[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"overdose\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:overdose":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,71,105,124,147],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100594689","a-universal-primary-care-based-intervention-to-reduce-youth-overdose-risk-100594689",false,"NCT07022717","A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk","A Universal Primary Care Based Pilot Intervention to Reduce Youth Overdose Risk","Inclusion Criteria for providers:\n\n* Physicians and advance practice providers within Pediatric Primary Care and Family Medicine at Boston Medical Center (BMC)\n* ≥ 2 clinic sessions per\u002Fweek\n\nExclusion Criteria for providers:\n\n* None\n\nInclusion criteria for youth:\n\n* Ages 13-26\n* Scheduled for a comprehensive physical exam with a provider who is participating in the trial\n* English speaking\n\nExclusion criteria for youth:\n\n* Caregivers of youth ages 13-17 unable to provide informed consent or are not English speaking\n* Cognitive limitation or intellectual disability that in the opinion of their provider would not\n* Any medical\u002Fpsychiatric condition that causes acute distress and requires emergency evaluation\n* Under legal custody of the Department of Children and Families (DCF)","ALL","13 Years",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23],"NA","Adolescent (ages 10-19) overdose deaths are the third leading cause of pediatric death and continue to rise in the United States. Healthcare providers have regular and trusted relationships with youth and have experience in providing public health injury prevention counseling. Youth have different motivations for using drugs, and many who experience fatal overdose do not have a history of opioid use. Primary care pediatric providers regularly provide developmentally appropriate injury prevention counseling for leading causes of pediatric fatal and nonfatal injury such as drowning prevention and firearms safety. However, there are no recommended, evidence-based overdose prevention interventions for youth, including in health care settings, even though research supports pediatricians and youth-serving clinicians providing harm reduction strategies such as naloxone distribution and overdose education. Among adults, overdose prevention education reduces overdose, is cost-effective, and can be learned by laypersons. Content commonly includes awareness of fentanyl in the drug supply, risk reduction (e.g., not using alone, risks of polysubstance use), and how to recognize and respond to an overdose, including the use of naloxone.\n\nThis study is a pilot two-arm cluster randomized controlled trial (RCT) of a brief overdose prevention education intervention that will be developed in collaboration with the Community Advisory Board (CAB). The primary outcome of this study is to assess the feasibility and acceptability of the brief youth overdose prevention intervention as measured by provider feasibility and acceptability as well as youth acceptability.",[26],"Overdose",[28,29,30,31,32],"Brief overdose prevention","Naloxone","Youth patients","Health care providers","Primary care","RECRUITING","2026-06-29",{"date":36,"type":37},"2026-06-30","ACTUAL",{"date":39,"type":37},"2025-08-25",{"date":41,"type":20},"2026-09",{"name":43,"class":44},"Boston Medical Center","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":45},"100609433","permanent-supportive-housing-overdose-prevention-study-100609433","NCT07214519","Permanent Supportive Housing Overdose Prevention+ Study","Preventing Overdose in Supportive Housing: Stepped Wedge Randomized Controlled Trial of a Multi-Sector, Upstream Intervention","POP+","We will be enrolling supportive housing agencies from NY and NJ to participate in this study. Trial enrollment and intervention delivery will occur at the level of the agency. There are anticipated to be 24 supportive housing agencies total that will be enrolled in the study; approximately 6 agencies will be randomly assigned to each of the four intervention waves in the stepped wedge randomized controlled trial.\n\nInclusion Criteria:\n\nSupportive Housing Agencies\u002FIndividuals who Work at Supportive Housing Agencies:\n\n* Serve at least 40 tenants in New York and\u002For New Jersey\n* Have a significant concern for overdose (as demonstrated by past year tenant overdose)\n* Be willing to complete all activities required for participation in the trial\n\nTenants who Live in Supportive Housing Agencies:\n\n* Must live in an enrolled Supportive Housing Agency\n* Must be 18 years and older\n\nExclusion Criteria:\n\n* See inclusion criteria.","18 Years",{"count":56,"type":20},2940,[23],"This community-partnered study examines a technical assistance intervention designed to help permanent supportive housing agencies implement evidence-based practices to prevent tenant overdose and improve tenant health.",[26,60],"Substance Use","NOT_YET_RECRUITING","2026-05-05",{"date":64,"type":37},"2026-05-06",{"date":66,"type":20},"2027-07-01",{"date":68,"type":20},"2031-03-31",{"name":70,"class":44},"NYU Langone Health",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100609621","the-community-paramedic-response-and-overdose-outreach-with-supportive-medical-legal-services-study-100609621","NCT07216963","The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study","The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services (CROSSROADS) Study","CROSSROADS","Inclusion Criteria:\n\n* 18 years old or older;\n* Has interacted with a CP team (and, thus, experienced a non-fatal opioid and\u002For stimulant overdose) in the last 30 days;\n* Has independent legal agency\n* Able to independently provide informed consent; and\n* Able to speak and understand English.\n\nExclusion Criteria:\n\n\\- Active, severe, and untreated mental illness that would make providing consent impossible",{"count":80,"type":20},400,[23],"The goal of this clinical trial is to develop and test the CROSSROADS intervention. CROSSROADS is designed for people who have recently survived an opioid and\u002For stimulant-related non-fatal overdose and had contact with staff from a Community Paramedic (CP) program.\n\nParticipants will be randomly placed into one of two groups:\n\n1\\) Standard of care from the CP program, or 2) CROSSROADS, which includes CP care plus a Medical-Legal Partnership (MLP). The MLP helps people with legal problems that can affect their health-- like issues with housing or public benefits.\n\nResearchers will test if the CROSSROADS intervention reduces drug use and involvement with the criminal legal system.\n\nPeople in the study will be followed for one year and asked to complete surveys at the beginning, and again at 1 month, 6 months, and 12 months.",[84,85,26,86],"Opioid Use Disorder","Overdose, Drug","Substance Use (Drugs, Alcohol)",[26,88,89,90,91,92,93,94],"Community Paramedic","Medical-Legal Services","Criminal Legal System","Consolidated Framework for Implementation Research","Paramedical Personnel","Human Centered Design","Criminal Legal","2026-04-07",{"date":97,"type":37},"2026-04-13",{"date":99,"type":20},"2026-09-01",{"date":101,"type":20},"2030-08-01",{"name":103,"class":44},"Duke University",4,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":121,"leadSponsor":123,"locationsCount":45},"100534227","overdose-prevention-centers-and-behavioral-health-100534227","NCT06236087","Overdose Prevention Centers and Behavioral Health","Assessing the Impact of Overdose Prevention Centers as a Polysubstance Use and Behavioral Health Intervention in New York City","Inclusion Criteria:\n\nAims 1 and 2:\n\n* are 18 years of age or older;\n* engaged in syringe service program and\u002For overdose prevention center services in New York City in the past 30 days before the date of enrollment;\n* are able to complete assessments in English or Spanish;\n* are competent to give written informed consent at the time of the interview;\n* are able to provide informed consent;\n* self-report use of illicit opioids (e.g., heroin, fentanyl), illicit stimulants (e.g., powder cocaine, crack, methamphetamine), counterfeit prescription pills (defined as prescription pills obtained through the illicit drug market) or any injection drug use in the past 30 days, and\n* are able to participate for at least 6 months following enrollment.\n\nAim 3\n\n* are 18 years of age or older;\n* are employed by a harm reduction program;\n* are able to complete assessments in English; and\n* are able to provide informed consent.\n\nExclusion Criteria:\n\n• Individuals not meeting the criteria detailed above for the respective Aims will not be eligible for participation in this study.",{"count":113,"type":20},500,"OBSERVATIONAL","The aims of this study are: (Aim 1) Identify sources of heterogeneous impacts of opioid prevention center (OPC) use on non-fatal and fatal overdose risk among individuals with histories of polysubstance use (PSU); (Aim 2) Estimate the impact of OPC use on treated psychiatric events among clients with histories of PSU, and; (Aim 3) Assess the barriers and facilitators of integrating mental health services into existing syringe service and OPC delivery models.",[26],"2026-02-27",{"date":119,"type":37},"2026-03-02",{"date":99,"type":20},{"date":122,"type":20},"2027-09-30",{"name":70,"class":44},{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":45},"100540682","emergency-medicine-peer-outreach-worker-engagement-for-recovery-100540682","NCT06320015","Emergency Medicine Peer Outreach Worker Engagement for Recovery","Emergency Department Community Health Worker-Peer Recovery Navigation for Linkage to Recovery: A Mixed Methods Evaluation","EMPOWER","Inclusion Criteria:\n\n1. Adults 18 years old or older\n2. Seen and treated at Rhode Island or The Miriam Hospital ED for a substance use-related concern including intoxication, withdrawal, opioid overdose, opioid withdrawal, or substance use-related infection\n3. Able to provide informed consent\n4. Able to provide at least two forms of contact (personal phone, social media, email, or contact information for family or friends)\n5. Participants may speak languages other than English but require use of interpreter services. Consents will be available in English, Spanish, and Portuguese, the three most spoken languages in the Providence metropolitan area.\n\nExclusion Criteria:\n\n1. Unable to provide informed consent\n2. In police custody, incarcerated, or have a court ordered treatment enrollment",true,{"count":80,"type":20},"This is an observational, prospective case-control study evaluating the effects of an emergency department community health worker-peer recovery specialist program (PCHW), the Substance Misuse Assistance Response Team (SMART). Aims of this study are to 1) understand participant experiences working with a SMART PCHW and identify possible mechanisms for successful recovery linkage; 2) Evaluate SMART effectiveness on patient-centered outcomes, building recovery capital, and recovery linkage; 3) Evaluate SMART implementation and effectiveness on patient outcomes over time.\n\nUsing a combination of surveys and data linkages to state administrative databases, study investigators will prospectively compare changes in addiction treatment engagement, recovery capital, health related social needs, acute care utilization, and death between people receiving a ED PCHW and those who do not. After consenting to study participation, participants will complete surveys at time of study enrollment and 3 and 6 months after their initial ED visit. Primary outcomes include engagement in addiction treatment, social services engagement, acute care utilization, and mortality will be assessed through linkages to state administrative databases.",[136,26,84,137],"Substance Use Disorders","Alcohol Use Disorder","2025-09-30",{"date":140,"type":37},"2025-10-06",{"date":142,"type":37},"2024-07-01",{"date":144,"type":20},"2026-10",{"name":146,"class":44},"University of California, Los Angeles",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":157,"conditions":158,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":45},"100606017","shelter-harm-reduction-evaluation-100606017","NCT07170072","Shelter HArm Reduction Evaluation","Community-based Evaluation of a Novel, System-wide Harm Reduction Strategic Plan for People Experiencing Homelessness in New York City","SHARE","Inclusion Criteria:\n\nFor Aims 1a, 1b, and 2: There will be no participant enrollment or direct contact with individuals as these aims will involve the use of an analytic dataset comprised of linked administrative NYC homeless services, Medicaid, and vital records. The dataset will include records for individuals who entered the NYC DHS single-adult shelter system during calendar years 2021-2026, as well as a matched comparison group(s) (as identified through Medicaid data) during the same years. The matched comparison group will be comprised of individuals age 18 and older with active Medicaid coverage at the time of observation.\n\nFor Aim 3 Homeless Services Client participant group: To be eligible for participation in this study, an individual must meet all of the following criteria:\n\n* Adult 18 year of age or older\n* Speak English\n* Is staying or has stayed in an NYC single-adult shelter that has implemented HRSP interventions\n* Report past-year drug use\n* Able and willing to provide consent\n\nFor Aim 3 Homeless Services Staff participant group: To be eligible for participation in this study, an individual must meet all of the following criteria:\n\n* 18 years of age or older\n* Speak English\n* Works at an adult shelter service provider agency that implemented HRSP or received HRSP interventions (role may include case manager, security staff, shelter director, medical staff, organizational leadership)\n* Able and willing to provide consent\n\nFor Aim 3 Homeless Services Stakeholder participant group: To be eligible for participation in this study, an individual must meet all of the following criteria:\n\n* 18 years of age or older\n* Speak English\n* Works in a role in which they have key insight to the HRSP interventions, including planning and implementation (role may include homeless services administrator or other key stakeholder)\n* Able and willing to provide consent\n\nExclusion Criteria:\n\nAims 1a, 1b, and 2: Children under age 18 years of age will be excluded.\n\nAim 3: Under age 18 years old, currently a prisoner (we are not sampling from locations where we expect to encounter prisoners), unable to communicate in English (because the interview and focus group guides will not be validated for use in other languages), and unable to provide informed consent.\n\nFor Aim 3 Homeless Services Client participant group: those who are not staying or have not stayed at a shelter with HRSP interventions and those who do not report past-year drug use will not be excluded.\n\nFor Aim 3 Homeless Services Staff participant group: those who have not been employed in a shelter with the HRSP interventions will be excluded. In alignment with standard techniques of purposeful sampling and the study goal of ensuring a range of experiences is captured in the qualitative interviews, additional targeting or exclusion criteria might be set by investigators as needed to ensure that a diverse range of experiences is included among qualitative interview participants.",{"count":156,"type":20},80,"The proposed study will use mixed methods research to examine overdose and other health-related impacts of harm reduction initiatives in NYC homeless shelters.",[26,159],"Harm Reduction","2025-09-05",{"date":162,"type":37},"2025-09-12",{"date":164,"type":37},"2025-07-01",{"date":166,"type":20},"2026-09-30",{"name":70,"class":44}]