[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pain-post-operative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pain-post-operative":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,86,113],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100643655","does-trendelenburg-positioning-during-pulmonary-recruitment-breaths-affect-post-laparoscopy-shoulder-pain-100643655",false,"NCT07631728","Does Trendelenburg Positioning During Pulmonary Recruitment Breaths Affect Post-laparoscopy Shoulder Pain","Trendelenburg Positioning During Pulmonary Recruitment Breaths: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Robot-assisted laparoscopic surgery for benign gynecologic indication\n* Surgery is booked for 60 minutes or longer\n* Reliable working phone number or email\n\nExclusion Criteria:\n\n* Patients with baseline opioid use\n* Patients with existing shoulder or neck pain\n* Active malignancy-related pain or surgery for malignant indication\n* Concomitant upper abdominal or thoracic surgery\n* Pre-existing emphysema, chronic obstructive pulmonary disease, or pneumothorax\n* Non-English speaking",true,"FEMALE","18 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate whether different positioning in the operating room during removal of laparoscopic surgical gas differs in post-surgery shoulder pain. An additional goal of this study is to evaluate whether positions change other post-surgery metrics such as bloating, time to passing gas, nausea and vomiting, and time to oral intake.\n\nResearchers will compare Trendelenburg positioning where your head is tilted down to supine (level or flat) positioning during removal of surgical gas.\n\nParticipants will be asked to complete brief surveys at 24 and 72-hours post-surgery.",[27,28,29],"Pain, Post-operative","Pneumoperitoneum","Urogynecologic Surgery",[31,32,33,34,35],"Trendelenburg","pneumoperitoneum","post-laparoscopy shoulder pain","post-laparoscopy pain","gynecologic surgery","NOT_YET_RECRUITING","2026-06-01",{"date":39,"type":40},"2026-06-08","ACTUAL",{"date":37,"type":21},{"date":43,"type":21},"2027-11",{"name":45,"class":46},"Ankita Gupta","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":5},"100567654","phase-4-comparing-analgesic-regimen-effectiveness-and-safety-for-surgery-for-kids-trial-100567654","NCT06671002","Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial","Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids (CARES for Kids) Trial","CARES for Kids","Inclusion Criteria:\n\n* No significant analgesic medication use before surgery as defined in the protocol. For this study, we define significant analgesic medication use before surgery as prescriptions reported by the child or caregiver for 6 days or more of opioid medications in the past 90 days (aligning with American Pediatric Guidelines that were published in September 2024 after the project was funded), excepting surgical team prescriptions within the week of surgery.\n* Undergo one the following: tonsil removal (with or without adenoid removal), gallbladder removal (laparoscopic), and knee scope (arthroscopy).\n\nExclusion Criteria:\n\n* Anticipated other surgery within 12 months\n* Anticipated life expectancy of \\\u003C12 months\n* Those that have legal guardians (due to special permission to enroll in trials)\n* Participants with complex chronic conditions per the Pediatric Medical Complexity Algorithm (e.g., trisomy 21)\n* Patients with contraindications to non-steroidal anti-inflammatory drug (NSAID) drugs in the NSAID arm, opioid drugs in the opioid arm, or acetaminophen will be excluded.\n* Liver disease\n* Acute psychiatric instability (defined as current uncontrolled severe depression, severe post-traumatic stress disorder (PTSD), or suicidal ideation), substance use disorder not in remission or treatment, and history of diversion of controlled substances (opioids)","ALL","12 Years","20 Years",{"count":59,"type":21},900,[61],"PHASE4","This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll. Eligible participants will be randomized to prescription of 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) plus acetaminophen or low dose opioids with the NSAIDs plus acetaminophen. The key question the study seeks to answer is which option will have the best outcomes and with the fewest side effects?",[64,65],"Surgery","Pain, Post Operative",[67,68,69,70,71,72,73,74,75],"Medications after surgery","NSAIDS","Acetaminophen","Opioids","Analgesics, non-narcotic","Tonsil removal","Gallbladder removal","Knee scope","Analgesics, opioid","RECRUITING","2026-03-02",{"date":79,"type":40},"2026-03-04",{"date":81,"type":40},"2025-01-10",{"date":83,"type":21},"2027-10-31",{"name":85,"class":46},"University of Michigan",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":99,"conditions":100,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":110,"locationsCount":112},"100450537","a-study-to-reduce-persistent-post-mastectomy-pain-using-opioid-free-anesthesia-100450537","NCT05146778","A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia","A Single-blinded Randomized-controlled Study to Reduce Persistent Post-mastectomy Pain Using Multimodal Opioid-free Anesthesia","RELIEF","Inclusion Criteria:\n\n* All of patients will undergo mastectomy with or without immediate breast reconstruction.\n\nExclusion Criteria:\n\n* Previous history of breast surgery\n* Allergy to drug\n* Other cancer history\n* Underlying psychologic disorder\n* Patients with chronic pain requiring pain killers\n* Baseline SpO2 \\\u003C95%\n* Left ventricular EF \\\u003C40%\n* Bradycardia as HR \\\u003C50 bpm\n* BMI \\>35kg\u002Fm2\n* Pregnant woman","19 Years","80 Years",{"count":97,"type":21},230,[24],"In 230 patients undergoing mastectomy, the investigators will compare opioid-free anesthesia (OFA) versus conventional opioid-based anesthesia in terms of chronic pain. The enrolled patients will be randomly assigned into two groups with 1:1 ratio. Chronic pain will be evaluated at 1 year after mastectomy based on the Breast Cancer Pain Questionnaire (BCPQ). Baseline pain sensitivity test and psychologic evaluation will be done before operation.",[101,102,103,65],"Breast Cancer","Mastectomy","Pain, Chronic","2025-11-18",{"date":106,"type":40},"2025-11-21",{"date":108,"type":40},"2021-12-16",{"date":83,"type":21},{"name":111,"class":46},"Gangnam Severance Hospital",1,{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":16,"sex":55,"minAge":18,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":122,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":112},"100509923","phase-4-preemptive-ibuprofen-effects-on-pain-perception-following-extraction-and-bone-graft-100509923","NCT05919745","Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft","Patient Perception of Pain Following Extraction and Bone Graft Surgery With or Without Preemptive Ibuprofen: A Randomized Clinical Trial","Inclusion Criteria\n\n* Age \\>18 years\n* Good general health (controlled conditions)\n* Fluent in English\n* Treatment-planned for single site extraction and bone graft surgery\n\nExclusion criteria\n\n* Pregnancy\n* Site with active infection i.e purulence, abscess formation\n* Patients experiencing pain pre-operatively\n* Oral surgery in more than one site\u002Fquadrant in the same session\n* Patients receiving surgery under sedation\n* Patients with any contraindication for oral bone grafting surgery (e.g., on anticoagulants, medication-related osteonecrosis of the jaw, etc.)\n* Patients experiencing acute or chronic oral pain due to conditions or previous interventions\n* Patients with diseases or taking medications that affect hard and soft tissue wound healing such as poorly controlled diabetes, bisphosphonate use, corticosteroid use, chemotherapy, immunosuppressive therapy, etc.\n* Current or chronic (≥4 weeks) use of anti-inflammatory, analgesic, corticosteroid or sedative medications in the past 6 months\n* Health conditions that contraindicate the use of NSAIDs, such as stomach ulcers, bleeding disorders, renal disfunction, liver cirrhosis or acute liver disease, etc.\n* Intake of medications that interact with NSAIDs or whose actions can be affected by NSAIDs, such as anticoagulant\u002Fantiplatelet medications, ACE inhibitors, diuretics, etc.\n* Allergy to ibuprofen, acetaminophen and\u002For aspirin, and study materials (e.g., sutures, grafts, membranes?).\n* Patients having 3 or more alcoholic beverages daily\n* Patients who are planned to undergo heart surgery or had heart surgery less than 6 months prior\n* Not fluent in English",{"count":121,"type":21},50,[61],"The goal of this randomized clinical trial is to compare patient-reported pain and oral health-related quality of life during the first postoperative week following extraction and bone graft surgery in patients who received preemptive ibuprofen versus placebo. Participants will receive ibuprofen 600mg or placebo by mouth with water 1 hour prior to extraction and bone graft surgery.\n\nThe primary question it aims to answer is:\n\n• Does preemptive ibuprofen have an effect on postoperative pain 1 hour following extraction and bone graft surgery compared to placebo?\n\nSecondary questions are:\n\n* Does preemptive ibuprofen have an effect on pain during the first 3 postoperative hours and 7 postoperative days following extraction and bone graft surgery compared to placebo?\n* Does preemptive ibuprofen have an effect on oral health-related quality of life during the 7 postoperative days following extraction and bone graft surgery compared to placebo?",[65,125],"Quality of Life","2024-09-25",{"date":128,"type":40},"2024-09-27",{"date":130,"type":40},"2023-10-19",{"date":132,"type":21},"2026-12",{"name":134,"class":46},"Marquette University"]