[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oxygen-toxicity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oxygen-toxicity":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,55,82,104,126,147],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":35,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100613193","effect-of-hydrogen-gas-on-hyperbaric-oxygen-toxicity-100613193",false,"NCT07263399","Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity","Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity - A Randomized Controlled Cross-Over Trial","Inclusion Criteria:\n\n* Military divers actively serving, aged 20-64 years\n* Meeting the Swedish Armed Forces physical standards for diving\n\nExclusion Criteria:\n\n* Ongoing infection or illness that may impact pulmonary function\n* Use of alcohol or smoking cigarettes within 48 hours\n* Diving with any breathing gas within 48 hours\n* Diving with oxygen-enriched gas (100% O₂) within 2 weeks\n* Use of medications that could affect oxidative stress, lung function, or neurological status\n* Medical history of serious diving-related injuries or long-term complications",true,"ALL","20 Years","64 Years",{"count":21,"type":22},32,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this trial is to investigate whether adding a small fraction of hydrogen gas to an oxygen-enriched breathing mixture can reduce pulmonary oxygen toxicity (POT) in healthy and active divers from the Swedish Armed Forces. The main questions it aims to answer are:\n\n* Does hydrogen gas reduce oxidative stress and changes in pulmonary function associated with prolonged hyperbaric oxygen exposure?\n* What are the underlying pathophysiological mechanisms of pulmonary oxygen toxicity?\n\nResearchers will compare oxygen-enriched breathing gas with 1-2% hydrogen to oxygen-enriched gas with 1-2% nitrogen (control) to see if hydrogen provides protective effects against POT during hyperbaric exposure.\n\nParticipants will:\n\n* Complete two hyperbaric exposure sessions (hydrogen vs. nitrogen), each lasting 240 minutes at 1.75 ATA\n* Undergo pulmonary function tests and sampling of blod and urin before and after each session\n* Serve as their own controls in a double-blind, randomized, crossover study design",[28,29,30,31,32,33,34],"Oxygen Toxicity","Oxidative Stress","Hyperoxia","Hyperbaric Oxygen","Healthy Subjects (HS)","Diving Medicine","Hydrogen-oxygen Gas",[36,37,38,39,31,40,41],"Pulmonary Oxygen Toxicity","Hydrogen Gas","Diving Physiology","Lung Function","Human Study","Military Divers","NOT_YET_RECRUITING","2025-12-01",{"date":45,"type":46},"2025-12-04","ACTUAL",{"date":48,"type":22},"2026-01",{"date":50,"type":22},"2030-12",{"name":52,"class":53},"Blekinge Institute of Technology","OTHER",2,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":16,"sex":17,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":67,"conditions":68,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100497785","oxygen-toxicity-mechanisms-in-humans-100497785","NCT05761756","Oxygen Toxicity: Mechanisms in Humans","Applied Physiology of Oxygen Toxicity: Mechanisms in Humans","Inclusion Criteria:\n\n* Equal numbers of male and female\n* Non-smokers\n* Aged 18-45 years\n* Males will be required to have VO2 peak \\> or equal to mL\u002Fkg min\n* and females \\> or equal to 30 mL\u002Fkg min\n\nExclusion Criteria:\n\n* Pregnancy\n* Cardiorespiratory disease, including hypertension\n* Neuromuscular disease\n* Anemia\n* History of hemoglobinopathy, including sick cell disease and trait","18 Years","45 Years",{"count":65,"type":22},62,[25],"The goal of this clinical trial is to learn about the mechanisms of oxygen toxicity in scuba divers. The main questions it aims to answer are:\n\n* How does the training of respiratory muscles affect oxygen toxicity?\n* How do environmental factors, such as sleep deprivation, the ingestion of commonly utilized medications, and chronic exposure to carbon dioxide, impact the risk of oxygen toxicity?\n* How does immersion in water affect the development of oxygen toxicity?\n\nParticipants will be asked to do the following:\n\n* Undergo a basic screening exam composed of health history, vital signs, and some respiratory function tests\n* Train their respiratory muscles at regular intervals\n* Exercise on a cycle ergometer both in dry conditions and underwater\u002Funder pressure in the context of medication, sleep deprivation, or carbon dioxide exposure\n\nResearchers will compare the performance of each subject before and after the possible interventions described above to see if there are changes in exercise performance, respiratory function, cerebral blood flow, and levels of gene expression.",[28,69,70],"Hypercapnia","Seizures","RECRUITING","2025-10-21",{"date":74,"type":46},"2025-10-23",{"date":76,"type":46},"2023-11-28",{"date":78,"type":22},"2026-08-31",{"name":80,"class":53},"Duke University",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":81},"100484598","comparison-of-two-oxygenation-targets-with-two-different-oximeters---impact-on-oxygen-flow-rates-and-oxygenation-100484598","NCT05590130","Comparison of Two Oxygenation Targets With Two Different Oximeters - Impact on Oxygen Flow Rates and Oxygenation","Oxygap pong","Inclusion Criteria:\n\n* ≥ 18 years of age\n* Patients admitted to postoperative cardiac surgery intensive care unit\n* Presence of an arterial catheter Specific for the extubate patient\n* Ongoing on conventional oxygen therapy at moderate flow (up to a maximum of 5L\u002Fmin) with SpO2 between 88 and 100% with the usual oximeter and nasal cannula.\n* SpO2 \\\u003C 92% ambient air Specific for the intubate patient FiO2 \\\u003C= 0.60 with SpO2 between 88 and 100% with usual oximeter SpO2 \\\u003C 92% with FiO2 0.21\n\nExclusion Criteria:\n\n* No SpO2 signal with oximeter in use\n* False nails or nail polish\n* Methemoglobinemia \\>0.015 on last available arterial gas\n* Patient in isolation (multi-resistant bacteria, C-Difficile, SARS-CoV-2 ...) Specific for the extubate patient\n* Expected to use another respiratory support within one hour of inclusion (NIV or nasal high flow oxygen) Planned extubation within one hour of inclusion",{"count":90,"type":22},40,[25],"The investigators recently evaluated 4 different oximeters among the most commonly used with arterial catheter in place and compared SpO2 with SaO2 obtained on arterial gas. Correlations between SaO2 and SpO2 were poor for all oximeters, as previously known, and SpO2-SaO2 bias were different between oximeters. Some oximeters (Masimo, Nellcor) had lower biases but they detected less well hypoxemia. Some oximeters underestimated SaO2 (Nonin) but detected very well hypoxemia, and some overestimated SaO2 (Philips). The investigators concluded that oximeters provide different informations to clinicians, and oxygenation targets should take into account for these differences.\n\nThe assumption is that the SpO2 target AND oximeter used will both have an impact on oxygen flows and that these effects will add up. With a high SpO2 target, oxygen flows will be significantly greater and with the Nonin oximeter, the required flows will be greater than with the Philips oximeter.\n\nNB: the results obtained were in a population with light skin pigmentation (96% of the patients were Fitzpatrick 1-2, reflecting the local hospitalized population).",[28,94],"Respiratory Failure","2025-08-27",{"date":97,"type":46},"2025-09-04",{"date":99,"type":46},"2022-11-16",{"date":101,"type":22},"2027-06",{"name":103,"class":53},"Laval University",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":81},"100372999","influence-of-freeo2-on-percentage-of-time-within-oxygen-saturation-target-using-noninvasive-ventilation-niv-and-continuous-positive-airway-pressure-cpap-for-patients-admitted-for-aecopd-or-bariatric-surgery-100372999","NCT04136717","Influence of FreeO2 on Percentage of Time Within Oxygen Saturation Target Using Noninvasive Ventilation (NIV) and Continuous Positive Airway Pressure (CPAP) for Patients Admitted for AECOPD or Bariatric Surgery","Influence of Automatic Oxygen Titration Device (FreeO2) on Percentage of Time Within Oxygen Saturation Target and Induced Hypercapnia During Noninvasive Ventilation for Patients Hospitalized for an Acute Exacerbation of COPD or a Bariatric Surgery","Inclusion Criteria (AECOPD):\n\n* Respiratory acidosis (pH \\\u003C= 7.35 and PaCO2 \\> 45 mmHg), with or without NIV (last blood gas available during hospitalization)\n* Oxygen therapy and\u002For SpO2 \\\u003C90% room air (FiO2 \\\u003C= 50% or nasal cannula \\\u003C= 7 L\u002Fmin to maintain SpO2 90%)\n* High flow nasal cannula with flow \\\u003C= 30 L\u002Fmin\n\nInclusion Criteria (Bariatric surgery post-op):\n\n* Patients using CPAP before the surgery (obstructive sleep apnea documented).\n* Patients with obesity hypoventilation syndrome in addition to obstructive sleep apnea can be included.\n\nExclusion Criteria:\n\n* Age \\\u003C 18\n* Pregnancy\n* Respiratory distress or other clinical situation requiring continuous NIV or CPAP\n* Glasgow \\\u003C 12 or agitation\u002Fdelirium\u002Fdementia (limiting NIV)\n* Any contraindication to NIV (state requiring immediate endotracheal intubation, pneumothorax, recent esophagus surgery)\n* Hemodynamic instability (at the beginning of the study) (increasing doses of vasopressors or inotropes)\n* Refusal to consent to the study\n\n  5 patient with AECOPD and 5 patient with bariatric surgery will be included.",{"count":112,"type":22},10,[25],"The main objective is to evaluate the FreeO2 device combined with noninvasive respiratory support technique for COPD patients and postoperative bariatric surgery patients.\n\nThe main hypothesis is that FreeO2 device for oxygen therapy associated with NIV or nasal high flow oxygen therapy (NHFOT) allows to reach better oxygenation and avoid hypoxemia and hyperoxia.",[116,28,117,118],"COPD Exacerbation","Abdominal Obesity","Surgery",{"date":97,"type":46},{"date":121,"type":46},"2019-10-28",{"date":123,"type":22},"2028-06",{"name":125,"class":53},"François Lellouche",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":23,"phases":135,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":81},"100565808","comparison-of-several-oxygenation-targets-with-different-oxygen-interfaces---impact-on-oxygen-flow-rates-100565808","NCT06646991","Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow Rates","Interfaces","Inclusion Criteria:\n\n* Adult (\\> or = 18 years old)\n* Ongoing on conventional oxygen therapy with peripheral oxygen saturation (SpO2) between 88 and 100% with the usual oximeter\n* SpO2 \\\u003C 92% ambient air with the usual oximeter\n\nExclusion Criteria:\n\n* No SpO2 signal with with the usual oximeter\n* False nails or nail polish\n* Severe anemia documented on last blood count during current hospitalization (haemoglobin (Hb) \\\u003C 80g\u002FL)\n* Oxygen flow \\> 6 L\u002Fmin",{"count":134,"type":22},20,[25],"Oxygen therapy is at the heart of the healthcare system. Oxygen flow rates depend on a number of confounding factors confounding factors (target used, skin pigmentation, pulse oximeter used, etc.) The investigators have recently have recently demonstrated that the combination of these factors (different peripheral oxygen saturation (SpO2) targets and different oximeters) can have a significant impact on oxygen flows rates. The effect on oxygen flow was not simply additive .\n\nThe aim of this study is to evaluate the impact of the interface used on oxygen flow rates in different patient populations (main objective). The investigatoers also evaluate the impact of the interface on carbon dioxide (PaCO2), in particular with closed oxygen masks, with which rebreathing is theoretically possible (secondary objective).\n\nsecondary objective).",[28,138,94],"COPD Bronchitis","2024-11-20",{"date":141,"type":46},"2024-11-22",{"date":143,"type":22},"2024-12",{"date":145,"type":22},"2025-12",{"name":103,"class":53},{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":157,"phases":4,"briefSummary":158,"conditions":159,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":81},"100564282","epidemiological-assessment-of-technical-diving-accidents-in-mainland-france-and-factors-predictive-of-severity-tekcare-100564282","NCT06627153","Epidemiological Assessment of Technical Diving Accidents in Mainland France and Factors Predictive of Severity (TEKCare)","Epidemiological Assessment of Technical Diving Accidents in Mainland France and Factors Predictive of Severity","TEKCare","Inclusion Criteria:\n\n* Civilian technical diver\n* Diving accident history (decompression sickness, biochemical accident or immersion pulmonary edema) following a technical dive in a trimix and\u002For rebreather dive\n* Treated in a hyperbaric center on the coast of mainland France\n\nExclusion Criteria:\n\n* Participation denied by the diver\n* Diving incident diagnosis not retained by the hyperbaric physician",{"count":156,"type":22},100,"OBSERVATIONAL","This retrospective study aims at an epidemiological description of the clinical presentation of medical problems in technical diving. It assess anthropometric data, diving experience and dive planification, clinical presentation, treatment received and pronostic to understand specificity of this community.",[160,161,28,162,163],"Decompression Sickness","Pulmonary Edema - Acute","Carbon Dioxide Poisoning","Nitrogen Narcosis","2024-10-02",{"date":166,"type":46},"2024-10-04",{"date":168,"type":22},"2025-01-01",{"date":170,"type":22},"2025-12-31",{"name":172,"class":53},"University Hospital, Brest"]