[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"palate-wound\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:palate-wound":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100559700","clinical-comparison-of-alb-prf-vs-prf-on-postoperative-morbidity-following-fgg-harvesting-100559700",false,"NCT06567548","Clinical Comparison of Alb-PRF vs PRF on Postoperative Morbidity Following FGG Harvesting","Clinical Comparison of Albumin Platelet Rich- Fibrin (Alb-PRF) Versus Platelet-rich Fibrin (PRF) on Postoperative Morbidity Following Free Gingival Graft Harvesting: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Patients in need of free gingival graft\n2. Medically free patients\n3. Adult patients above 18 years old.\n4. Patients accepting a 1-month follow-up period (cooperative patients).\n5. Patients who will provide an informed consent.\n\nExclusion Criteria:\n\n1. Smokers\n2. Pregnant and lactating women\n3. Patients with poor oral hygiene\n4. Patients who had previous periodontal surgery in the area of interest",true,"ALL","18 Years","70 Years",{"count":21,"type":22},39,"ESTIMATED","INTERVENTIONAL",[25],"NA","Clinical Comparison of Albumin Platelet Rich- Fibrin (Alb- PRF) versus Platelet-rich fibrin (PRF) on Postoperative Morbidity Following Free Gingival Graft Harvesting: A Randomized Controlled Clinical Trial(RCT)\n\nStudy settings:\n\n* The study will be conducted in the Oral Medicine and Periodontology department, Faculty of Dentistry - Cairo University, Egypt.\n* Patients will be selected from the Department of Oral Medicine and Periodontology-Cairo University outpatient clinic.\n\nExpected Duration of Participation and Number of Participants: Research Duration: 28 days Number of Participants: 39 volunteers\n\nWork Plan:\n\nDuring the first visit, preoperative photographs will be taken. Then, participants will be randomly assigned (using a website) into three groups:\n\nGroup A: Application of Alb-PRF at the donor site of the free gingival graft. Group B: Application of PRF at the donor site of the free gingival graft. Control: Application of Gelatin Sponge at the donor site.\n\n* 10 ml of venous blood will be drawn from the patient to prepare Alb-PRF and PRF membranes for placement at the donor site.\n* The membrane or gelatin sponge will be placed at the donor site and sutured.\n\nPostoperative Protocol:\n\nAfter surgery, patients will be instructed to take 600 mg of ibuprofen, and 0.12% chlorhexidine gluconate mouthwash for two weeks postoperatively.\n\nAnalgesics will be recommended only if there is pain, and no antibiotics will be prescribed.\n\nPatients will receive verbal and written dietary advice postoperatively. They will be encouraged to avoid heat sources and adhere to a diet of cold and soft foods.\n\nCleaning the adjacent palatal side of the surgical site will be prohibited to avoid irritation, while gentle cleaning will be recommended after dressing removal.\n\nIn case of postoperative problems such as unusual bleeding or gum recession, patients will be provided with contact information for their physician for early intervention.\n\nDuring Visual Analog Scale (VAS) pain recording, patients will be instructed only to describe pain from the palate and to track additional analgesic intake and consumed tablets. Follow-up visits will be scheduled on days 3, 7, 14, 21, and 28 postoperatively.\n\nPostoperative Follow-up:\n\nPalatal sutures will be removed after 7 days post-surgery. On days 14, 21, and 28, wound healing, tissue color match, complete re-epithelialization of the wound, and clinical wound healing area will be monitored.",[28],"Palate; Wound",[30,31,32],"PRF","Alb-PRF","FGG","RECRUITING","2026-03-23",{"date":36,"type":37},"2026-03-27","ACTUAL",{"date":39,"type":37},"2025-11-27",{"date":41,"type":22},"2027-01-30",{"name":43,"class":44},"Cairo University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100599591","early-phase-1-effect-of-cyanoacrylate-tissue-adhesive-versus-collagen-sponge-on-palatal-donor-site-healing-100599591","NCT07086482","Effect of Cyanoacrylate Tissue Adhesive Versus Collagen Sponge on Palatal Donor Site Healing","Effect of Cyanoacrylate Tissue Adhesive Versus Collagen Sponge on Palatal Donor Site Healing After Harvesting a Free Gingival Graft: a Randomized Controlled Clinical Trial","RCT","Inclusion Criteria:\n\n* Low-moderate anesthetic risk (ASA I-II)\n* No restriction on ethnicity or gender\n* Patients requiring FGG from the palate for periodontal plastic surgery\n* Clinically healthy gingiva after phase I therapy\n* Full-mouth plaque index grades 0 and 1\n* Bleeding scores \\\u003C15%\n\nExclusion Criteria:\n\n* Patients who smoke \\> 10 cigarettes\u002Fday\n* Patients with coagulation disorders\n* Systemic diseases\n* Patients on certain medications that may affect periodontal tissues\n* Pregnant and lactating patient\n* Patients with allergies to drugs that will be prescribed during the treatment phase\n* Pathological mental conditions (dementia, psychosis) and lack of cooperation\n* Excessive gag reflex",{"count":54,"type":22},22,[56],"EARLY_PHASE1","The goal of this clinical trial is to learn if the use of cyanoacrylate glue (PeriAcryl) is effective in healing of the palatal donor site in adults requiring a free gingival graft.\n\nThe main question\\[s\\] it aims to answer \\[is\u002Fare\\]:\n\nDoes PeriAcryl accelerate the palatal tissue healing compared with the use of collagen sponge? Does PeriAcryl usage leave the patients more satisfied?\n\nResearcher will compare the outcomes of participants treated with PeriAcryl to those treated with collagen sponge to see if PeriAcryl accelerated the healing process of palatal tissues and led to fewer postoperative complications.\n\nParticipants will:\n\n* be assigned to a study group using PeriAcryl or control group using Collagen sponge.\n* be followed-up to monitor healing and gather clinical information.",[28],[60,61,62,63],"palatal donor area","Cyanoacrylate glue","wound healing","free gingival graft","2025-08-13",{"date":66,"type":37},"2025-08-17",{"date":68,"type":37},"2025-08-04",{"date":70,"type":22},"2026-04-20",{"name":72,"class":44},"Beirut Arab University",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":102},"100557636","comparison-of-palatal-wound-healing-in-diabetic-and-non-diabetic-patients-100557636","NCT06540690","Comparison of Palatal Wound Healing in Diabetic and Non-diabetic Patients","Comparison of Palatal Wound Healing in Diabetic and Non-diabetic Patients: Controlled Clinical Trial and in Vitro Study","Inclusion Criteria:\n\n* Patients with at least 18 years, systemically healthy, with good oral hygiene, assessed by plaque index and gingival index less than 25% (Ainamo, Bay, 1975);\n* Patients with no morphological or pathological conditions on the palatine donor area;\n* Patients who present indication for extraction and ridge preservation;\n* The tooth included in the study, as well as, the adjacent teeth do not present loss of periodontal insertion;\n* Patients who agreed to and sign the formal consent to participate in the study after receiving an explanation of risks and benefits from an individual who was not a member of the present study (Resolution no. 118 - May, 2012, and Ethics and Code of Professional Conduct in Dentistry - 118\u002F12).\n* Patients diagnosed with type 2 diabetes for more than 5 years who are using oral hypoglycemic agents or insulin supplementation, with HbA1c levels ranging from ≥ 6.1% to 8.5%.\n* Non-diabetic patients with HbA1c levels below 6.1%.\n\nExclusion Criteria:\n\n* Patients with systemic problems (cardiovascular, blood dyscrasias, immunodeficiency, and diabetes, among others) that will contraindicate the surgical procedure;\n* Patients taking medications known to interfere with the wound healing process or that contraindicate the surgical procedure;\n* Smokers patients;\n* Pregnant or lactating patients;\n* Patients who had had periodontal surgery on the study area;\n* Patients who presents opportunistic oral lesions, mainly colonized the palate region;\n* Use of dental prosthesis with palatal cover;\n* Thin palatal mucosa (\\~2.0mm).","80 Years",{"count":83,"type":22},50,[25],"This study aims to characterize and compare the closure of open wounds in the palatal mucosa of diabetic and non-diabetic patients, evaluate clinical, patient-centered and immunological parameters as well as wound microbiome composition.",[28,87,88],"Wound Heal","Diabetes",[90,91,92,88],"Periodontology","Wound healing","Controlled Clinical Trial","2024-08-02",{"date":95,"type":37},"2024-08-06",{"date":97,"type":37},"2023-08-01",{"date":99,"type":22},"2027-01-06",{"name":101,"class":44},"Universidade Estadual Paulista Júlio de Mesquita Filho",2]