[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pain-management-during-cataract-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pain-management-during-cataract-surgery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100563298","phase-2-prednisolone-acetate-eye-drops-for-pain-intervention-in-second-eye-cataract-surgery-100563298",false,"NCT06614348","Prednisolone Acetate Eye Drops for Pain Intervention in Second Eye Cataract Surgery","A Randomized Controlled Study of Prednisolone Acetate Eye Drops for Pain Intervention in Second Eye Cataract Surgery","Inclusion Criteria:\n\n* Age between 50-80 years old;\n* A clear diagnosis of age-related cataract, having completed the first eye cataract surgery at our hospital, and planning to have the second eye cataract surgery with the same doctor;\n* The interval between the two surgeries is ≤30 days;\n* Capable of cooperating to complete iris optical coherence tomography angiography examination;\n* Based on our team\\'s previous research, a predictive scoring formula for pain during the second eye surgery has been derived (Predicted score = 1.36 + 4.93 \\* preoperative iris vessel area density - 0.24 \\* surgical interval (weeks)), and the calculated predicted score is \\>2.\n\nExclusion Criteria:\n\n* History of ocular trauma, ocular surgery, uveitis, fundus disease, glaucoma, or recent history of episcleritis, keratitis, severe dry eye, and other ocular surface disease episodes;\n* Participation in intraocular or systemic medication clinical trials within the past 6 months;\n* Having an autoimmune disease or currently undergoing immunosuppressive therapy;\n* Having a psychiatric disorder such as anxiety or depression;\n* History of using glucocorticoid eye drops for treatment in the second eye within the past month;\n* Long-term use of drugs that can cause intraoperative floppy iris syndrome, such as alpha-blockers;\n* Severe complications occurred during or after the first eye surgery (e.g., posterior capsule rupture, zonular exercise, nuclear drop into the vitreous cavity, postoperative endophthalmitis, glaucoma, etc.).","ALL","50 Years","80 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This study aims to evaluate the efficacy, safety, and potential mechanisms of prednisolone acetate eye drops for pain management in patients undergoing second-eye surgery for age-related cataracts.\n\nResearchers will compare prednisolone acetate eye drops to sodium hyaluronate eye drops to see if prednisolone acetate eye drops work to relieve intraoperative and postoperative pain during second-eye cataract surgery.\n\nParticipants will:\n\n1. Receive prednisolone acetate eye drops or sodium hyaluronate eye drop four drops within 2 hours before cataract surgery\n2. Finish cataract surgery and routine postoperative follow-up\n3. Pain questionnaire completed after cataract surgery",[27,28],"Age Related Cataract","Pain Management During Cataract Surgery",[30,31,32],"cataract surgery","pain","second-eye cataract surgery","NOT_YET_RECRUITING","2024-09-24",{"date":36,"type":37},"2024-09-26","ACTUAL",{"date":39,"type":21},"2024-10-08",{"date":41,"type":21},"2025-11-30",{"name":43,"class":44},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","OTHER"]