[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pain-perception\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pain-perception":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,45,72,99,129,169,191,215],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100642999","investigation-of-pain-modulation-phenotypes-in-female-patients-with-fibromyalgia-100642999",false,"NCT07640607","Investigation of Pain Modulation Phenotypes in Female Patients With Fibromyalgia","Inclusion Criteria:\n\n1. Having received a diagnosis of fibromyalgia according to the 2016 ACR diagnostic criteria\n2. Female patients aged 18-65\n3. Being literate\n4. Having signed the informed consent form upon agreeing to participate in the study\n\nExclusion Criteria:\n\n1. Being under 18 or over 65 years of age\n2. Having any condition that may lower the pain threshold or cause chronic pain (Rheumatoid Arthritis, Ankylosing Spondylitis, systemic inflammatory diseases, malignancies, etc.)\n3. Any neurological condition (stroke, traumatic brain injury, multiple sclerosis, Parkinson's disease, central nervous system malignancies…)\n4. Peripheral artery disease\n5. Severe cardiopulmonary insufficiency (stage 3-4)\n6. Uncontrolled systemic diseases such as hypertension and diabetes\n7. Presence of an active infection\n8. Pregnancy\n9. Presence of cognitive impairment, hearing loss, or communication difficulties that would prevent understanding of questionnaires and protocols","FEMALE","18 Years","65 Years",{"count":19,"type":20},82,"ESTIMATED","OBSERVATIONAL","Fibromyalgia is characterized by altered pain processing, including impaired descending pain inhibition and central sensitization. While both mechanisms have been independently associated with disease severity, their interrelationship remains unclear. This cross-sectional study aims to investigate whether central sensitization symptoms mediate the relationship between conditioned pain modulation and fibromyalgia impact.",[24,25,26,27,28],"Fibromyalgia (FM)","Quantitative Sensory Testing","Central Sensitization","PRESSURE PAIN THRESHOLD","Pain Perception",[30,31,32],"Fibromyalgia","Pain sensitization","Conditioned pain modulation","NOT_YET_RECRUITING","2026-06-05",{"date":36,"type":37},"2026-06-11","ACTUAL",{"date":39,"type":20},"2026-06-01",{"date":41,"type":20},"2026-09-01",{"name":43,"class":44},"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100638429","effect-of-super-pen-computer-controlled-intraligamentary-injection-on-pain-perception-in-pediatric-patients-undergoing-extraction-of-primary-molars-100638429","NCT07575035","EFFECT OF SUPER PEN COMPUTER-CONTROLLED INTRALIGAMENTARY INJECTION ON PAIN PERCEPTION IN PEDIATRIC PATIENTS UNDERGOING EXTRACTION OF PRIMARY MOLARS","EFFECT OF SUPER PEN COMPUTER-CONTROLLED INTRALIGAMENTARY INJECTION ON PAIN PERCEPTION IN PEDIATRIC PATIENTS UNDERGOING EXTRACTION OF PRIMARY MOLARS (RANDOMIZED CONTROLLED CLINICAL TRIAL)","Inclusion Criteria:\n\n* Age 5-7 years.\n* Children free from systemic diseases or special healthcare needs (ASAI).14\n* No previous negative dental experiences.15\n* Positive or definitely positive preoperative behaviour, according to the Frankl Behaviour Rating Scale (scores 3 or 4) (Appendix I).16\n* Mandibular primary molars indicated for extraction.17,18\n* Parental consent to participate in the study.\n\nExclusion Criteria:\n\n* Root resorption exceeding one-third of root length or signs of mobility.\n* Fractured roots\n* Ankylosed roots.\n* Active infection or pathosis at the injection site.\n* History of allergy to local anesthetics.","ALL","5 Years","7 Years",{"count":56,"type":20},30,"INTERVENTIONAL",[59],"NA","The aim of this study to evaluate the effectiveness of CC-ILA using Super pen in eliminating pain during the extraction of mandibular primary molars, compared to the conventional Inferior Alveolar Nerve Block (IANB).",[28],"2026-05-03",{"date":64,"type":37},"2026-05-08",{"date":66,"type":20},"2026-05-01",{"date":68,"type":20},"2026-08-01",{"name":70,"class":44},"Shatha Musaad Alharthi",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":52,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":57,"phases":82,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100612366","music-therapy-to-reduce-anxiety-and-pain-in-chronic-pain-patients-during-procedures-100612366","NCT07252648","Music Therapy to Reduce Anxiety and Pain in Chronic Pain Patients During Procedures","Effect of Peri-Operative Music Therapy on Anxiety, Pain Catastrophising, and Pain in Chronic Pain Patients Undergoing Interventional Pain Procedures - A Randomised Controlled Trial","Inclusion Criteria:\n\n* aged ≥21years\n* chronic pain ≥3 months\n* scheduled for interventional pain procedures\n\nExclusion Criteria:\n\n* presence of hearing impairment\n* lack of capacity to consent\n* non-interventional pain procedures, e.g. lignocaine infusion, ketamine infusion\n* pregnant women","21 Years",{"count":81,"type":20},110,[59],"This study aims to find out whether listening to music before, during, and after pain procedures can help reduce anxiety, pain catastrophising, and acute pain in patients with chronic pain. Music therapy may provide a simple, safe, and non-drug way to help patients relax and feel more comfortable.\n\nIn this study, adult patients with chronic pain who are scheduled for interventional pain procedures at Singapore General Hospital will be randomly assigned to one of two groups. One group will listen to self-selected music through headphones and speakers before, during, and after the procedure. The other group will receive standard care without music.\n\nResearchers will measure anxiety, pain catastrophising, and pain levels before and after the procedure using validated questionnaires. The main outcome will be the level of anxiety after the procedure. Other outcomes include pain catastrophising scores, pain scores during local anaesthetic injection, and overall patient satisfaction.\n\nThis study will help determine if music therapy can be routinely used to improve comfort and emotional well-being for patients undergoing interventional pain procedures.",[85,86,87,28,88],"Chronic Pain","Anxiety","Music Therapy","Pain Catastrophizing",[88,87,86,85],"2026-04-23",{"date":92,"type":37},"2026-04-29",{"date":94,"type":20},"2026-03-30",{"date":96,"type":20},"2026-12-31",{"name":98,"class":44},"Singapore General Hospital",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":52,"minAge":16,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":57,"phases":109,"briefSummary":110,"conditions":111,"keywords":114,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":71},"100628892","turkish-validity-and-reliability-of-the-behavioral-indicators-of-pain-scaleescid-100628892","NCT07467551","Turkish Validity and Reliability of the Behavioral Indicators of Pain Scale(ESCID)","Reliability and Validity of the Turkish Version of the Behavioral Indicators of Pain Scale in Mechanically Ventilated Intensive Care Unit Patients","Inclusion Criteria:\n\n* Individuals aged 18 years and older\n* Patients who are intubated, receiving mechanical ventilation, and unable to establish verbal communication (Glasgow Coma Scale score \\\u003C14)\n* Patients who have been hospitalized in the intensive care unit for at least 24 hours\n\nExclusion Criteria:\n\n* Presence of postoperative complications\n* Hemodynamic instability\n* History of diagnosed cognitive or psychiatric disorders\n* History of epilepsy or use of neuromuscular blocking agents\n* History of spinal cord injury affecting motor function of all four extremities\n* Individuals with a Richmond Agitation-Sedation Scale (RASS) score of -5 (unresponsive)\n* Cases with suspected brain death","85 Years",{"count":108,"type":20},50,[59],"A significant proportion of patients hospitalized in intensive care units (ICUs) require mechanical ventilation, and the treatments applied during this process may cause pain. Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Although it is associated with delirium and agitation, pain is often an overlooked symptom in ICU patients, and a large proportion of mechanically ventilated patients continue to experience moderate to severe pain. The most common type of pain in critically ill patients is nociceptive pain, which may result from invasive procedures such as tracheal intubation, catheter insertion, aspiration, wound care, and patient repositioning. Additionally, the noisy and unfamiliar ICU environment and patients' inability to express themselves may further increase the perception of pain.\n\nRegular assessment of pain is associated with many positive outcomes, including more effective pain management, appropriate use of analgesic and sedative medications, and shorter duration of mechanical ventilation and ICU stay. Although self-reporting of pain is considered the gold standard, many patients receiving mechanical ventilation are unable to communicate their pain. Therefore, various behavioral pain assessment scales are used to evaluate pain in ICU patients. One of these tools is the Behavioral Indicators of Pain Scale (Escala de Conductas Indicadoras de Dolor - ESCID), which was developed to assess pain in critically ill adult patients receiving mechanical ventilation who are unable to communicate. However, a Turkish version of this scale has not yet been developed. Therefore, the aim of this study is to translate the ESCID scale into Turkish, perform its cultural adaptation, and test the validity and reliability of the Turkish version.",[112,28,113],"Mechanical Ventilation","Intensive Care (ICU)",[115,116,117,118],"mechanical ventilation","intensive care","intubation","pain","RECRUITING","2026-03-13",{"date":122,"type":37},"2026-03-16",{"date":124,"type":37},"2026-03-01",{"date":126,"type":20},"2027-07-01",{"name":128,"class":44},"Saglik Bilimleri Universitesi",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":136,"sex":52,"minAge":16,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":57,"phases":140,"briefSummary":141,"conditions":142,"keywords":148,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":71},"100615273","pain-perception-and-exercise-induced-hypoalgesia-across-circadian-rhythms-100615273","NCT07290465","Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms","Exploring Pain Perception Through Exercise-Induced Hypoalgesia Across Circadian Rhythms for Healthy Participants","Inclusion Criteria:\n\n* Healthy participants\n* age 18 to 40 years\n* good level of English that allow the enrolled participant to provide informed consent and complete the questionnaires provided\n* being categorized as \"moderate\" in the International Physical Activity Questionnaire (IPAQ)\n\nExclusion Criteria:\n\n* inability to report pain intensity reliably\n* consumption of narcotics or tobacco products\n* regularly taking pain medications and analgesics\n* pregnant or planning to get pregnant\n* surgery within the last 12 months\n* acute or chronic pain conditions\n* uncontrolled hypertension\n* cardiovascular diseases, pulmonary diseases, neurological diseases with significant changes in somatosensory and pain perception, metabolic diseases, serious systemic diseases or conditions that restrict normal daily activities, inflammatory conditions (e.g. rheumatoid arthritis), or orthopedic injuries\n* intolerable pain during the pain perception test\n* serious psychiatric conditions (e.g., schizophrenia and bipolar disorder) or psychological disorders (e.g., depression) that may affect pain thresholds (16).\n* Severe sleep disorders and circadian rhythm disturbances\n* BMI \\> 30\n* serious fatigue or delayed-onset muscle soreness (9) at least 24 h after exercise sessions or a sudden change in activity for more than one week",true,"40 Years",{"count":139,"type":20},56,[59],"The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years.\n\nThe main questions it aims to answer are:\n\n* Does the time of day (morning vs. evening) influence changes in pain perception following exercise?\n* Do chronotype, sex, or stimulation site (bony vs. muscular) alter the magnitude of this effect?\n\nParticipants will:\n\n* Complete questionnaires\n* Undergo quantitative sensory testing\n* Attend both morning and evening sessions in randomized crossover order",[143,144,28,145,146,147],"Exercise Induced Hypoalgesia","Circadian Rhythm","Healthy Participants","Chronotype","Physical Therapy",[149,28,144,146,145,150,151,152,153,154,155,156,147,157,158,159],"Exercise-Induced Hypoalgesia","High-Intensity Functional Training","Supervised Deep Breathing","Pressure Pain Threshold (PPT)","Pain pressure tolerance threshold (PPTol)","Quantative Sensory Testing","Bony Landmarks","Muscular Landmarks","Randomized Control Trial","Crossover","Pain Management","2025-12-04",{"date":162,"type":37},"2025-12-18",{"date":164,"type":20},"2026-01",{"date":166,"type":20},"2026-04",{"name":168,"class":44},"Medipol University",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":52,"minAge":53,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":57,"phases":179,"briefSummary":180,"conditions":181,"keywords":4,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":71},"100580768","effectiveness-of-vibratory-versus-cold-stimuli-on-pain-perception-in-children-100580768","NCT06841601","Effectiveness of Vibratory Versus Cold Stimuli on Pain Perception in Children","Effectiveness of Vibratory Versus Cold Stimuli on Pain Perception During Needle Insertion in Children","Inclusion Criteria:\n\n1. Patients indicated for simple restorative procedures.\n2. Children with physical status ASA I, II.\n3. Children with no learning disabilities\n4. Positive or definitely positive behavior during preoperative assessments according to the Frankl Scale.\n5. Patients whom parents will give consent to participate\n\nExclusion Criteria:\n\n1. Patients allergic to local anesthesia or having a family history of allergy to local anesthesia.\n2. Patients with acute oral or facial infection (swelling and\u002For cellulites)\n3. Having active sites of pathosis in the area of injection that could affect anesthetic assessment.\n4. Children with special health care needs.","9 Years",{"count":178,"type":20},72,[59],"Local anesthesia is an anxiety-provoking procedure. Pain control is important for effective behavior guidance, specially among pediatric patients.\n\nThis study aims to evaluate the effectiveness of Buzzy® as a topical anesthetic in pain perception through two ways: once using vibration mode without the cold pack and the other using the cold pack without vibration and comparing it to topical anesthetic gel during different anesthetic techniques Methods: A randomized controlled clinical trial involving 72 healthy cooperative patients aged 5-9 years. They will be allocated to receive local anesthesia either using the vibration mode of Buzzy Bee (test group) or the cold pack of Buzzy Bee (test group) or conventional topical anesthetic gel (control group). Pain response will be assessed using Visual Analog Scale (VAS) and SEM scale.",[28],"2025-02-20",{"date":184,"type":37},"2025-02-24",{"date":186,"type":20},"2025-02-23",{"date":188,"type":20},"2025-03-25",{"name":190,"class":44},"Alexandria University",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":136,"sex":52,"minAge":16,"maxAge":137,"enrollmentInfo":198,"targetDuration":4,"studyType":57,"phases":200,"briefSummary":201,"conditions":202,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":71},"100567415","pain-perception-and-the-autonomic-nervous-system-100567415","NCT06667895","Pain Perception and the Autonomic Nervous System","Influences of the Autonomic Nervous System on Experimental Pain Sensitization","Inclusion Criteria:\n\n1. Over 18 and below 40 years of age\n2. Good general health\n3. Able to give informed consent\n\nExclusion Criteria:\n\n1. Any major medical or psychiatric condition (e.g. heart disease, diabetes, autoimmune disorders, infectious diseases, major depressive disorder), any chronic pain condition, any respiratory problems, any acute pain at time of study\n2. Inability to follow study instructions, e.g. due to language problems\n3. Pregnancy (female participants will be asked if pregnancy could be possible)\n4. Increased alcohol (\\>2 (for women)\u002F4 (for men) standard glasses per day or \\>5 (for women)\u002F4 (for men) glasses at least once a month within a few hours) or caffeine consumption (≥ 400mg per day)\n5. Consumption of alcohol, drugs, analgesics within the last 24 h\n6. Consumption of more than 100 mg of caffeine within the last 8 h\n7. Scar tissue or generally reduced sensitivity in the designated testing site areas\n8. Shoe size \\< 38 (if experiment is conducted at the feet)\n9. History of cardiovascular disease or carotid artery disease\n10. Medication or Substances inferring with the autonomic nervous system or with pain sensitivity (e.g. Benzodiazepines, Nicotine)",{"count":199,"type":20},146,[59],"In this study, we want to investigate how pain processing and sensation are related to a certain part of the nervous system, the so-called autonomic nervous system.\n\nFor this purpose, we apply heat and pressure stimuli to the skin and test pain processing by means of ratings scales and sensory tests. Breathing, heart rate and sweat response are also measured. To assess the spinal cord level, we measure muscle response (measured by electromyography, EMG) to electrical stimulation. Additionally, sensory nerves will be stimulated at the ear and participants will also be given various questionnaires to complete.",[203,28,204,26,205],"Autonomic Nervous System Modulation","Pain Sensitivity","Vagus Nerve Stimulations","2024-10-30",{"date":208,"type":37},"2024-10-31",{"date":210,"type":20},"2024-11-04",{"date":212,"type":20},"2026-08",{"name":214,"class":44},"Schweinhardt Petra",{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":136,"sex":52,"minAge":53,"maxAge":223,"enrollmentInfo":224,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":71},"100566788","quantitative-sensory-testing-to-study-pain-perception-in-autism-100566788","NCT06659731","Quantitative Sensory Testing to Study Pain Perception in Autism","Pain Perception in Autism. Study Through Quantitative Sensory Testing and Psychophysiological Correlates","PPiA","Inclusion Criteria for the clinical sample:\n\n* Children and adolescent\n* age between 5 and 17 years old\n* Autism diagnosis according to DSM-V criteria\n\nInclusion Criteria for the control sample:\n\n* healthy children and adolescent (without neurological, and psychiatric, diagnoses)\n* age between 5 and 17 years old\n\nExclusion Criteria:\n\nComorbidities with (for the clinical sample) or diagnosis of (for the control sample):\n\n* peripheral neuropaties;\n* psychiatric diagnosis as psychosis,\n* Tourette Syndrome,\n* neurological diagnoses as epilepsy,\n* sensory deficit or loss;\n* genetic diseases","17 Years",{"count":108,"type":20},"This study aims at assess sensory perception, and pain perception, in neurodivergent children and adolescent in the autism spectrum. To achieve this goal, the quantitive sensory testing (QST), a controlled and replicable protocol, will be used, to assess perception in different sensory modalities: heat sensations, mechanical detection threshold and pain threshold. As secondary aim, the cortical processing of thermal painful stimuli will be collected through electroencephalography (EEG) in order to investigate if there are differences in the cortical processing of painful stimuli between clinical sample and control sample, and if it could be associated with differences in the subjective experience between the two groups. Finally, it will be explored the association between such differences, and indexes of psychopathology and dispositional measures.",[227,28],"Autism Spectrum Disorder (ASD)",[229,230,231,232,233],"autism spectrum disorder (ASD)","pain perception","somatosensory profile","children","QST","2024-10-24",{"date":236,"type":37},"2024-10-26",{"date":238,"type":37},"2024-07-17",{"date":240,"type":20},"2025-09",{"name":242,"class":44},"IRCCS Eugenio Medea"]