[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pacing-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pacing-therapy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,73,103,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100642820","posterosuperior-bundle-pacing-for-prevention-of-atrial-fibrillation-in-patients-with-sinus-node-dysfunction-100642820",false,"NCT07645066","Posterosuperior Bundle Pacing for Prevention of Atrial Fibrillation in Patients With Sinus Node Dysfunction","A Prospective, Multicenter, Randomized Controlled Trial Evaluating the Effect of Posterosuperior Bundle Pacing on Atrial Fibrillation Prevention in Patients With Sinus Node Dysfunction","PSB-AF","Inclusion Criteria:\n\n* Age ≥18 years\n* Indication for permanent pacemaker implantation, including:\n* Sinus node dysfunction, defined as at least one of the following:\n* Symptomatic sinus bradycardia\n* Tachy-brady syndrome\n* Chronotropic incompetence\n* Sinus pause \u002F arrest\n* Atrioventricular block (if present); if ventricular pacing is required, left bundle branch area pacing is planned\n* Expected survival \\>1 year\n* Panned implantation of a device capable of detecting atrial high-rate episodes\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Persistent atrial fibrillation (AF) (\\>7 days), long-standing persistent AF, permanent AF, or prior atrioventricular node ablation\n* Prior cardiac implantable electronic device (CIED) requiring replacement, upgrade, or revision\n* Indication for cardioverter-defibrillator (ICD) or cardiac resynchronization therapy (CRT-D)\n* Prior cardiac surgery, severe hepatic or renal dysfunction, or other life-threatening systemic diseases\n* Acute myocardial infarction within 3 months before enrollment\n* Persistent left superior vena cava or dextrocardia\n* Pregnant or breastfeeding women, or women of childbearing potential not using effective contraception\n* Participation in another clinical trial that may interfere\n* Any condition that, in the opinion of the investigator, makes participation unsuitable","ALL","18 Years",{"count":20,"type":21},300,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate whether posterosuperior bundle (PSB) pacing reduces the incidence of atrial fibrillation (AF) in patients with sinus node dysfunction (SND) undergoing pacemaker implantation. Approximately 300 patients will be enrolled and randomized to receive atrial pacing at either the PSB region or the right atrial appendage (RAA). The primary endpoint is the occurrence of AF episodes lasting ≥6 minutes, as detected by device or surface electrocardiogram. Patients will be followed for up to 24 months.",[27,28],"Pacing Therapy","Cardiac Pacing",[30,31,32,33],"Posterosuperior bundle pacing","Right atrial appendage pacing","Physiological pacing","atrial pacing","NOT_YET_RECRUITING","2026-06-08",{"date":37,"type":38},"2026-06-12","ACTUAL",{"date":40,"type":21},"2026-06-01",{"date":42,"type":21},"2029-02-01",{"name":44,"class":45},"Shanghai Tong Ren Hospital","OTHER",10,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},"100638995","immediate-electrophysiological-effects-of-different-atrial-pacing-sites-on-p-wave-characteristics-100638995","NCT07603648","Immediate Electrophysiological Effects of Different Atrial Pacing Sites on P-Wave Characteristics","Prospective Within-Subject Evaluation of Immediate Electrophysiological Effects of Multiple Atrial Pacing Sites on Atrial Activation and P-Wave Morphology","Multi-site AP","Inclusion Criteria:\n\n* Age ≥18 years\n* Sinus rhythm at baseline\n* Indication for permanent pacemaker implantation with planned atrial lead placement\n* Willing and able to provide written informed consent\n\nExclusion Criteria:\n\n* Long-standing persistent or permanent atrial fibrillation, or prior atrioventricular node ablation\n* Prior cardiac implantable electronic device (CIED) requiring revision, replacement, or upgrade\n* Indication for implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D)\n* Significant valvular heart disease, cardiomyopathy, or prior cardiac surgery\n* Angina or acute myocardial infarction within 3 months before enrollment\n* Chronic use of antiarrhythmic drugs\n* Severe hepatic or renal dysfunction, or other serious systemic diseases\n* Participation in another clinical study that may interfere with the objectives of this study",{"count":56,"type":21},35,[24],"This is a prospective, single-center, non-randomized, within-subject interventional study. The purpose is to compare the immediate effects of different atrial pacing sites on atrial electrical activation, as reflected by P-wave characteristics on surface electrocardiography (ECG).\n\nDuring pacemaker implantation, short-term pacing will be performed sequentially at multiple predefined atrial sites, including the right atrial appendage (RAA), atrial septum, Bachmann's bundle (BB) area, and posterosuperior bundle (PSB) regions. ECG parameters will be recorded at each site to evaluate differences in P-wave duration and morphology.",[27,28],[33,61,62,30],"physiological pacing","Bachmann's bundle pacing","RECRUITING","2026-05-18",{"date":66,"type":38},"2026-05-22",{"date":68,"type":38},"2026-03-31",{"date":70,"type":21},"2026-10-31",{"name":44,"class":45},2,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":72},"100614199","central-haemodynamics-and-pacing-for-av-block-100614199","NCT07276490","Central Haemodynamics and Pacing for AV Block","The Pacing in Atrioventricular Block: a Comparative Evaluation of Central Haemodynamics, Cardiac Function, and Quality of Life","PACE-CCQ","Inclusion Criteria:\n\n* Age 18-80 years\n* Diagnosis of atrioventricular block\n* Expected survival \\>1 year\n\nExclusion Criteria:\n\n* Reduced left ventricular ejection fraction (EF \\\u003C45%)\n* Expected ventricular pacing burden \\\u003C20%\n* Inter-arm systolic blood pressure difference \\>15 mmHg\n* Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days\n* Secondary hypertension\n* Orthostatic hypotension\n* Clinically significant valvular heart disease\n* Congenital heart disease\n* Pulse wave analysis or pulse wave velocity measurement cannot be reliably performed\n* Pregnancy or breastfeeding\n* Withdrawal of consent by the subject\n* Loss of contact during the study","80 Years",{"count":83,"type":21},124,[24],"A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.",[87,27,88,89],"Atrioventricular Block","Right Ventricular Pacing","Conduction System Pacing",[91,92,93],"conduction system pacing","atrioventricular block","right ventricular pacing","2026-03-06",{"date":96,"type":38},"2026-03-09",{"date":98,"type":38},"2025-11-28",{"date":100,"type":21},"2027-12-31",{"name":102,"class":45},"University of Tartu",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":112,"phases":4,"briefSummary":113,"conditions":114,"keywords":115,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":126},"100593699","solutions-to-the-challenges-of-conduction-system-pacing-100593699","NCT07009834","Solutions to the Challenges of Conduction System Pacing","CSA","Inclusion Criteria:\n\n1. Patients with a ventricular pacing indication: high grade atrioventricular block and symptomatic trifasicular, bifasicular block or left bundle branch block LBBB for cardiac resynchronisation therapy\n2. Adults willing to take part (ages 18 - 100 years old)\n3. Able to give consent.\n\nExclusion Criteria:\n\n1. Unable to give consent\n2. Children age \\\u003C 18 years and adults \\> 100 years old\n3. Pregnant patients As per standard of care, female patients of child-bearing age will have a urine pregnancy test prior to their procedure.","100 Years",{"count":20,"type":21},"OBSERVATIONAL","Conduction system pacing is a new way of stimulating the heart using pacemaker wires. Traditional pacemakers stimulate the heart muscle which causes disordered heart beats: the walls of the heart move at different times. This wears down the heart over time.\n\nConduction system pacemakers stimulate the heart's electrical system directly producing natural heart beats that are much less disordered. Unfortunately, these pacemakers can only be implanted by a small group of experts at specialised centres with specialist equipment. This study aims to allow conduction system pacemakers to be offered to any patient at any hospital by simplifying the process of inserting the pacemaker wires and the improving the pacemaker's ability to interpret electrical traces.\n\nFirstly, the best locations in the heart for conduction system pacemaker wires using specialised electrical traces, MRI and ultrasound scans will be identified. Features that can be seen on X-ray to guide doctors to these locations will then be identified. Secondly, the investigators will collect electrical information from the pacemaker wires and additional electrical traces to develop an algorithm that can make the interpretation the electrical traces more accurate.",[89,27],[116,108],"Challenges of conduction system pacing","2025-07-09",{"date":119,"type":38},"2025-07-14",{"date":121,"type":38},"2023-11-06",{"date":123,"type":21},"2026-11-06",{"name":125,"class":45},"Imperial College London",1,{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":135,"targetDuration":137,"studyType":112,"phases":4,"briefSummary":138,"conditions":139,"keywords":143,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":126},"100574207","one-year-pacing-dependency-after-tavr-100574207","NCT06756282","One Year Pacing Dependency After TAVR","Pacing Dependence at 1 Year Follow-up in Patients Implanted With a Pacemaker After TAVR: a Multicenter Observational Study.","PACETAVI","Inclusion Criteria:\n\nall patients who need a permanent pacemaker implantation after TAVR\n\nExclusion Criteria:\n\nPatients who have already a pace maker before TAVR",{"count":136,"type":21},90,"12 Months","Pace maker implantation after the procedure of TAVR can be estimated at 15% of patients. However, some studies have shown that the conduction disturbances after TAVR could resolve over time, and that roughly between one- and two-thirds of patients who required a permanent pace maker implantation post TAVR were not found to be dependent at subsequent follow-up. This study aims to evaluate a cohort of patients permanently implanted with a pacemaker post-TAVR for high-grade conductive disorders and to describe the prevalence of effective pacemaker stimulation at 1 year follow-up. Secondary objectives include the evaluation of the prevalence of effective stimulation 3 months after implantation of the pace maker , description of the types of conductive disorders associated with atrial and\u002For ventricular stimulation, description of the initial indication for pacemaker implantation, description of the characteristics of the population with or without stimulation dependency. The objective is to better rationalize indication of permanent stimulation after TAVI",[140,141,27,142],"Patients Above 18 Years","Patient Discharge","Aortic Stenosis (Treated With TAVI)",[144,145,146,147],"transcatheter aortic valve replacement (TAVR)","permanent pacing","conductive disorders","pacing dependency","2025-01-02",{"date":150,"type":38},"2025-01-03",{"date":152,"type":38},"2024-11-13",{"date":154,"type":21},"2027-10-13",{"name":156,"class":45},"University Hospital, Montpellier"]