[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pacemaker-ddd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pacemaker-ddd":129},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,65,91,116,140],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100440466","conduction-system-pacing-with-left-bundle-branch-pacing-as-compared-to-standard-right-ventricular-pacing-100440466",false,"NCT05015660","Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing","LEFT Bundle Pacing vs Standard Right Ventricular Pacing for Heart Failure","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Patients with an ejection fraction of \\>35%\n3. Patients with an indication for ventricular pacing and high-degree atrioventricular block where the degree of anticipated RV pacing is \\>90% including:\n\n   1. Third degree AV block\n   2. Symptomatic or asymptomatic second-degree AV block\n   3. First degree AV block ≥ 280ms with a narrow QRS, or ≥ 240ms with an intraventricular delay (QRS duration ≥120ms)\n4. Echocardiogram within the last 3 months, with ability to have DICOM images\n\nExclusion Criteria:\n\n1. Indication for an implantable cardioverter defibrillator\n2. Presence of a mechanical tricuspid valve\n3. Any prior attempt at implantation of an ICD, CRT, HBP, or LBBP\n4. Lack of capacity to consent\n5. Other serious medical condition with life expectancy of \\\u003C2 years\n6. Pregnancy\n7. Patients in whom the conduction system abnormality is expected to be transient or recover over time\n8. Patients with permanent atrial fibrillation","ALL","18 Years",{"count":19,"type":20},1300,"ESTIMATED","INTERVENTIONAL",[23],"NA","High burden right ventricular (RV) pacing has been shown to increase cardiovascular mortality, incidence of heart failure (HF), worsen left ventricular (LV) function and accelerate the development of atrial fibrillation (AF). High percentage ventricular pacing and wider paced QRS in the setting of normal baseline LV ejection fractions have consistently been shown to be independent risk factors for pacing-induced cardiomyopathy. Left bundle branch pacing (LBBP) has emerged as a potential alternative pacing mechanism that may avoid LV dyssynchrony and pacing-induced LV dysfunction by mimicking native electrical conduction.",[26,27],"Pacemaker DDD","Heart Block",[29],"left bundle branch pacing","RECRUITING","2026-03-09",{"date":33,"type":34},"2026-03-11","ACTUAL",{"date":36,"type":34},"2022-09-01",{"date":38,"type":20},"2030-01-01",{"name":40,"class":41},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":42},"100588151","remote-alert-pathway-to-optimize-care-of-cardiac-implantable-electrical-devices-100588151","NCT06937658","Remote Alert Pathway To Optimize CaRe of Cardiac Implantable Electrical Devices","RAPTOR-CIED","Inclusion Criteria:\n\n1. Adult aged \\> 18 years\n2. Clinically stable by investigator assessment\n3. Has a newly implanted or existing wireless CIED: single, dual-chamber, biventricular, subcutaneous\u002Fextravascular, and leadless systems are all eligible, including pacemakers or implantable cardioverter-defibrillators (ICDs)\n4. CIED is from one of the 4 major CIED manufacturers in the US market (99% of implants in the US): Medtronic, Boston Scientific, Abbott, Biotronik\n5. Currently enrolled in remote monitoring as part of standard of care\n6. Primary clinical electrophysiology follow-up at the enrolling center\n7. Understands spoken and written English, Spanish, or Portuguese\n8. Has sufficient cognitive function to answer standardized questions about study rationale and procedures.\n\nExclusion Criteria:\n\n1. Presence of insertable cardiac monitor, either in isolation or in combination with any other CIED\n2. Listed for cardiac transplantation prior to enrollment (N.B. if a patient becomes listed for transplantation during the study, they may continue study participation)\n3. Participation in another study related to novel CIED technology or remote monitoring.",{"count":51,"type":20},120,[23],"The Remote Alert Pathway to Optimize Care of Cardiac Implantable Electrical Devices (RAPTOR-CIED) Study is a pragmatic, multi-center, randomized trial with 1:1 patient-level randomization comparing the safety and effectiveness of alert-driven care versus guideline-based care for patients with wireless cardiac implantable electrical devices (CIEDs).\n\nThe study will be conducted in 2 phases: a Feasibility Phase and a Main Phase. This registration outlines the goals and design features of the Feasibility Phase of the study.",[26,55],"Implantable Defibrillator User","2026-01-05",{"date":58,"type":34},"2026-01-07",{"date":60,"type":34},"2025-05-01",{"date":62,"type":20},"2026-06-30",{"name":64,"class":41},"Beth Israel Deaconess Medical Center",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":74,"phases":4,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":42},"100507205","left-bundle-branch-area-mapping-for-conduction-system-pacing-100507205","NCT05884359","Left Bundle Branch Area Mapping for Conduction System Pacing","Inclusion Criteria:\n\n* 30 consecutive patients ages 18 through 88 that undergo Left Bundle Branch area pacemaker implantation.\n\nExclusion Criteria:\n\n* Recent MI-less than 3 months\n* Recent Percutaneous Coronary Revascularization-less than 2 weeks\n* Recent Open-Heart Procedures (CABG, Valvular procedures, etc.)-less than 1 month\n* Patients who are acutely ill and unstable, from the investigator's perspective, but require an urgent permanent pacemaker","88 Years",{"count":73,"type":20},30,"OBSERVATIONAL","This study will utilize 3D mapping as a tool to explore electro-anatomical and electrocardiographic characteristics of the Left Bundle Branch Area. We plan on prospectively reviewing the data found from 3D mapping the left bundle branch implantation cases and using the data to improve understanding of electro-anatomical characteristics of this area for a better definition of the implantation target and depth.",[77,26],"Left Bundle-Branch Block",[79,80,81],"left bundle branch block","pacemaker","physiologic stimulation","2025-12-09",{"date":84,"type":34},"2025-12-17",{"date":86,"type":34},"2023-06-01",{"date":88,"type":20},"2026-12",{"name":90,"class":41},"Steward St. Elizabeth's Medical Center of Boston, Inc.",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":74,"phases":4,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":42},"100505994","non-invasive-method-for-evaluation-of-cardiac-resynchronization-therapy-100505994","NCT05868616","Non-Invasive Method for Evaluation of Cardiac Resynchronization Therapy","NIME-CRT","Inclusion Criteria:\n\n* Patients referred for CRT implantation or postoperative control at Oslo University Hospital based on the European Society of Cardiology (ESC) guidelines (2021), and criteria below:\n\n  1. Sinus rhythm.\n  2. New York Heart Association class II \u002F III heart failure on diagnosis and on optimal medical therapy.\n  3. Left bundle branch block.\n  4. QRS duration ≥ 130 ms.\n  5. Left ventricular ejection fraction ≤ 40%.\n  6. Patients must have echocardiography examination before implantation\n  7. Informed consent obtained from the patient.\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years and \\> 80 years;\n2. Ongoing atrial fibrillation;\n3. Complete atrioventricular block","80 Years",{"count":100,"type":20},80,"Left bundle branch block (LBBB) exists in about 25% of patients with congestive heart failure and is associated with worsened prognosis. Cardiac resynchronization therapy (CRT) has been one of the most important advancements in the past two decades for patients with LBBB heart failure. However, 30-40% of patients receiving a CRT do not benefit from it. In this study, the investigators will test a noninvasive device to evaluate acute effect of CRT during implantation and at follow-up CRT controls. In addition, echocardiography will be performed during CRT turned ON and OFF to visualize the changes in intraventricular flow and functional parameters of the heart.",[103,26,104,105,106],"Heart Failure","Cardiomyopathies","Heart Diseases","Cardiovascular Diseases","2025-08-05",{"date":109,"type":34},"2025-08-06",{"date":111,"type":34},"2023-03-21",{"date":113,"type":20},"2031-03",{"name":115,"class":41},"Oslo University Hospital",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":74,"phases":4,"briefSummary":126,"conditions":127,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":42},"100313243","prospective-database-for-prediction-of-atrial-fibrillation-in-pacemaker-and-icd-patients-100313243","NCT03357926","Prospective Database for Prediction of Atrial Fibrillation in Pacemaker and ICD Patients","SAFE-ME - Prospective Database for Prediction of Atrial Fibrillation in Pacemaker and ICD Patients","SAFE-ME","Inclusion Criteria:\n\n* Implanted pacemaker or implanted cardioverter defibrillator (ICD) with atrial lead\n* CHADS-VASc Score of 2 or more\n* Sinus rhythm or atrial paced rhythm\n* Atrial stimulation rate 50% or less\n* ModeSwitch rate 50% or less since last pacemaker interrogation\n\nExclusion Criteria:\n\n* pacemaker or ICD malfunction\n* atrial fibrillation (AF) at time of pacemaker \u002F ICD interrogation\n* AF during 24-hour Holter ECG monitoring\n* permanent AF",{"count":125,"type":20},250,"Atrial fibrillation (AF) is associated with a five-fold increased risk of cerebrovascular stroke. While the risk of stroke in patients with known AF can be calculated via AF stroke prediction risk scores, the prediction of AF occurrence per se in individual patients remains difficult.\n\nWe will recruit 250 patients with an implanted dual-chamber Pacemaker (PM) or an implantable cardioverter Defibrillator (ICD) with atrial lead to ensure continuous rhythm monitoring during follow up. At baseline, we will gather clinical and device data of patients. For AF prediction based on surface Electrocardiography (ECG), 24-h Holter ECG monitoring will be performed. After 6 months, we will assess the occurrence of AF during the study period via interrogation of PM\u002FICD. The resulting data will be used to develop algorithms including clinical, device and ECG data for prediction of the development of AF in individual patients. If possible, we will develop a risk score of high accuracy by combination of demographical, clinical and technical parameters of device patients. The resulting risk score could potentially help to facilitate the decision if anticoagulation is necessary in patients with either risk of AF or embolic stroke of unknown origin. Furthermore, Hayn et al. (AIT Austrian Institute of Technology) are currently developing algorithms to predict the occurrence of AF surface ECG data. It is an additional aim of this project to support the development of this algorithm in pacemaker and ICD patients and to increase the accuracy of AF prediction with clinical parameters and other parameters available to patients with implanted pacemaker (PM) or implanted cardioverter-defibrillator (ICD).",[128,129,130],"Atrial Fibrillation","Pacemaker Ddd","ICD","2024-11-19",{"date":133,"type":34},"2024-11-21",{"date":135,"type":34},"2017-03-01",{"date":137,"type":20},"2025-12",{"name":139,"class":41},"Medical University of Graz",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":148,"targetDuration":150,"studyType":74,"phases":4,"briefSummary":151,"conditions":152,"keywords":156,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":42},"100394507","pacing-to-maintain-physiologic-ventricular-activation-100394507","NCT04416958","Pacing to Maintain Physiologic Ventricular Activation","Pacing for Cardiac Resynchronisation Using the Intrinsic Conduction System to Maintain Physiologic Ventricular Activation","Pace-Conduct","Inclusion Criteria:\n\n* Pacemaker or ICD Implantation aiming to avoid pacing induced ventricular dyssynchrony according to current guidelines\n* age \\>= 18 years\n\nExclusion Criteria:\n\n* no informed consent for the procedure given\n* no follow-up data",{"count":149,"type":20},200,"1 Year","Right ventricular pacing causes ventricular dyssynchrony and may be associated with impaired outcome. In the last decade, several approaches for more physiological pacing became available and were implemented in the latest guidelines. However, compared to conventional device implantation, cardiac resynchronization, His bundle pacing and left bundle area pacing remain demanding procedures in the individual case. Goal of the single center observational \"Pace conduct\" study is to evaluate implantation success, safety and outcome of pacing methods that maintain physiologic ventricular activation.",[26,153,154,155,77,130],"His Bundle Pacing","LBB Area Pacing","Pacing-Induced Cardiomyopathy",[157,158,159],"His bundle pacing","LBB area pacing","cardiac resynchronisation therapy","2024-10-11",{"date":162,"type":34},"2024-10-15",{"date":164,"type":34},"2018-01-01",{"date":166,"type":20},"2030-12-31",{"name":168,"class":41},"Klinikum-Fuerth"]