[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pancreas-fistula\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pancreas-fistula":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100479104","compliance-with-eras-protocol-in-pancreatic-surgery-stress-response-and-outcomes-100479104",false,"NCT05518643","Compliance With ERAS Protocol in Pancreatic Surgery, Stress Response and Outcomes","Enhanced Recovery Program, Patient Reported Outcomes, Surgery-specific Outcomes and Stress Response After Pancreatic Surgery: A Prospective Observational Cohort Study by the Thessalic Pancreas Study Group (ThePANas).","Inclusion Criteria:\n\n* all pancreatic surgery patients\n* above the age of 18\n* fluent greek speakers\n* without communication barriers\n\nExclusion Criteria:\n\n* younger than 18 years-old\n* unable or unwilling to participate\n* other surgical procedures\n* communication barriers\n* lost to follow-up","ALL","18 Years",{"count":19,"type":20},120,"ESTIMATED","1 Year","OBSERVATIONAL","The purpose of this study is to evaluate the impact of compliance with enhanced recovery after surgery (ERAS) program on patient reported outcomes (PROs), surgery-specific outcomes and stress response after pancreatic surgery.\n\nThis prospective observational study will include all consecutive patients undergoing pancreatic surgery over a period of three years (2022 - 2025) at two sites, namely University General Hospital of Larissa and IASO Thessalias, in Greece. Patients will be prospectively enrolled after written informed consent. Data will be collected on patient characteristics, surgical and anaesthetic techniques, complications, and length of stay. Quality of life questionnaires will be administered to patients preoperatively, on the fith postoperative day, first follow-up after discharge, one month and six months after the operation. The stress response will be assessed by measuring the Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio (NLR and PLR) preoperatively, and on the first five postoperative days. Data will be collected on pancreatic surgery-specific complications such as delayed gastric emptying (DGE), post-pancreatectomy haemorrhage (PPH) and postoperative pancreatic fistula (POPF) formation. Anonymised data will be uploaded by the principal investigator on a protected excel spreadsheet for analysis.",[25,26,27,28,29,30,31],"ERAS","Pancreas Cancer","Pancreas; Fistula","Delayed Gastric Emptying","Surgery-Complications","Pancreatic Hemorrhage","PROMs",[25,26,31,33,29,34,35,36],"Stress response to surgery","PLR","NLR","Quality of Life","RECRUITING","2025-04-16",{"date":40,"type":41},"2025-04-22","ACTUAL",{"date":43,"type":41},"2022-07-15",{"date":45,"type":20},"2025-06",{"name":47,"class":48},"University of Thessaly","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":49},"100574811","assessing-pancreatic-fistula-rates-after-distal-pancreatectomy-using-aeon-endostapler-100574811","NCT06764134","Assessing Pancreatic Fistula Rates After Distal Pancreatectomy Using AEON Endostapler","Study Protocol for an Investigator Initiated, Observational Prospective Study, Evaluating the Rate of Postoperative Pancreatic Fistula in Distal Pancreatectomy Using AEON™ Endostapler","AEON-DP","Inclusion Criteria:\n\n* Age 18 years or older.\n* Ability to understand the nature and consequences of the study.\n* Provision of written informed consent.\n* Scheduled for minimally invasive or open distal pancreatectomy (DP) for any indication, with or without splenectomy and\u002For left adrenalectomy.\n\nExclusion Criteria:\n\n* Inability to comply with study procedures or follow-up.\n* Multivisceral resection beyond left adrenalectomy.\n* History of previous pancreatic surgeries.\n* Expected lack of compliance with the study protocol.\n* Participation in another trial that may interfere with the intervention or outcomes of this study.",{"count":59,"type":20},110,"This prospective, observational study evaluates the rate of postoperative pancreatic fistula (POPF) following distal pancreatectomy (DP) using the AEON™ Endostapler. The study involves 110 patients undergoing DP and assesses primary outcomes based on the International Study Group of Pancreatic Fistula (ISGPF) classification, alongside secondary perioperative parameters. The findings aim to optimize surgical techniques, reduce complications, and improve healthcare outcomes.",[27,26,62,29,63],"Pancreatic Disease","Surgery","2025-01-02",{"date":66,"type":41},"2025-01-08",{"date":68,"type":41},"2024-11-01",{"date":70,"type":20},"2025-10-31",{"name":72,"class":48},"University Hospital Heidelberg",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":49},"100393386","radiofrequency-assisted-transection-of-the-pancreas-vs-stapler-100393386","NCT04402346","Radiofrequency-assisted Transection of the Pancreas vs Stapler","Radiofrequency-assisted Transection of the Pancreas vs Stapler. A Phase III Randomized Clinical Trial.","TRANSPAIRE","Inclusion Criteria:\n\n* Solid or cystic, benign or malign pancreas neoplasms.\n* Patients undergoing a distal pancreatectomy, i.e pancreas transection beyond \\> 2 cm from the SMV (assessed by computer tomography or RM) with or without splenectomy\n* Both open and laparoscopic approaches are valid.\n\nExclusion Criteria:\n\n* Patients who required a pancreatectomy with transection at the level of the neck.\n* Non-intervention group: only stapler transection will be accepted, other pancreatic transection methods will be excluded.\n* Patients ASA≥IV\n* Absence of informed consent\n* Underage (\\\u003C18 years)",{"count":59,"type":20},"INTERVENTIONAL",[84],"NA","Main objective: The main end-point of this study is to compare in a randomized clinical trial that radiofrequency-assisted pancreas transection (RF) reduces the incidence of postoperative pancreatic fistula (POPF) compared to the classical method of transection (stapler). As secondary end-points, other clinical and demographic variables of the patients will be evaluated (sex, age, ASA classification, consistency of the pancreas, as well as the type of procedure, open or laparoscopic surgery, estimated intraoperative bleeding, pancreatic duct size, duration of intervention, type of tumor and quality of lymphatic resection). Methodology: Phase III prospective multicenter study in patients undergoing distal pancreatectomy for any origin. All consecutive patients who undergo a distal pancreatectomy for any cause in a multicenter setting will be included. A simple randomization of the participants to the RFA group or to the control group (stapler) will be carried out. The incidence of pancreatic fistula will be assessed as main variable; predictive multivariable models with multiple regression for quantitative variables, logistic regression for categorical variables and Cox regression for survival analyzes. In addition to histological study, molecular analysis of resection specimen and clinical and radiological follow-up with volumetry of necrosis in the area of post-pancreatectomy transection will be performed.",[27],[88,89,90],"Pancreas fistula","Distal pancreatectomy","Radiofrequency","2024-06-05",{"date":93,"type":41},"2024-06-07",{"date":95,"type":41},"2021-02-15",{"date":97,"type":20},"2025-06-30",{"name":99,"class":48},"Patricia Sanchez Velazquez"]