOT_YET_RECRUITING","2021-06-08",{"date":122,"type":39},"2021-06-09",{"date":124,"type":21},"2021-06-02",{"date":126,"type":21},"2026-12-30",{"name":128,"class":46},"Second Affiliated Hospital, School of Medicine, Zhejiang University"]