[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pain-postoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pain-postoperative":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,138,0,25,[9,60,89,116,148,172,196,219,250,287,305,323,347,367,397,425,447,468,495,519,550,577,601,632,658],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100053446","phase-4-intravenous-dexamethasone-with-single-shot-versus-continuous-brachial-plexus-block-for-rebound-pain-after-shoulder-surgery-100053446",false,"NCT07699744","Intravenous Dexamethasone With Single-Shot Versus Continuous Brachial Plexus Block for Rebound Pain After Shoulder Surgery","Pain Management Protocol Optimization for Rebound Pain Prevention and Enhanced Recovery After Shoulder Surgery: A Randomized Noninferiority Trial of Intravenous Dexamethasone Combined With Single-Shot Versus Continuous Brachial Plexus Block","Inclusion Criteria:\n\n* Adult patients aged 19 to 79 years scheduled for elective shoulder surgery under brachial plexus block and monitored anesthesia care (MAC)\n\nExclusion Criteria:\n\n* Pre-existing neurological deficit of the brachial plexus\n* Emergency surgery\n* American Society of Anesthesiologists (ASA) physical status classification IV or higher\n* Contraindication or history of hypersensitivity to local anesthetics or dexamethasone\n* Severe pulmonary disease (e.g., chronic obstructive pulmonary disease)\n* Body mass index (BMI) ≥ 35 kg\u002Fm²\n* Long-term use of steroids\n* Long-term use of analgesics\n* Inability to cooperate or communicate\n* Pregnancy","ALL","19 Years","79 Years",{"count":21,"type":22},92,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Shoulder surgery often causes severe pain after the operation. To control this pain, doctors commonly perform a nerve block (interscalene brachial plexus block), which numbs the shoulder area. However, when the effect of a single-injection nerve block wears off, many patients experience sudden, intense pain known as \"rebound pain\".\n\nOne way to prevent rebound pain is to place a thin catheter near the nerves so that local anesthetic can be given continuously for a longer period (continuous nerve block). However, this method is technically demanding and can cause problems such as catheter dislodgement, infection, and inconvenience for patients. Another simpler option is to give a single-injection nerve block together with an intravenous (IV) injection of dexamethasone, a steroid medication known to prolong the effect of nerve blocks and reduce rebound pain.\n\nThe purpose of this study is to determine whether a single-injection nerve block combined with IV dexamethasone (5 mg) is not inferior to a continuous nerve block in preventing rebound pain after shoulder surgery. A total of 92 adult patients scheduled for elective shoulder surgery will be randomly assigned to one of the two groups. The main outcome is the rebound pain score, defined as the difference between the last pain score recorded in the recovery room (while the nerve block is still working) and the highest pain score reported within the first 24 hours after the nerve block. The investigators expect that the simpler single-injection method with IV dexamethasone will provide comparable pain control while avoiding the complications and inconvenience of catheter-based continuous nerve blocks.",[28,29,30,31],"Pain, Postoperative","Rebound Pain","Shoulder Injuries","Rotator Cuff Injuries",[33,34,35,36,37,38,39,40,41,42,43,44,45,46],"Rebound pain","Interscalene brachial plexus block","Single-shot nerve block","Continuous peripheral nerve block","Perineural catheter","Dexamethasone","Intravenous dexamethasone","Shoulder surgery","Rotator cuff repair","Regional anesthesia","Postoperative analgesia","Multimodal analgesia","Non-inferiority trial","Enhanced recovery after surgery","NOT_YET_RECRUITING","2026-07-09",{"date":50,"type":51},"2026-07-13","ACTUAL",{"date":53,"type":22},"2026-07-15",{"date":55,"type":22},"2027-07-15",{"name":57,"class":58},"Seoul National University Hospital","OTHER",1,{"id":61,"slug":62,"hasResults":12,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":4,"eligibilityCriteria":66,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":4,"studyType":23,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":59},"100471170","randomized-control-trial-cryoablation-as-an-adjunct-to-surgical-stabilization-of-rib-fractures-100471170","NCT05415384","Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures","Single Center, Randomized Control Trial of Cryoablation During Surgical Stabilization of Rib Fractures","Inclusion Criteria:\n\n* The patient is admitted to the trauma service.\n* The patient has multiple displaced rib fractures (≥2 ribs), offered fixation, and consents to SSRF\n* The patient is not being treated for chronic pain\n* The patient is \\>18 years of age.\n* Surgery anticipated \\\u003C120 hours from injury\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years or ≥ 80 years\n* Flail chest: either radiographic or clinical. Radiographic flail chest is defined on CT chest as ≥ 2 ribs each fractured in ≥ 2 places. Clinical flail is defined as visualization of a segment of chest wall with paradoxical motion on physical exam.\n* Moderate or severe traumatic brain injury (Intra-cranial hemorrhage visualized on CT head with GCS at the time of consideration for enrollment \\\u003C 12)\n* Prior or expected emergency exploratory laparotomy during this admission\n* Prior or expected emergency thoracotomy during this admission\n* Prior or expected emergency craniotomy during this admission\n* Spinal cord injury\n* Pelvic fracture that has required, or is expected to require, operative intervention during this admission\n* The patient was unable to accomplish activities of daily living independently prior to injury (e.g., dressing, bathing, preparing meals)\n* The patient is incarcerated\n* The patient is known to be pregnant\n* Unable to perform Video Assisted Thoracoscopy (VATS) at time of SSRF due to lung isolation or previous pathology","18 Years","80 Years",{"count":70,"type":22},80,[72],"NA","To determine if patients with intraoperative cryoablation have better analgesia results compared to the control group of Surgical Stabilization of Rib Fractures (SSRF) without cryoablation",[28,75],"Rib Fracture Multiple",[77,78],"Locoregional pain","thoracotomy","RECRUITING","2026-06-26",{"date":82,"type":51},"2026-06-29",{"date":84,"type":51},"2022-08-01",{"date":86,"type":22},"2026-11",{"name":88,"class":58},"Wake Forest University Health Sciences",{"id":90,"slug":91,"hasResults":12,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":95,"targetDuration":97,"studyType":98,"phases":4,"briefSummary":99,"conditions":100,"keywords":103,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":59},"100577856","postoperative-pain-of-robotic-endoscopic-and-open-lateral-neck-dissection-100577856","NCT06803732","Postoperative Pain of Robotic, Endoscopic and Open Lateral Neck Dissection","Inclusion Criteria:\n\n* Patients underwent lateral neck dissection via robotic, endoscopic or open approach\n* Clinical diagnosis of differentiated thyroid cancer\n* Clinical diagnosis of metastatic lateral lymph nodes\n\nExclusion Criteria:\n\n* Participants with distant metastasis\n* Participants with history of neck surgery or radiation\n* Participants with vocal fold fixation by preoperative fibrolaryngoscope",{"count":96,"type":22},600,"6 Months","OBSERVATIONAL","Postoperative pain is a good indicator to confirm the advantages of the surgical methods in the era of minimally invasive surgery. Lateral neck dissection requires extensive dissection which may leads to postoperative numbness and pain. Robotic thyroid surgery has the advantage of precise and careful dissection and avoid the L-shape incision in the open approach. The study aims to explore the pain intensity and severity of lateral neck dissection on operation day, postoperative month 1 and postoperative month 3 among the robotic, endoscopic and open approach.",[28,101,102],"Thyroid Diseases","Surgery",[104,105,106],"Lateral neck dissection","Robotic thyroid surgery","Minimally invasive surgery","2026-06-20",{"date":109,"type":51},"2026-06-24",{"date":111,"type":51},"2024-11-01",{"date":113,"type":22},"2027-12-31",{"name":115,"class":58},"Shanghai 6th People's Hospital",{"id":117,"slug":118,"hasResults":12,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":23,"phases":126,"briefSummary":128,"conditions":129,"keywords":134,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":59},"100644172","phase-3-liposomal-bupivacaine-plus-plain-bupivacaine-versus-dexamethasone-plus-plain-bupivacaine-in-the-supraclavicular-brachial-plexus-block-in-patients-with-risk-factors-for-severe-acute-postoperative-pain-100644172","NCT07665762","Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain","Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain: a Randomized Controlled Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologist (ASA) status I-III\n* Age 18-90 years old\n* Scheduled for distal radial fracture fixation (Open reduction and internal fixation with volar approaching locking plate)\n* Informed consent obtained\n* Patients identified to be at an elevated risk of suffering from poor postoperative pain control. Patients with one or more of the following risk factors:\n\n  * Severe preoperative pain: defined as worse numerical rating scale (NRS) pain score equal or higher than 6\u002F10 with arm movements at day before surgery.\n  * Preoperative use of opioid: use of strong opioids such as morphine, oxycodone\n  * Depressive symptoms: Patient health questionnaire (PHQ-9) score of 10 or above\n  * Anxiety symptoms: General Anxiety Disorder (GAD-7) score of 10 or above\n  * Higher energy and high-grade fracture cases - road traffic accident, fall from height, open fractures, combined distal radius and distal ulna fractures, fractures requiring external fixation, fractures with severe articular comminution or severe metaphyseal extension, comminuted fractures requiring more than a single volar approach incision and a single volar locking plate implant\n\nExclusion Criteria:\n\n* Revision surgery\n* Previous fractures or surgery in the affected distal radius\n* Surgery involving more than the affected arm\n* Cases with baseline (pre-injury) QuickDASH score worse (higher) than 10 out of 100\n* Respiratory compromise (requires long term oxygen)\n* History of seizures\n* Pre-existing neurological disorder\u002Fdeficit\n* Alcohol or substance abuse\n* Impaired mental state\n* Local infection\n* Allergy to analgesic drugs: local anaesthetic drugs, paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), opioids\n* Impaired renal function (defined as effective glomerular filtration rate \\\u003C 30ml\u002Fmin\u002F1.73m2\n* Impaired liver function (defined as plasma bilirubin over 34μmol\u002FL; international normalized ratio \\[INR\\] ≥1.7, alanine aminotransferase \\[ALT\\] over 100U\u002FL, aspartate aminotransferase \\[AST\\] over 100U\u002FL)\n* Coagulopathy (platelet count \\\u003C100,000\u002Fml and\u002For INR ≥ 1.5) or the use of anticoagulants (not including aspirin) that precludes the use of supraclavicular BPB\n* Pregnancy\n* Patient refusal for regional nerve blocks\n* Patient refusal to join the clinical trial\n* Patient unable\u002Funwilling to attend post-op rehabilitation programme","90 Years",{"count":125,"type":22},90,[127],"PHASE3","The supraclavicular brachial plexus block (BPB) is a frequently used anaesthetic method for upper limb surgeries, including distal radial fracture surgery. Adding liposomal bupivacaine to BPB has shown promise in enhancing postoperative pain control. A previous randomized controlled trial demonstrated that it reduced pain scores and OBAS compared to plain bupivacaine alone, especially on postoperative day (POD) 1. Adding adjuncts to non-liposomal local anaesthetics can also enhance and prolong postoperative pain relief. The effectiveness of liposomal bupivacaine compared to adjuncts like dexamethasone and dexmedetomidine remains unclear. Since liposomal bupivacaine is more expensive, it is crucial to compare its analgesic efficacy with these alternatives. A randomized controlled trial comparing liposomal bupivacaine versus dexamethasone in the interscalene BPB for shoulder surgery found that liposomal bupivacaine resulted in statistically significantly lower pain scores and less pain interference in the Brief Pain Inventory, although the reduction was not considered clinically relevant. Its high cost may therefore limit its routine use unless specific clinical contexts where its efficacy is maximized are identified. Notably, patients with risk factors like psychological factors, preoperative pain, and prior analgesic use may benefit most from its application.\n\nA randomized controlled trial to compare the analgesic efficacy of liposomal bupivacaine plus plain bupivacaine versus dexamethasone plus plain bupivacaine in supraclavicular BPB for patients at higher risk of poor acute pain control post distal radial fracture surgery will be conducted. Patients with severe preoperative pain, opioid use, depressive symptoms, anxiety symptoms, and\u002For higher energy and high-grade fracture cases will be selected. The primary outcome measured is the intensity of acute postoperative pain with movement in the first 48 hours after surgery. Important secondary outcomes include pain intensity at rest, opioid consumption, OBAS scores, chronic pain, and upper limb functionality.",[28,130,38,131,132,133],"Liposomal Bupivacaine","Supraclavicular Brachial Plexus Block","High Risk Factors","Distal Radial Fracture",[135,136,137,138,139],"supraclavicular brachial plexus block","liposomal bupivacaine","dexamethasone","distal radial fracture","pain","2026-06-18",{"date":109,"type":51},{"date":143,"type":22},"2026-06-15",{"date":145,"type":22},"2029-03-01",{"name":147,"class":58},"The University of Hong Kong",{"id":149,"slug":150,"hasResults":12,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":23,"phases":157,"briefSummary":159,"conditions":160,"keywords":162,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":59},"100554409","phase-1-patient-controlled-administration-of-liquid-acetaminophen-100554409","NCT06498713","Patient Controlled Administration of Liquid Acetaminophen","Patient Controlled Self-Administration of Oral Liquid Medication: Acetaminophen Trial","Inclusion Criteria:\n\nParticipants\n\n* Adult patients older than 18 years old admitted to SRC for total shoulder and reverse total shoulder arthroplasty\n\nNurses\n\n* The nurse who will administer acetaminophen to a study patient.\n\nExclusion Criteria:\n\nParticipants\n\n* Pregnant patient\n* Patients that cannot swallow pills or cannot take liquid (for example due to risk of aspiration)\n* Emergency surgery\n* Chronic pain\n* On home opioids, any other pain modulating medications including benzodiazepine, Neurontin, ketamine.\n* Past medical or social history of substance abuse disorder, including ethanol misuse disorder, marijuana misuse disorder\n* History of any psychiatric disorders including anxiety, depression, any cognitive dysfunction\n* Any patients who cannot provide informed consents on their own (those who would need Legally Authorized Representatives (LARs) or surrogates)\n* Liver dysfunction limiting amount of safe oral acetaminophen\n* baseline hyperbilirubinemia (ex: chronic liver disease, Gilbert's)\n* patients unable to take PO\n* Patients with neurologic, neuromuscular, or movement disorders unable to drink from a cup.\n\nNurses\n\n* any nurse who is not involved in the direct care of a study patient, or who is not comfortable with setting up the PCA pump.",{"count":156,"type":22},24,[158],"PHASE1","This is a proof of concept pilot study investigating the feasibility and acceptability of patient controlled oral medication administration, using the commonly used and low risk medication in the hospital, oral acetaminophen.",[161,28],"Pain",[163],"Pain Management","2026-06-17",{"date":140,"type":51},{"date":167,"type":51},"2024-11-19",{"date":169,"type":22},"2026-12",{"name":171,"class":58},"Yale University",{"id":173,"slug":174,"hasResults":12,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":23,"phases":181,"briefSummary":182,"conditions":183,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":195},"100429589","phase-3-prevention-of-persistent-pain-with-lidocaine-infusions-in-breast-cancer-surgery-plan-100429589","NCT04874038","Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)","Inclusion Criteria:\n\n1. Age ≥18 years old\n2. Undergoing a unilateral or bilateral lumpectomy or mastectomy, inclusive of all pathologies, including prophylactic surgery (e.g., family history or BRCA gene mutation)\n\nExclusion Criteria:\n\n1. Previous breast surgery within 6 months of index surgery\n2. Undergoing any autologous flap procedure during index surgery\n3. Presence known chronic pain disorder involving surgical site or ipsilateral chest wall, shoulder, or arm during the 3-months prior to index surgery\n4. Documented hypersensitivity or allergy to lidocaine\n5. Surgery not planned to be performed under general anesthesia and\u002For planned use of regional or neuraxial anesthetic techniques before surgery (i.e., epidural, paravertebral, serratus plane block, pectoralis or modified pectoralis block)\n6. History of ventricular tachycardia, ventricular fibrillation, or atrioventricular block without a pacemaker\n7. Known cirrhotic liver disease\n8. Pregnant\n9. Unlikely to comply with follow-up (e.g. no fixed address, language difficulties that would impede valid completion of questionnaires, plans to move out of town)","100 Years",{"count":180,"type":22},1602,[127],"Phase III, international multicentre, parallel group, blinded, 1:1 randomized controlled trial to determine the effect of an intraoperative intravenous lidocaine infusion on reducing the development of persistent pain 3-months after breast cancer surgery.",[184,185,28,186],"Post-mastectomy Pain Syndrome","Breast Cancer","Pain, Chronic",{"date":188,"type":51},"2026-06-22",{"date":190,"type":51},"2021-09-22",{"date":192,"type":22},"2026-11-01",{"name":194,"class":58},"University Health Network, Toronto",17,{"id":197,"slug":198,"hasResults":12,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":203,"enrollmentInfo":204,"targetDuration":4,"studyType":23,"phases":205,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":215,"leadSponsor":217,"locationsCount":59},"100642944","comparison-of-the-rhomboid-intercostal-block-and-serratus-posterior-superior-intercostal-plane-block-100642944","NCT07650877","Comparison of the Rhomboid Intercostal Block and Serratus Posterior Superior Intercostal Plane Block","Comparison of the Effects of Ultrasound-Guided Rhomboid Intercostal Block and Serratus Posterior Superior Intercostal Plane Block on Postoperative Acute Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery","Inclusion Criteria:\n\n* Patients undergoing elective VATS\n* Patients aged 18-75 years\n* Patients with ASA (American Society of Anesthesiologists) class I-III\n* Patients who have given informed consent\n\nExclusion Criteria:\n\n* Patients allergic to local anesthetics\n* Patients with bleeding disorders or those undergoing anticoagulant therapy\n* Pregnant and breastfeeding women\n* Patients with impaired consciousness, inability to communicate, or mental\u002Fcognitive impairment\n* Patients who refuse block application\n* Patients with infection in the area where the block will be applied","75 Years",{"count":125,"type":22},[72],"Video-assisted thoracic surgery (VATS) is widely performed for the management of various thoracic pathologies and is generally associated with reduced surgical trauma compared with open thoracotomy. Nevertheless, patients may still experience considerable postoperative pain, which can adversely affect respiratory function, mobilization, and recovery. Various regional analgesic techniques have been incorporated into multimodal pain management strategies for VATS, including thoracic paravertebral block (TPVB), erector spinae plane block (ESPB), intercostal nerve block, serratus anterior plane block (SAPB), rhomboid intercostal block (RIB), and serratus posterior superior intercostal plane block (SPSIPB). Among these approaches, ultrasound-guided TPVB has traditionally been regarded as a reference regional analgesic technique. More recently, interfascial plane blocks have gained increasing attention because of their technical simplicity and favorable safety profile. RIB and SPSIPB are two novel interfascial plane blocks that may provide effective postoperative analgesia following thoracic surgery. The present study aims to compare the analgesic efficacy of RIB and SPSIPB in patients undergoing VATS and to evaluate their impact on postoperative pain outcomes.",[28,208,209,210,211],"Multimodal Analgesia","Rhomboid Intercostal Block","Serratus Posterior Superior Intercostal Plane Block","Thoracic Surgery, Video-Assisted",{"date":213,"type":51},"2026-06-16",{"date":143,"type":51},{"date":216,"type":22},"2026-11-30",{"name":218,"class":58},"Ankara City Hospital Bilkent",{"id":220,"slug":221,"hasResults":12,"nctId":222,"briefTitle":223,"officialTitle":223,"acronym":224,"eligibilityCriteria":225,"healthyVolunteers":226,"sex":17,"minAge":67,"maxAge":227,"enrollmentInfo":228,"targetDuration":4,"studyType":23,"phases":230,"briefSummary":232,"conditions":233,"keywords":236,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":245,"completionDateStruct":246,"leadSponsor":248,"locationsCount":59},"100641067","phase-2-phase-ii-randomized-double-blind-placebo-controlled-clinical-trial-to-evaluate-the-efficacy-and-safety-of-omega-3-fatty-acids-as-an-adjunct-to-morphine-in-acute-postoperative-pain-100641067","NCT07657468","Phase II, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Omega-3 Fatty Acids as an Adjunct to Morphine in Acute Postoperative Pain","O3MORPH","Inclusion Criteria:\n\n1. Able to provide written informed consent prior to any study procedures;\n2. Able to communicate clearly with the Investigator and staff;\n3. Males and females aged 18 to 65;\n4. American Society of Anesthesiologists (ASA) risk class of I to II;\n5. Patients with an indication for laparoscopic cholecystectomy.\n\nExclusion Criteria:\n\n* Patients with reduced kidney function (serum creatinine level above 2 mg\u002Fdl).\n* Sensitive to local anesthetics.\n* A history of hepatic insufficiency.\n* Chronic pain.\n* Patients with diabetes.\n* Patients with Body Mass Index (BMI) greater than 35 kg\u002Fm2.\n* Daily intake of analgesics or corticosteroids.\n* Patients with Inflammatory bowel disease.\n* Chronic opioid use.",true,"65 Years",{"count":229,"type":22},40,[231],"PHASE2","This is a single-center, randomized, double-blind, placebo-controlled, parallel-group proof-of-concept study to evaluate the analgesic efficacy and safety of omega-3 fatty acids as an adjunct to morphine for acute postoperative pain following laparoscopic cholecystectomy.\n\nPatients will receive either omega-3 fatty acid supplementation or a placebo before and after surgery. At the end of surgery, a loading dose of morphine of 0.04 mg\u002Fkg body weight will be administered intravenously as a bolus in both groups. The primary endpoint will be the total amount of rescue morphine used during the first 24 postoperative hours.",[234,235],"Pain Postoperative","Analgesia",[237,238,239,240,241,242],"analgesia","post-operation pain","analgesic adjunct","morphine reduction","omega-3 fatty acids","lapararoscopic cholecystectomy","2026-06-13",{"date":140,"type":51},{"date":143,"type":22},{"date":247,"type":22},"2026-10-31",{"name":249,"class":58},"National University of La Rioja",{"id":251,"slug":252,"hasResults":12,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":256,"eligibilityCriteria":257,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":4,"enrollmentInfo":258,"targetDuration":4,"studyType":23,"phases":260,"briefSummary":261,"conditions":262,"keywords":268,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":59},"100611379","peng-block--lia-for-endoprosthesis-surgery-100611379","NCT07239817","PENG Block + LIA For Endoprosthesis Surgery","PENG 360°: PENG Block + LIA Nella Endoprotesi di Anca.","PENG 360°","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form.\n* Scheduled for hip endoprosthesis surgery for femoral fracture with an anterior approach.\n* Age 18 years or older.\n* Willing and able to comply with the study protocol.\n\nExclusion Criteria:\n\n* Failure to provide informed consent.\n* Age less than 18 years.\n* Known allergy to local anesthetics or other medications used in the protocol.\n* Presence of infection at the planned injection site.\n* Pre-existing hip prosthesis or prior major surgery on the same hip (e.g., revision surgery).\n* ASA physical status class \\> IV.\n* Administration of intraoperative opiates or conversion to general anesthesia.",{"count":259,"type":22},100,[72],"The goal of this clinical trial is to learn if a new local anesthesia technique can control pain as well as the standard spinal anesthesia for adults having hip endoprosthesis surgery. The main questions it aims to answer are:\n\n* Is the new local anesthesia technique as effective as standard spinal anesthesia in managing pain during the first two days after surgery?\n* Does the new technique allow participants to move their leg sooner after the operation?\n\nResearchers will compare the new local anesthesia technique (numbing medicine injected directly around the hip joint) to standard spinal anesthesia (a numbing injection in the back) to see if the new technique works just as well for pain control while possibly causing fewer side effects like nausea.\n\nParticipants who join this study will be randomly placed into one of two groups.\n\nOne group will receive the standard spinal anesthesia before their surgery.\n\nThe other group will receive the new local anesthesia technique before their surgery.\n\nAfter the operation, researchers will track the amount of extra pain medicine each participant uses and will check their ability to move their hip, knee, and foot.",[263,264,28,265,266,267],"Hip Fractures","Arthroplasty, Replacement, Hip","Anesthesia and Analgesia","Nerve Block","Local Anesthesia Infiltration",[269,270,271,272,273,274,275,276,277],"Pericapsular Nerve Group Block","PENG block","Local Infiltration Analgesia","Spinal Anesthesia","Hip Arthroplasty","Postoperative Pain","Femoral Fractures","Ultrasound Guidance","Early Mobilization","2026-06-10",{"date":280,"type":51},"2026-06-12",{"date":282,"type":51},"2025-12-09",{"date":284,"type":22},"2026-12-30",{"name":286,"class":58},"ASST Gaetano Pini-CTO",{"id":288,"slug":289,"hasResults":12,"nctId":290,"briefTitle":291,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":226,"sex":293,"minAge":67,"maxAge":4,"enrollmentInfo":294,"targetDuration":4,"studyType":23,"phases":295,"briefSummary":296,"conditions":297,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":299,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":303,"locationsCount":59},"100541060","analgesic-efficacy-of-surgeon-administered-transversus-abdominis-plane-blocks-for-caesarean-section-100541060","NCT06324942","Analgesic Efficacy of Surgeon-administered Transversus Abdominis Plane Blocks for Caesarean Section.","Inclusion Criteria:\n\n* ASA status II to III\n* All patients undergoing elective CS under regional anesthesia at any gestational age.\n\nExclusion Criteria:\n\n* \\- Known drug allergy to local anesthetics\n* Planned general anesthetic\n* NSAID use contraindicated post partum\n* Chronic pain disorder or chronic narcotic use\u002Fdependence\n* Planned vertical abdominal incision\n* Planned Cesarean Hysterectomy.\n* Placenta Previa or suspected Placenta Accreta","FEMALE",{"count":70,"type":22},[72],"The purpose of this research study is to evaluate whether or not adding a Transversus Abdominis Plane Block (TAP block) improves pain control for patients having a cesarean section. A TAP block is a type of nerve block where at the end of the surgery an injection of a long acting local anesthetic is made into the abdominal wall. In studies in patient's having other abdominal surgeries this has reduced the amount of narcotics patients need for pain control. This may also led to patients being more active after surgery and maybe spending less time in hospital.",[298,28],"Cesarean Section Complications",{"date":143,"type":51},{"date":301,"type":51},"2025-02-19",{"date":169,"type":22},{"name":304,"class":58},"University of Calgary",{"id":306,"slug":307,"hasResults":12,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":4,"enrollmentInfo":312,"targetDuration":4,"studyType":23,"phases":313,"briefSummary":314,"conditions":315,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":317,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":321,"locationsCount":59},"100342336","phase-4-liposomal-bupivacaine-versus-plain-bupivacaine-after-intercostal-injections-for-pain-management-after-thoracoscopy-100342336","NCT03737292","Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy","Comparison of Plasma Concentration And Efficacy Of Liposomal Bupivacaine And Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy","Inclusion Criteria:\n\n1\\. Male or female patients over age 18 undergoing minimally invasive thoracic surgeries including but not limited to:\n\n1. VATS wedge resection \u002Fsegmentectomy\n2. VATS lobectomy.\n3. Robot assisted thoracoscopic wedge resection\u002Fsegmentectomy.\n4. Robot assisted thoracoscopic lobectomy procedures.\n\nExclusion Criteria:\n\n1. Patients under18 years of age\n2. Patients weighing less than 48 kg\n3. Pregnant and lactating females will be excluded from the trial\n4. Patients preoperatively taking narcotics for chronic pain in proximity to surgical site\n5. Patients with previous ipsilateral thoracic surgery\n6. Patients undergoing pleurectomy\u002Fmechanical pleurodesis.\n7. Patients with high likelihood of conversion from thoracoscopic procedure to open thoracotomy as determined by an operating surgeon\n8. Patients with pre-existing painful conditions (CRIPS, fibromyalgia, neuropathy)\n9. Patients unable to reliably communicate pain scores such as patients with dementia, alterations in mental status\n10. Patients with hypersensitivity to local anesthetics and pain medications used in the study\n11. Patients with previous thoracic spine surgeries\n12. Patients with increased creatinine (over 1.5mg\u002Fdl)\n13. Patients with liver dysfunction\n14. Non-English speaking patients",{"count":229,"type":22},[25],"The purpose of this study is to assess pharmacokinetics of liposomal bupivacaine (Exparel) after multilevel intercostal injections of this local anesthetic for pain control during and after thoracoscopic surgeries.\n\nThe specific aim of this study is to evaluate plasma concentration of bupivacaine after intraoperative intercostal injections of 266 mg of liposomal bupivacaine and compare it to plasma concentrations of bupivacaine after intercostal injections of 2mg\u002Fkg of 0.5% plain Bupivacaine with maximal dose of 30 ml or 150 mg.\n\nThe hypothesis of the study is that plasma concentration of bupivacaine after intercostal injections of 266 mg of liposomal bupivacaine will be similar to concentrations after injections of plain bupivacaine, and will remain below the toxic level threshold range of 2000-3000 ng\u002FmL (2-3 mg\u002FL) at which central nervous system and cardiovascular adverse events would be expected to occur.\n\nThe secondary objective is to evaluate if intercostal injections of 266 mg of liposomal bupivacaine will significantly reduce opioid consumption and postsurgical pain, within the first 48 hours and up to 3 months after minimally invasive thoracic surgeries, to determine if both acute and chronic post-thoracotomy pain can be decreased by intraoperative intercostal injections of liposomal bupivacaine.\n\nAdditionally, the rate of pneumonia, the rate of atrial fibrillation and length of hospital stay will be assessed as secondary outcomes after thoracic surgeries. These outcomes can be affected by the level of postoperative pain and inflammation.\n\nSignificance of this study: If positive, the results of this research have the potential to significantly improve pain management after thoracoscopic surgery.\n\nBased on prior experience, prolonged analgesia after liposomal bupivacaine injection is safe, and may help reduce perioperative opioid consumption and decrease opioid related complications. It will improve patient comfort, eliminate need for indwelling neuraxial catheters and risks associated with them.",[28,316],"Pharmacokinetics",{"date":280,"type":51},{"date":319,"type":51},"2019-04-09",{"date":169,"type":22},{"name":322,"class":58},"Milton S. Hershey Medical Center",{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":12,"sex":17,"minAge":330,"maxAge":4,"enrollmentInfo":331,"targetDuration":4,"studyType":23,"phases":333,"briefSummary":334,"conditions":335,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":346},"100414452","phase-2-pain-relief-after-trapeziectomy-ibuprofen--acetaminophen-versus-oxycodone-100414452","NCT04676802","Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone","Pain Relief After Trapeziectomy Without Opioids: Ibuprofen & Acetaminophen Versus Oxycodone","Inclusion Criteria:\n\n* Undergoing trapeziectomy for thumb osteoarthritis\n\nEnglish proficient,\n\nExclusion Criteria:\n\n* Pregnancy\n\nCurrent use of opioids\n\nConcurrent surgeries (ex. trapeziectomy combined with carpal tunnel release)\n\nInability to complete study forms (education, cognitive ability, mental status, medical status)\n\nAllergy or intolerance to Ibuprofen, Acetaminophen and\u002For Oxycodone\n\nLiver or kidney dysfunction, abnormal liver enzymes restricting use of acetaminophen or ibuprofen\n\nHistory of chronic heart failure, upper gastrointestinal bleeding or coagulopathy\n\nHistory of complex regional pain syndrome","45 Years",{"count":332,"type":22},121,[231],"In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the efficacy of a combination of non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen and acetaminophen, in comparison to a morphine analogue substance (oxycodone) for pain management in the first 30 days after surgery.",[28,336],"Osteoarthritis Thumb","2026-06-08",{"date":339,"type":51},"2026-06-11",{"date":341,"type":51},"2021-12-27",{"date":343,"type":22},"2027-08",{"name":345,"class":58},"Stanford University",2,{"id":348,"slug":349,"hasResults":12,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":68,"enrollmentInfo":354,"targetDuration":4,"studyType":23,"phases":355,"briefSummary":356,"conditions":357,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":59},"100466246","phase-4-intrathecal-morphine-for-analgesia-in-video-assisted-and-robotic-assisted-thoracic-surgery-100466246","NCT05351229","Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery","Intrathecal Morphine for Postoperative Analgesia in Video-Assisted and Robotic-Assisted Thoracic Surgery: A Randomized, Placebo-controlled, Double-blinded Clinical Trial","Inclusion Criteria:\n\n* Age 18-80 years old\n* Undergoing elective video-assisted thoracoscopic or robotic assisted surgery for anatomical lung resection\n* General anesthesia with anticipated intraoperative extubation.\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) classification of 4 or 5\n* Anticipated postoperative intubation\n* Significant liver disease\n* Preoperative use of intravenous inotropes and\u002For vasopressor support\n* Preoperative mechanical ventilation\n* Preoperative use of mechanical circulatory support device (intraaortic balloon pump, ventricular assist device, extracorporeal membrane oxygenation)\n* Severe pulmonary disease (home oxygen requirement and\u002For current oral steroid use)\n* Morphine allergy\n* Opioid or alcohol abuse\n* Chronic pain\n* Renal failure\n* Inability to comprehend English language\n* Bleeding disorder\n* Abnormal preoperative coagulation\n* Infection\n* Patient refusal\n* Failed spinal",{"count":125,"type":22},[25],"VATS\u002FRATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS\u002FRATS. The optimal strategy for pain management has not been defined. In this randomized, placebo-controlled, double-blinded clinical investigation, investigators hypothesize that 5 mcg\u002Fkg intrathecal morphine will decrease postoperative analgesic consumption and reduce pain.",[28],"2026-06-05",{"date":360,"type":51},"2026-06-09",{"date":362,"type":51},"2023-09-29",{"date":364,"type":22},"2027-09-01",{"name":366,"class":58},"Northwestern University",{"id":368,"slug":369,"hasResults":12,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":68,"enrollmentInfo":374,"targetDuration":4,"studyType":98,"phases":4,"briefSummary":375,"conditions":376,"keywords":378,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":59},"100613519","ipack-block-vs-periarticular-infiltration-for-tka-pain-control-100613519","NCT07267650","iPACK Block vs. Periarticular Infiltration for TKA Pain Control","Postoperative Analgesic Outcomes of iPACK Block Versus Periarticular Infiltration in Total Knee Arthroplasty: A Retrospective Cohort Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status II-III.\n* Scheduled for elective, primary, unilateral total knee arthroplasty for osteoarthritis.\n* Able to provide written informed consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate or contraindication to regional anesthesia.\n* Known allergy to any study medications (local anesthetics, NSAIDs, tramadol, morphine, paracetamol).\n* History of chronic opioid use (defined as daily use for \\>3 months)\n* Pre-existing peripheral neuropathy in the operative limb.\n* Severe renal or hepatic insufficiency.\n* Cognitive impairment preventing the use of pain scales or questionnaires.\n* Revision or bilateral knee arthroplasty.",{"count":259,"type":22},"This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA). The primary purpose is to evaluate whether a combination of two specific nerve blocks administered by an anesthesiologist (Femoral Triangle Block + iPACK block) resulted in superior postoperative pain control compared to a hybrid combination of a nerve block and a local infiltration administered by the surgeon (FTB + Periarticular Infiltration \\[PAI\\]).\n\nThe hypothesis is that the FTB + iPACK combination is associated with a significant reduction in Numeric Rating Scale (NRS) pain scores with movement at 24 hours postoperatively. This is a retrospective, observational cohort study conducted at a single center, involving medical records of patients who underwent primary unilateral TKA. Data from patients who received either FTB + iPACK or FTB + PAI as part of their standard clinical care will be extracted and analyzed retrospectively.",[28,377],"Osteoarthritis, Knee \u002F Osteoarthritis, Hip",[379,380,274,163,235,266,381,382,383,271,384,385,386,387],"Total Knee Arthroplasty","TKA","Femoral Triangle Block","FTB","iPACK block","Timed Up and Go Test","Straight Leg Raise","Periarticular Infiltration","Regional Anesthesia","2026-05-28",{"date":390,"type":51},"2026-06-01",{"date":392,"type":22},"2026-05-01",{"date":394,"type":22},"2026-08-01",{"name":396,"class":58},"Turgutlu State Hospital",{"id":398,"slug":399,"hasResults":12,"nctId":400,"briefTitle":401,"officialTitle":402,"acronym":4,"eligibilityCriteria":403,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":4,"enrollmentInfo":404,"targetDuration":4,"studyType":23,"phases":406,"briefSummary":407,"conditions":408,"keywords":410,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":59},"100509732","comparing-mindfulness-based-breath-training-and-heart-rate-variability-biofeedback-for-shoulder-surgery-patients-in-the-postoperative-pain-100509732","NCT05917262","Comparing Mindfulness-based Breath Training and Heart Rate Variability Biofeedback for Shoulder Surgery Patients in the Postoperative Pain.","Comparing Preoperative Mindfulness-based Breath Training and Heart Rate Variability Biofeedback for Shoulder Surgery Patients in the Postoperative Pain, Shoulder Function, Emotion, Sleep, Quality of Life, Cognitive Function, and Electroencephalography","Inclusion Criteria:\n\nshoulder pain patients with\n\n* (1) pain ≥3months and ≥3 days per week\n* (2) pain intensity ≥ 40 (VAS scale from 0 no pain to 100 very painful)\n* (3) the surgical indication would be based on orthopedics opinions\n\nExclusion Criteria:\n\n* history of shoulder surgery in the prior 3 years\n* osteoporotic vertebral fractures or rheumatologic diseases\n* chronic widespread pain syndromes (fibromyalgia or chronic fatigue syndrome)\n* neurological disease (i.e., stroke, parkinson's disease, etc..)\n* psychiatric disease (i.e., dementia, depression, schizophrenia, etc)\n* cancer\n* patients who practiced yoga, meditation, chi-qong, mindfulness, or deep breathing exercises more than three times per week",{"count":405,"type":22},120,[72],"Although shoulder surgeries can effectively relieve pain intensity and restore shoulder function, some patients reported persistent post-operative pain at the 6-month post-surgery follow-up visit. This randomized study aims to determine the effectiveness of three different types of bio-psychosocial support to pre-operative shoulder surgery patients. This study will examine the differential effects of brief mindfulness-based breathing, heart rate variability biofeedback (HRV-BF), and cognitive behavioral pain psychoeducation for pre-operative patients.",[28,409],"Shoulder Pain",[411,412,413,414,415],"Shoulder pain","Postoperative pain","mindfulness","HRV","biofeedback","2026-05-21",{"date":418,"type":51},"2026-05-22",{"date":420,"type":51},"2023-11-13",{"date":422,"type":22},"2026-12-31",{"name":424,"class":58},"Chang Gung Memorial Hospital",{"id":426,"slug":427,"hasResults":12,"nctId":428,"briefTitle":429,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":226,"sex":17,"minAge":431,"maxAge":4,"enrollmentInfo":432,"targetDuration":4,"studyType":23,"phases":434,"briefSummary":435,"conditions":436,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":441,"completionDateStruct":443,"leadSponsor":445,"locationsCount":59},"100459261","anesthetic-optimization-in-pediatric-lefort-surgeries-100459261","NCT05260320","Anesthetic Optimization in Pediatric LeFort Surgeries","Inclusion Criteria:\n\n* Undergoing Le Fort osteotomy at Johns Hopkins Hospital\n* Age \\>= 14 years\n\nExclusion Criteria:\n\n* Contraindications to standardized anesthetic protocol (intervention arm)","14 Years",{"count":433,"type":22},50,[72],"This study will propose and evaluate a standardized LeFort osteotomy anesthetic protocol for pediatric patients at Johns Hopkins Hospital. There are two cohorts to this study: a prospective cohort who will receive the study anesthesia protocol and a historical cohort that received standard of care. The investigators hope this will help to minimize unnecessary postoperative pain management, inpatient stay, and long-term morbidity and mortality in these patients.",[437,28],"Le Fort","2026-05-18",{"date":440,"type":51},"2026-05-20",{"date":442,"type":51},"2025-05-02",{"date":444,"type":22},"2027-07",{"name":446,"class":58},"Johns Hopkins University",{"id":448,"slug":449,"hasResults":12,"nctId":450,"briefTitle":451,"officialTitle":452,"acronym":4,"eligibilityCriteria":453,"healthyVolunteers":12,"sex":17,"minAge":454,"maxAge":4,"enrollmentInfo":455,"targetDuration":4,"studyType":23,"phases":456,"briefSummary":457,"conditions":458,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":4},"100639139","peng-vs-femoral-nerve-block-for-pain-control-in-hip-surgery-100639139","NCT07597551","PENG vs. Femoral Nerve Block for Pain Control in Hip Surgery","Comparative Study Between Continous Ultrasound Guided Pericapsular Nerve Group (PENG) Block Versus Femoral Nerve Block For Perioperative Pain Control In Hip Surgeries","Inclusion Criteria:\n\n* Aged 40 years or older.\n\n  * Presenting for hip surgeries\n  * No contraindications to regional anesthesia.\n  * Time of surgery up to 3 hours\n  * ASA I-III\n  * Able to provide written informed consent.\n  * Able to reliably report pain and other symptoms to the research team.\n  * Undergoing elective or emergency hip surgeries.\n\nExclusion Criteria:\n\n* Inability to provide first-person consent due to cognitive impairment.\n\n  * Presence of a language barrier that would preclude reliable reporting of symptoms or understanding study procedures.\n  * More than ASA III. 4\n  * Previous neurological deficit in the lower limbs.\n  * Local infection at block area.\n  * Lengthy surgeries more than 3 hours.","40 Years",{"count":259,"type":22},[72],"The aim of this study is to compare the efficacy of the ultrasound- guided pericapsular nerve group (PENG) block versus the femoral nerve block (FNB) for postoperative pain control in patients undergoing hip surgeries, specifically evaluating pain scores and quadriceps strength.",[28],"2026-05-16",{"date":461,"type":51},"2026-05-19",{"date":463,"type":22},"2026-05-15",{"date":465,"type":22},"2027-05-15",{"name":467,"class":58},"Benha University",{"id":469,"slug":470,"hasResults":12,"nctId":471,"briefTitle":472,"officialTitle":473,"acronym":4,"eligibilityCriteria":474,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":68,"enrollmentInfo":475,"targetDuration":4,"studyType":23,"phases":477,"briefSummary":478,"conditions":479,"keywords":481,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":486,"lastUpdatePostDateStruct":487,"startDateStruct":489,"completionDateStruct":491,"leadSponsor":493,"locationsCount":59},"100490149","influence-of-nociception-level-monitor-nol-guided-analgesic-delivery-on-robot-assisted-colorectal-surgery-100490149","NCT05662371","Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery","Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on the Perioperative Course, Quality of Recovery and Hospital Stay in Robot-assisted Colorectal Surgery","Inclusion Criteria:\n\n* American Society of Anaesthesiologists score III-IV\n* Scheduled for elective major robot-assisted colorectal surgeries\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* planned spinal or epidural anaesthesia\n* all forms of regional anaesthesia, including wound infiltration\n* nonelective procedures\n* pregnancy or lactation\n* atrial fibrillation",{"count":476,"type":22},60,[72],"Being relatively new, the NOL monitor may offer interesting observations in perioperative nociception levels and appropriate analgesic consumption in diverse surgeries, including robot-assisted surgery. These observations may supplement the current efforts towards further advantages in rapid restitution. Therefore, the investigators planned a trial where intra-operative analgesics were guided using an NOL monitor to study if intra-operative NOL guidance influences peri-operative analgesic consumption, postoperative length of stay and quality of recovery of patients subjected for robot-assisted surgery.",[480,28],"Opioid Use, Unspecified",[482,483,484,485],"Nociception,","robotic surgery,","opioids,","postoperative recovery","2026-05-11",{"date":488,"type":51},"2026-05-14",{"date":490,"type":51},"2023-08-01",{"date":492,"type":22},"2027-03-31",{"name":494,"class":58},"University of Southern Denmark",{"id":496,"slug":497,"hasResults":12,"nctId":498,"briefTitle":499,"officialTitle":500,"acronym":4,"eligibilityCriteria":501,"healthyVolunteers":226,"sex":17,"minAge":502,"maxAge":227,"enrollmentInfo":503,"targetDuration":4,"studyType":23,"phases":505,"briefSummary":506,"conditions":507,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":512,"completionDateStruct":514,"leadSponsor":516,"locationsCount":59},"100639167","phase-2-dexa-vs-dexmedetomidine-with-bupivacaine-in-tap-block-for-laparotomy-analgesia-100639167","NCT07590752","\"Dexa vs Dexmedetomidine With Bupivacaine in TAP Block for Laparotomy Analgesia","Comparison Of Dexamethasone Versus Dexmedetomidine As An Adjuvant To 0.25% Bupivacaine In Ultrasound Guided Tap Block On Post-Op Analgesia Duration In Patients Undergoing Laparotomy","Inclusion Criteria:\n\n* Patients undergoing laparotomy.\n* Patients aged 25 to 65 years.\n* Both genders.\n* Patients with ASA Class I, II.\n\nExclusion Criteria:\n\n* Patients who do not give consent.\n* Patients with Comorbidities like DM, HTN, CKD, CLD.\n* Patients with bleeding disorders.\n* Infection at site of injection.\n* Allergy to any drug, local anaesthetic, or other drugs used.\n* Patients with polytrauma.","25 Years",{"count":504,"type":22},96,[231,127],"Transversus abdominis plane block is a regional anesthetic technique which blocks the abdominal neural afferents by introducing local anesthetic into the neuro-fascial plane between the internal oblique and the transversus abdominis muscle and gives analgesia from the skin to parietal peritoneum. There are studies showing evidence of improved post operative analgesia with addition of adjuvants such as dexmedetomidine or dexamethasone in comparison with plane local anesthesia in terms of time to rescue analgesia and the overall quantity of analgesic used post operatively.",[28,508,509],"Opioid Use","Laparotomy","2026-05-08",{"date":463,"type":51},{"date":513,"type":51},"2024-03-03",{"date":515,"type":22},"2026-07-04",{"name":517,"class":518},"Sahiwal medical college sahiwal","OTHER_GOV",{"id":520,"slug":521,"hasResults":12,"nctId":522,"briefTitle":523,"officialTitle":524,"acronym":525,"eligibilityCriteria":526,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":227,"enrollmentInfo":527,"targetDuration":4,"studyType":23,"phases":528,"briefSummary":529,"conditions":530,"keywords":533,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":542,"startDateStruct":544,"completionDateStruct":546,"leadSponsor":548,"locationsCount":59},"100635258","bupivacaine-lidocaine-vs-bupivacaine-for-ultrasound-guided-popliteal-sciatic-nerve-block-100635258","NCT07550348","Bupivacaine-Lidocaine vs Bupivacaine for Ultrasound-Guided Popliteal Sciatic Nerve Block","Bupivacaine-Lidocaine Combination Versus Bupivacaine Alone for Ultrasound-Guided Popliteal Sciatic Nerve Block in Elective Lower Extremity Surgery: A Prospective Randomized Double-Blind Trial","PSSNB-BL","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status classification I, II, or III\n* Scheduled for elective distal lower extremity surgery (below-knee)\n* Body mass index (BMI) between 18 and 35 kg\u002Fm²\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Morbid obesity (BMI ≥35 kg\u002Fm²)\n* Known allergy or hypersensitivity to any local anesthetic agent\n* Severe cardiac, hepatic, or renal disease\n* Pre-existing neurological deficits or peripheral neuropathy\n* Use of anticoagulant therapy\n* History of prior surgery or significant scar tissue in the popliteal fossa\n* Pregnancy\n* Chronic opioid use at home",{"count":476,"type":22},[72],"This prospective, randomized, double-blind clinical trial aims to compare the efficacy of two local anesthetic regimens for ultrasound-guided popliteal sciatic nerve block in adult patients undergoing elective distal lower extremity surgery.\n\nEligible participants (ages 18-65, ASA physical status I-III, BMI 18-35 kg\u002Fm²) will be randomized into two equal groups of 30. Patients in Group BL will receive a combination of 10 mL 2% lidocaine and 10 mL 0.5% bupivacaine, while patients in Group B will receive 20 mL 0.5% bupivacaine alone, administered via ultrasound-guided popliteal sciatic nerve block prior to surgery.\n\nThe primary outcome is the onset time of sensory and motor blockade. Secondary outcomes include block success rate, duration of sensory and motor block, postoperative opioid consumption, pain scores assessed by the Numeric Rating Scale (NRS) at 2, 4, 8, 12, and 24 hours postoperatively, Quality of Recovery-15 (QoR-15) score, and incidence of rebound pain.\n\nThe study is conducted at Ataturk University Research Hospital, Department of Anesthesiology and Reanimation, Erzurum, Turkey.",[531,266,28,532],"Lower Extremity","Pain, Nerve",[534,535,536,537,538,42,43,539,540,541],"Popliteal sciatic nerve block","Bupivacaine","Lidocaine","Local anesthetic","Ultrasound-guided nerve block","Block onset time","Lower extremity surgery","QoR-15",{"date":543,"type":51},"2026-05-12",{"date":545,"type":51},"2025-12-01",{"date":547,"type":22},"2027-03-01",{"name":549,"class":58},"Ataturk University",{"id":551,"slug":552,"hasResults":12,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":226,"sex":17,"minAge":67,"maxAge":4,"enrollmentInfo":557,"targetDuration":4,"studyType":23,"phases":559,"briefSummary":560,"conditions":561,"keywords":567,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":570,"startDateStruct":572,"completionDateStruct":574,"leadSponsor":575,"locationsCount":59},"100579224","comparison-of-pain-relief-methods-for-hip-surgery-a-study-on-two-different-nerve-block-techniques-100579224","NCT06821516","Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques","Comparison of Analgesic Effectiveness Between Pericapsular Nerve Group (PENG) Block and Lumbar Erector Spinae Plane Block in Patients Undergoing Total Hip Arthroplasty With Spinal Anesthesia: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Voluntary willingness to participate in the study.\n* Patients who will undergo Total Hip Arthroplasty surgery.\n* Patients aged over 18 years.\n* ASA score I-II-III.\n* Patients who are fully oriented and can cooperate.\n\nExclusion Criteria:\n\n* ASA score IV-V.\n* Patients who refuse to participate in the study.\n* Patients under 18 years of age.\n* Presence of active infection in the area to be operated on.\n* Chronic pain and continuous analgesic use.\n* Patients with coagulation disorders.\n* Patients who cannot cooperate with postoperative pain follow-up.\n* Patients with allergies to local anesthetic agents.\n* Presence of neuropathy or myopathy in the operated extremity.",{"count":558,"type":22},52,[72],"This prospective randomized comparative study aims to compare the analgesic efficacy of pericapsular nerve group block (PENG) and lumbar erector spinae plane block (L-ESP) groups to relieve postoperative pain in participants over the age of 18 undergoing total hip arthroplasty under spinal anesthesia. The main question it aims to answer is:\n\nTo demonstrate whether PENG block or L-ESP block is more effective in postoperative analgesia in patients undergoing total hip arthroplasty surgery based on pain scores, opioid consumption, and patient satisfaction.\n\nTotal hip arthroplasties cause severe pain with movement in the postoperative period. After surgery, the movements of the participants are severely restricted, which increases the possibility of complications. In this study, the participants' pain status, VAS score, opioid consumption through patient-controlled analgesia, and patient satisfaction will be measured with a questionnaire for 24 hours at predetermined time points and then compared. Both types of blocks have pain-relieving effects. This study will only investigate which one is more effective in reducing pain, and there will be no deficiency in relieving the pain of the participants.",[562,28,266,563,564,565,566],"Opioid Consumption, Postoperative","PENG Block","Lumbar Erector Spinae Plane Block","Hip Replacement, Total","Postoperative Analgesia",[568,564,569,43],"Pericapsular Nerve Group (PENG) Block","Total Hip Arthroplasty",{"date":571,"type":51},"2026-05-07",{"date":573,"type":51},"2025-01-21",{"date":390,"type":22},{"name":576,"class":518},"Başakşehir Çam & Sakura City Hospital",{"id":578,"slug":579,"hasResults":12,"nctId":580,"briefTitle":581,"officialTitle":582,"acronym":4,"eligibilityCriteria":583,"healthyVolunteers":12,"sex":293,"minAge":67,"maxAge":584,"enrollmentInfo":585,"targetDuration":4,"studyType":23,"phases":587,"briefSummary":588,"conditions":589,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":593,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":599,"locationsCount":59},"100547208","opioid-free-anaesthesia-in-breast-cancer-surgery-100547208","NCT06404983","Opioid-free Anaesthesia in Breast Cancer Surgery","A Comparative Evaluation of Opioid Free Anaesthesia Technique Versus the Conventional Technique in Oncological Breast Surgery","Inclusion Criteria:\n\n* adult patients\n* breast cancer surgery (mastectomy, lumpectomy, with or without lymph node excision) under general anaesthesia\n\nExclusion Criteria:\n\n* under 18 years\n* patient refusal\n* opioid use (systemic or not) for any reason (e.g., chronic malignant pain)\n* language barrier (difficulty in communicating in Greek language)\n* allergy to the administered agents\n* severe arrhythmia or other serious cardiac disease\n* severe liver and kidney failure\n* dementia, psychiatric diseases, and\u002For preoperative cognitive impairment","99 Years",{"count":586,"type":22},200,[72],"Background:\n\nVarious analgesic modalities are adopted for perioperative analgesia in breast cancer surgeries. Opioid-free and opioid-sparing techniques are gaining popularity due to the lack of opioid-dependent undesirable effects, including respiratory depression, urinary retention, nausea and vomiting, constipation, itching, opioid-induced hyperalgesia, tolerance, addiction, and immune system disorders.\n\nThe goal of this prospective randomized clinical trial is to investigate the impact of opioid-free anaesthesia (OFA) versus conventional general anaesthesia (CGA) on postoperative analgesic requirements after breast cancer surgery (lumpectomy\u002Fmastectomy, with or without axillary lymph node excision).\n\nSecondary objectives include comparative perioperative evaluation of cognitive function and postoperative adverse events during the first 48 hours atfter surgery. Comparative evaluation of intraoperative haemodynamics and hospital length of stay are also secondary objectives, as well as the incidence of neuropathic pain assessed by validated questionnaires at 3 and 6 months postoperatively.\n\nDuring the preoperative screening, body measurements, age, gender, ASA (American Society of Anesthesiologists) physical status classification, educational level (using a 6-level scale: elementary, middle school, high school, higher education, higher education, and postgraduate\u002Fdoctoral degree), home medication, and comorbidities (using the Charlson Comorbidity Index) are recorded.\n\nIntraoperatively, the duration of anaesthesia, duration of surgery, associated intraoperative data (e.g., haemodynamic instability, adverse effects associated with protocol-administered pharmaceutical agents, etc.), and medications administered (type and quantity) are recorded.\n\nThe investigators expect to recruit at least 100 participants per group.",[185,590,28,186,591,592],"Anesthesia","Opioid Free Anaesthesia","Cancer Recurrence",{"date":594,"type":51},"2026-05-06",{"date":596,"type":51},"2022-12-28",{"date":598,"type":22},"2027-09-12",{"name":600,"class":58},"University of Ioannina",{"id":602,"slug":603,"hasResults":12,"nctId":604,"briefTitle":605,"officialTitle":606,"acronym":607,"eligibilityCriteria":608,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":178,"enrollmentInfo":609,"targetDuration":4,"studyType":23,"phases":610,"briefSummary":611,"conditions":612,"keywords":617,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":626,"completionDateStruct":628,"leadSponsor":630,"locationsCount":59},"100527265","promoting-sleep-to-alleviate-pain---arthroplasty-100527265","NCT06145516","Promoting Sleep to Alleviate Pain - Arthroplasty","Preoperative Sleep-promotion to Achieve Improved Postoperative Pain Control and Recovery: a Randomized, Controlled Trial","PROSAP-A","Inclusion Criteria:\n\n* age ≥18 years\n* insomnia severity index score \\>10\n* fulfill DSM-V criteria for persistent insomnia disorder\n* average pain numerical rating scale (NRS) score ≥4 (scale 0 - 10) and\u002For movement-related pain NRS score ≥4 after 5 minutes walking\n* scheduled to undergo primary (first-time, i.e., not revision surgery) TKA or THA due to osteoarthritis\n\nExclusion Criteria:\n\n* uncontrolled medical disorders\n* nightshift work\n* ongoing major depressive disorder, bipolar disorder, psychotic disorder, substance dependence\n* current history or high likelihood of primary sleep disorders (other than insomnia), including obstructive sleep apnea syndrome, narcolepsy, nocturnal myoclonus\n* severely impaired vision (precluding ability to take part of study interventions)",{"count":259,"type":22},[72],"PROSAP-A is a perioperative randomized, controlled trial with a 12-month follow-up period after total knee arthroplasty (TKA) or total hip arthroplasty (THA), aiming to investigate both acute and long-term postoperative effects of preoperative sleep-promotion. Participants with clinically significant insomnia symptoms will be randomized to a brief, hybrid version of cognitive behavioral therapy for insomnia (CBT-I) or sleep education therapy, administered over a 4-week period, prior to surgery. The primary objective is to evaluate effects of preoperative sleep-promotion on acute postoperative pain control. Secondary objectives include evaluation of postoperative sleep, recovery, mental health, cognitive function and alterations in blood biomarkers.",[613,614,615,102,28,616],"Osteoarthritis, Knee","Osteoarthritis, Hip","Insomnia","Postoperative Complications",[618,619,620,621,622,623],"osteoarthritis","total knee arthroplasty","total hip arthroplasty","insomnia","sleep disturbance","postoperative pain","2026-04-29",{"date":594,"type":51},{"date":627,"type":51},"2025-09-01",{"date":629,"type":22},"2030-12-01",{"name":631,"class":58},"Uppsala University",{"id":633,"slug":634,"hasResults":12,"nctId":635,"briefTitle":636,"officialTitle":637,"acronym":4,"eligibilityCriteria":638,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":203,"enrollmentInfo":639,"targetDuration":4,"studyType":23,"phases":641,"briefSummary":642,"conditions":643,"keywords":647,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":651,"startDateStruct":652,"completionDateStruct":654,"leadSponsor":656,"locationsCount":59},"100496585","phase-4-the-effect-of-zolpidem-on-outcomes-following-lumbar-spine-fusion-100496585","NCT05746143","The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion","The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion: A Randomized Control Trial","Inclusion Criteria:\n\n* degenerative lumbar disease\n* age of 18-75\n* undergoing open primary one- to three-level lumbar fusion\n\nExclusion Criteria:\n\n* currently use a sleep aid nightly\n* diagnosed with insomnia or sleep apnea\n* history of delirium with opiates or zolpidem\n* allergic to opiates or zolpidem\n* had previous lumbar spine surgery\n* undergoing minimally invasive lumbar fusion,\n* undergoing lumbar fusion for fracture, infection, tumor, or an inflammatory spondyloarthropathy",{"count":640,"type":22},140,[25],"The purpose of this study is to evaluate if peri-operative zolpidem for posterior lumbar spinal fusion improves patient reported outcomes following surgery.",[644,645,28,646],"Spine Fusion","Lumbar Spine Degeneration","Lumbar Spine Spondylosis",[648,649,650],"Lumbar Spine Fusion","Zolpidem","Postoperative Outcomes",{"date":392,"type":51},{"date":653,"type":51},"2022-02-01",{"date":655,"type":22},"2030-12-31",{"name":657,"class":58},"University of Southern California",{"id":659,"slug":660,"hasResults":12,"nctId":661,"briefTitle":662,"officialTitle":663,"acronym":4,"eligibilityCriteria":664,"healthyVolunteers":12,"sex":17,"minAge":67,"maxAge":665,"enrollmentInfo":666,"targetDuration":668,"studyType":98,"phases":4,"briefSummary":669,"conditions":670,"keywords":673,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":678,"lastUpdatePostDateStruct":679,"startDateStruct":681,"completionDateStruct":683,"leadSponsor":685,"locationsCount":59},"100635778","fascial-plane-blocks-and-quality-of-recovery-in-cardiac-surgery-100635778","NCT07557108","Fascial Plane Blocks and Quality of Recovery in Cardiac Surgery","Pecto-Intercostal Fascial Plane Block-Based Multimodal Analgesia to Improve Quality of Recovery After Median Sternotomy: A Randomized Non-Inferiority Trial Comparing Retro-Intercostal Fascial Plane Block and Rectus Sheath Block","Inclusion Criteria:\n\n* Patients who have provided written informed consent\n* Open-heart surgery performed under elective conditions via median sternotomy with cardiopulmonary bypass (on-pump)\n* American Society of Anesthesiologists (ASA) physical status class II or III\n* Aged 18-70 years\n\nExclusion Criteria:\n\n* Off-pump surgical procedure\n* Emergency or repeat cardiac surgery\n* Known allergy to induction agents or local anesthetics\n* Body mass index (BMI) \\>35 kg\u002Fm²\n* Coagulopathy\n* Infection at the surgical site\n* Left ventricular ejection fraction (LVEF) \\\u003C40%\n* Renal insufficiency (estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73 m²) or hepatic insufficiency \\[Presence of major systemic diseases such as acute decompensated cirrhosis characterized by bilirubin \\>12 mg\u002FdL, INR \\>2.5, or hepatic encephalopathy, in accordance with the European Association for the Study of the Liver-Chronic Liver Failure Consortium criteria\\]\n* Psychiatric disorders\n* History of chronic pain or regular use of analgesics (corticosteroids, analgesics, anticonvulsants)\n* Cognitive impairments that could interfere with the assessment of postoperative pain\n* Patients with impaired physical and verbal performance","70 Years",{"count":667,"type":22},123,"1 Year","In this randomized trial, the investigators will test the hypothesis that combining regional analgesia techniques-which have the potential to improve the quality of postoperative recovery following median sternotomy-with PIFB will accelerate recovery. Additionally, it is anticipated that RIFB, an alternative fascial plane block, will demonstrate non-inferior (at least as effective as) performance compared to RSB, thereby providing flexibility and ease of application in clinical practice.",[671,28,672],"Cardiovascular Surgical Procedures","Cardiovascular Diseases",[671,674,675,163,676,677],"Anesthesia, Conduction","Acute Postoperative Pain","Enhanced Recovery After Surgery","Anesthesia, Regional","2026-04-28",{"date":680,"type":51},"2026-05-04",{"date":682,"type":51},"2026-04-05",{"date":684,"type":22},"2026-12-20",{"name":686,"class":58},"Ordu University"]