[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pain-management\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pain-management":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,167,0,25,[9,46,71,91,141,184,208,237,258,281,309,338,365,389,414,436,464,482,503,532,553,579,602,636,659],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100054326","dose-response-effects-of-a-brief-audio-guided-mindfulness-intervention-for-acute-pain-100054326",false,"NCT07562412","Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain","Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain While Awaiting Orthopedic Care","Inclusion Criteria:\n\n* Receiving treatment at Tallahassee Orthopedic Center\n* Understanding English instructions fluently\n* Being 18 years of age or older\n\nExclusion Criteria:\n\n* Unable to consent because of physical or mental incapacity.","ALL","18 Years",{"count":20,"type":21},300,"ESTIMATED","INTERVENTIONAL",[24],"NA","This project is a single-site, three-arm, randomized controlled trial investigating whether different length audio-recorded mindfulness practices differentially decrease pain among patients in a waiting room awaiting orthopedic care.",[27,28,29,30,31,32],"Pain","Pain Management","Mindfulness","Orthopedic","Acute Pain","Chronic Pain","RECRUITING","2026-07-10",{"date":36,"type":37},"2026-07-13","ACTUAL",{"date":39,"type":37},"2026-04-29",{"date":41,"type":21},"2027-04-30",{"name":43,"class":44},"Florida State University","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":45},"100053280","phase-3-reck-vs-exparel-in-robotic-nephrectomy-100053280","NCT07092566","R.E.C.K vs Exparel in Robotic Nephrectomy","Efficacy of Ropivacaine Epinephrine Clonidine Ketorolac (R.E.C.K) vs Exparel in Robotic Nephrectomy: a Randomized, Prospective Trial","Inclusion Criteria:\n\n1. Ability to understand and willingness to sign an IRB-approved informed consent\n2. Age ≥ 18 years at the time of consent.\n3. Planned robotic partial or radical nephrectomy\n\nExclusion Criteria:\n\n1. Determined not to be a candidate to receive R.E.C.K or Exparel per the enrolling investigator\n2. Known pregnancy\n3. Chronic opioid use within 30 days (as per patient report) prior to randomization (defined as ≥ 30 MME\u002Fday)\n4. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness\u002Fsocial situations that would limit compliance with study requirements as determined by the investigator.\n5. Known allergy to R.E.C.K. and\u002For Exparel",{"count":54,"type":21},170,[56],"PHASE3","The purpose of the study is to evaluate the efficacy of R.E.C.K (ropivacaine epinephrine clonidine ketorolac) vs Exparel during robotic partial and radical nephrectomy in a single institution, prospective, randomized trial. The study will evaluate post operative Numerical Rating Score (NRS) pain scores, post operative pain medication intake (opioids and over-the-counter pain medicines) and length of stay across the two patient cohorts. The findings will help to inform whether the increased cost of Exparel when compared to R.E.C.K is justified.",[59,60,28],"Renal Carcinoma","Nephrectomy \u002F Methods",[62,63],"Analgesics","Nephrectomy",{"date":36,"type":37},{"date":66,"type":37},"2025-11-14",{"date":68,"type":21},"2027-10",{"name":70,"class":44},"Wake Forest University Health Sciences",{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":84,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":45},"100053460","phase-4-the-effect-of-multimodal-pain-regimen-on-use-of-narcotics-after-rotator-cuff-tear-repair-100053460","NCT07076069","The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair","Inclusion Criteria:\n\n* Adults with rotator cuff tears who have failed conservative therapy and are now undergoing arthroscopic rotator cuff repair.\n\nExclusion Criteria:\n\n* Patients without capacity to consent for the study\n* Patients not able to have local nerve block\n* Patients who underwent previous shoulder surgery on the same side, kindling revision rotator cuff repair\n* Patients who are unable to record and verbalize their pain level due to altered mental status\n* Patients who are unable to tolerate any of the medications included in the multimodal pain regimen or standard pain regimen due to severe allergies or inability to consume medication\n* Patients with history of previously diagnosed alcohol or drug abuse, renal impairment, peptic ulcer disease, and gastrointestinal bleeding\n* Patients who are pregnant",{"count":78,"type":21},130,[80],"PHASE4","The goal of this clinical trial is to understand which group of pain control medications work best in adults after rotator cuff surgery.",[83,28],"Rotator Cuff Repairs",{"date":36,"type":37},{"date":86,"type":37},"2025-07-21",{"date":88,"type":21},"2028-06",{"name":90,"class":44},"Montefiore Medical Center",{"id":92,"slug":93,"hasResults":12,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":104,"conditions":105,"keywords":114,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":45},"100601587","phase-1-fentanyl-intranasal-for-retinopathy-of-prematurity-screening-in-preterm-infants-100601587","NCT07112430","Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants","Intranasal Fentanyl to Reduce Pain Intensity Associated With Retinopathy of Prematurity Screening in Preterm Infants: A Randomized Control Trial","FIREFLY","Inclusion Criteria\n\n* Preterm infants born ≤31 weeks gestational age and\u002For with birth weight \\\u003C1250 g\n* Scheduled to undergo routine retinopathy of prematurity (ROP) screening as part of standard NICU care\n* Clinically stable at the time of screening, defined as not requiring acute resuscitative support (no bag-mask ventilation, intubation, or chest compressions within the preceding 24 hours) and maintaining stable cardiorespiratory parameters on baseline respiratory support\n* Written informed consent obtained from a parent or legally authorized representative\n\nExclusion Criteria\n\n* Congenital anomalies or conditions affecting the nasal passages that would interfere with intranasal drug administration\n* Receipt of systemic opioids, benzodiazepines, barbiturates, or other sedative\u002Fanalgesic medications within 24 hours prior to the ROP examination\n* Known hypersensitivity or prior adverse reaction to fentanyl",{"count":100,"type":21},58,[102,103],"PHASE1","PHASE2","The goal of this clinical trial is to learn whether intranasal fentanyl (a pain medicine given as a nasal spray) can reduce pain and is safe to use during routine eye examinations for retinopathy of prematurity (ROP) in preterm infants. ROP is an eye condition that can affect babies born too early and requires regular eye examinations. The main questions this study aims to answer are: Does intranasal fentanyl lower pain during ROP screening? Is intranasal fentanyl safe for preterm infants? Researchers will compare intranasal fentanyl with a placebo (a saltwater spray that contains no medicine) to determine whether the medicine lowers pain during ROP screening.\n\nParticipants will receive either intranasal fentanyl or placebo before their routine ROP eye examination, in addition to the standard comfort measures normally used during the procedure. Researchers will measure participants' pain and monitor their heart rate, oxygen levels, and any side effects during and after the examination.",[106,107,28,108,109,110,111,112,113],"Neonatal Pain","Retinopathy of Prematurity (ROP)","Infant, Premature","Fentanyl","Infant, Newborn","Neonatal Intensive Care Units","Analgesia","Intranasal Drug Administration",[115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130],"intranasal fentanyl","fentanyl","neonatal analgesia","procedural pain","ROP screening","Retinopathy of Prematurity","Preterm infants","Premature infants","infant pain","Non-invasive analgesia","Opioid analgesia","Intranasal drug delivery","Neonatal intensive care","NICU","Pain management in neonates","Infant procedural sedation","NOT_YET_RECRUITING","2026-06-26",{"date":134,"type":37},"2026-06-30",{"date":136,"type":21},"2026-09-09",{"date":138,"type":21},"2028-06-01",{"name":140,"class":44},"Marsha Campbell-Yeo",{"id":142,"slug":143,"hasResults":12,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":148,"sex":17,"minAge":149,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":153,"conditions":154,"keywords":167,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":183},"100644951","the-impact-of-enhanced-music--natural-visuals-on-emotional-health-100644951","NCT07676110","The Impact of Enhanced Music & Natural Visuals on Emotional Health","Impacts of Music, Audio Enhancements, Audio Guidance, and Visuals on Physical and Emotional Well-being. (Emotional Health - Longitudinal 1 Randomized, Controlled Multi-center Study)","Inclusion Criteria:\n\n* You are 13 years of age or older\n* You can read, write, and speak English at a 5th-grade level or higher\n* You are legally capable of providing informed consent (adult participants) or capable of providing assent (child participants)\n* To the best of your knowledge, you are willing and able to commit to the session(s) and activities of this study\n* You are willing and able to use the sound-delivery and data-collection apparatus of this study\n* You are willing to use your own personal equipment. Depending on the study, you may need to have your own ear buds\u002Fheadphones and\u002For a \"smart\" device with internet and\u002For Bluetooth access (e.g., smartphone, iPad).\n* You have normal hearing in both ears.\n* You never experience ringing noises or buzzing sensations in your ears (tinnitus)\n* You do not use a heart\u002Fcardiac pacemaker and do not have any history of cardiac rhythm disturbances, such as cardiac conduction delays or blocks\n* You have no known history of fainting, fainting, spells or seizures, spinning sensations, or trouble with balance (medical terms include epilepsy, seizures, syncope, vertigo, nystagmus)\n* You do not use of any of the following medications: Beta blockers, steroids, ephedrine, acute anti-anxiety medication (e.g., benzodiazepines such as diazepam\u002FValium, lorazepam\u002FAtivan or clonazepam\u002FKlonopin), or acute or chronic pain medications (including narcotics and codeine)\n* For any study session, you will not be under the influence of any substances that could prevent safe participation and will not have consumed e.g., alcohol, THC, Psilocybin, or other mood-altering drugs in the 12 hours preceding the session.\n\nExclusion Criteria:\n\n\\-",true,"13 Years",{"count":151,"type":21},200,[24],"The investigators are conducting research on factors related to the self-regulation of mood and arousal states across a range of everyday activities as well as different levels of stress. Behavioral interventions-such as meditation, listening to music, or visualizing art or nature-offer important alternatives and\u002For adjunctive strategies to pharmaceutical tools or other mechanisms supporting physical and emotional well-being. This research will expand on the knowledge base regarding the impact of biophysical stimulation and\u002For frame of mind on an individual's self-directed management of physical and emotional health. Motivation, confidence, and composure are critical aspects of self-efficacy, framing a person's mindset to make healthy choices across daily activities.\n\nThe research in this protocol is carried out across multiple sites and studies by means of digital tools and a consistent participant experience workflow. Together, these resources are intended to support individuals across multiple self-directed experiences utilized in the maintenance of their basic health. Before, during, and after session experiences, the participant provides objective (physiological) responses and\u002For subjective (self-report) responses and reflections; some studies also include interviews or focus groups. The combined set of responses can be summarized, connected to other measures, and input to machine learning models to improve personalization of stimuli. By studying the effects of soundBrilliance experiences across a variety of contexts and participant samples, the investigators can better refine each element of the stimulus to improve satisfaction, tolerance, and targeted outcomes.",[155,156,157,158,159,160,161,162,163,164,28,165,166],"Emotion Management Skills","Lifestyle, Healthy","Lifestyle Intervention","Recovery","Exercise and Recovery","Exercise Training","Anxiety and Mood Disorders","Sleep","Motivation","Comfort","Rehabilitation","Creativity and Mindfulness",[168,169,170,171,172,173],"Music","Visuals","Visual Imagery","Biophysical Stimuli","Emotional Health","Emotional Management","2026-06-23",{"date":134,"type":37},{"date":177,"type":37},"2026-05-25",{"date":179,"type":21},"2027-06",{"name":181,"class":182},"soundBrilliance LLC","INDUSTRY",3,{"id":185,"slug":186,"hasResults":12,"nctId":187,"briefTitle":188,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":22,"phases":194,"briefSummary":195,"conditions":196,"keywords":197,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":206,"locationsCount":45},"100644616","phase-2-pilot-randomized-control-trial-comparing-oral-ketamine-and-oral-oxycodone-for-pain-control-in-emergency-department-patients-100644616","NCT07670507","Pilot Randomized Control Trial Comparing Oral Ketamine and Oral Oxycodone for Pain Control in Emergency Department Patients","PKORCT","Inclusion Criteria:\n\n* ED patient aged 18 years or older AND\n* English proficient AND\n* Able to give informed consent AND\n* Has a painful condition in the ED that includes any of the following: Musculoskeletal extremity pain, Musculoskeletal back or neck pain, Other nociceptive extremity pain\n* AND treating provider has deemed the patient necessitating 'second line pain therapy' (meaning: opioids or ketamine)\n\nExclusion Criteria:\n\nAny of the following:\n\n* Prisoner status\n* Pregnant\n* Non-English proficient\n* Cannot give informed consent\n* Requires emergent intravenous pain medicine (as deemed by the treating provider)\n* Prior participation in the study\n* Previous diagnosis of opioid use disorder\n* Previous ketamine addiction\n* Patient is in hospice or other palliative care measures\n* Contraindication to ketamine, including: Cystitis or bladder pain, Intracranial hypertension, Known coronary artery disease, Age greater than 75 years old, History of prior adverse reaction to ketamine or oxycodone, History or current major psychiatric disorder (as deemed by the treating ED clinician) or history of psychosis","75 Years",{"count":193,"type":21},60,[103,56],"The goal of this pilot randomized clinical trial is to learn if oral ketamine intervention can control pain in emergency department patients whose providers feel the need for additional pain medication. The main questions it aims to answer are:\n\n* Does oral ketamine result in a different mean change in pain scores compared with oral oxycodone?\n* Is there a difference in the need for additional opioid administration within 24 hours after the initial dose of study medication (oral ketamine vs oral oxycodone)?\n\nResearchers will compare oral ketamine to oral oxycodone to see if there is a difference in pain control or the need for additional opioid administration.\n\nParticipants will:\n\n* Fill out a survey prior to study medication administration assessing pain scores, pain presentation, and medication history\n* Be randomized to and receive a dose of oral ketamine or oral oxycodone as the study medication for pain control\n* Fill out a survey assessing pain control, side effects, and safety outcomes\n* Receive follow-up phone calls at 1 and 3 months after enrollment to assess pain and opioid use",[28],[198,199,200],"oral ketamine","pain control","oxycodone","2026-06-22",{"date":132,"type":37},{"date":204,"type":21},"2026-06-24",{"date":41,"type":21},{"name":207,"class":44},"Albany Medical College",{"id":209,"slug":210,"hasResults":12,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":215,"enrollmentInfo":216,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":218,"conditions":219,"keywords":224,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":4},"100644066","penglfcn-block-vs-qipb-for-total-hip-arthroplasty-100644066","NCT07667231","PENG+LFCN Block vs QIPB for Total Hip Arthroplasty","Comparison Between Quadro-iliac Plane Block (QIPB) and Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve Block for Total Hip Arthroplasty: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* American Society of Anesthesiologists physical status I-III\n* Scheduled for elective unilateral primary total hip arthroplasty\n* Surgery planned under spinal anesthesia\n* Ability to understand and use the Numeric Rating Scale\n* Written informed consent provided\n\nExclusion Criteria:\n\n* Refusal to participate\n* Revision total hip arthroplasty\n* Bilateral total hip arthroplasty\n* Contraindication to spinal anesthesia\n* Contraindication to peripheral nerve block\n* Known allergy to local anesthetics or study drugs\n* Coagulopathy or anticoagulant use incompatible with neuraxial\u002Fregional anesthesia\n* Infection at the block injection site\n* Pre-existing neurological deficit involving the operative lower extremity\n* Peripheral neuropathy\n* Chronic opioid use\n* Cognitive impairment or inability to communicate reliably\n* Severe hepatic or renal failure\n* Body mass index \\>35 kg\u002Fm²\n* Pregnancy","80 Years",{"count":193,"type":21},[24],"This randomized clinical trial aims to evaluate and compare the analgesic efficacy and functional outcomes of the quadro-iliac plane block (QIPB) and the pericapsular nerve group (PENG) block combined with lateral femoral cutaneous nerve(LFCN) block in patients undergoing total hip arthroplasty. The primary outcome is the Numeric Rating Scale (NRS) within the first 48 hours after surgery. Secondary outcomes include postoperative total opioid consumption, ıncidence of quadriceps motor block, time to first ambulation, block performance time, falls, length of hospital stay, block- related complications(hematoma,local anesthetic systemic complications, vascular puncture, and infection), patient satisfaction assessed using a Likert scale, and incidence of postoperative nausea and vomiting.",[220,221,222,28,223],"Quadro-Iliac Plane Block","Pericapsular Nerve Group Block (PENG Block)","Hip Arthroplasty, Total","Lateral Femoral Cutaneous Nerve Block",[225,226,227],"QIPB","PENG","LFCN","2026-06-20",{"date":230,"type":37},"2026-06-25",{"date":232,"type":21},"2026-11-15",{"date":234,"type":21},"2027-09-15",{"name":236,"class":44},"Antalya City Hospital",{"id":238,"slug":239,"hasResults":12,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":215,"enrollmentInfo":243,"targetDuration":4,"studyType":22,"phases":244,"briefSummary":245,"conditions":246,"keywords":248,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":254,"startDateStruct":255,"completionDateStruct":256,"leadSponsor":257,"locationsCount":4},"100644181","comparison-between-quadro-iliac-plane-block-qipb-and-supra-inguinal-fascia-iliaca-compartment-block-s-ficb-for-total-hip-arthroplasty-100644181","NCT07667218","Comparison Between Quadro-iliac Plane Block (QIPB) and Supra-Inguinal Fascia Iliaca Compartment Block (S-FICB) for Total Hip Arthroplasty","Comparison Between Quadro-iliac Plane Block (QIPB) and Supra-Inguinal Fascia Iliaca Compartment Block (S-FICB) for Total Hip Arthroplasty: a Randomized Controlled Trial",{"count":193,"type":21},[24],"This randomized clinical trial aims to evaluate and compare the analgesic efficacy and functional outcomes of the quadro-iliac plane block (QIPB) and the supra-inguinal fascia iliaca compartment block (S-FICB) in patients undergoing total hip arthroplasty.\n\nThe primary outcome is the Numeric Rating Scale (NRS) within the first 48 hours after surgery. Secondary outcomes include postoperative total opioid consumption, ıncidence of quadriceps motor block, time to first ambulation, block performance time, falls, length of hospital stay, block- related complications(hematoma,local anesthetic systemic complications, vascular puncture, and infection), patient satisfaction assessed using a Likert scale, and incidence of postoperative nausea and vomiting.",[220,247,222,28],"Supra-inguinal Fascia Iliaca Block",[249,250,251,252,253],"QİPB","S-FICB","HİP","PAİN","ARTHROPLASTY",{"date":204,"type":37},{"date":232,"type":21},{"date":234,"type":21},{"name":236,"class":44},{"id":259,"slug":260,"hasResults":12,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":4,"eligibilityCriteria":264,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":215,"enrollmentInfo":265,"targetDuration":4,"studyType":22,"phases":267,"briefSummary":268,"conditions":269,"keywords":270,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":45},"100642398","breestim-in-managing-neuropathic-pain-after-spinal-cord-injury-sci-100642398","NCT07659743","BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI)","A Randomized, Double-blind, Sham-controlled, Parallel-group Trial Designed to Evaluate the Efficacy of BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI)","Inclusion Criteria:\n\n* has a history of SCI \\> 1 year\n* has a DN4 (Douleur Neuropathique en 4 Questions) score of 4 or greater\n* has neuropathic pain \\>3 months\n* is stable on oral pain medications at least one month\n* Able to tolerate BreEStim treatment for 1 minute\n\nExclusion Criteria:\n\n* is on a mechanical ventilator\n* is currently having active urinary tract infection (UTI)\n* does not have any residual sensation in the arms\n* has other pain (musculoskeletal, visceral etc.), but not neuropathic, e.g., shoulder pain from wheelchair use\n* has a pacemaker to avoid possible side effect of electrical stimulation\n* is not able to follow commands, or to give consent\n* has asthma or other pulmonary disease\n* has a history of cardiac pathology, implanted pacemakers, or current use of rhythm altering medication like beta-blockers\n* has baclofen pump or deep brain implants\n* has respiratory tract\u002Fsinus infection and rhinorrhea\n* has low motor neuron injury that no responses will be triggered by electrical stimulation\n* has severe mental disorders (e.g., depression, substance abuse) and is receiving active treatment and frequent monitoring\n* is not medically stable",{"count":266,"type":21},66,[24],"The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and sham BreEStim and Transcutaneous Electrical Nerve Stimulation (TENS) in management of neuropathic pain in patients after spinal cord injury (SCI).",[28],[271,272],"neuropathic pain","BreEStim","2026-06-18",{"date":174,"type":37},{"date":276,"type":21},"2026-10-01",{"date":278,"type":21},"2029-09-30",{"name":280,"class":44},"The University of Texas Health Science Center, Houston",{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":285,"acronym":286,"eligibilityCriteria":287,"healthyVolunteers":12,"sex":17,"minAge":288,"maxAge":289,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":292,"briefSummary":293,"conditions":294,"keywords":297,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":45},"100644346","phase-3-influence-of-superficial-parasternal-intercostal-plane-block-on-internal-thoracic-artery-caliber-to-facilitate-surgical-harvesting-in-cabg-100644346","NCT07663435","Influence of Superficial Parasternal Intercostal Plane Block on Internal Thoracic Artery Caliber to Facilitate Surgical Harvesting in CABG","IMA CABG PIPB","Inclusion Criteria:\n\n* • Age group: Adult patients from age of 22 to 65 years.\n\n  * Sex: Both sexes\n  * Patients undergoing CABG with IMA harvesting\n\nExclusion Criteria:\n\n* • Patients with pre-existing active bloodstream infection or systemic infection\n\n  * Refuse consent\n  * IMA graft not suitable\n  * Morbidly obese (BMI \\> 40 )\n  * Hemodynamic instability\n  * Severe pulmonary disease\n  * Previous thoracic surgeries (makes it difficult to harvest IMA)\n  * Advanced malignancy or chronic disease with life expectancy less than six months\n  * Emergency surgery","22 Years","65 Years",{"count":291,"type":21},50,[56],"Influence of Superficial Parasternal Intercostal Plane Block (SPIPB) on Internal Thoracic Artery (ITA) Caliber and Surgical Harvesting Efficiency in Coronary Artery Bypass Grafting (CABG)",[28,295,296],"Parasternal Block","CABG Graft Integrity",[298,299,300],"IMA","CABG","SPIPB","2026-06-17",{"date":174,"type":37},{"date":304,"type":21},"2026-07",{"date":306,"type":21},"2026-12-31",{"name":308,"class":44},"Ain Shams University",{"id":310,"slug":311,"hasResults":12,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":12,"sex":317,"minAge":18,"maxAge":4,"enrollmentInfo":318,"targetDuration":4,"studyType":22,"phases":320,"briefSummary":321,"conditions":322,"keywords":326,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":336,"locationsCount":45},"100630405","phase-2-paracervical-block-with-combined-ketorolac-and-lidocaine-for-osmotic-dilator-placement-100630405","NCT07487246","Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement","Effects of Paracervical Block With Combined Ketorolac and Lidocaine on Perceived Pain in Osmotic Dilator Placement for Abortion, a Randomized Controlled Trial","PCB-KinD","Inclusion criteria:\n\nAge \\>\u002F= 18 years English or Spanish speaking Ability and willingness to sign the informed consent Ability and willingness to comply with the terms of the study including possessing active cell phone with text messaging capabilities Voluntary request for pregnancy termination Ultrasound-confirmed intrauterine pregnancy with an estimated gestational age of 16+0-23+6 weeks gestational age Require osmotic dilator placement one day prior to procedural abortion according to institutional protocol Seeking outpatient abortion services at Rush University Medical Center\n\nExclusion criteria:\n\nHave taken NSAIDs less than 6 hours prior to their clinic visit Contraindications to lidocaine such as allergy to lidocaine, cardiac arrhythmia or heart block, and porphyria Allergic reaction or sensitivity to NSAIDs History of peptic ulcer or gastrointestinal bleed, history of gastric bypass (RYGB) or recent history in last 6 months of gastric sleeve; history of inflammatory bowel disease (Ulcerative colitis, Crohn's disease) Uncontrolled hypertension, heart failure, ischemic heart disease, peripheral arterial disease, cerebrovascular disease Acute renal failure or chronic renal disease Chronic liver disease History of bleeding diathesis Untreated acute cervicitis or pelvic inflammatory disease Require or request PO benzodiazepine or IV sedation for placement of osmotic dilators Require more than 1 day of osmotic dilators Chronic or current narcotic use Current recreational drug use (excluding cannabis) Require transabdominal\u002Ftransvaginal injection for induced fetal demise prior to abortion","FEMALE",{"count":319,"type":21},76,[103],"The purpose of this study is to improve pain management for participantswho need osmotic dilators for cervical preparation the day before their second trimester abortion procedure.",[28,323,324,325],"Abortion","Second Trimester Abortion","Dilation and Evacuation",[327,328,329,330],"randomized controlled trial","osmotic dilators","ketorolac","paracervical block","2026-06-15",{"date":301,"type":37},{"date":334,"type":21},"2026-06-29",{"date":41,"type":21},{"name":337,"class":44},"Rush University Medical Center",{"id":339,"slug":340,"hasResults":12,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":4,"eligibilityCriteria":344,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":345,"targetDuration":4,"studyType":22,"phases":347,"briefSummary":348,"conditions":349,"keywords":352,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":45},"100642090","coeliac-plexus-vs-splanchnic-nerve-neurolysis-for-upper-abdominal-cancer-pain-100642090","NCT07653906","Coeliac Plexus vs Splanchnic Nerve Neurolysis for Upper Abdominal Cancer Pain","Effect of Coeliac Plexus Versus Splanchnic Nerve Neurolysis in Pain Management With Upper Abdominal Malignancies","Inclusion Criteria:\n\n* Adult patient\n* Both genders\n* Diagnosed case of upper abdominal malignancy (pancreatic, gastric, hepatic, or biliary origin)\n* Experiencing moderate to severe pain (≥5 on a 10 point visual analog scale)\n* Patients who are conscious and can communicate\n* No Contraindication for nerve block (e.g., coagulopathy, anticoagulant drugs)\n\nExclusion Criteria:\n\n* Previous coeliac plexus block, splanchnic nerve block, or major abdominal nerve ablation\n* Severe spinal deformities or anatomical distortion at the coeliac plexus or splanchnic nerve site\n* Local or systemic infection at or near the block site\n* Known allergy to local anesthetics or neurolytic agents\n* Pregnancy\n* Lactating mother\n* Cognitive impairment or psychiatric illness",{"count":346,"type":21},44,[24],"The goal of this clinical trial is to determine whether Neurolytic Splanchnic Nerve Block (NSNB) reduces pain in adults with upper abdominal malignancies. It will also evaluate the safety of Neurolytic Splanchnic Nerve Block (NSNB). The main questions it aims to answer are:\n\nDoes NSNB reduce pain intensity compared to Neurolytic Coeliac Plexus Block (NCPB), as measured by the Visual Analog Scale (VAS)? What adverse effects do participants experience when receiving Neurolytic Splanchnic Nerve Block (NSNB)?\n\nInvestigators will compare Neurolytic Splanchnic Nerve Block (NSNB) with Neurolytic Coeliac Plexus Block (NCPB) to determine which intervention provides more effective and safer pain relief.\n\nParticipants will:\n\n* receive either NSNB or NCPB under fluoroscopic guidance\n* be monitored immediately and for 2 hours after the procedure for any complications Have their pain intensity recorded immediately after the procedure, and at 7 days, 1 month, and 3 months\n* be evaluated for quality-of-life using European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 3 (EORTC QLQ-C30) at 1 month and 3 months.\n* have their opioid consumption tracked throughout the study.",[350,28,351],"Abdominal Neoplasms","Neurolytic Techniques",[353,354,355,356],"Upper abdominal cancer","Splanchnic nerve block","Coeliac plexus block","Analgesic efficacy","2026-06-12",{"date":301,"type":37},{"date":360,"type":37},"2026-05-01",{"date":362,"type":21},"2027-01-31",{"name":364,"class":44},"Bangladesh Medical University",{"id":366,"slug":367,"hasResults":12,"nctId":368,"briefTitle":369,"officialTitle":370,"acronym":4,"eligibilityCriteria":371,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":372,"enrollmentInfo":373,"targetDuration":4,"studyType":22,"phases":374,"briefSummary":375,"conditions":376,"keywords":380,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":384,"completionDateStruct":385,"leadSponsor":387,"locationsCount":45},"100642380","the-effect-of-intravenous-dexketoprofen-on-the-severity-and-incidence-of-rebound-pain-100642380","NCT07642674","The Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain","Evaluation of the Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain in Patients Undergoing Interscalene Brachial Plexus Block","Inclusion Criteria:\n\nAge 18-70 years ASA score of I-III Arthroscopic shoulder surgery\n\nExclusion Criteria:\n\nPatients who do not wish to participate in the study Creatinine clearance \\\u003C50 mL\u002F min Patients for whom NSAID use is contraindicated due to heart failure, Patients with psychiatric or cognitive dysfunction that would impair their ability to assess visual analog scale (VAS) pain scores Patients for whom peripheral nerve block is contraindicated","70 Years",{"count":266,"type":21},[24],"Orthopedic shoulder surgeries are associated with severe postoperative pain, particularly within the first 24-48 hours after surgery. In postoperative pain management, single or continue interscalene brachial plexus blocks, acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids administered as needed are commonly used as components of multimodal analgesia.\n\nRebound pain is defined as severe postoperative pain (VAS ≥ 7) occurring within the first 24 hours after resolution of the block. It is considered an adverse effect of regional anesthesia and typically develops 8-12 hours after a single-shot nerve block. Risk factors for rebound pain include pre-existing pain, female sex, younger age, bone surgery, lack of intraoperative dexamethasone administration, and inadequate analgesia.\n\nThe primary objective of this study is to evaluate the effect of intravenous dexketoprofen administered during the postoperative period on the incidence and severity of rebound pain in patients undergoing shoulder surgery with interscalene brachial plexus block",[377,28,378,379],"Postoperative Pain","Rebound Pain","Interscalene Block",[381],"Rebaund pain, Interscalene block, postoperative pain","2026-06-11",{"date":357,"type":37},{"date":382,"type":37},{"date":386,"type":21},"2027-01-01",{"name":388,"class":44},"Eskisehir Osmangazi University",{"id":390,"slug":391,"hasResults":12,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":12,"sex":17,"minAge":289,"maxAge":4,"enrollmentInfo":396,"targetDuration":4,"studyType":22,"phases":398,"briefSummary":399,"conditions":400,"keywords":402,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":408,"startDateStruct":409,"completionDateStruct":410,"leadSponsor":412,"locationsCount":4},"100641840","phase-2-effect-of-opioid-sparing-anesthesia-on-postoperative-opioid-consumption-and-pain-in-elderly-patients-undergoing-spine-surgery-100641840","NCT07588802","Effect of Opioid-Sparing Anesthesia on Postoperative Opioid Consumption and Pain in Elderly Patients Undergoing Spine Surgery","Effect of Opioid-Sparing Anesthesia on Postoperative Opioid Consumption and Pain in Spine Surgery","Inclusion Criteria:\n\n* Aged ≥ 65 years\n* Undergoing multilevel level (≥2 levels) spine surgery under general anesthesia\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Diagnosed with severe cognitive impairment or psychiatric disorders that impair participation or communication\n* Pregnant or breastfeeding\n* Patients with contraindications to any of the medications in the study protocol (unstable angina, recent myocardial infarction, cerebral or aortic aneurysms, increased intracranial pressure, increased intraocular pressure, psychosis or schizophrenia, pheochromocytoma, epilepsy, second- or third-degree atrioventricular block, bradycardia (heart rate \\\u003C 50bpm), liver failure, hypotension (systolic BP \\\u003C80 mmHg))\n* Drug or alcohol abuse\n* Refuse to participate",{"count":397,"type":21},120,[103],"The goal of this clinical trial is to learn if an anesthesia management strategy called opioid-sparing anesthesia could help reduce postoperative opioid consumption, pain intensity and enhance recovery in elderly patients undergoing spine surgery. The main questions it aims to answer are:\n\nDoes opioid-sparing anesthesia reduce postoperative opioid consumption?\n\nDose opioid-sparing anesthesia improve postoperative pain and enhance recovery?\n\nResearchers will compare opioid-sparing anesthesia to routine anesthesia which is used most common in clinical practice to see if opioid-sparing anesthesia lead to fewer postoperative opioid consumption and better pain and recovery outcomes.\n\nParticipants will randomly assigned to one of two groups. One group will receive opioid-sparing anesthesia management , while the other group will receive routine anesthesia management during general anesthesia.\n\nParticipants will provide two rectal swab samples for analysis, complete five questionnaires once preoperatively, and then complete five questionnaires daily for three days postoperatively.",[401,28],"Opoid Managment",[403,404,405,406,407],"Opioid-sparing anesthesia","Opioid consumption","postoperative pain","elderly patients","spine surgery",{"date":331,"type":37},{"date":304,"type":21},{"date":411,"type":21},"2027-05",{"name":413,"class":44},"Massachusetts General Hospital",{"id":415,"slug":416,"hasResults":12,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":4,"eligibilityCriteria":420,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":289,"enrollmentInfo":421,"targetDuration":4,"studyType":22,"phases":423,"briefSummary":424,"conditions":425,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":429,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":45},"100620761","comparison-of-cumulative-opioid-consumption-between-variable-rate-feedback-infusion-and-fixed-rate-basal-infusion-modes-of-intravenous-pca-following-mixed-surgery-100620761","NCT07361822","Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery","Prospective Randomized Controlled Study of Individualized PCA Model Based on Multi-dimensional Strategies (Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes)","Inclusion Criteria:\n\n* aged between 18 to 65 years;\n* American Society of Anesthesiologists physical status Ⅰ - Ⅲ;\n* Patients scheduled for elective mixed surgery were enrolled. Mixed surgeries included thoracic, abdominal, spinal, orthopaedic, and cranial procedures performed using either minimally invasive or open approaches.\n\nExclusion Criteria:\n\n* Allergy to PCA medications;\n* Presence of chronic pain syndromes;\n* Presence of psychiatric disorders, or severe cardiovascular, cerebrovascular, renal, or hepatic dysfunction.",{"count":422,"type":21},1170,[24],"Perioperative pain management affects patient recovery. However, the rate of moderate to severe postoperative pain is as high as 73.8%, which hinders recovery and increases the risk of complications. Although opioids are the first-line analgesics, excessive use leads to adverse reactions. The traditional fixed-rate PCA mode is difficult to match the changes in postoperative pain. This study will compare different PCA mode optimization strategies, assuming that they can reduce opioid dosage, improve analgesic effect, and reduce adverse reactions, providing high-quality evidence-based basis for postoperative analgesia and promoting individualized and intelligent management.",[426,28,427,428],"Surgery","Opioid Consumption","Patient-controlled Analgesia",{"date":357,"type":37},{"date":431,"type":37},"2025-12-30",{"date":433,"type":21},"2027-12-30",{"name":435,"class":44},"Beijing Tiantan Hospital",{"id":437,"slug":438,"hasResults":12,"nctId":439,"briefTitle":440,"officialTitle":441,"acronym":4,"eligibilityCriteria":442,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":289,"enrollmentInfo":443,"targetDuration":4,"studyType":22,"phases":445,"briefSummary":446,"conditions":447,"keywords":450,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":456,"lastUpdatePostDateStruct":457,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":45},"100617670","ultrasound-guided-regional-blocks-for-postoperative-analgesia-after-laparoscopic-cholecystectomy-100617670","NCT07321639","Ultrasound-Guided Regional Blocks for Postoperative Analgesia After Laparoscopic Cholecystectomy","Comparison of the Effectiveness of Ultrasound-Guided Recto-Intercostal Fascial Plane Block and Transversus Abdominis Plane Block in Postoperative Analgesia Management of Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* ASA physical status I-II\n* Scheduled for elective laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics or opioid medications\n* Infection at the planned block site\n* History of alcohol or drug dependence\n* Use of anticoagulant therapy\n* Refusal to participate in the study",{"count":444,"type":21},90,[24],"Ultrasound (US)-guided recto-intercostal fascial plane block (RIFPB) is a recently described abdominal wall block performed by injecting local anesthetic between the rectus abdominis muscle and the costal cartilage of the 7th rib. Due to the cranial attachment of the rectus muscle, this technique provides effective analgesia to the sternal, epigastric, and upper-mid abdominal regions, corresponding to the T6-T10\u002F11 dermatomal levels. RIFPB may be used as an adjunct technique for thoracic procedures or as a standalone block for abdominal surgery.\n\nUltrasound-guided transversus abdominis plane block (TAPB) is performed by injecting local anesthetic into the fascial plane between the internal oblique and transversus abdominis muscles. TAPB provides sensory blockade of the anterolateral abdominal wall at the T6-L1 dermatomal levels and is widely used for postoperative analgesia following abdominal surgeries, including laparoscopic cholecystectomy.\n\nThis study aims to compare the effectiveness of US-guided RIFPB and TAPB on postoperative pain control after laparoscopic cholecystectomy.",[448,31,28,449],"Laparoscopic Cholecystectomy","Plane Blocks",[451,452,453,454,455,404],"Laparoscopic cholecystectomy","Postoperative analgesia","Recto-intercostal fascial plane block","Transversus abdominis plane block","Regional anesthesia","2026-06-10",{"date":382,"type":37},{"date":459,"type":37},"2026-01-19",{"date":461,"type":21},"2027-07-15",{"name":463,"class":44},"Istanbul Medipol University Hospital",{"id":465,"slug":466,"hasResults":12,"nctId":467,"briefTitle":468,"officialTitle":469,"acronym":4,"eligibilityCriteria":470,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":215,"enrollmentInfo":471,"targetDuration":4,"studyType":472,"phases":4,"briefSummary":473,"conditions":474,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":475,"lastUpdatePostDateStruct":476,"startDateStruct":477,"completionDateStruct":479,"leadSponsor":480,"locationsCount":45},"100424769","mcid-and-pass-for-acute-pain-and-quality-of-recovery-after-orthopedic-surgery-100424769","NCT04811209","MCID and PASS for Acute Pain and Quality of Recovery After Orthopedic Surgery","Determining the Minimum Clinically Important Difference (MCID) and Patient Acceptable Symptom State (PASS) for Acute Pain and Quality of Recovery After Orthopedic Surgery","Inclusion Criteria:\n\n* Adult patients aged 18-80 years\n* ASA class I - III\n* Primary elective surgery\n* unilateral major shoulder surgery e.g., stabilization and arthroplasty procedures:\n* unilateral total hip replacement\n* unilateral total knee replacement, and\n* spinal decompression + fusion involving ≥ 2 levels.\n* Hospital admission for ≥ 24 hours after the surgery\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* Poor English comprehension\n* Psychiatric disorders e.g., dementia\n* Known allergies to morphine \u002F hydromorphone\n* Chronic substance abuse and use of recreational drugs\n* Any medical disorder that impairs accurate and objective completion of questionnaires",{"count":20,"type":21},"OBSERVATIONAL","This study seeks to define what constitutes an MCID and a PASS in patients undergoing a variety of elective major orthopedic surgery.",[28],"2026-06-08",{"date":456,"type":37},{"date":478,"type":37},"2021-06-21",{"date":306,"type":21},{"name":481,"class":44},"University Health Network, Toronto",{"id":483,"slug":484,"hasResults":12,"nctId":485,"briefTitle":486,"officialTitle":486,"acronym":4,"eligibilityCriteria":487,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":488,"targetDuration":4,"studyType":22,"phases":490,"briefSummary":491,"conditions":492,"keywords":4,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":495,"lastUpdatePostDateStruct":496,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":501,"locationsCount":45},"100643213","phase-4-the-effect-of-bupivacaine-liposomes-on-postoperative-pain-in-lung-transplant-patients-after-intercostal-nerve-block-a-randomized-controlled-study-100643213","NCT07641647","The Effect of Bupivacaine Liposomes on Postoperative Pain in Lung Transplant Patients After Intercostal Nerve Block: a Randomized Controlled Study","Inclusion Criteria:\n\n* Patients with end-stage lung disease undergoing bilateral lung transplantation; Age \\>18 years; Expected discontinuation of mechanical ventilation within 48 hours after surgery; The patient or legally authorized representative signs the informed consent form and agrees to participate in the study and follow-up.\n\nExclusion Criteria:\n\n* Body mass index ≤18 kg\u002Fm² or ≥35 kg\u002Fm²; Allergy or contraindication to local anesthetics; Preoperative tracheal intubation or requirement for extracorporeal life support; Expected use of other types of nerve block; Active systemic infection or infection at the planned block site; Severe hepatic insufficiency; Severe renal impairment; Chronic pain, neuropathic pain, long-term use of analgesics, or use of other psychotropic medications; Preoperative cognitive impairment, cerebrovascular disease, or history of psychiatric disorders; Severe coagulation dysfunction; Concomitant surgery during the same operative session; Pregnant or breastfeeding women.",{"count":489,"type":21},88,[80],"The goal of this clinical trial is to evaluate the efficacy and safety of liposomal bupivacaine for postoperative analgesia in adult patients undergoing lung transplantation. The main questions it aims to answer are:\n\nDoes liposomal bupivacaine reduce postoperative opioid consumption after lung transplantation? Does liposomal bupivacaine relieve postoperative pain without increasing adverse events?\n\nResearchers will compare patients receiving liposomal bupivacaine combined with bupivacaine hydrochloride with patients receiving bupivacaine hydrochloride alone to see whether liposomal bupivacaine provides better postoperative analgesia and reduces opioid requirements after lung transplantation.\n\nParticipants will:\n\nReceive lung transplantation under standard perioperative care. Receive intercostal nerve block with either liposomal bupivacaine combined with bupivacaine hydrochloride or bupivacaine hydrochloride alone.\n\nBe assessed for postoperative opioid consumption, pain scores, recovery-related outcomes, and adverse events after surgery.",[493,28,494],"Lung Transplantation","Liposomal Bupivacaine","2026-06-07",{"date":382,"type":37},{"date":498,"type":21},"2026-07-01",{"date":500,"type":21},"2028-07-01",{"name":502,"class":44},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":504,"slug":505,"hasResults":12,"nctId":506,"briefTitle":507,"officialTitle":508,"acronym":509,"eligibilityCriteria":510,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":511,"targetDuration":4,"studyType":22,"phases":513,"briefSummary":514,"conditions":515,"keywords":517,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":528,"leadSponsor":530,"locationsCount":45},"100640495","combined-distal-femoral-nerve-block-for-pain-control-after-knee-replacement-100640495","NCT07629388","Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement","Comparative Study Assessing the Efficacy of a Combined Distal Femoral Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty (TKA)","FEM-COMB","Inclusion Criteria:\n\n* Adult patients aged over 18 years.\n* Scheduled for total knee arthroplasty with multimodal analgesia.\n* Affiliated with or benefiting from a social security system.\n* Able to understand the study information and provide written informed consent.\n\nExclusion Criteria:\n\n* Emergency surgery.\n* Weight under 50 kg.\n* Body mass index over 40 kg\u002Fm².\n* Contraindication to nefopam, non-steroidal anti-inflammatory drugs, local anesthetics, or morphine.\n* Preoperative opioid use.\n* Antidepressant or gabapentinoid treatment.\n* Other planned surgical or medical procedures during the study period.\n* Participation in another clinical trial, or currently in an exclusion period from another trial.\n* Inability to understand study information for linguistic, psychological, cognitive, or literacy reasons.\n* Pregnancy, possible pregnancy without effective contraception, or breastfeeding.\n* Protected adults, including those under guardianship, curatorship, legal protection, detention, or otherwise unable to give informed consent.",{"count":512,"type":21},240,[24],"The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery. The main questions it aims to answer are:\n\n* Does the combined distal femoral nerve block reduce the amount of opioid needed in the post-anesthesia recovery room?\n* Does it preserve quadriceps muscle strength while improving postoperative pain control?\n\nResearchers will compare the combined distal femoral nerve block to a saphenous nerve block alone to see if the combined block provides better analgesia without reducing leg strength.\n\nParticipants will:\n\n* Receive either the combined distal femoral nerve block or the saphenous nerve block alone before surgery.\n* Also receive standard multimodal pain management, including anesthesia, surgical site infiltration, and postoperative pain medications.\n* Be assessed for pain, opioid use, nausea and vomiting, quadriceps strength, time to first standing, hospital stay length, and patient satisfaction from surgery until discharge.",[516,28],"Pain After Total Knee Arthroplasty",[518,519,520,521,405,522,523],"total knee arthroplasty","distal femoral nerve block","saphenous nerve block","femoral triangle block","opioid consumption","regional anesthesia","2026-06-04",{"date":526,"type":37},"2026-06-05",{"date":177,"type":21},{"date":529,"type":21},"2027-05-25",{"name":531,"class":44},"Ramsay Générale de Santé",{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":4,"eligibilityCriteria":538,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":539,"targetDuration":4,"studyType":22,"phases":540,"briefSummary":541,"conditions":542,"keywords":543,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":546,"startDateStruct":547,"completionDateStruct":549,"leadSponsor":551,"locationsCount":45},"100608142","imagined-acupuncture-for-postoperative-pain-after-spinal-surgery-100608142","NCT07197710","Imagined Acupuncture for Postoperative Pain After Spinal Surgery","Assessing the Efficacy of Imagined Acupuncture for Postoperative Acute Pain Management in Spinal Surgery","Inclusion Criteria:\n\n* Undergoing 1- to 2-level primary spine surgery\n* Aged 18 years or older\n* Willing and able to receive postoperative imagined acupuncture (VGAIT)\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Undergoing revision surgery or procedures involving more than 3 spinal levels\n* History of prior spinal surgery\n* Intraoperative complications likely to interfere with postoperative pain assessment\n* Diagnosed with severe cognitive impairment or psychiatric disorders that impair participation or communication\n* Pregnant or breastfeeding\n* Unable to cooperate with treatment or pain assessments Individuals with uncorrectable vision impairment that would interfere with viewing study videos or completing study questionnaires.",{"count":397,"type":21},[24],"The goal of this clinical trial is to evaluate whether imagined acupuncture can reduce postoperative acute pain in adult patients undergoing spinal surgery. The main questions it aims to answer are:\n\nDoes video-guided imagined acupuncture improve postoperative pain control?\n\nDoes the intervention reduce opioid consumption and improve functional recovery in the immediate postoperative period?\n\nResearchers will compare the imagined acupuncture group to the control education video group to see if imagery-based intervention leads to better pain outcomes and reduced analgesic use.\n\nParticipants will:\n\nWatch a 30-minute video once daily for 7 consecutive days after surgery\n\nComplete pain and function assessments during the hospital stay and postoperative follow-up",[28],[544,545],"Postoperative Acute Pain","Imagined Acupuncture",{"date":475,"type":37},{"date":548,"type":37},"2025-10-01",{"date":550,"type":21},"2026-09-19",{"name":552,"class":44},"Jingping Wang, MD, Ph.D.",{"id":554,"slug":555,"hasResults":12,"nctId":556,"briefTitle":557,"officialTitle":558,"acronym":4,"eligibilityCriteria":559,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":560,"targetDuration":4,"studyType":22,"phases":562,"briefSummary":563,"conditions":564,"keywords":568,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":575,"leadSponsor":577,"locationsCount":45},"100642849","development-of-a-pain-rehabilitation-program-for-chronic-pain-after-sci-100642849","NCT07634796","Development of a Pain Rehabilitation Program for Chronic Pain After SCI","Feasibility of a New Digital Pain Rehabilitation Program for People With SCI","Inclusion Criteria:\n\n* two years since injury\n* Stable pain medication?\n\nExclusion Criteria:\n\n* severe cognitive impairment\n* Alcohol or drug abuse\n* does not understand Swedish",{"count":561,"type":21},32,[24],"Pain rehabilitation programs are essential for optimal treatment of chronic pain and are usually based on the biopsychosocial model. This is, however, not standard care for people with chronic pain after a spinal cord injury (SCI) due to a biomedical focused perspective of SCI and lack of adapted programs.\n\nThe aims of this feasibility study:\n\n1. Develop a new digital pain rehabilitation program, adapted for the needs of people living with an SCI.\n2. To investigate the feasibility and acceptability of a new digital pain rehabilitation program.",[565,32,566,567,28],"Spinal Cord Injuries","Neuropathic Pain","Interprofessional Team Collaboration",[569,570],"participatory design","feasibility study","2026-06-02",{"date":573,"type":37},"2026-06-09",{"date":276,"type":21},{"date":576,"type":21},"2027-09",{"name":578,"class":44},"Umeå University",{"id":580,"slug":581,"hasResults":12,"nctId":582,"briefTitle":583,"officialTitle":583,"acronym":4,"eligibilityCriteria":584,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":289,"enrollmentInfo":585,"targetDuration":4,"studyType":22,"phases":586,"briefSummary":587,"conditions":588,"keywords":591,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":594,"startDateStruct":596,"completionDateStruct":597,"leadSponsor":599,"locationsCount":45},"100626942","comparison-of-postoperative-analgesic-effects-of-quadro-iliac-plane-block-and-transversus-abdominis-plane-blocks-in-inguinal-hernia-surgery-100626942","NCT07442188","Comparison of Postoperative Analgesic Effects of Quadro-iliac Plane Block and Transversus Abdominis Plane Blocks in Inguinal Hernia Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* Patients with an American Society of Anesthesiologists (ASA) physical status classification of I-III.\n* Patients with a body mass index (BMI) between 18 and 30 kg\u002Fm².\n* Patients scheduled to undergo unilateral inguinal hernia repair under general anesthesia in the operating room.\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 65 years.\n* Patients with an ASA physical status classification of IV or higher.\n* Patients with advanced comorbidities.\n* Patients with a history of bleeding diathesis.\n* Patients with infection at the site of the planned procedure.\n* Patients with a BMI below 18 kg\u002Fm² or above 30 kg\u002Fm².",{"count":193,"type":21},[24],"Inguinal hernia repair is one of the most commonly performed surgical procedures worldwide. Despite being classified as a minor surgical intervention, moderate to severe postoperative pain is reported in approximately 60% of patients. In a subset of these patients, acute postoperative pain may persist and evolve into chronic post-surgical inguinal pain, significantly affecting quality of life.\n\nIn recent years, beyond the use of systemic intravenous analgesics, ultrasound-guided fascial plane blocks have been increasingly incorporated into multimodal analgesia protocols with the aim of reducing postoperative opioid consumption and improving pain control. However, the current literature does not provide definitive evidence regarding the superiority of one block technique over another in this surgical population.\n\nThe primary objective of the present study is to compare the analgesic efficacy of the Quadro-iliac Plane Block (QIPB) and the transversus abdominis plane block (TAPB) in patients undergoing inguinal hernia repair.",[589,28,590],"Peripheral Nerve Block","Hernia, Inguinal",[592,593],"Quadro Iliac Plane Block","Transversus Abdominis Plane Block",{"date":595,"type":37},"2026-06-03",{"date":571,"type":37},{"date":598,"type":21},"2026-10-19",{"name":600,"class":601},"Ankara Etlik City Hospital","OTHER_GOV",{"id":603,"slug":604,"hasResults":12,"nctId":605,"briefTitle":606,"officialTitle":607,"acronym":4,"eligibilityCriteria":608,"healthyVolunteers":148,"sex":17,"minAge":18,"maxAge":215,"enrollmentInfo":609,"targetDuration":4,"studyType":22,"phases":611,"briefSummary":612,"conditions":613,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":629,"startDateStruct":630,"completionDateStruct":632,"leadSponsor":634,"locationsCount":45},"100610370","phase-3-suzetrigine-in-total-hip-arthroplasty-100610370","NCT07226700","Suzetrigine in Total Hip Arthroplasty","A Randomized, Placebo-controlled, Double-blind Trial of Suzetrigine in Total Hip Arthroplasty","Inclusion Criteria:\n\n* Patients undergoing primary THA (posterior approach) with participating surgeons\n* Age 18 to 80 years old\n* Planned discharge to home\n* Planned use of neuraxial anesthesia\n* American Society of Anesthesiologists (ASA) Physical Status 1 - 3\n\nExclusion Criteria:\n\n* ASA greater than 3\n* Chronic opioid use (daily MME of greater than 30 mg for at least 3 months and within 1 month of surgery)\n* History of chronic pain syndromes or uncontrolled pain (i.e. complex regional pain syndrome, fibromyalgia, implanted spinal cord stimulator)\n* History of QT prolongation\n* Presence of automated implantable cardioverter defibrillator, pacemaker or cardiac resynchronization device\n* Evidence of misuse, aberrant use, or addiction to alcohol or an illicitly used drug of abuse, or had a positive test for drugs of abuse\n* Inability to comply with any component of the study protocol\n* Younger than 18 or greater than 80 years old at the time of enrollment\n* Patient already on Suzetrigine\n* Allergy or contraindication to Suzetrigine or excipients (eg moderate to severe liver disease\u002FChild Pugh B or C, use of strong CYP3 inhibitors or inducers)\n* Contraindications to neuraxial anesthesia or any other part of the study protocol\n* Participation in another investigational drug or device study\n* Pregnancy",{"count":610,"type":21},210,[56],"Total hip and knee joint replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery. Despite widespread use of multimodal regimens, many patients still rely on opioids, which can cause sedation, nausea, constipation, and long-term dependency. Evaluating Suzetrigine in this high-need population may improve recovery trajectories, reduce opioid consumption, and support enhanced recovery protocols. Given the growing surgical volume and the emphasis on opioid-sparing strategies, rigorous investigation of Suzetrigine's efficacy in joint replacement is of high clinical value. In this study, patients undergoing primary total hip replacement will be randomized to receive either Suzetrigine or placebo for seven days, with the loading dose administered prior to surgery. The primary outcome is cumulative 48-hour opioid consumption in oral morphine equivalents starting from entry into the post-anesthesia care unit (PACU).",[614,615,616,617,618,619,620,28,27,621,622,623,624,625,626,627,628],"Total Hip Arthroplasty (THA)","Total Hip Arthroplasty \\(THA\\)","Total Hip Replacement","Total Hip Replacement Surgery","Total Hip Replacements","Total Hip Replacement Arthroplasty","Suzetrigine","Nav 1.8","JOURNAVX","Opioid Cessation","Opioid Consumption, Postoperative","Multimodal Analgesia","Randomized Controlled Trial","Randomized Controlled Study","Randomized Controlled Trials",{"date":595,"type":37},{"date":631,"type":37},"2025-11-03",{"date":633,"type":21},"2028-11-01",{"name":635,"class":44},"Hospital for Special Surgery, New York",{"id":637,"slug":638,"hasResults":12,"nctId":639,"briefTitle":640,"officialTitle":641,"acronym":4,"eligibilityCriteria":642,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":289,"enrollmentInfo":643,"targetDuration":4,"studyType":22,"phases":645,"briefSummary":646,"conditions":647,"keywords":649,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":652,"lastUpdatePostDateStruct":653,"startDateStruct":655,"completionDateStruct":656,"leadSponsor":658,"locationsCount":45},"100638017","comparison-of-analgesic-effects-of-acb-versus-acb-combined-with-bifes-block-in-meniscopathy-surgery-100638017","NCT07603323","Comparison of Analgesic Effects of ACB Versus ACB Combined With BiFeS Block in Meniscopathy Surgery","Comparison of Analgesic Effects of Adductor Canal Block Versus Adductor Canal Block Combined With BiFeS (Biceps Femoris Short Head) Block in Meniscopathy Surgery","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* American Society of Anesthesiologists (ASA) score I-II-III\n* Body Mass Index (BMI) between 18-30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Patients under 18 and over 65 years of age\n* ASA score IV and above\n* Patients with a history of bleeding diathesis\n* BMI below 18 or above 30 kg\u002Fm2",{"count":644,"type":21},135,[24],"Meniscopathy surgeries are commonly associated with moderate postoperative pain, particularly during early mobilization and rehabilitation. Inadequate postoperative analgesia may negatively affect functional recovery, delay ambulation, increase opioid consumption, and contribute to opioid-related adverse effects. Therefore, effective multimodal analgesic strategies are of considerable importance in patients undergoing arthroscopic knee procedures.\n\nAdductor canal block (ACB) is a widely used regional anesthesia technique that provides effective analgesia while largely preserving quadriceps muscle strength. However, its limited effect on posterior knee capsule innervation may result in insufficient control of posterior knee pain. Recently, the biceps femoris short head (BiFeS) block has been described as a novel motor-sparing fascial plane block targeting the posterolateral knee capsule and may provide additional analgesic benefit when combined with ACB.\n\nIn this study, it was aimed to compare the postoperative analgesic efficacy of adductor canal block alone and adductor canal block combined with BiFeS block in patients undergoing surgery for meniscopathy.",[648,589,28],"Meniscopathy Surgery",[648,650,651],"Adductor Canal Block","Biceps Femoris Short Head Block","2026-05-27",{"date":654,"type":37},"2026-05-29",{"date":652,"type":37},{"date":657,"type":21},"2027-05-21",{"name":600,"class":601},{"id":660,"slug":661,"hasResults":12,"nctId":662,"briefTitle":663,"officialTitle":664,"acronym":4,"eligibilityCriteria":665,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":289,"enrollmentInfo":666,"targetDuration":4,"studyType":22,"phases":668,"briefSummary":669,"conditions":670,"keywords":672,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":675,"lastUpdatePostDateStruct":676,"startDateStruct":677,"completionDateStruct":679,"leadSponsor":680,"locationsCount":45},"100631603","recto-intercostal-fascial-plane-block-in-cholecystectomy-100631603","NCT07502833","Recto-intercostal Fascial Plane Block in Cholecystectomy","Recto-intercostal Fascial Plane Block Reduces Intraoperative Opioid and Volatile Anesthetic Use: a Randomized Trial in Cholecystectomy","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* Scheduled for elective laparoscopic cholecystectomy\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Known allergy to local anesthetics\n* Coagulopathy or anticoagulant therapy\n* Infection at the injection site\n* Body weight less than 75 kg\n* Severe hepatic or renal dysfunction\n* Pregnancy or breastfeeding",{"count":667,"type":21},64,[24],"This study aims to evaluate whether an ultrasound-guided recto-intercostal fascial plane block performed before surgical incision in patients undergoing laparoscopic cholecystectomy reduces intraoperative opioid and volatile anesthetic consumption. Additionally, the study assesses its effects on postoperative pain and the incidence of nausea and vomiting.",[28,671],"Recto Intercostal Nerve Block",[673,674,522,405],"cholecystektomy","rectointercostal facial plane block","2026-05-23",{"date":652,"type":37},{"date":678,"type":37},"2026-01-03",{"date":177,"type":21},{"name":600,"class":601}]