[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pain-after-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pain-after-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,49,82,107,134,160,192,211,239,264,297,326,351,378],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100625929","intraoperative-bupivacaine-injection-to-reduce-acute-and-chronic-pain-after-tvttvt-o-surgery-randomized-double-blind-trial-100625929",false,"NCT07429019","Intraoperative Bupivacaine Injection to Reduce Acute and Chronic Pain After TVT\u002FTVT-O Surgery. Randomized Double-Blind Trial","Reduction of Post-surgery Pelvic Pain by Bupivacaine Injection During TVT\u002F TVT-O Procedure","PAIN-TVT","Inclusion Criteria:\n\n* Women aged 18 years or older\n* Scheduled to undergo vaginal surgery including TVT or TVT-O procedure for stress urinary incontinence\n* Able and willing to provide written informed consent\n* Willing to complete postoperative follow-up assessments for at least 6 months\n\nExclusion Criteria:\n\n* Planned concomitant abdominal, laparoscopic, or robotic surgery\n* Pre-existing chronic pelvic pain\n* Diagnosis of fibromyalgia\n* Diagnosis of endometriosis\n* Inability to complete follow-up assessments\n* Inability to provide informed consent","FEMALE","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized, double-blind controlled trial will evaluate whether intraoperative injection of bupivacaine at the sling insertion site reduces postoperative pelvic and thigh pain in women undergoing TVT or TVT-O surgery for stress urinary incontinence. Women aged 18 years and older scheduled for vaginal surgery including a mid-urethral sling procedure will be randomly assigned to receive either 0.5% bupivacaine or saline injection at the surgical site at the end of the procedure.\n\nPostoperative pain will be assessed using the Numerical Rating Scale (NRS) within 24 hours after surgery, at one month, and at least six months postoperatively. The study will also evaluate opioid consumption and examine the relationship between early postoperative pain and the development of chronic postsurgical pain. The results may help determine whether local anesthetic injection during sling surgery can improve short- and long-term pain outcomes.",[27,28,29,30],"Pain After Surgery","PSP","Chronic Pain Syndrome","Local Anesthesia Infiltration",[32,33,34,35,36],"TVT","TVTO","Mid Urethral Sling","pain","chronic pain syndrom","NOT_YET_RECRUITING","2026-06-20",{"date":40,"type":41},"2026-06-23","ACTUAL",{"date":43,"type":21},"2026-07-01",{"date":45,"type":21},"2027-10-01",{"name":47,"class":48},"Hadassah Medical Organization","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100610585","phase-4-tegileridine-for-postoperative-pain-after-adolescent-scoliosis-surgery-100610585","NCT07229495","Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery","Efficacy and Safety of Tegileridine for Postoperative Analgesia Following Adolescent Scoliosis Correction Surgery: A Prospective, Multicentre, Double-Blind, Non-Inferiority, Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 10 years to less than 18 years.\n* Scheduled to undergo posterior spinal fusion (PSF) surgery for scoliosis under general anesthesia.\n* American Society of Anesthesiologists (ASA) physical status classification I to III.\n* The participant and their parent or legal guardian voluntarily provide written informed consent prior to any study-related procedures.\n\nExclusion Criteria:\n\n* History of difficult airway, severe respiratory depression (SpO₂ \\\u003C 90%), acute or severe bronchial asthma.\n* History of severe cardiovascular or cerebrovascular disease, such as myocardial infarction, unstable angina, second-degree or higher atrioventricular block, NYHA Class III or higher heart failure, or stroke.\n* Known or suspected gastrointestinal obstruction, including paralytic ileus.\n* Known hypersensitivity to opioids or any component of the study drug formulation.\n* History of psychiatric disorders (e.g., schizophrenia, depression) or cognitive impairment.\n* Diagnosis of neuromuscular scoliosis or presence of any other chronic pain condition that may interfere with postoperative pain assessment.\n* Chronic use of opioid analgesics or use of any analgesic medication within 48 hours prior to surgery.\n* Planned postoperative admission to the intensive care unit (ICU).\n* Any other condition deemed by the investigator to be inappropriate for participation in the study.","ALL","10 Years","17 Years",{"count":60,"type":21},171,[62],"PHASE4","The goal of this clinical trial is to see if a new pain medicine called Tegileridine is at least as effective as morphine (the standard treatment) for pain relief after spinal surgery in teenagers with scoliosis. This type of study is called a \"non-inferiority\" trial. The study will also carefully compare the safety of both medicines.\n\nThe main questions it aims to answer are:\n\nIs Tegileridine no worse than morphine at controlling pain in the first 24 hours after surgery? How do the side effects (like sleepiness or nausea) of Tegileridine compare to those of morphine? Researchers will compare two different doses of Tegileridine against morphine. Neither the participants nor the doctors assessing them will know which medicine is being given.\n\nParticipants in this study will:\n\nReceive one of the three pain medicine options through a pump (called a PCA pump) that they can control themselves after surgery.\n\nUse the pump for up to 48 hours. Regularly rate their pain levels using a simple number scale. Have their health closely monitored by the study team during this time.",[65,27,66],"Scoliosis; Adolescence","Analgesia, Patient-controlled",[68,69,70,71,72],"Tegileridine","Postoperative Pain","Adolescent","Patient-Controlled Analgesia","Scoliosis","2026-06-15",{"date":75,"type":41},"2026-06-17",{"date":43,"type":21},{"date":78,"type":21},"2027-09-30",{"name":80,"class":48},"Peking Union Medical College Hospital",6,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":106},"100633984","phase-2-a-clinical-trial-evaluating-the-efficacy-and-safety-of-hsk55718-in-patients-for-postoperative-pain-treatment-in-abdominal-surgery-100633984","NCT07533786","A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Abdominal Surgery","A Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo- and Active-Controlled Phase II Clinical Study to Evaluate the Efficacy and Safety of HSK55718 Injection for Postoperative Pain Treatment in Abdominal Surgery","Inclusion Criteria:\n\n* Age ≥18 years old, regardless of gender;\n* 18 kg\u002Fm2≤BMI≤30 kg\u002Fm2;\n* American Society of Anesthesiologists (ASA) gradeⅰ-ⅲ;\n* Accept abdominal surgery under general anesthesia;\n* Within 4 hours after the end of surgery, NRS≥4 in the resting state at any time;\n* Fully understand and voluntarily participate this trial, and sign the informed consent form;\n\nExclusion Criteria:\n\n* A history of cardiovascular, respiratory, neurological, or psychiatric diseases that meet the protocol-defined exclusion criteria.\n* Clinically significant abnormalities in laboratory tests during the screening period.\n* A history of severe drug allergy or known allergy to the investigational drug.\n* Continuous use of opioid analgesics for more than 10 days for any reason within 3 months prior to randomization.\n* Use of any medication that may affect analgesia, where the last dose was administered less than 5 half-lives of that drug before randomization.\n* A history of drug abuse, substance abuse, and\u002For alcohol abuse within the past year.\n* Pregnant or lactating women.\n* Participation in another drug clinical trial within 3 months prior to the screening period.\n* Presence of any sensory dysfunction.\n* Presence of any painful physical condition.\n* Subjects with any other factor considered by the investigator to be ineligible for participation in the trial.",{"count":90,"type":21},200,[92],"PHASE2","This is a multi-center, randomized, double-blind, double-dummy, placebo\u002Factive-controlled study. 200 subjects undergoing abdominal surgery under general anesthesia are planned to be enrolled and randomized into the HSK55718 group, morphine group, and placebo group.",[27],"RECRUITING","2026-05-24",{"date":98,"type":41},"2026-05-28",{"date":100,"type":41},"2026-05-22",{"date":102,"type":21},"2026-11-22",{"name":104,"class":105},"Haisco Pharmaceutical Group Co., Ltd.","INDUSTRY",2,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":133},"100640030","impact-of-nol---nociception-level-index-intraoperative-monitoring-on-perioperative-outcomes-in-spine-surgery---a-quality-improvement-pilot-100640030","NCT07608276","Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot","Inclusion Criteria:\n\n* Age \\> 18 years old.\n* ASA I-III\n* Elective spine surgery (laminectomy, spinal fusion, and disc replacement) under general anesthesia.\n* Opioid tolerant and patients with documented chronic pain may be included\n* Patient able to provide informed consent\n\nExclusion Criteria:\n\n* • Use of any type of anesthesia other than general anesthesia (neuraxial, epidural analgesia or local regional anesthesia)\n\n  * Use of intraoperative methadone\n  * Non-sinus heart rate\n  * Pregnancy\u002Flactation\n  * Chronic use of psychoactive drugs within 90 days prior to surgery\n  * Patients currently using IV opioids (IV drug abuse)\n  * Allergy or intolerance to any of the study anesthesia related drugs\n  * History of severe cardiac arrhythmias within the last 12 months\n  * Surgeries less than 1.5 hours (from incision to extubation)",{"count":114,"type":21},100,[24],"The objective of this study is to evaluate the clinical impact of the NOL nociception level index monitoring on intraoperative and post operative patient outcomes and institutional metrics when used to guide intraoperative analgesia dosing in patients undergoing spine surgery under general anesthesia when compared to a case controlled retrospective cohort.",[118,27,119],"Spine Surgery","Anesthesia , Analgesia",[121,35,122,123],"nociception","NOL nociception level index","quality improvement","2026-05-20",{"date":126,"type":41},"2026-05-27",{"date":128,"type":21},"2026-05",{"date":130,"type":21},"2027-03",{"name":132,"class":48},"Medasense Biometrics Ltd",1,{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":141,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":148,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":156,"leadSponsor":158,"locationsCount":133},"100637067","riss-versus-lower-thoracic-esp-block-for-analgesia-after-laparoscopic-abdominal-surgery-a-randomized-trial-100637067","NCT07593300","RISS Versus Lower Thoracic ESP Block for Analgesia After Laparoscopic Abdominal Surgery: A Randomized Trial","Analgesic Efficacy of Ultrasound-Guided Rhomboid Intercostal and Subserratus (RISS) Block Versus Lower Thoracic Erector Spinae Plane Block (ESPB) After Abdominal Laparoscopic Surgery","Inclusion Criteria:\n\n* Patients scheduled for laparoscopic abdominal surgery (e.g., cholecystectomy, colectomy, sleeve gastrectomy, hernia repair, appendectomy).\n* Age from 18 - 60 years old.\n* Both sexes.\n* American Society of Anesthesiology (ASA) classification I, II. (i.e., ASA I: a normal healthy patient; ASA II: patients with mild controlled systemic disease.\n\nExclusion Criteria:\n\n* Patients who refuse the research consent.\n* Allergy to local anesthetic drugs.\n* Cardiac arrhythmia.\n* Bleeding tendency (including pre-existing blood disease and patients on full anticoagulant therapy).\n* Morbid obese patients (BMI\\>35 kg\u002Fm2)\n* Vascular compromise of lower extremity (e.g., Burger disease, Raynaud's disease).\n* Connective tissue disease (e.g., Scleroderma).\n* Suspected malignancy or intra-abdominal infection.",true,"60 Years",{"count":144,"type":21},70,[24],"The goal of this clinical trial is to investigate the analgesic efficacy of ultrasound-guided Romboid Intercostal and Subserratus (RISS) block versus lower thoracic Erector Spinae Plane (ESP) block after laparoscopic abdominal surgery. The main questions it aims to answer are:\n\nDoes ultrasound-guided Romboid Intercostal and Subserratus (RISS) block is effective as the lower thoracic Erector Spinae Plane (ESP) block for intra and postoperative analgesia after laparoscopic abdominal surgery for the first 24 hours? What complications do participants have when doing these interventions?\n\nResearchers will compare the analgesic efficacy of ultrasound-guided Romboid Intercostal and Subserratus (RISS) block with the lower thoracic Erector Spinae Plane (ESP) block after laparoscopic abdominal surgery.\n\nParticipants will:\n\nStart general anesthesia and be given either block according to the randomization chart.\n\nThe blood pressure and heart rate will be measured at intervals to determine if the participants need extra intraoperative analgesics.\n\nNumerical Rating Scale (NRS) will be used postoperatively to test pain severity.\n\nRescue morphine analgesia will be measured and compared in both groups.\n\nAny complications will be reported.\n\nPatient and surgeon satisfaction will be measured.",[27],[149,150,151],"Erector Spine Plane Block","Laparoscopic surgery","Rhomboid Intercostal block","2026-05-13",{"date":154,"type":41},"2026-05-18",{"date":124,"type":21},{"date":157,"type":21},"2026-12-31",{"name":159,"class":48},"Misr University for Science and Technology",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":22,"phases":170,"briefSummary":171,"conditions":172,"keywords":178,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":188,"leadSponsor":190,"locationsCount":106},"100615087","virtual-reality-as-a-method-for-pain-and-anxiety-control-during-first-trimester-procedural-abortion-100615087","NCT07288047","Virtual Reality as a Method for Pain and Anxiety Control During First Trimester Procedural Abortion","Virtual Reality as an Adjunctive Agent for the Management of Pain and Anxiety During First Trimester Procedural Abortion: a Randomized Controlled Trial","CALM-VR","Inclusion Criteria:\n\n* Patients at Planned Parenthood of Western Pennsylvania who have decided to undergo and are eligible for a procedural abortion.\n* 18 years old or older\n* \\\u003C14 weeks gestation on day of abortion\n* Able to comprehend written English\n* Willing to comply with the study protocol\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* History of vertigo\n* History of epilepsy\n* Claustrophobia\n* Significant hearing or visual impairments (such as deafness or blindness)\n* Require hearing aids\n* Have an implanted medical device, such as cardiac pacemaker or defibrillator\n* Require misoprostol for cervical preparation\n* Prior unsuccessful attempt at abortion during this pregnancy",{"count":169,"type":21},72,[24],"The goal of this clinical trial is to learn whether use of a virtual reality (VR) headset showing a meditative nature video will help reduce pain and anxiety during a first trimester procedural abortion. Investigators will enroll 72 patients undergoing a first trimester procedural abortion with usual care to manage pain and anxiety compared to use of a VR headset in addition to usual care to see if use of the VR headset will decrease pain and anxiety and increase satisfaction with the procedure.",[173,174,27,175,176,177],"Abortion, First Trimester","Pain Management","Satisfaction","Satisfaction With Care","Anxiety After Surgery",[179,180,181,182,183],"satisfaction","virtual reality","procedural abortion","pain control","anxiety control","2026-05-01",{"date":186,"type":41},"2026-05-06",{"date":184,"type":41},{"date":189,"type":21},"2026-10-30",{"name":191,"class":48},"Study Investigator",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":200,"briefSummary":201,"conditions":202,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":4},"100635365","phase-2-a-clinical-trial-evaluating-the-efficacy-and-safety-of-hsk55718-in-patients-for-postoperative-pain-treatment-in-orthopedic-surgery-100635365","NCT07551739","A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Orthopedic Surgery","A Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled Phase II Clinical Study to Evaluate the Efficacy and Safety of HSK55718 Injection for Postoperative Pain Treatment in Orthopedic Surgery","Inclusion Criteria:\n\nAge ≥18 years old, regardless of gender; 18 kg\u002Fm2≤BMI≤30 kg\u002Fm2; American Society of Anesthesiologists (ASA) gradeⅰ-ⅲ; Accept abdominal surgery under general anesthesia; Within 4 hours after the end of surgery, NRS≥4 in the resting state at any time; Fully understand and voluntarily participate this trial, and sign the informed consent form;\n\nExclusion Criteria:\n\nA history of cardiovascular, respiratory, neurological, or psychiatric diseases that meet the protocol-defined exclusion criteria.\n\nClinically significant abnormalities in laboratory tests during the screening period.\n\nA history of severe drug allergy or known allergy to the investigational drug. Continuous use of opioid analgesics for more than 10 days for any reason within 3 months prior to randomization.\n\nUse of any medication that may affect analgesia, where the last dose was administered less than 5 half-lives of that drug before randomization.\n\nA history of drug abuse, substance abuse, and\u002For alcohol abuse within the past year.\n\nPregnant or lactating women. Participation in another drug clinical trial within 3 months prior to the screening period.\n\nPresence of any sensory dysfunction. Presence of any painful physical condition. Subjects with any other factor considered by the investigator to be ineligible for participation in the trial.",{"count":90,"type":21},[92],"This is a multi-center, randomized, double-blind, placebo\u002Factive-controlled study. 200 subjects undergoing orthopedic surgery under general anesthesia are planned to be enrolled and randomized into the HSK55718 group, morphine group, and placebo group.",[27],"2026-04-20",{"date":205,"type":41},"2026-04-27",{"date":207,"type":21},"2026-04",{"date":209,"type":21},"2026-11",{"name":104,"class":105},{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":22,"phases":220,"briefSummary":221,"conditions":222,"keywords":225,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":133},"100621268","comparison-of-the-analgesic-efficacy-of-erector-spinae-plane-block-in-breast-conserving-surgery-versus-serratus-anterior-block-combined-with-additional-pecto-intercostal-ii-block-100621268","NCT07368413","Comparison of the Analgesic Efficacy of Erector Spinae Plane Block in Breast-Conserving Surgery Versus Serratus Anterior Block Combined With Additional Pecto-Intercostal II Block","Comparison of Analgesic Efficacy and Opioid Consumption of Erector Spinae Plane Block Versus Serratus Anterior Block With Additional Pecto-Intercostal II Block in Breast-Conserving Surgery","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* ASA physical status I-III\n* No history of bleeding or coagulation disorders\n* Absence of neuropathy\n* Preoperative breast region NRS score \\\u003C 4\n\nExclusion Criteria:\n\n* systemic or regional infection\n* known allergy to local anesthetics\n* Unwillingness to participate in the study","75 Years",{"count":144,"type":21},[24],"This prospective randomized study will compare the effects of Erector Spinae Plane Block (ESPB) and Serratus Anterior Plane Block combined with Pectoral Nerve Block Type II (SAPB + PECS II) on intraoperative analgesia and postoperative opioid consumption in patients undergoing breast cancer surgery. Seventy patients (ASA I-III, aged 18-75 years) will be randomized into two groups using the sealed envelope method. Ultrasound-guided blocks will be performed preoperatively by the same anesthesiologist, with Group 1 receiving ESPB and Group 2 receiving a combined SAPB + PECS II technique performed through a single skin puncture (single needle entry site) with sequential injections into the two target fascial planes. All patients will undergo surgery under general anesthesia and receive postoperative analgesia via morphine patient-controlled analgesia. Pain scores and total opioid consumption will be statistically analyzed, with p \\\u003C 0.05 considered significant.",[223,27,224],"Pain Management in Breast Surgery","Regional Anaesthesia",[226,35,224,227,228,229],"breast surgery","Serratus Anterior Plane Block","Pectoral Nerve Block Type 2","Erector Spinae Plane Block",{"date":231,"type":41},"2026-04-21",{"date":233,"type":41},"2026-04-10",{"date":235,"type":21},"2026-07-31",{"name":237,"class":238},"Kayseri City Hospital","OTHER_GOV",{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":22,"phases":248,"briefSummary":249,"conditions":250,"keywords":251,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":133},"100595002","using-mindfulness-in-an-enhanced-recovery-after-surgery-protocol-to-support-recovery-after-colorectal-surgery-100595002","NCT07026786","Using Mindfulness in an Enhanced Recovery After Surgery Protocol to Support Recovery After Colorectal Surgery","Using Mindfulness in an Enhanced Recovery After Surgery Protocol to Support Recovery After Colorectal Surgery: A Single Center RCT Feasibility Study","Inclusion Criteria:\n\n* Patients scheduled for a bowel resection and enrolled in the UH Institutional ERAS pathway\n* Patients will be admitted to the inpatient hospital for at least one day postoperatively\n* Aged 18 or older\n* Receiving surgery at designated University Hospitals locations (Cleveland Medical Center, Ahuja, St. John's Medical Center)\n* English-speaking\n* Access to the internet via phone, laptop, or iPad\n\nExclusion Criteria:\n\n* Surgery for palliative purposes only\n* Surgery for ostomy take-down only\n* Discharged on day of surgery\n* History of substance use disorder\n* Allergy or intolerance to all opioids\n* Insufficient English proficiency\n* No access to the internet outside clinical settings\n* Significant visual, hearing or cognitive impairment",{"count":247,"type":21},50,[24],"This study teaches participants who are having colorectal surgery how to use mindfulness to feel calmer and manage pain better. Participants will be randomized (like a flip of a coin) into one of two groups: Mindfulness Intervention or Standard Treatment. Those in the Mindfulness group will have a 30-minute Zoom session before surgery to learn simple mindfulness exercises like deep breathing, using senses, and staying focused on the present.\n\nOn the day after surgery, participants will watch a short video review of the mindfulness exercises.\n\nRegardless of the group assigned, participants may be asked to complete questionnaires, and some participants will be asked to complete a semi-structured interview via Zoom, about 2 weeks to 1 month after surgery. Additionally, access to the mindfulness curriculum will be provided to those not randomized to that group. Investigators will collect information such as age, surgery details, pain levels, and pain medication usage. Participants will also fill out surveys before and after surgery to assess physical and mental well-being. All personal information will be kept safe, and interviews or Zoom sessions will be deleted after notes are taken without names attached.\n\nParticipants will be in this study for about 4 weeks.",[27,177],[252,253,254],"Colorectal surgery patients","Mindfulness","Enhanced Recovery After Surgery","2026-04-07",{"date":257,"type":41},"2026-04-13",{"date":259,"type":41},"2026-02-20",{"date":261,"type":21},"2027-09-01",{"name":263,"class":48},"University Hospitals Cleveland Medical Center",{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":4,"enrollmentInfo":271,"targetDuration":4,"studyType":22,"phases":273,"briefSummary":274,"conditions":275,"keywords":278,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":133},"100609992","preoperative-opioid-tapering-before-spine-surgery-100609992","NCT07221786","Preoperative Opioid Tapering Before Spine Surgery","A Pilot Study of the Feasibility of Preoperative Opioid Tapering Before Spine Surgery Using Cognitive Behavioral Therapy and Measuring Postoperative Outcomes","Inclusion:\n\n* at least 18 years old\n* scheduled for major spine surgery (i.e. at least 1 level of fusion) with hospital admission of at least one night\n* scheduled for spine surgery at least 4 weeks ahead of time\n* takes between 40 and 200 oral morphine equivalents daily\n\nExclusion:\n\n* inability to use a computer or tablet for telemedicine encounters\n* non-English-speaking\n* inability to complete assessments\n* positive screen on the Columbia Suicide Screening Assessment",{"count":272,"type":21},45,[24],"This is a pilot study in which patients taking opioids chronically who are scheduled for spine surgery at least 4 weeks in advance will be randomly assigned to one of two groups: opioid tapering with education alone or opioid tapering with education plus cognitive behavioral therapy (CBT). The primary objective is to determine the proportion of each group that is successful in achieving their opioid tapering goals by the time of surgery.",[276,27,277],"Opioid Consumption, Postoperative","Opioid Dependency",[279,280,281,282,283,284,285,286,287],"spine surgery","pain management","opioids","opioid use","depression","anxiety","opioid dependence","opioid tapering","cognitive behavioral therapy","2026-03-23",{"date":290,"type":41},"2026-03-24",{"date":292,"type":41},"2025-12-01",{"date":294,"type":21},"2026-12",{"name":296,"class":48},"Thomas Jefferson University",{"id":298,"slug":299,"hasResults":11,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":303,"eligibilityCriteria":304,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":305,"targetDuration":4,"studyType":307,"phases":4,"briefSummary":308,"conditions":309,"keywords":313,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":324,"locationsCount":133},"100629530","tourniquet-exposure-and-risk-of-chronic-pain-after-severe-limb-trauma-100629530","NCT07475871","Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma","Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma: A Prospective Cohort Study","TOURNI-PAIN","Inclusion Criteria:\n\n* Age ≥18 years\n* Severe upper or lower limb trauma\n* Documented tourniquet use (prehospital or in-hospital)\n* Available documentation of tourniquet duration\n* Informed consent\n\nExclusion Criteria:\n\n* Pre-existing chronic limb pain\n* Known severe peripheral neuropathy\n* Cognitive inability to complete follow-up\n* Expected survival \\\u003C48 hours",{"count":306,"type":21},150,"OBSERVATIONAL","Severe limb trauma often requires the use of a tourniquet to stop life-threatening bleeding. While tourniquets are essential for saving lives, prolonged interruption of blood flow may lead to tissue ischemia, nerve injury, and inflammatory responses that could contribute to the development of chronic pain.\n\nThe TOURNI-PAIN Study is a prospective observational study designed to investigate whether the duration of tourniquet use during the treatment of severe limb injuries is associated with an increased risk of persistent pain after recovery. The study will enroll adult patients with major upper or lower limb trauma who required tourniquet application in the prehospital or hospital setting.\n\nResearchers will collect information about the duration and characteristics of tourniquet use, details of the injury, surgical treatment, and recovery. Participants will be followed for up to 6 months after injury to assess pain levels, possible neuropathic pain, functional recovery, and quality of life.\n\nThe goal of this research is to better understand whether longer tourniquet exposure increases the risk of long-term pain. The findings may help improve trauma care practices by balancing the life-saving benefits of hemorrhage control with strategies that minimize long-term complications and improve recovery for patients with severe limb injuries.",[310,27,311,312],"Pain","Phantom Limb Pain After Amputation","Military Combat Stress Reaction",[314,315,316,317],"Tourniquet","Chronic Pain","Phantom Limb Pain","Trauma Rehabilitation","2026-03-16",{"date":320,"type":41},"2026-03-18",{"date":322,"type":21},"2026-03-15",{"date":322,"type":21},{"name":325,"class":48},"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)",{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":22,"phases":335,"briefSummary":336,"conditions":337,"keywords":339,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":133},"100629306","phase-4-effect-of-intraoperative-morphine-on-postoperative-pain-after-cabg-100629306","NCT07472959","Effect of Intraoperative Morphine on Postoperative Pain After CABG","The Effect of Intraoperative Morphine Use on Postoperative Pain in Coronary Artery Bypass Surgery: A Randomized, Controlled Clinical Trial","Inclusion Criteria:\n\n* patients aged 18 to 80 years\n* classified as American Society of Anesthesiologists (ASA) III\n* who are scheduled for elective coronary artery bypass grafting.\n\nExclusion Criteria:\n\n* Chronic opioid use.\n* Severe liver or kidney disease.\n* History of alcohol or substance abuse.\n* Left ventricular ejection fraction below 40%.\n* Inability to be weaned from mechanical ventilation within 12 hours after completion of surgery.\n* Undergoing combined cardiac surgery, including valve procedures.\n* Requirement for intra-aortic balloon pump (IABP) support.\n* Surgery performed on a beating heart.\n* Emergency surgery.\n* Reoperation due to bleeding or other complications.\n* Refusal to participate in the study.","80 Years",{"count":20,"type":21},[62],"Ethics committee approval was obtained for this study, which was planned as a prospective, randomized, controlled, single-center trial to be conducted in patients undergoing coronary artery bypass grafting (CABG) surgery between December 2025 and March 2026.\n\nPatients eligible for inclusion were randomized into two groups at a 1:1 ratio using a random number list generated via the random.org website. Randomization was performed by an independent investigator who was not involved in the study procedures. The allocation sequence was placed into sequentially numbered, opaque, sealed envelopes. Upon enrollment of each patient, the next numbered envelope was opened to determine group assignment.\n\nPatients who did not complete the study protocol or did not receive the allocated medication were excluded from the analysis, and a per-protocol analysis approach was applied. The randomization list was kept confidential and was accessible only to authorized statistical personnel. Patients were followed in two groups: the Control Group (Group C) and the Morphine Group (Group M).\n\nAll procedures were performed at the Istanbul University-Cerrahpaşa Cardiology Institute. After obtaining written informed consent, all patients were transferred to the operating room, where an 18G intravenous cannula was inserted, followed by premedication with midazolam 0.03 mg\u002Fkg (IV).\n\nStandard monitoring included 5-lead electrocardiography (ECG), heart rate measurement, invasive arterial blood pressure monitoring, and peripheral oxygen saturation assessment. Anesthesia induction was standardized for all patients using midazolam 0.15 mg\u002Fkg, fentanyl 10 µg\u002Fkg, and rocuronium 0.6 mg\u002Fkg (IV). Orotracheal intubation was performed using an endotracheal tube of appropriate size according to the patient's age and sex.\n\nFollowing intubation, mechanical ventilation was initiated and adjusted to maintain end-tidal carbon dioxide (EtCO₂) levels between 35 and 45 mmHg. Anesthesia maintenance was achieved using a total intravenous anesthesia (TIVA) technique with continuous infusions of propofol (1-10 mg\u002Fkg\u002Fh), fentanyl (2-4 µg\u002Fkg\u002Fh), and rocuronium (20 mg\u002Fh), targeting a bispectral index (BIS) value between 40 and 60. Prior to surgical incision, patients in the Morphine Group (Group M) received 5 mg intravenous morphine, administered with careful consideration of their hemodynamic status.\n\nDuring surgery, all patients were placed on cardiopulmonary bypass (CPB). After completion of graft anastomoses and stabilization of vital signs, patients were weaned from CPB. At this stage, patients in Group M received an additional 5 mg intravenous morphine. In contrast, patients in the Control Group (Group K) continued to receive perioperative fentanyl infusion.\n\nPostoperatively, patients were transferred to the intensive care unit (ICU) while intubated and mechanically ventilated. Extubation was performed according to clinical criteria. In the ICU, all patients received intravenous paracetamol 1000 mg every 6 hours and tramadol 100 mg intravenously. Pain intensity was assessed using the Numerical Rating Scale (NRS) \u002F Visual Analog Scale (VAS). If the pain score exceeded 4, 3 mg intravenous morphine was administered, and total morphine consumption was recorded.\n\nPreoperative variables collected included age, sex, height, weight, body mass index (BMI), and American Society of Anesthesiologists Physical Status (ASA PS) classification. Intraoperative variables included administered drug doses, duration of surgery, cardiopulmonary bypass time, and total anesthesia duration.\n\nIn the postoperative period, the duration of mechanical ventilation in the intensive care unit (ICU), the presence of nausea and vomiting, postoperative ileus, and respiratory depression will be recorded. In addition, pain intensity at the thoracic tube insertion site, sternum, and saphenous vein graft incision will be assessed at the 1st, 2nd, 4th, 8th, and 24th hours following extubation using the Numerical Rating Scale (NRS) \u002F Visual Analog Scale (VAS). All pain assessments will be performed and recorded by a blinded observer. Pain associated with the urinary catheter will also be evaluated using the NRS.\n\nProlonged postoperative ileus will be defined as the presence of abdominal distension and absence of bowel sounds in a patient without mechanical intestinal obstruction who experiences nausea or vomiting and fails to pass flatus or stool for more than three postoperative days. The severity and frequency of postoperative nausea and vomiting (PONV) will be assessed. Respiratory depression will be defined as a suppressed ventilatory response to hypercapnia or hypoxemia.",[338,69,27],"Cardiac Surgery Patient",[35,280,340,341,342],"pain measurement","Cardiac Surgical Procedures","Cardiovascular Surgical Procedures","2026-03-13",{"date":318,"type":41},{"date":346,"type":41},"2026-02-01",{"date":348,"type":21},"2026-05-31",{"name":350,"class":48},"Istanbul University - Cerrahpasa",{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":358,"enrollmentInfo":359,"targetDuration":4,"studyType":22,"phases":360,"briefSummary":361,"conditions":362,"keywords":367,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":4},"100626011","phase-4-post-operative-pain-relief-zynrelef-or-periarticular-injections-in-ratka-100626011","NCT07430085","Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA","Postoperative Pain Outcomes After Use of Bupivacaine-Meloxicam Extended-Release Solution in Robot Assisted Total Knee Arthroplasty: A Prospective Study","Inclusion Criteria:\n\nMales or females aged 18-89 years\n\nDiagnosed with knee osteoarthritis requiring surgical intervention\n\nIndicated for unilateral RATKA\n\nExclusion Criteria:\n\nPediatric, pregnant, or incarcerated patients\n\nBMI of more than 45 kg\u002Fm2\n\nProlonged opioid use history of \\>5 mg\u002Fday for \\>1 month\n\nHistory of contralateral TKA \\\u003C2 years prior to the index TKA\n\nType 1 Hypersensitivity to NSAIDs or local anesthetics\n\nDiagnosis of severe renal disease","89 Years",{"count":306,"type":21},[62],"Prospective Cohort of patients who are scheduled for a Robot Assisted Total Knee Arthroplasty (RATKA). A prospective survey of patient reported outcome measures (Numeric Rating Scale) will be obtained postoperatively of 72 hours, as well as at the postoperative opioid consumption after 72 hours.",[363,364,365,27,366],"Periarticular Block","Osteoarthritis (OA)","Osteoarthritis (OA) of the Knee","Knee Arthroplasty, Total",[368],"Zynrelef","2026-02-24",{"date":371,"type":41},"2026-02-27",{"date":373,"type":21},"2026-01-31",{"date":375,"type":21},"2028-02-28",{"name":377,"class":48},"Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)",{"id":379,"slug":380,"hasResults":11,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":384,"eligibilityCriteria":385,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":386,"enrollmentInfo":387,"targetDuration":4,"studyType":22,"phases":388,"briefSummary":389,"conditions":390,"keywords":392,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":133},"100622203","melatonin-on-post-operative-pain-after-cs-100622203","NCT07380568","Melatonin on Post Operative Pain After CS","The Effect of Preoperative Oral Melatonin on Postoperative Pain Control After Cesarean Section: A Dose Comparison Study","CS","Inclusion Criteria:\n\n* \\- Women aged 18-40 years.\n* Scheduled for elective cesarean section.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Known hypersensitivity to melatonin or opioids\n* Chronic use of analgesics, sedatives, or antidepressants.\n* History of sleep disorders or psychiatric illness.\n* Complicated pregnancies (e.g., preeclampsia, gestational diabetes).\n* Body mass index (BMI) \\> 35 kg\u002Fm².\n* Emergency cesarean sections.\n* Severe systemic diseases (e.g., liver or kidney dysfunction).","45 Years",{"count":20,"type":21},[24],"The goal of this clinical trial is to learn if melatonin will decrease pain after C.S. The main questions it aims to answer are:\n\nDoes melatonin lower the number of times participants need to use a rescue analgesia? What medical problems do participants have when taking melatonin? Researchers will compare different doses of melatonin to see the ideal dose to decrease pain after C.S.\n\nParticipants will:\n\nTake melatonin 30 min before C.S and will be observed for 24 hours for pain and consumption of other analgesia",[174,27,391],"Cesarean Section Pain",[393],"melatonin and pain after C.S","2026-01-24",{"date":396,"type":41},"2026-02-02",{"date":398,"type":41},"2025-10-10",{"date":400,"type":21},"2026-04-01",{"name":402,"class":48},"Benha University"]