[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oxygen-reserve-index\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oxygen-reserve-index":55},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,39,71,97,126,150],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100634371","ori-monitoring-in-low-and-normal-flow-anesthesia-applications-100634371",false,"NCT07538817","ORI MONITORING IN LOW AND NORMAL FLOW ANESTHESIA APPLICATIONS","EVALUATION OF OXYGEN RESERVE INDEX IN LOW AND NORMAL FLOW ANESTHESIA APPLICATIONS IN LAPAROSCOPIC NEPHRECTOMY CASES IN LATERAL DECUBIT POSITION","Inclusion Criteria:\n\n* Ages 18-75\n* ASA I,II\n* elective surgery laparoscopic nephrectomy\n\nExclusion Criteria:\n\n* ASA III,IV,V\n* BMI \\> 35\n* Those with serious respiratory disease\n* Medications that cause peripheral circulation disorders\n* Patients who started with laparoscopic surgery and then underwent open surgery",true,"ALL","18 Years","75 Years",{"count":21,"type":22},48,"ESTIMATED","OBSERVATIONAL","Oxygen administration is essential in the perioperative period to prevent hypoxia; however, excessive oxygen may cause hyperoxia and related complications. While pulse oximetry is effective in detecting hypoxemia, it is insufficient for identifying hyperoxia when SpO₂ exceeds 97%, often necessitating invasive arterial blood gas analysis. The Oxygen Reserve Index (ORI) is a noninvasive, real-time monitoring parameter reflecting moderate hyperoxic ranges (PaO₂ 100-200 mmHg) and provides early warning of oxygenation changes before SpO₂ alterations occur. Combined use of ORI and pulse oximetry may enable optimal oxygen titration and prevention of both hypoxemia and hyperoxemia.\n\nLaparoscopic nephrectomy is widely performed due to its clinical advantages. In our practice, low and normal fresh gas flow anesthesia are commonly used. Low-flow anesthesia offers benefits such as preservation of heat and humidity, reduced cost, and improved airway physiology. This study aims to determine optimal oxygenation levels during laparoscopic nephrectomy under low and normal fresh gas flow conditions using ORI monitoring.",[26,27],"HYPEROXY","OXYGEN RESERVE INDEX","NOT_YET_RECRUITING","2026-04-13",{"date":31,"type":32},"2026-04-20","ACTUAL",{"date":31,"type":22},{"date":35,"type":22},"2026-08-20",{"name":37,"class":38},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":56,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":70},"100624863","oxygen-reserve-index-ori-in-identifying-desaturation-100624863","NCT07415161","Oxygen Reserve Index (ORi) in Identifying Desaturation","The Role of Oxygen Reserve Index (ORi) in Identifying Early Desaturation During Endolaryngeal Surgery: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective endolaryngeal surgery\n* Planned general anesthesia with apneic intermittent ventilation\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age under 18 years\n* Preoperative chronic hypoxemia (baseline SpO₂ \\\u003C 95%)\n* Patients transferred from the intensive care unit\n* ASA physical status IV or higher\n* Refusal or inability to provide informed consent",{"count":47,"type":22},80,"INTERVENTIONAL",[50],"NA","This randomized clinical trial investigates whether Oxygen Reserve Index (ORi) monitoring enables earlier detection of impending hypoxemia compared with conventional pulse oximetry during apneic intermittent ventilation in adult patients undergoing endolaryngeal surgery under general anesthesia. By providing continuous, noninvasive assessment of oxygen reserve in the hyperoxic range, ORi may offer an earlier warning of oxygen depletion before peripheral oxygen saturation declines. The study compares time to reventilation thresholds, arterial blood gas parameters, and perioperative respiratory outcomes between ORi-guided and standard SpO₂-guided monitoring strategies.",[53,54,55],"Apneic Oxygenation","Endolarengeal Surgery","Oxygen Reserve Index",[57,58,59],"oxygen reserve index","pulse oximetry","apneic ventilation","2026-02-15",{"date":62,"type":32},"2026-02-17",{"date":64,"type":22},"2026-01-27",{"date":66,"type":22},"2026-03-25",{"name":68,"class":69},"Istanbul University","OTHER",1,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":48,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100621788","ori-guided-fio-titration-in-prone-spine-surgery-impact-on-postoperative-atelectasis-assessed-by-lung-ultrasound-100621788","NCT07375173","ORI-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound","Oxygen Reserve Index-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound","Inclusion Criteria:\n\n1. Adults aged 18 to 80 years\n2. Patients with an ASA physical status of I, II, or III\n3. Individuals with a body mass index (BMI) between 18 and 35 kg\u002Fm²\n\nExclusion Criteria:\n\n1. History of or active upper or lower respiratory tract infection within the past month\n2. Pulmonary emphysematous\u002Fbullous disease or COPD\n3. Pre-existing significant atelectasis or consolidation (Preoperative LUS showing a score of 3 consolidation or ≥2 regions with a score ≥2)\n4. Severe obstructive sleep apnea requiring CPAP therapy\n5. NYHA class III-IV heart failure, EF \\\u003C35%, or severe valvular disease\n6. Severe arrhythmia or hemodynamic instability requiring high-dose vasopressors\n7. Body mass index (BMI) \\>35 kg\u002Fm²\n8. Severe anemia (Hb \\\u003C9 g\u002FdL) or polycythemia (Hb \\>18 g\u002FdL)\n9. Non-diagnostic or unclear preoperative lung ultrasound images\n10. Preoperative SpO₂ ≤ 94%\n11. Inability to apply the sensor due to finger deformity, or inadequate signal caused by digital hypoperfusion","80 Years",{"count":80,"type":22},74,[50],"Atelectasis is a frequent pulmonary complication after general anesthesia, often triggered by preoxygenation and intraoperative hyperoxia. High inspiratory oxygen fractions (FiO₂) can promote absorption atelectasis, ventilation-perfusion mismatch, hemodynamic alterations, and oxidative injury.\n\nThis study evaluates the effect of two intraoperative oxygen management strategies-oxygen reserve index (ORI)-guided FiO₂ titration versus fixed 50% FiO₂-on postoperative atelectasis in patients undergoing thoracolumbar spine surgery under general anesthesia. Atelectasis severity will be assessed using lung ultrasonography (LUS), scored across 12 thoracic regions (0-3 per region, total 0-36), while respiratory function changes will be examined via preoperative and 24-hour postoperative spirometry (FVC, FEV₁, FEV₁\u002FFVC).\n\nBecause postoperative spirometry may be influenced by pain, Numeric Rating Scale (NRS) scores will be recorded to help distinguish true restrictive patterns from pain-limited respiratory effort.\n\nThe study aims to determine whether ORI-guided FiO₂ titration can reduce postoperative atelectasis and improve respiratory outcomes compared with a fixed FiO₂ approach.",[84,85,86,87,55],"Atelectases, Postoperative Pulmonary","Prone Position","Spine Surgery","Lung Ultrasound","2026-01-24",{"date":90,"type":32},"2026-01-29",{"date":92,"type":22},"2026-03-15",{"date":94,"type":22},"2026-11-30",{"name":96,"class":38},"Ankara Etlik City Hospital",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":108,"conditions":109,"keywords":112,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":70},"100618028","the-effectiveness-of-oxygen-reserve-index-in-early-detection-of-desaturation-in-geriatric-patients-scheduled-for-oncological-surgery-100618028","NCT07326293","The Effectiveness of Oxygen Reserve Index in Early Detection of Desaturation in Geriatric Patients Scheduled for Oncological Surgery","The Effectiveness of Oxygen Reserve Index in Early Detection of Desaturation in Geriatric Patients Scheduled for Oncological Surgery; a Prospective, Observational Study.","Inclusion criteria for the files\u002Frecords\u002Fmaterials to be included in the study:\n\nRecords of patients aged 65 years and older, classified as ASA physical status I-III, who are scheduled for elective oncologic surgery.\n\nExclusion criteria for the files\u002Frecords\u002Fmaterials to be included in the study:\n\nRecords of patients with advanced coronary artery disease; advanced heart failure and\u002For valvular heart disease; carotid artery stenosis; left ventricular ejection fraction below 30%; rapid atrial fibrillation; body mass index (BMI) greater than 35 kg\u002Fm²; anticipated difficult airway; advanced-stage malignancy; or dementia.","65 Years","100 Years",{"count":107,"type":22},44,"This prospective observational study aims to evaluate the relationship between the Oxygen Reserve Index (ORI) and tolerable apnea time in geriatric patients undergoing elective oncologic surgery under general anesthesia.\n\nPatients aged 65 years and older will be monitored using standard anesthesia monitoring and Masimo Rainbow SET® Pulse CO-Oximetry during anesthesia induction and tracheal intubation.\n\nTolerable apnea time will be defined as the duration from the end of ventilation after intubation to a decrease in peripheral oxygen saturation (SpO₂) to 94%.\n\nThe primary objective is to assess the association between ORI warning time and tolerable apnea time. Secondary objectives include evaluating the association between ORI values, arterial blood gas parameters at predefined time points, and the Clinical Frailty Scale.",[110,111,55],"Desaturation","Apnea, Hypoxia",[113,114,115],"oxygen reserve indec","geriatric","desaturation","RECRUITING","2026-01-02",{"date":119,"type":32},"2026-01-08",{"date":121,"type":32},"2025-12-16",{"date":123,"type":22},"2026-02-16",{"name":125,"class":69},"Ankara City Hospital Bilkent",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":133,"enrollmentInfo":134,"targetDuration":136,"studyType":23,"phases":4,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":70},"100602158","the-role-of-oxygen-reserve-index-ori-in-apneic-ventilation-100602158","NCT07119866","The Role of Oxygen Reserve Index (ORi) in Apneic Ventilation","The Role of Oxygen Reserve Index (ORi) Monitoring in Optimizing Apneic Ventilation for Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* 18-60 years\n* ASA 1-2\n* Mallampati score \\\u003C2\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n\nExclusion Criteria:\n\n* \\\u003C18 and \\>60 years\n* ASA 3-4\n* Initial ORI value below 0.24","60 Years",{"count":135,"type":22},60,"1 Day","Background: The Oxygen Reserve Index (ORI) is a non-invasive parameter utilizing multi-wavelength pulse co-oximetry. ORI can provide early warnings of deteriorating oxygenation before changes are reflected in SpO₂ levels. This study aimed to investigate the feasibility of non-ventilated intubation in patients undergoing cholecystectomy as a means to achieve safe intubation without nasogastric tube placement, with reduced trauma and cost, and improved time efficiency.",[55,139,140,141],"Apnea","Ventilation","Body Mass Index","2025-08-06",{"date":144,"type":32},"2025-08-13",{"date":146,"type":22},"2025-08-07",{"date":148,"type":22},"2025-08-30",{"name":125,"class":69},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":158,"conditions":159,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":70},"100581235","comparison-of-the-time-to-reach-end-tidal-oxygen-value-of-90-and-oxygen-reserve-index-decline-times-during-preoxygenation-in-sarcopenic-and-non-sarcopenic-patients-100581235","NCT06847672","Comparison of the Time to Reach End-Tidal Oxygen Value of 90 and Oxygen Reserve Index Decline Times During Preoxygenation in Sarcopenic and Non-Sarcopenic Patients","Comparison of the Time to Reach End-Tidal Oxygen Value of 90 and Oxygen Reserve Index Decline Times During Preoxygenation in Sarcopenic and Non-Sarcopenic Patients Using the 6-Minute Walk Test","Inclusion Criteria:\n\n* Patients who agree to participate in the study.\n* Patients scheduled for major abdominal oncologic surgery.\n\nExclusion Criteria:\n\n* Patients with severe cardiopulmonary disease.\n* Patients with walking disabilities.",{"count":47,"type":22},"The purpose of this study is to compare the time required to reach an end-tidal oxygen (EtO2) value of 90% and the time until the Oxygen Reserve Index (ORI) drops below 0.55 during preoxygenation in sarcopenic and non-sarcopenic patients. The study aims to investigate the impact of sarcopenia on the oxygenation process.",[160,161,55],"Sarcopenia","Preoxygenation","2025-02-21",{"date":164,"type":32},"2025-02-26",{"date":166,"type":22},"2025-03-01",{"date":168,"type":22},"2025-08-31",{"name":125,"class":69}]