[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oxygen-consumption\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oxygen-consumption":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100601367","surface-electrical-myography-oxygen-consumption-effort-and-weaning-in-the-mechanically-ventilated-patient-in-the-intensive-care-unit-100601367",false,"NCT07109570","Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit","Surface Electrical Myography, Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU): SERA-Effort Study","SERA-Effort","Inclusion Criteria:\n\n* 18 years of age or older\n* Esophageal catheter in situ (standard of care)\n* Eligible for an SBT in the near future according to the LUMC SBT protocol currently valid\n\nExclusion Criteria:\n\n* Severe cardiac failure NYHA class IV without mechanical support (LVAD or Impella)\n* COPD Gold IV\n* Pregnancy\n* Patients with ECMO","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","2 Days","OBSERVATIONAL","The goal of this observational study is to measure effort using esophageal pressure measurements, oxygen consumption and diaphragm activity in mechanically ventilated Intensive Care Unit patients during a Spontaneous Breathing Trial. The main question aims to answer whether the sEMG signal derived from the SERA device, effort parameters and oxygen consumption have an association with weaning failure.\n\nParticipants will be measured while performing a spontaneous breathing trial.",[26,27,28,29,30,31,32],"Critical Illness","Intensive Care Units (ICUs)","Weaning Failure","Mechanical Ventilation","Spontaneous Breathing Trial","Diaphragm Electrical Activity","Oxygen Consumption","RECRUITING","2025-11-20",{"date":36,"type":37},"2025-11-26","ACTUAL",{"date":39,"type":37},"2025-07-08",{"date":41,"type":21},"2029-06",{"name":43,"class":44},"Leiden University Medical Center","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":58,"studyType":23,"phases":4,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100601269","a-study-on-cardiopulmonary-exercise-tolerance-standards-for-healthy-chinese-population-100601269","NCT07108296","A Study on Cardiopulmonary Exercise Tolerance Standards for Healthy Chinese Population","Multi-center Clinical Cohort Study on Cardiopulmonary Exercise Tolerance Standards in Chinese Healthy Population","MCCS-CCPETS","Inclusion Criteria:\n\n* Detailed medical history taken, with no symptoms of discomfort reported\n* Good physical condition, with no history of severe chronic diseases\n* No history of long - term medication use\n* Willing to undergo cardiopulmonary exercise testing, with no ST - T segment changes observed during the test\n* Age: 18 - 65 years old\n* BMI: 18.5 - 28kg\u002Fm²\n* No smoking history or quit smoking for ≥5 years\n* Physical examination reports within 2 years show no significant abnormalities.\n\nExclusion Criteria:\n\n* Pre - test resting blood pressure ≥160\u002F100 mmHg (1 mmHg=0.133 kPa)\n* Chronic cardiovascular diseases, such as heart failure, coronary atherosclerotic heart disease, hypertension, congenital heart disease, cardiomyopathy, and severe arrhythmias\n* Respiratory diseases, such as chronic obstructive pulmonary disease, asthma, pulmonary artery hypertension, bronchiectasis, and respiratory failure\n* Digestive system diseases, such as peptic ulcer, gastrointestinal bleeding, hepatitis, liver cirrhosis, ulcerative colitis, Crohn's disease, chronic pancreatitis, and chronic cholecystitis\n* Endocrine system diseases, such as hyperthyroidism, hypothyroidism, diabetes, and other diseases with clear hormone abnormalities\n* Acute or chronic kidney diseases, blood system diseases, malignant tumors, and bone and joint diseases that affect activity\n* No history of acute infection within 2 weeks\n* Unable to cooperate with the examination\n* Contraindications to cardiopulmonary exercise testing: acute myocardial infarction",true,"65 Years",{"count":57,"type":21},4620,"1 Day","This project intends to conduct a large-sample, prospective, multicenter clinical cohort study in healthy populations. By utilizing a digital cardiopulmonary rehabilitation clinical data research platform, The investigators aim to achieve automated, standardized, and uniform collection, analysis, and AI modeling of large-scale cardiopulmonary exercise testing (CPET) data. The ultimate goals are:\n\nTo establish reference standards for cardiopulmonary exercise capacity in the Chinese healthy population.\n\nTo develop machine learning-based predictive models for key CPET variables (e.g., peak VO₂) tailored to Chinese demographics.\n\nTo compare performance differences between domestically produced and imported CPET devices.",[32,61],"Cardiorespiratory Fitness",[63,64,65,66,67],"Peak Oxygen Uptake","VO2@AT","Cardiopulmonary Exercise Tolerance","Prediction Model","Healthy Population","NOT_YET_RECRUITING","2025-08-06",{"date":71,"type":37},"2025-08-11",{"date":73,"type":21},"2025-09-01",{"date":75,"type":21},"2027-03-30",{"name":77,"class":44},"Affiliated Hospital of Changchun University of Chinese Medicine",15,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},"100546168","oxygen-consumption-vo2-effort-and-weaning-in-the-mechanically-ventilated-patient-in-the-intensive-care-unit-icu-100546168","NCT06391424","Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU)","Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU): EXTUBATE Study","EXTUBATE","Inclusion Criteria:\n\n* Age above 18 years\n* \\> 24 hours mechanically ventilated\n* Eligible for a spontaneous breathing trial according to the clinical team\n* Regular SBT (\"Regulier SBT\") according to the Leiden University Medical Center (LUMC) protocol\n* Hemodynamically stable\n* Esophageal Catheter in situ\n\nExclusion Criteria:\n\n* Severe chronic obstructive pulmonary disease (COPD) (Gold class IV) if it results in a non regular SBT according to the LUMC protocol.\n* Heart failure (LVEF \\\u003C30%) if it results in a non regular SBT according to the LUMC protocol\n* Known pregnancy",{"count":20,"type":21},"In patients who are mechanically ventilated for more than 72 hours weaning failure is a common issue. The Spontaneous breathing trial (SBT) is often done to assess if the patient can be extubated with a high chance of success. However, re-intubation rates are between 15 - 20 % after a successful SBT. The rapid shallow breathing index (RSBI) is an important parameter used in an SBT. Because the high incidence of extubation failure (re-intubation within 48 hours) a search for a better parameter than the RSBI is warranted. Using the measured end-tidal oxygen (etO2) of mechanically ventilated patients it is possible to calculate the VO2, which is a measure of patient effort. The VO2 is a parameter with the potential to predict weaning success or failure, together with other parameters of patient effort like the work of breathing (WOB), pressure time product (PTP) and esophageal pressure swings, reflecting muscle strength of the diaphragm. Therefore, the investigators want to investigate if these parameters are associated with an SBT success or failure.",[26,90,32,28,29,30],"Intensive Care Unit","2024-09-02",{"date":93,"type":37},"2024-09-19",{"date":95,"type":37},"2024-01-01",{"date":97,"type":21},"2026-01",{"name":43,"class":44},2]