[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pain-visceral-somatic-or-neuropathic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pain-visceral-somatic-or-neuropathic":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,44,80,109,134,155],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100641478","post-operative-pain-and-vagal-stimulation-100641478",false,"NCT07659314","Post Operative Pain and Vagal Stimulation","\"Evolution of Postoperative Anal Pain Following Elective Proctological or Rectal Surgery Under the Effect of Transcutaneous Vagal Auricular Stimulation: a Feasibility Study - VAGANAL - Postoperative Pain and Vagal Stimulation\"","VAGANAL","Inclusion Criteria:\n\n* Adult patient\n* Underwent anal or rectal surgery via the transanal route\n* Managed on an outpatient basis or in conventional hospitalization\n* Having signed a consent to participate in the study\n\nExclusion Criteria:\n\n* Patient operated on as an emergency\n* Rectal surgery via abdominal approach or requiring an abdominal approach during the procedure\n* Known epileptic patient\n* Patient with a pacemaker\n* Patient refusing to participate in the study\n* Pregnant, breastfeeding, or laboring woman\n* Patient not affiliated with a social security scheme\n* Person deprived of liberty by judicial or administrative decision\n* Person subject to compulsory psychiatric care - Any contraindication mentioned in the instructions for use of the medical device under investigation\n\nExclusion Criteria:\n\n* Unscheduled conversion from the transanal route to the abdominal route during surgery","ALL","18 Years","120 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","Anorectal surgery is a type of surgery that can cause anal pain, particularly in the context of hemorrhoid surgery or anal fissure surgery. Generally, the period of discomfort related to the pain lasts about two weeks. There is a nerve (the vagus nerve) whose stimulation via a probe placed in the ear can reduce stress and chronic pain. Its ease of use makes it a promising tool for treating pain. Vagal auricular stimulation could be an interesting option in the management of postoperative pain of the anus and rectum. Its efficacy or feasibility in this context has never been evaluated.\n\nThe aim of this study is to evaluate the feasibility in this context and to assess the extend of pain reduction associated with perioperative nerve vagus stimulation by a medical device (Transcutaneous Electrical Nerve Stimulator (TENS ECO Plus)). It is offered to adult patients undergoing transanal anal or rectal surgery on an outpatient or inpatient basis as part of a scheduled procedure.\n\nPatients to be included in the study are selected during the initial pre-operative consultation with the surgeon. Once the surgical indication is confirmed and the patient fulfills the study eligibility criteria, the investigator provides them with oral information about the study. The patient is also given an information sheet (written in language understandable to the patient) and a consent form.\n\nDuring this initial visit, demographic data and information regarding the surgical indication are collected.\n\nStimulation begins two days before surgery (twice daily), followed by stimulation on the morning of surgery, one hour before arrival in the operating room. Successful completion of the stimulation, as well as any complications, are recorded in the patient diary.\n\nOn the day of surgery (day 0), data concerning the procedure and the maximum visual analogue scale (VAS) are collected in the recovery room. Analgesic consumption is also recorded.\n\nOn the evening of the procedure, stimulation is performed and adherence is recorded.\n\nMaximum and mean VAS are collected on postoperative day 1 and then daily in the patient diary for 15 days.\n\nVagus nerve stimulation is performed morning and evening for 15 days. VAS scores, adherence, analgesic consumption, the date of the first bowel movement and its painfulness, as well as any complications related to the stimulation are noted in the patient diary. On day 3 (+\u002F- 2 days) after the procedure, and at the end of the 15-day postoperative period, the patient will be contacted by phone or text message by the investigator team to remind them to complete the notebook.\n\nOn day 30 (+\u002F- 5 days), the patient returns for a follow-up visit. The patient diary and equipment are collected. Complications are recorded, as well as quality of life during the postoperative month (SF-36 form).\n\nFor patients, the expected benefits are significant, as postoperative quality of life is expected to improve through reduced pain. Furthermore, decreasing the use of step II and III analgesics should shorten the recovery period and promote better overall recovery.",[28,29,30],"Rectal Surgery","Pain (Visceral, Somatic, or Neuropathic)","Vagal Nerve Stimulation","NOT_YET_RECRUITING","2026-06-29",{"date":34,"type":35},"2026-07-01","ACTUAL",{"date":37,"type":22},"2026-11-09",{"date":39,"type":22},"2028-01-09",{"name":41,"class":42},"University Hospital, Angers","OTHER_GOV",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":43},"100631210","phase-2-virtual-menstrual-pain-approaches-in-females-100631210","NCT07497711","Virtual Menstrual Pain Approaches in Females","Virtual Auricular Acupressure and Baduanjin Qigong Exercise for Preventing Menstrual Pain in Females: A Randomized Clinical Trial","AABQ","Inclusion Criteria:\n\n* 16 - 35 years of age\n* Regular menstrual cycles (28 days ± 7 days) in 3 months prior to enrollment\n* Two or more episodes of menstrual cramps in the past 2 months, scored at least 4 points on the worst pain item of the Brief Pain Inventory (BPI)\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Ability to download, install, and navigate the study-specific digital content and use its core functions for training, self-guided intervention administration, and data entry\n* Ability to understand the nature of the study and willingness to give informed consent.\n\nExclusion Criteria:\n\n* Uncontrolled neurological diseases, immunodeficiency, bleeding disorders, and allergies\n* The presence of another Axis I disorder not in remission\n* Lactating or pregnant, or those planning to become pregnant in the coming half year\n* Undergoing other trials for pain management during the study period\n* Plan to initiate other pain therapies for menstrual pain management in the proceeding 3 months","FEMALE","16 Years","35 Years",{"count":56,"type":22},145,[58,59],"PHASE2","PHASE3","This research study is testing two self-care approaches that may help prevent or reduce period pain in young females with recurrent painful menstrual cramps. Participants will be placed by chance into 1 of 3 groups: auricular acupressure, Baduanjin qigong, or a self-care education comparison group. The auricular acupressure and Baduanjin groups will receive online training and then practice the treatment on their own for 12 weeks. The main question is whether these two approaches can reduce the severity of menstrual pain. The study will also look at whether they can improve other symptoms that often happen with period pain, such as tiredness, poor sleep, anxiety, low mood, trouble concentrating, and reduced physical function. Researchers will also study stool and blood-related biological markers to better understand whether changes in gut bacteria and body metabolism may be linked to symptom improvement. A total of 145 participants will take part in the study at NTU, and any side effects or other safety concerns will be checked every week.",[29,62,63,64,65,66,67,68],"Women of Reproductive Age","Mental Disorder","Digital Health","Acupressure","Traditional Exercise","Host-Gut Microbiota Interaction","Metabolomics","RECRUITING","2026-06-18",{"date":72,"type":35},"2026-06-23",{"date":74,"type":35},"2026-04-15",{"date":76,"type":22},"2029-03-20",{"name":78,"class":79},"Nanyang Technological University","OTHER",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":89,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":43},"100601425","characteristics-of-persistent-pain-composition-following-total-hip-or-knee-arthroplasty-a-descriptive-study-100601425","NCT07110324","Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study","PAIN-COMPO","Inclusion Criteria:\n\n* All patients with persistent moderate-severe pain (NRS\\>3) after THA, TKA and UKA\n* Acceptance to be contacted.\n\nExclusion Criteria:\n\n* Re-operation\n* Luxation\n* Do not want to be contacted\n* Post-operative complications such as prosthesis infection, thromboembolism or fracture of the prosthesis.",{"count":88,"type":22},100,"1 Year","OBSERVATIONAL","Despite high success rates of hip and knee arthroplasty, up to 20% of patients report moderate-to-severe pain (NRS \\> 3) persisting beyond the expected healing period. This investigator-initiated, descriptive cohort study will re-invite approximately 100 consenting patients with persistent postoperative pain-identified from a pool of \\~7 000 respondents-to complete standardized assessments of neuropathic (DN4), nociplastic (IASP criteria + Fibromyalgia Survey Questionnaire) and nociceptive (KOOS\u002FHOOS pain domains) pain. Primary outcomes are the prevalence of potential nociplastic pain and the proportion experiencing significant pain in two or more mechanistic categories. Secondary analyses will compare baseline vs. re-evaluated DN4 scores, FSQ and KOOS\u002FHOOS distributions, and examine differences between patients with and without possible neuropathic pain. Findings will inform targeted pre- and postoperative pain management strategies.",[29,93,94,95],"Hip Arthroplasty Replacement","Knee Arthroplasty, Total","Survey and Questionnaire",[97,98,99],"Pain","hip arthroplasty","knee arthroplasty","2026-03-31",{"date":102,"type":35},"2026-04-01",{"date":104,"type":35},"2025-06-26",{"date":106,"type":22},"2026-12-01",{"name":108,"class":79},"Rigshospitalet, Denmark",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":123,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":43},"100618353","comparison-of-conventional-buccal-nerve-block-versus-buccal-nerve-trunk-block-during-extraction-of-posterior-mandibular-teeth-100618353","NCT07330518","Comparison of Conventional Buccal Nerve Block Versus Buccal Nerve Trunk Block During Extraction of Posterior Mandibular Teeth","Comparison of Conventional Buccal Nerve Block Versus Buccal Nerve Trunk Block for Anaesthesia of Buccal Mucosa During Extraction of Mandibular Posterior Teeth","Buccal Trunk","Inclusion Criteria:\n\n* Patients aged 20 to 60 years\n* Patients of both gender\n* Patient requiring extraction of mandibular molars\n\nExclusion Criteria:\n\n* Pregnant women\n* Pathologies associated with teeth i.e. cysts, tumors\n* Patients on radiotherapy or chemotherapy\n* Patients with mandibular fracture","20 Years","60 Years",{"count":88,"type":22},[25],"This randomised control trial will compare the efficacy of conventional buccal nerve block versus buccal trunk block using visual analogue scale to evaluate pain and additional anesthesia injection during extraction of mandibular molars.",[29],[124],"Buccal Trunk Block","2026-02-01",{"date":127,"type":35},"2026-02-04",{"date":129,"type":22},"2026-03-20",{"date":131,"type":22},"2027-01-01",{"name":133,"class":79},"Watim Medical & Dental College",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":141,"sex":17,"minAge":18,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":154,"locationsCount":43},"100615770","distolingual-infiltration-verses-conventional-nerve-block-in-mandibular-third-molar-extraction-100615770","NCT07296926","Distolingual Infiltration Verses Conventional Nerve Block in Mandibular Third Molar Extraction","Comparison of Efficacy of Distolingual Infiltration in Conjugation With Conventional Inferior Alveolar Nerve Block to Conventional Inferior Alveolar Nerve Block Alone for Extraction of Mandibular Third Molar","Inclusion Criteria:\n\n* Healthy individuals\n\n  * Male and female\n  * Age 18-45 years\n  * Mandibular third molar impaction - all positions\n  * Mandibular third molar impaction - all classes\n\nExclusion Criteria:\n\n* ASA status III and above\n\n  * Patients requiring multiple extractions in the same appointment\n  * Allergy to lignocaine\n  * Patients in whom adrenaline is contraindicated\n  * Medically compromised individuals e.g. poorly controlled diabetes, hypertension",true,"45 Years",{"count":144,"type":22},120,[25],"This randomized controlled trial will compare the effectiveness of adding distolingual infiltration to conventional inferior alveolar and buccal nerve blocks for mandibular third molar extraction. A total of 120 patients will be allocated into two groups. Pain during flap elevation and bone guttering will be assessed using the Visual Analogue Scale.",[29],"2025-12-30",{"date":150,"type":35},"2026-01-06",{"date":152,"type":35},"2024-08-15",{"date":74,"type":22},{"name":133,"class":79},{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":141,"sex":17,"minAge":18,"maxAge":142,"enrollmentInfo":162,"targetDuration":4,"studyType":23,"phases":164,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":171,"leadSponsor":172,"locationsCount":43},"100612003","postoperative-pain-and-swelling-after-flap-vsflapless-technique-for-mandibular-third-molar-surgery-100612003","NCT07247929","Postoperative Pain and Swelling After Flap vsFlapless Technique For Mandibular Third Molar Surgery","Comparison of Postoperative Pain and Swelling in Flap Versus Flapless Technique for Surgical Removal of Partially Impacted Mandibular Third Molars: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18-45 years\n\n  * Either gender\n  * Partially impacted mesioangular mandibular third molar confirmed clinically and radiographically\n  * Second episode of pericoronitis\n  * Swelling present on the affected side\n  * No bone recession or periodontal disease on radiograph\n\nExclusion Criteria:\n\n* HIV or HBV infection\n\n  * Diabetes or other metabolic disorders\n  * Bleeding disorders including von Willebrand disease, thalassemia, hemophilia, thrombocytosis, or thrombocytopenia\n  * Periapical infection or acute pericoronitis at time of surgery\n  * Severe trismus\n  * Immunocompromised status",{"count":163,"type":22},160,[25],"This randomized controlled trial evaluates postoperative pain and facial swelling following surgical removal of partially impacted mandibular third molars using flap versus flapless techniques. The aim is to determine which method results in lower postoperative morbidity on the second postoperative day.",[29],"2025-11-20",{"date":169,"type":35},"2025-11-25",{"date":152,"type":35},{"date":74,"type":22},{"name":133,"class":79}]