[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oxygenation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oxygenation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,81,107,136,162],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100610009","induction-agent-choice-with-early-mortality-and-prognostic-outcomes-in-critically-ill-patients-100610009",false,"NCT07222007","Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients","Association of Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients: A Large-Scale Retrospective Cohort Analysis","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Admission to the surgical ICU for critical care\n* Administration of one of the studied induction agents\n* Availability of complete clinical data\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Absence of documented induction agent administration\n* Incomplete or missing medical records","ALL","18 Years",{"count":19,"type":20},4,"ESTIMATED","OBSERVATIONAL","The aim of this retrospective cohort study is to compare the safety and efficacy of induction agents for tracheal intubation in critically ill adult patients.",[24,25,26,27,28,29],"Critically Ill","Intubation Complication","Oxygenation","Airway Management","Propofol","Ketamine",[31],"intubation, critically ill patients, airway management","RECRUITING","2026-04-11",{"date":35,"type":36},"2026-04-14","ACTUAL",{"date":38,"type":20},"2026-04-18",{"date":40,"type":20},"2026-07-01",{"name":42,"class":43},"Zeliha Alicikus","OTHER_GOV",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100606051","eit-vs-dynamic-compliance-guided-peep-titration-during-laparoscopic-gynecological-surgery-100606051","NCT07170514","EIT vs Dynamic Compliance Guided PEEP Titration During Laparoscopic Gynecological Surgery","Electrical Impedance Tomography vs Dynamic Compliance Guided Positive End-expiratory Pressure Titration During Laparoscopic Gynecological Surgery: A Multi-center, Prospective Randomized Trial - TITRANT","TITRANT","Inclusion criteria:\n\n* Patient scheduled for elective laparoscopic gynaecological surgery\n* Age \\> 18 years\n* Signed consent to participate in the trial\n\nExclusion criteria:\n\n* Age \\\u003C 18 years\n* American Society of Anesthesiologists (ASA) physical status IV\n* History of severe restrictive or chronic obstructive pulmonary disease (COPD, Global Initiative for Chronic Obstructive Lung Disease grades III or IV)\n* Uncontrolled bronchial asthma\n* Pulmonary metastases\n* History of any thoracic surgery\n* Need for thoracic drainage before surgery\n* Congestive heart failure (NYHA grades III or IV)\n* Extreme obesity (BMI\\>35 kg m-2)\n* Lack of patient's consent","FEMALE",{"count":55,"type":20},200,"INTERVENTIONAL",[58],"NA","The goal of this randomized controlled clinical trial is to compare the pulmonary protective effects of two different positive end-expiratory pressure (PEEP) titrating methods in patients with non-injured lungs undergoing laparoscopic gynecological surgery.\n\nDespite dynamic pulmonary compliance (Cdyn) guided lung protective ventilation has several proven advantages, the investigators hypothesize that optimizing intraoperative mechanical ventilation using electrical impedance tomography (EIT) may further improve patient outcomes, enhance postoperative recovery, shorten in-hospital stay and reduce healthcare related costs.\n\nThe main questions aim to answer are:\n\n* May EIT-guided PEEP titration reduce the mechanical power of ventilation and improve oxygenation more significantly than the Cdyn-guided method?\n* What effect might a decrease in mechanical power of ventilation have on postoperative pulmonary complications?\n\nParticipants will:\n\n* Receive an EIT-guided or a Cdyn-guided PEEP titration procedure during laparoscopic gynecological surgery.\n* Be assessed for mechanical power of ventilation, oxygenation, atelectasis and postoperative pulmonary complications during and 2 days after surgery.\n* Be followed-up for mortality until the 28th postoperative day.",[61,62,26],"Mechanical Power","Postoperative Pulmonary Complications (PPCs)",[64,65,66,67,68,69,70],"electrical impedance tomography","dynamic pulmonary compliance","positive end-expiratory pressure","mechanical power","pulmonary protective ventilation","Pao\u002FFiO2","postoperative pulmonary complications","2026-04-09",{"date":35,"type":36},{"date":74,"type":36},"2025-11-10",{"date":76,"type":20},"2027-10-30",{"name":78,"class":79},"Pest County Flór Ferenc Hospital","OTHER",3,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":56,"phases":91,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":44},"100581645","deep-breathing-exercises-and-incentive-spirometry-after-rib-fracture-100581645","NCT06853002","Deep Breathing Exercises and Incentive Spirometry After Rib Fracture","Comparison Between Deep Breathing Exercises and Incentive Spirometry After Rib Fracture","Inclusion Criteria:\n\n* Patients who developed rib fractures due to thoracic trauma\n\nExclusion Criteria:\n\n* Patients who are unconscious\n* Patients with a history of chronic obstructive pulmonary disease or asthma\n* Patients with an Injury Severity Score (ISS) ≥ 16\n* Patients who require mechanical ventilation","80 Years",{"count":90,"type":20},104,[58],"Chest trauma patients constitute approximately 10-15% of all traffic accidents. Many complications may occur after chest trauma, including rib fracture, pneumothorax, hemothorax, lung contusion, flail chest, atelectasis, respiratory failure and even death. Atelectasis is the most common of these complications. This study planned to investigate the effects of spirometry and deep breathing exercises on oxygenation after rib fracture.",[94,26],"Rib Fractures",[94,96,97],"Breathing exercises","Postoperative complications","2026-03-13",{"date":100,"type":36},"2026-03-16",{"date":102,"type":36},"2025-02-15",{"date":104,"type":20},"2026-11-01",{"name":106,"class":79},"Samsun University",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":56,"phases":118,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":44},"100599624","phase-1-the-impact-of-remimazolam-tosilate-on-oxygenation-and-postoperative-cognitive-function-in-elderly-patients-undergoing-thoracoscopic-lobectomy-100599624","NCT07086911","The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy","The Impact of Tosylate Remimazolam on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy","Inclusion Criteria:\n\n* Patients scheduled for thoracoscopic surgery under general anesthesia at the First Affiliated Hospital of Kunming Medical University;\n* Age 65 to 75 years old;\n* BMI18-30 kg\u002Fm ²;\n* ASA grades I to III;\n* There are no contraindications to any related drugs;\n* Both the patient and their family members agreed to participate in this study and signed the informed consent form\n\nExclusion Criteria:\n\n* Patients with severe sinus bradycardia (heart rate \\\u003C50 beats per minute) and atrioventricular block;\n* Respiratory tract infection and the use of non-steroidal anti-inflammatory drugs or hormone drugs within 2 weeks before the operation;\n* Those with central nervous system and psychological disorders;\n* Have taken anticholinergic drugs, anticonvulsants, anti-anxiety drugs, antidepressants, etc. in the past half year;\n* Severe liver and kidney dysfunction and immune system diseases, uncontrolled hypertension and diabetes;\n* History of preoperative radiotherapy and chemotherapy;\n* Patients with communication barriers who are unable to cooperate to complete the test;\n* The OLV \\\u003C 60 min or interim thoracotomy patients;\n* Intraoperative blood loss \\> 1500ml;\n* Patients transferred to the ICU ward after the operation.","65 Years","75 Years",{"count":117,"type":20},150,[119,120],"PHASE1","PHASE2","Background: During thoracoscopic lobectomy in elderly patients, one-lung ventilation (OLV) is a common procedure. However, this process is prone to cause hypoxemia and postoperative cognitive dysfunction (POCD), which seriously affect the postoperative recovery and prognosis of patients. At present, there is still a need for further exploration and optimization of effective anesthetic drugs and regimens to improve intraoperative oxygenation and reduce the occurrence of POCD in such patients. Remimazolam besylate, as a novel anesthetic drug, has not yet had its advantages in thoracoscopic surgery in elderly patients fully clarified. This study is conducted to explore its effects on oxygenation and postoperative cognitive function in this specific surgical setting, so as to provide new references for clinical drug use and improve the perioperative management and postoperative outcomes of elderly patients.\n\nObjective:To mainly investigate the effects of remimazolam besylate on oxygenation and intrapulmonary shunting during one-lung ventilation in elderly patients undergoing thoracoscopic surgery, as well as its impact on postoperative cognitive dysfunction.\n\nResearch Content:The research content includes the observation and evaluation of oxygenation index, shunt fraction, cognitive function status, intraoperative conditions (such as OLV duration, blood loss, etc.),hemodynamic indicators, blood gas analysis indicators, serum indicators, and postoperative recovery status (such as postoperative sedation, pain, adverse reactions, pulmonary complications, hospital stay duration, etc.) in elderly patients undergoing thoracoscopic lobectomy.\n\nResearch Methods:\n\nStudy Design: A randomized controlled study will be adopted. Case Selection: Inclusion Criteria: Patients aged 65-75 years old, with a BMI of 18-30 kg\u002Fm², ASA classification of I-III, no contraindications to related drugs, and consent from the patient and their family to participate in the study and sign the informed consent form, who are scheduled for thoracoscopic surgery under general anesthesia at the First Affiliated Hospital of Kunming Medical University from December 2024 to December 2025, will be selected. Exclusion Criteria: Patients with severe arrhythmias, preoperative respiratory tract infections, central nervous system diseases, hepatic or renal insufficiency, immune system diseases, a history of preoperative radiotherapy or chemotherapy, communication barriers, etc., will be excluded. Exclusion Criteria: Patients with OLV duration less than 60 minutes or conversion to thoracotomy, intraoperative blood loss greater than 1000 ml, and those transferred to the ICU after surgery will be excluded.\n\nGrouping and Anesthesia Methods: Patients will be randomly divided into three groups: Remimazolam Group (R Group), Propofol Group (P Group), and Remimazolam Combined with Propofol Group (C Group), with 50 cases in each group. After anesthesia induction, the three groups will be maintained with different drugs and doses until 10 minutes before the end of the surgery, while remifentanil will be combined, and the infusion rate of the drugs will be adjusted according to the BIS value.\n\nData Collection: Detailed records will be kept of the patient's general information, intraoperative conditions, perioperative cardiovascular reactions, blood gas analysis indicators, serum indicators, as well as postoperative cognitive function assessment, sedation and pain assessment, adverse reactions, and complications.\n\nSample Size Calculation: Based on the oxygenation index at 60 minutes of OLV, which is the primary endpoint, and in combination with relevant literature and statistical requirements, the sample size for each group is calculated to be 58. Considering the dropout and withdrawal rates, the final sample size for each group is determined to be 70.\n\nStatistical Analysis: SPSS 27.0 software will be used. Normal distribution measurement data, non-normal distribution measurement data, and count data will be analyzed using independent sample t-test, Wilcoxon rank-sum test, and chi-square test or Fisher's exact probability method, respectively. A P value less than 0.05 will be considered statistically significant.\n\nTechnical and Feasibility Assurance: Relying on the clinical resources and technical platform of the First Affiliated Hospital of Kunming Medical University, as well as the research team's proficiency in thoracic anesthesia techniques and the operation of related equipment, the smooth conduct of the study will be ensured.",[123,124,26,125],"Remimazolam Besylate","Thoracoscopic Lobectomy","Postoperative Cognitive Dysfunction","NOT_YET_RECRUITING","2025-07-17",{"date":129,"type":36},"2025-07-25",{"date":131,"type":20},"2025-08",{"date":133,"type":20},"2026-12",{"name":135,"class":79},"Jinqiao Qian",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":44},"100578942","neonatal-oximeter-bias-study-100578942","NCT06817850","Neonatal Oximeter Bias Study","Evaluation of the Differences Between Simultaneous SpO2s Readings in the NICU: a Multicenter Observational Study","NOB","Inclusion Criteria:\n\n* Observations of any infant in the neonatal ICU with two simultaneous oximeter monitors may be included. The sites' Ethics Committee must review the protocol, approve participation and determine if Informed Consent is required. If required, it might be prospective, that is prior to collecting any data, or retrospective.\n\nExclusion Criteria:\n\n* Observations are to be made at the convenience of the Investigative team. They should reflect routine situation, and not be selected to specifically capture problems. Thus, the photo should be taken immediately with both displays are on in the view, and not delayed until something interesting happens. Observations should not be made if any of the following exclusion criteria are meet. If after collection, any of these are meet, the data should not be included as an Observation on the Observation-CRF.\n\n  * One oximeter monitoring post ductal SpO2 in infant with clinically relevant shunt.\n  * Monitor and A-FiO2 Oximeter not reading between 70-100%\n  * Less than 5 minutes between repeat Observations\n  * No more than 5 measurements per day per subject with sensors in same position and same oximeters (i.e., every time either sensor is moved, 5 new Observations can be made that day).\n  * Presence of motion artifact\n  * Presence of sensor integrity alarms\u002Falerts",{"count":145,"type":20},40,"The study aims to determine if there is a systematic difference (bias) between pulse oximeters used in control systems for automated oxygen delivery (A-FiO2) and those used in monitoring systems.\n\nWhen using A-FiO2 systems there are commonly two oximeter probes on the infant with two difference readouts. Nurses report frustration that the two readings are often markedly different. It is understandable that physiological differences between sensor sites might reflect different regional oxygen saturation levels. It is also possible that there is a relevant systematic bias between difference monitors and sensors.\n\nTherefore, a large systematic multicenter study is needed to determine whether these frequent differences should be ignored as physiological noise or considered clinically relevant.",[148,26],"Neonatal Respiratory Distress",[150,151,152],"pulse oximetry","automated FiO2 control","SpO2","2025-03-24",{"date":155,"type":36},"2025-03-25",{"date":157,"type":20},"2025-03-15",{"date":159,"type":20},"2025-10-31",{"name":161,"class":79},"Czech Technical University in Prague",{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":56,"phases":171,"briefSummary":172,"conditions":173,"keywords":179,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":44},"100583690","high-flow-nasal-oxygen-for-preoxygenation-in-emergency-surgery-patients-with-full-stomachs-100583690","NCT06879600","High-Flow Nasal Oxygen for Preoxygenation in Emergency Surgery Patients With Full Stomachs","Research on Pre-Anesthetic Blood Oxygenation Effect of High-Flow Nasal Oxygen for Emergency Surgery Patients With Full Stomachs","HFNC","Inclusion Criteria:\n\n* Emergency surgical patients at risk of gastric fullness requiring endotracheal intubation.\n* Patients aged 18 years or older.\n* Health status classified as ASA I or II.\n* Mallampati classification I or II.\n\nExclusion Criteria:\n\n* Patients with a predicted difficult airway, facial deformities, or an inability to achieve a proper mask seal.\n* Patients with respiratory diseases.\n* Pregnant patients.\n* Patients allergic to anesthesia or resuscitation drugs.\n* Patients who do not consent to participate in the study.",{"count":55,"type":20},[58],"Patients with full stomachs face a high risk of regurgitation and aspiration under general anesthesia. To minimize the time between the loss of airway protective reflexes and successful tracheal intubation, rapid sequence induction intubation is commonly used. However, these patients are particularly vulnerable to hypoxemia during anesthesia induction, especially in emergency cases. Pre-oxygenation before induction is crucial for ensuring patient safety during apnea.\n\nHigh-flow nasal oxygen (HFNO) therapy, which consists of an air\u002Foxygen blender, an active humidifier, and a single heated circuit, has recently gained widespread use in intensive care units (ICUs) for managing hypoxemic respiratory failure. HFNC can deliver a constant fraction of inspired oxygen (FiO₂) from 0.21 to 1.0 at high flow rates (up to 60 L\u002Fmin or higher). Its advantages include generating continuous positive airway pressure, reducing anatomical dead space, improving ventilation-perfusion matching, enhancing mucociliary clearance, and decreasing the work of breathing.\n\nGiven these benefits, HFNO has the potential to improve pre-oxygenation before and during anesthesia induction in emergency surgery patients with full stomachs.",[174,26,175,176,177,178],"High-flow Nasal Cannula","General Anesthesia","Induction Anesthesia","Emergency Surgery Patients","Full Stomach",[180,181,182,177,183],"High-flow nasal cannula","oxygenation","Induction anesthesia","full stomach","2025-03-10",{"date":186,"type":36},"2025-03-17",{"date":188,"type":36},"2023-07-19",{"date":190,"type":20},"2026-12-31",{"name":192,"class":79},"Nguyen Dang Thu"]