[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"p53-mutations\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:p53-mutations":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100522854","phase-2-arsenic-trioxide-combined-with-chemotherapy-for-the-treatment-of-p53-mutated-pediatric-cancer-100522854",false,"NCT06088030","Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric Cancer","Clinical Research on Efficacy and Safety of Arsenic Trioxide Combined With Chemotherapy in p53-mutated Pediatric Cancer Patients：A Prospective，Single-arm, Multi-center Study","Inclusion Criteria:\n\n1. Pathological diagnosis basis of malignant tumor；\n2. Patients not more than 18 years old;\n3. Patient has either germline or somatic p53 mutations, which was shown to be partially\u002Fcompletely restored to function by ATO in in vitro experiments (http:\u002F\u002Fwww.rescuep53.net);\n4. There are measurable lesions;\n5. Guardians agreed and signed informed consent.\n\nExclusion Criteria:\n\nPatients with one or more critical organs failure such as heart, brain, kidney failure.","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","This prospective, single-arm, multi-center clinical trial aims to explore and evaluate the efficacy and safety of arsenic trioxide combined with chemotherapy for pediatric cancer with p53 mutation.",[26,27,28],"Pediatric Cancer","Li-Fraumeni Syndrome","p53 Mutations",[30],"Arsenic Trioxide","RECRUITING","2024-01-02",{"date":34,"type":35},"2024-01-03","ACTUAL",{"date":37,"type":35},"2023-12-13",{"date":39,"type":20},"2031-12-14",{"name":41,"class":42},"Yang Li","OTHER"]