[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pain-assessment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pain-assessment":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,49,89,116,148,176,198],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100566459","phase-2-supplemental-postoperative-bupivacaine-following-non-surgical-endodontic-treatment-100566459",false,"NCT06655454","Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment","The Effects of Supplemental Postoperative 0.5% Bupivacaine With 1:200,000 Epinephrine Following Non-Surgical Endodontic Treatment on Patients' Quality of Life, Pain, and Analgesic Consumption","Inclusion Criteria:\n\n1. Medical ASA Class I or II\n2. Patients above 18 years old\n3. Patients with a blood pressure below 160\u002F100\n4. Patients who are treatment planned and have agreed to have emergency endodontic therapy or non-surgical root canal therapy with a pulpal diagnosis of symptomatic irreversible pulpitis according to the AAE Glossary of Endodontic Terms.\n5. Patients must be able to comprehend and complete all study protocols, written consent, and questionnaires in English.\n\nExclusion Criteria:\n\n1. Medical ASA III or above\n2. Patients who reported the use of tobacco or nicotine-containing products such as vapes, e-cigarettes, gums, or pouches and will not in the 48 hours following treatment\n3. Patients who reported the use of any marijuana products or illicit drugs in the 48 hours prior to treatment and will not in the next 48 hours.\n4. Patients who have taken opioids to control pain.\n5. Pregnant patients\n6. Patients with a blood pressure of 160\u002F100 or greater\n7. Patients with a known hypersensitivity or allergy to any local anesthetic agent of the amide group, or any other components of the two anesthetic solutions such as epinephrine, sodium metabisulfite used in the study.\n8. Patients who have more than one tooth with odontogenic pain at the time of the screening.\n9. Patients who are unable to consent and do not understand or are unable to read the questionnaires.\n10. Patients who have had 4 1.7 ml carpules or more of anesthetic (Lidocaine and\u002F or Septocaine, 1:100,000) during standard care of treatment.","ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","The study will investigate the impact of an additional injection of long-acting anesthetic on pain level, quality of life, and use of pain medication after a nonsurgical endodontic treatment. The long-acting anesthetic will be compared to a mock injection group and a group with no additional anesthetic to determine any differences in effects.",[26,27,28],"Pain Assessment","Quality of Life (QOL)","Analgesic Use",[30,31,32,33,34,35],"bupivacaine","nonsurgical endodontic treatment","root canal therapy","irreversible pulpitis","pain management","anesthetic use","RECRUITING","2026-04-08",{"date":39,"type":40},"2026-04-13","ACTUAL",{"date":42,"type":40},"2024-11-01",{"date":44,"type":20},"2026-12-31",{"name":46,"class":47},"New York University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":57,"targetDuration":59,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":71,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":48},"100613134","developing-a-multimodal-cancer-pain-database-to-support-ai-based-automatic-pain-assessment-100613134","NCT07262632","Developing a Multimodal Cancer Pain Database to Support AI-Based Automatic Pain Assessment","SENSAI: Seeing, hEaring, seNsing: Smart, Effortless and Objective Pain Assessment With Mobile AI Technology - DataBase Development","SENSAI-DBD","Inclusion Criteria:\n\n* Adult patients (≥18 years)\n* Diagnosed with cancer, active\n* Able to communicate verbally in Dutch or English\n* Able to provide written informed consent.\n* Pain group specific:\n* Experiencing pain related to cancer\n* Admitted to the hospital due to pain\n* Control group specific:\n* Not experiencing pain (NRS = 0)\n* Admitted to the hospital for chemotherapy\n\nExclusion Criteria:\n\n* Cognitive, physical, or medical limitations that prevent participation in the audiovisual recording sessions or affect facial expressions or voice (e.g. facial paralysis, tracheostomy, severe speech impairment).\n* Critical illness or end-of-life care where participation would impose an additional burden.\n* Experiencing pain not associated with cancer\n* Infectious isolation precautions that prevent safe data collection",{"count":58,"type":20},200,"3 Weeks","OBSERVATIONAL","The goal of this observational study is to collect short video and sound recordings of people with cancer to create a secure database that can be used in future research to develop an artificial intelligence (AI) tool for pain assessment. The main aim is to build a large, high-quality collection of audiovisual data showing how people with cancer express themselves when they do and do not have pain.\n\nParticipants will include adults with cancer who are admitted to the oncology ward for pain treatment and a control group admitted for chemotherapy who have no pain. After giving consent, participants will:\n\n* Be recorded on video (from the shoulders up) for up to 60 seconds while reading a short sentence and describing their pain or daily experience.\n* Complete a short questionnaire about their mood and pain expression.\n* Allow researchers to collect some information from their medical record, such as their pain score, medications, and cancer type.\n\nThese recordings will be securely stored and used to create a database for future AI research. No medical tests, new treatments, or extra hospital visits are involved. This study will provide the foundation for developing future AI-based tools that could support doctors and patients in monitoring and managing pain more accurately and easily.",[63,26,64,65,66,67,68,69,70],"Cancer-related Pain","Artificial Intelligence (AI)","Oncology","Oncology Pain","Database","Facial Expression","Voice","Cancer",[63,72,64,65,66,67,73,74,75,76,77,78,79],"Pain assessment","Facial Action Unit","Vocalizations","Acoustic","Automatic assessment","Machine learning","Audiovisual data","Paralinguistics","2026-03-10",{"date":82,"type":40},"2026-03-11",{"date":84,"type":40},"2025-12-01",{"date":86,"type":20},"2027-12-31",{"name":88,"class":47},"Dr. Mark Mulder",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":16,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":21,"phases":100,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":48},"100579735","dietary-wild-blueberries-and-joint-health-100579735","NCT06828159","Dietary Wild Blueberries and Joint Health","Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain","Inclusion Criteria:\n\n* Adults with documented multi-joint\u002Fknee arthritis\n\nExclusion Criteria:\n\n* inability to give informed consent\n* pregnancy or lactation\n* planned knee replacement surgery\n* allergy or contraindication to berries\n* recent trauma of the knee responsible of the symptomatic knee\n* intra-articular injection in the target knee\u002Fhip in the last 3 months\n* oral corticosteroid therapy ≥ 5 mg\u002Fday (prednisone equivalent) at baseline\n* use of berry extracts in the last 3 months\n* special diets\n* cancer treatment\n* bone diseases","40 Years","75 Years",{"count":99,"type":20},50,[101],"NA","The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.",[104,105,26,106],"Gut -Microbiota","Inflammation Biomarkers","Joint Pain","2025-11-03",{"date":109,"type":40},"2025-11-05",{"date":111,"type":40},"2025-09-01",{"date":113,"type":20},"2028-03",{"name":115,"class":47},"University of Nevada, Las Vegas",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":21,"phases":124,"briefSummary":125,"conditions":126,"keywords":130,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":48},"100595898","refining-multiple-artificial-intelligence-strategies-for-automatic-pain-assessment-investigations-ruggi-study-100595898","NCT07038434","Refining mUltiple Artificial intelliGence strateGies for Automatic Pain Assessment Investigations: RUGGI Study","RUGGI","Inclusion Criteria:\n\n* Adults (≥18 years old) with chronic pain, defined according to IASP and ICD-11 as pain that persists or recurs for more than three months.\n* Diagnosed with either:\n* Chronic primary pain (e.g., fibromyalgia, irritable bowel syndrome, chronic headaches)\n* Chronic secondary non-cancer pain (e.g., low back pain, osteoarthritis, post-surgical pain)\n* Chronic cancer-related pain (due to cancer or its treatment)\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Current treatment with psychotropic drugs or presence of active psychiatric disorders (e.g., psychosis, major depression).\n* Known history of alcohol or substance abuse.\n* Pregnancy or breastfeeding.\n* Age under 18 years.\n* Inability to provide informed consent (e.g., due to cognitive impairment).",{"count":58,"type":20},[101],"This single-center, non-profit, observational-interventional study aims to develop artificial intelligence (AI) models for the automatic assessment of chronic pain (APA - Automatic Pain Assessment). The study will enroll adult patients with chronic pain of various origins (oncologic and non-oncologic). Participants will undergo multidimensional evaluations that include clinical assessments, self-report questionnaires, bio-signal collection (e.g., EEG, EDA, HRV, GSR, PPG), and facial expression analysis via infrared thermography and video recordings.\n\nThe primary objective is to calibrate and test machine learning and deep learning models to recognize and predict the presence and severity of pain using multimodal data inputs. Secondary objectives include evaluating the effectiveness of pain treatments, assessing quality of life, and developing a standardized APA dataset for future research.\n\nAll data collection procedures are non-invasive and safe, and include tools like wearable sensors and standardized neurocognitive tests. The study is approved by the Italian Ethics Committee (Comitato Etico Territoriale Campania 2) and complies with GDPR and EU AI regulations.",[127,128,129,26],"Chronic Pain","Cancer Pain","Neuropathic Pain",[131,132,133,134,135,136,137,138,127],"Artificial Intelligence","Machine Learning","Deep Learning","Automatic Pain Assessment","Facial Expression Analysis","Natural Language Processing","Stroop Test","Bio-signals","2025-06-17",{"date":141,"type":40},"2025-06-26",{"date":143,"type":40},"2025-05-06",{"date":145,"type":20},"2026-01",{"name":147,"class":47},"Valentina Cerrone",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":156,"sex":16,"minAge":157,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":21,"phases":161,"briefSummary":162,"conditions":163,"keywords":164,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":4},"100579663","effect-of-starpen-cclad-in-injection-and-extraction-100579663","NCT06827223","Effect of Starpen CCLAD in Injection and Extraction","Comparative Evaluation of the Effect of Computer-controlled Starpen Automatic Injection Device Versus Traditional Syringe on Pain Perception During Nerve Block Anesthesia and Extraction of Mandibular Primary Molars: a Randomized Controlled Trial","Starpen CCLAD","Inclusion Criteria:\n\n* Children aged 6-8 years\n* Cooperative children (Rating 3 or 4 based on the Frankl behavior scale)\n* Medically fit children (ASA I).\n* Children are mentally capable of communication.\n* First dental visit.\n* Patient requiring extraction of lower primary molars due to root caries, crown fractures, periapical disease, and failed pulpotomies.\n\nExclusion Criteria:\n\n* Children with a behavioral management problem.\n* Parental refusal of participation.\n* Children with a previous history of local anesthesia injection.\n* Medically unfit children (other than ASA I).\n* Uncooperative children (other than Frankl 3,4).\n* Children under medications (antibiotics and analgesics) for the previous 48 hours that could alter the pain perception.\n* Teeth that showed any signs of mobility, ankylosis, or root resorption affecting more than one-third of the root",true,"6 Years","8 Years",{"count":160,"type":20},66,[101],"The present study aims to evaluate the effect of computer-controlled Starpen automatic injection device versus the traditional syringe on pain perception during Injection of nerve block anesthesia and extraction of mandibular primary molars.",[26],[165],"Starpen CCLADS","NOT_YET_RECRUITING","2025-02-10",{"date":169,"type":40},"2025-02-14",{"date":171,"type":20},"2025-02",{"date":173,"type":20},"2026-03",{"name":175,"class":47},"Cairo University",{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":21,"phases":184,"briefSummary":185,"conditions":186,"keywords":4,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":48},"100575933","implementing-music-therapy-for-video-assisted-thoracoscopic-surgery-patients-a-quality-improvement-initiative-100575933","NCT06778720","Implementing Music Therapy for Video-Assisted Thoracoscopic Surgery Patients: A Quality Improvement Initiative","Inclusion Criteria:\n\n* Adults aged 18 years and older with lung mass diagnosis undergoing VATS\n\nExclusion Criteria:\n\n* Individuals with dementia, neurocognitive disorders, or chronic pain conditions.",{"count":183,"type":20},20,[101],"The purpose of this project is to introduce and implement music therapy as an evidence-based pain management protocol focused on reducing postoperative pain levels among Video-Assisted Thoracoscopic Surgery (VATS) patients in the Post-Anesthesia Care Unit (PACU) of the project site. The clinical question guiding this initiative is: In adult patients undergoing a VATS procedure, does the implementation of music therapy lead to lower postoperative pain scores in the PACU compared to no intervention within an 8-week timeframe? The investigator will ask eligible patients their immediate pain scores upon arrival into the PACU and then start music of patient's choice via over-the-ear headphones. Pain scores will be rechecked 30 minutes after implementation of music therapy. The standard of care pain medications and\u002For usual care will not be withheld or altered after surgery in lieu of music therapy.",[26,187,188],"VATS","Music Therapy","2025-01-12",{"date":191,"type":40},"2025-01-16",{"date":193,"type":20},"2025-01-14",{"date":195,"type":20},"2025-03-10",{"name":197,"class":47},"Cedars-Sinai Medical Center",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":21,"phases":207,"briefSummary":208,"conditions":209,"keywords":214,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":48},"100553420","assessment-of-pain-using-a-pain-diagnostic-system-that-measurs-facial-movement-using-100553420","NCT06485856","ASSESSMENT OF PAIN USING A PAIN DIAGNOSTIC SYSTEM THAT MEASURS FACIAL MOVEMENT USING","Cukurova University","Inclusion Criteria:\n\n* 18 years and over,\n* Those with intubation\u002Ftracheostomy,\n* Conscious, unable to communicate verbally,\n* Glaskow coma score 13-15,\n* Patients who agreed to participate in the study\n\nExclusion Criteria:\n\n* Those with any facial abnormality that may alter facial expression analysis (facial paralysis, Poland-mobius syndrome)\n* Those with neurological and mental disorders,\n* Having a history of chronic pain,\n* Those who have a condition that requires them to be in the prone position all the time (Pilonidal Sinus, ARDS, etc.),\n* Patients who cannot speak the same language as the healthcare professional",{"count":206,"type":20},46,[101],"Pain is a subjectively difficult, abstract and comprehensive concept that is at the core of the whole study, emerging in relation to various advancements, and detailed description. For non-controlling, stress-free, stress-or-thickness training for thromboembolic, pulmonary and other organ modalities, re-admission from discharge, thromboembolic, pulmonary and other reasons.\n\nThe scales of use in the assessment of pain in the conscious surgical patient who cannot communicate verbally, into the pain, are physically subjective. Ekman and Friesen are planning the movements of their muscles to be performed by an Action Coding process that could be experienced in 1978. system; It has been applied in pain, in the evaluation of pain in the postoperative period and in children, in the new clinical practice, and in the new and clinical practice.\n\nHealth professionals may be biased in diagnosing pain, especially in intensive care patients, and may underestimate pain. In the literature, it is seen that the child who is made with pain in his patients in education in the field of medicine is not used in his experiences, similar to the pain that measures the tastes of the faces of the single scales. In this context, standardized, continuous, objective and scalable pain measures indicate the practice environment. The aim of these people is to evaluate the pain in our surgical patients who cannot communicate clearly and clearly with pain diagnosis that measures facial movement.",[210,26,211,212,213],"Nursing","Critical Care","Technology","Facial Recognition",[215,72,216,217,212],"Nurse","Intensive care","Facial diagnosis","2024-06-26",{"date":220,"type":40},"2024-07-03",{"date":222,"type":40},"2024-05-15",{"date":224,"type":20},"2024-12-15",{"name":226,"class":47},"Fatmagül Üstünel"]