[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pain-intensity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pain-intensity":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,68,102,129],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100633385","phase-4-dexmedetomidine-esketamine-combination-and-chronic-postsurgical-pain-after-spinal-surgery-100633385",false,"NCT07525999","Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery","Effect of Perioperative Use of Dexmedetomidine-esketamine Combination on Incidence of Chronic Postsurgical Pain After Spinal Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged \\>= 40 years and \\\u003C 80 years;\n2. Scheduled to undergo elective posterior cervical, thoracic or lumbar spine surgery under general anesthesia, with an expected operative duration \\>= 2 hours;\n3. Requirement for patient-controlled intravenous analgesia (PCIA) postoperatively.\n\nExclusion Criteria:\n\n1. Severe uncontrolled hypertension preoperatively (baseline ward blood pressure: SBP \\> 180 mmHg or DBP \\> 110 mmHg);\n2. Severe bradycardia (heart rate \\\u003C= 50 bpm), sick sinus syndrome, atrioventricular block of grade II or higher without pacemaker implantation, or a history of myocardial infarction within one year, severe heart failure (NYHA class \\>= III), or rapid ventricular arrhythmia;\n3. Preoperative history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension;\n4. Preoperative history of hyperthyroidism or pheochromocytoma;\n5. Inability to communicate preoperatively due to coma, severe dementia, or language impairment;\n6. Severe cardiac insufficiency (preoperative LVEF \\\u003C 30% or NYHA class IV), severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (preoperative dialysis), or ASA physical status \\>= grade IV;\n7. Other conditions deemed inappropriate for study participation by the investigator or attending physician.","ALL","40 Years","80 Years",{"count":20,"type":21},274,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP). In previous studies, perioperative use of dexmedetomidine or esketamine is each associated with improved analgesia after surgery. Recent studies suggest that combined use of dexmedetomidine and esketamine may produce synergetic effects in improving analgesia. This trial is designed to test the hypothesis that perioperative combined use of dexmedetomidine and esketamine may reduce CPSP in patients after spinal surgery.",[27,28,29,30,31],"Spinal Surgery","Pain Intensity","Dexmedetomidine","Esketamine","Postoperative Analgesia",[33,34,29,30,35],"Spinal surgery","Pain intensity","Postoperative analgesia","NOT_YET_RECRUITING","2026-04-13",{"date":39,"type":40},"2026-04-16","ACTUAL",{"date":42,"type":21},"2026-04",{"date":44,"type":21},"2027-12",{"name":46,"class":47},"Peking University First Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":65,"leadSponsor":67,"locationsCount":48},"100633179","phase-4-dexmedetomidine-esketamine-combination-and-moderate-to-severe-pain-after-spinal-surgery-100633179","NCT07523321","Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery","Effect of Perioperative Use of Dexmedetomidine-esketamine Combination on Incidence of Moderate-to-severe Pain After Spinal Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged \\>= 40 years but \\\u003C 80 years;\n2. Scheduled to undergo elective posterior cervical, thoracic, or lumbar spine surgery with an expected duration \\>= 2 hours under general anesthesia;\n3. Required patient-controlled intravenous analgesia (PCIA) after surgery.\n\nExclusion Criteria:\n\n1. Uncontrolled preoperative hypertension (ward systolic blood pressure \\> 180 mmHg or diastolic blood pressure \\> 110 mmHg);\n2. Severe bradycardia (heart rate \\\u003C= 50 bpm), sick sinus syndrome, atrioventricular block of grade II or higher without pacemaker implantation, a history of myocardial infarction within one year, or presence of rapid ventricular arrhythmia;\n3. History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis, or prresence of intracranial hypertension;\n4. Uncontrolled hyperthyroidism or pheochromocytoma;\n5. Inability to communicate due to coma, severe dementia, or language barrier;\n6. Severe cardiac insufficiency (preoperative left ventricular ejection fraction \\\u003C 30% or New York Heart Association Functional classification IV), severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (preoperative dialysis), or American Society of Anesthesiologists physical status \\>= IV;\n7. Other conditions that are considered unsuitable for study participation.",{"count":20,"type":21},[24],"Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP). In previous studies, perioperative use of dexmedetomidine or esketamine is each associated with improved analgesia after surgery. Recent studies suggest that combined use of dexmedetomidine and esketamine may produce synergetic effects in improving analgesia. This trial is designed to test the hypothesis that perioperative combined use of dexmedetomidine and esketamine may improve analgesia and reduce moderate-to-severe pain in patients after spinal surgery.",[27,28,29,30,31],[33,34,29,30,35],"2026-04-09",{"date":63,"type":40},"2026-04-14",{"date":42,"type":21},{"date":66,"type":21},"2027-05",{"name":46,"class":47},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":48},"100545373","phase-3-non-steroidal-anti-inflammatory-in-cardiac-surgery-100545373","NCT06381063","Non-steroidal Anti-inflammatory in Cardiac Surgery","Effect of Non-steroidal Anti-inflammatory Drugs in Pain Management After Cardiac Surgery","KETOPAIN","Inclusion Criteria:\n\n* scheduled for cardiac surgery (aortic valve replacement, coronary artery bypass graft, mitral valve repair or replacement, intracardiac tumor, aortic root repair)\n* under cardiopulmonary bypass\n* Affiliation to the French national healthcare system\n* Written consent obtained\n\nExclusion Criteria:\n\n* age\\\u003C18\n* weight\\\u003C50 kg\n* chronic use of NSAID\n* mini-invasive surgery\n* NSAID contraindication\n* NSAID allergy\n* Nefopam contraindication\n* Paracetamol contraindication\n* Tramadol contraindication\n* Urgent surgery\n* Endocarditis\n* Immunosuppressive drug\n* HIV infection with CD4\\\u003C200 mm3\n* Organ transplantation\n* Stage 4 or 5 chronic kidney disease\n* Gastro duodenal ulcer\n* Pregnancy\n* Depression\n* Auto immune disease","18 Years",{"count":78,"type":21},238,[80],"PHASE3","Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.",[83,84,85,28,86],"Acute Postoperative Pain","Non-steroidal Anti-inflammatory Drugs","Cardiac Surgery","Multimodal Pain Management",[83,88,89,90,91],"non-steroidal anti-inflammatory drugs","cardiac surgery","pain intensity","multimodal pain management","RECRUITING","2025-07-18",{"date":95,"type":40},"2025-07-23",{"date":97,"type":40},"2024-03-27",{"date":99,"type":21},"2027-07",{"name":101,"class":47},"Centre Hospitalier Universitaire, Amiens",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":108,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":4},"100581507","do-emotions-and-pain-combined-affect-mechanical-pain-thresholds-and-other-pain-related-variables-in-individuals-with-chronic-pain-100581507","NCT06851208","Do Emotions and Pain Combined Affect Mechanical Pain Thresholds and Other Pain-related Variables in Individuals with Chronic Pain?","Inclusion Criteria:\n\n* Above 18 years of age\n* Fluent in Swedish\n* Persistent chronic pain with duration \\> 6 months\n\nExclusion criteria:\n\n\\- Known neurological disease","19 Years",{"count":110,"type":21},180,[112],"NA","The purpose of this study is to investigate if different emotional states could influence mechanical pain thresholds and other pain - related variables such as pain tolerance, pain intensity and pain - related negative affect in individuals with chronic pain.",[115,28],"Pain Thresholds",[117,118,119],"Pressure pain thresholds","Pain","Emotions","2025-02-26",{"date":122,"type":40},"2025-02-28",{"date":124,"type":21},"2026-03-01",{"date":126,"type":21},"2026-06-30",{"name":128,"class":47},"Linnaeus University",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":136,"minAge":76,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":148,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":4},"100572471","the-use-of-virtual-reality-technology-during-oocyte-retrieval-for-in-vitro-fertilization-100572471","NCT06733701","The Use of Virtual Reality Technology During Oocyte Retrieval for in Vitro Fertilization","The Use of Virtual Reality Technology During Oocyte Retrieval for in Vitro Fertilization: a Randomized Controlled Pilot Study","Inclusion Criteria:\n\n\\- All adults undergoing their first oocyte retrieval\n\nExclusion Criteria:\n\n* severe visual impairment\n* contraindications to using VR technology according to manufacturer specifications including:\n* severe motion sickness\n* epilepsy\u002Fprevious seizure\n* claustrophobia\n* current migraine\n* heart disease\n* use of medical devices such as cardiac pacemaker or hearing aids","FEMALE","43 Years",{"count":139,"type":21},50,[112],"Ultrasound-guided oocyte retrieval (OR) is a short, but oftentimes painful procedure, during which the follicles are punctured trans-vaginally to obtain oocytes for in vitro fertilization (IVF). Conscious sedation is the most commonly used method of pain relief, yet several studies have shown that more than half of women report moderate to high levels of pain and up to 7% of women report extreme or unacceptable levels of pain during OR. Adjuvant virtual reality (VR) therapy has been explored to reduce psychological stress during dental procedures, burn wound care, colonoscopy, as well as other minor procedures. Hence, the purpose of this study is to evaluate the use of VR technology during IVF treatment, particularly with respect to tolerability, patient satisfaction, and pain reduction during oocyte retrieval.",[143,144,145,28,146,147],"Oocyte Retrieval","Adverse Events","Procedural Anxiety","Satisfaction","Medication Administration",[149,143,150,151],"Virtual Reality","In Vitro Fertilization","Randomized Control Trial","2024-12-13",{"date":154,"type":40},"2024-12-18",{"date":156,"type":21},"2025-01-15",{"date":158,"type":21},"2025-12-31",{"name":160,"class":47},"Mount Sinai Hospital, Canada"]