[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oxygen-consumption-vo2\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oxygen-consumption-vo2":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100601225","o2-consumption-and-co2-production-after-hemodynamic-optimization-in-shock-100601225",false,"NCT07107724","O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock","Oxygen Consumption And Carbon Dioxide Production Following Hemodynamic Optimization In Shock: The OxyCarDio Study","OxyCarDio","Inclusion Criteria:\n\nHypotension (MAP\\\u003C 65mmHg or sudden drop in MAP \\> 15 mmHg) and one of the following conditions:\n\n* Heart rate \\> 120 bpm\n* Urinary output \\\u003C 0.5 ml\u002Fkg\u002Fh for at least two hours\n* Lactate \\> 2 mmol\u002FL\n\nExclusion Criteria:\n\n* Urgent need for surgery\n* Urgent need for veno-arterial ECMO or severe hemodynamic instability\n* Consistent risk of imminent death\n* Severe ARDS or severe respiratory failure (p\u002FF \\\u003C 100 mmHg) and\u002For FiO2\\>0.8\n* Severe heart failure (NYHA 4 and\u002For EF\\\u003C25%)\n* Need for intermittent or continuous renal replacement therapy (IRRT or CRRT)\n* Anemia defined as Hb\\\u003C8 g\u002FdL\n* VO2 variability \\\u003C 5% throughout ten minutes of stabilization before procedure start\n* Intraabdominal hypertension, defined as intraabdominal pressure \\> 18 mmHg\n* Pregnancy\n* Withdrawal or refuse of informed consent\n* Terminal disease\n* Do-not-resuscitate order.","ALL","18 Years",{"count":20,"type":21},36,"ESTIMATED","OBSERVATIONAL","The goal of this prospective observational study is to analyse change in VO2 and VCO2 measured via a dedicated ventilator after hemodynamic optimization maneuvers in adult patients admitted to the ICU with any sign of shock.\n\nThe main questions it aims to answer are:\n\n1. Do common maneuvers for hemodynamic optimization (fluid bolus and\u002For vasopressor administration) have any impact on tissue perfusion in terms of oxygen consumption (VO2) and carbon dioxide production (VCO2) measured by a dedicated ventilator?\n2. Are the values measured by exhaled gas comparable to those calculated by the measurement of dissolved veno-arterial gas?\n\nParticipants enrolled in the study will receive advanced hemodynamic monitoring with MostCare Up (Vygon ®) and their hemodynamic instability will be managed according to most recent guidelines and based on clinical decision of treating physicians.",[25,26],"Hemodynamic Instability","Oxygen Consumption (V̇O2)","RECRUITING","2025-07-30",{"date":30,"type":31},"2025-08-06","ACTUAL",{"date":33,"type":31},"2025-07-29",{"date":35,"type":21},"2027-12",{"name":37,"class":38},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER"]