[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"overweight-childhood\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:overweight-childhood":36},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100460586","brain-health-in-youth-with-normal-weight-overweight-and-obesity-at-risk-for-type-2-diabetes-t2d-100460586",false,"NCT05277558","Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)","Brain Health Across the Metabolic Continuum in Youth at Risk for Type 2 Diabetes (T2D)","Metabrain","Inclusion Criteria:\n\n* 12-17 yrs. old at visit 1, 12-19 yrs. old at visit 2, Tanner II or above (determined through an exam by a pediatric endocrinologist or certified nurse practitioner trained in pediatric endocrinology), otherwise healthy except for obesity, \\\u003C450 lbs. (due to MRI scanner limits), able and willing to lie flat within the MRI scanner and do cognitive testing, fluent in English.\n\nExclusion Criteria:\n\n* Syndromic obesity, history of bariatric surgery, insulin treatment (metformin allowed if \\\u003C 6 months) for T2D, contraindications for MRI (metal, claustrophobia), braces, pregnant (pregnancy test will be done on post-menarchal girls) or breastfeeding, inability to participate in cognitive testing due to sensory or language issues, intellectual disability, special education, pharmacologic treatment for Attention Deficit Hyperactivity Disorder (ADHD), prematurity (\\\u003C36 weeks gestation), complications at birth, neurologic co-morbidities (e.g., seizures, stroke, head injury with \\>10 min loss of consciousness), significant psychiatric disorders (e.g., schizophrenia, bipolar disorder, current major depression), taking psychoactive medications (e.g., antipsychotics) that would interfere with testing or reporting illegal drug use. Self-reported smoking and alcohol use and length of time with obesity will be assessed by history (although these measures may not be fully reliable).",true,"ALL","12 Years","17 Years",{"count":22,"type":23},117,"ESTIMATED","OBSERVATIONAL","Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, inflammation, β-cell dysfunction and dysglycemia) that pose a risk for the brain. Investigators will determine which of these factors are most associated with differences in brain structure and function among groups, over time, and how these effects differ from normal neurodevelopment.",[27,28,29,30,31,32,33,34,35,36,37],"Type2 Diabetes","Type 2 Diabetes Mellitus in Obese","Dysglycemia","Microvascular Complications","Brain Structure","Obesity, Childhood","Diabetes in Adolescence","Inflammation","Insulin Resistance","Overweight, Childhood","Cognitive Decline",[39],"Brain, Health, Youth, Type 2 Diabetes Mellitus, overweight, obesity","RECRUITING","2025-12-16",{"date":43,"type":44},"2025-12-18","ACTUAL",{"date":46,"type":44},"2022-05-24",{"date":48,"type":23},"2027-10-31",{"name":50,"class":51},"Washington University School of Medicine","OTHER",2,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":95},"100570296","the-bloom-study---a-safe-and-healthy-start-in-life-100570296","NCT06705400","The Bloom Study - a Safe and Healthy Start in Life","Inclusion Criteria:\n\nAll children born from first-time mothers being in gestation week 20 between November 1st 2024 and October 31st 2025.\n\nExclusion Criteria:\n\nNot being able to receive digital post.","0 Months","6 Months",{"count":62,"type":23},3500,"INTERVENTIONAL",[65],"NA","The aim of the Bloom Study is to promote healthy weight development among infants through a home-based health promoting intervention implemented in the Danish setting of community health nurses. The intervention begins during pregnancy and runs until the child reaches the age of 30 months.\n\nThe Bloom Intervention was developed over a six-year period from 2017 to 2023 according to the Intervention Mapping approach and based on a co-creation process.\n\nThe Bloom Intervention is evaluated in a cluster-randomized trial involving 22 Danish municipalities (11 intervention and 11 control). All children born from first-time mothers over a period of 12 months are invited to participate.",[36,68],"Obesity in Children",[70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85],"The Bloom Study","Intervention","Infants","Weight status","Community health nurses","Home-based","Randomized controlled trial","Children","Multi-component","Health promotion and prevention","Overweight","Obesity","Food habits and meals","Motor skills and movement","Screen use","Sleep","2025-12-15",{"date":88,"type":44},"2025-12-22",{"date":90,"type":44},"2024-11-01",{"date":92,"type":23},"2029-03-31",{"name":94,"class":51},"University of Southern Denmark",1,{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":18,"minAge":104,"maxAge":20,"enrollmentInfo":105,"targetDuration":4,"studyType":63,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":95},"100549344","comparative-effectiveness-of-a-healthy-lifestyle-and-asthma-management-program-in-person-vs-online-100549344","NCT06432790","Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person vs. ONline","Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person vs. ONline (CHAMPION)","CHAMPION","Caregiver-proxies will be 18 years old or older, English or Spanish speaking, and a primary caregiver of a child meeting the following criteria:\n\nInclusion criteria\n\n* Age 4-17.9 years at time of screening\n* BMI ≥ 85th percentile\n* Asthma or reactive airway disease diagnosis, per child's Electronic Health Record (EHR) documentation and caregiver report\n\nExclusion criteria\n\n* Diagnosis of anorexia nervosa, per child's EHR or caregiver report\n* Pregnant, per child's EHR\n* Plan to change pediatricians in the next year, per caregiver report\n* Opted out of research, per child's EHR\n* Sibling currently enrolled in the research trial, per enrollment log or caregiver report","4 Years",{"count":106,"type":23},500,[65],"The goal of this study is to evaluate the effectiveness of CHAMPION (\"Comparative-effectiveness of a Healthy lifestyle and Asthma Management Program, In-person vs ONline\"), a primary care-based intervention to address childhood obesity and asthma, and test the effectiveness of a telehealth-only version of the program. Intensive Health Behavior and Lifestyle Treatment (IHBLT), when delivered via telehealth vs. in-person among children with overweight or obesity and persistent asthma.",[36,32,110],"Asthma in Children",[112],"telehealth","2025-11-14",{"date":115,"type":44},"2025-11-18",{"date":117,"type":44},"2024-07-17",{"date":119,"type":23},"2028-07-31",{"name":121,"class":51},"Massachusetts General Hospital"]