[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pancreatic-necrosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pancreatic-necrosis":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100558632","necrosectomy-with-cryotechnology-for-accelerated-removal-100558632",false,"NCT06553651","Necrosectomy With Cryotechnology for Accelerated Removal","NECTAR","Inclusion Criteria:\n\n* Subjects aged 18 years and above, inclusive of both males and females.\n* Patients with symptomatic pancreatic necrosis resulting from acute pancreatitis, indicated for endoscopic necrosectomy following endoscopic ultrasound (EUS)-guided drainage.\n* Imaging indicative of ≥30% necrotic material within the pancreas.\n* Walled-off pancreatic necrosis (WOPN) size ≥6 cm.\n* Subjects able to tolerate repeated endoscopic procedures.\n* Capacity for providing informed consent.\n* Understanding of study requirements, provision of written informed consent, and willingness and ability to attend required follow-up assessments through 21 (+\u002F- 7) days.\n\nExclusion Criteria:\n\n* Inability to provide informed consent.\n* Unwillingness to undergo repeated endoscopies.\n* Presence of documented Pseudoaneurysm \\> 1cm within the WOPN.\n* Intervening gastric varices or unavoidable blood vessels within the access tract.\n* Use of dual antiplatelet therapy or therapeutic anticoagulation that cannot be temporarily discontinued.\n* Any condition deemed by the investigator to compromise the safety of undergoing an endoscopic procedure.\n* Pregnancy, lactation, or absence of reliable contraception in women of childbearing potential.\n* Current enrollment in another investigational trial with potential to interfere with this study's endpoint analyses.","ALL","18 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","Pancreatic necrosis is a serious complication of acute pancreatitis. Pancreatic necrosis involves the irreversible death of pancreatic tissue, which can lead to severe health issues, including infections and an increased risk of death. An endoscopic procedure called direct endoscopic necrosectomy (DEN) is typically performed to remove this necrotic pancreatic tissue as a minimally invasive treatment. This procedure is performed using a thin, flexible, lighted tube called an endoscope and endoscopic instruments that are used with working channels through the scope. Current methods for removing necrotic tissue involve using endoscopic devices such as snares, baskets, nets, and forceps. However, these standard methods are often not very effective because the necrotic tissue can be sticky and hard to grasp. This DEN procedure is part of regular clinical care to treat this condition and remove necrotic tissue from the pancreas.\n\nFor this research study, the same DEN procedure will be followed with the exception of the device used for the removal of the necrotic tissue. Instead of using forceps, snares, or other traditional tools, a cryoprobe will be used. Cryoprobes work by using extremely cold temperatures to freeze and adhere to the necrotic tissue, making it easier to remove. This method might be better because it can secure larger tissue samples and potentially reduce complications associated with traditional methods. Cryotechnology is successfully used in endoscopy to remove necrotic tissue, foreign bodies and more, but has not been extensively tested in pancreatic necrosis. Cryoprobes are FDA approved medical devices with an established safety record. They are used successfully in very sensitive areas such as the lungs. This study aims to evaluate the safety and effectiveness of cryotechnology for DEN.",[26,27,28,29,30,31],"Pancreatic Necrosis","Acute Pancreatitis","Acute Pancreatic Necrosis","Necrosis","Necrosis Pancreas","Walled-Off Pancreatic Necrosis",[33,34,35,36,37,38],"Direct Endoscopic Necrosectomy (DEN)","Endoscopic Necrosectomy","Pancreatic Necrosectomy","Necrosectomy","Cryotherapy","Cryotechnology","RECRUITING","2026-06-23",{"date":42,"type":43},"2026-06-25","ACTUAL",{"date":45,"type":20},"2026-12",{"date":47,"type":20},"2029-06",{"name":49,"class":50},"Christopher C. Thompson, MD, MSc","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":51},"100529875","registry-of-patients-undergoing-endoscopic-management-of-pancreatic-fluid-collections-100529875","NCT06179459","Registry of Patients Undergoing Endoscopic Management of Pancreatic Fluid Collections","Inclusion Criteria:\n\n* Age ≥ 18 years\n* All patients undergoing endoscopic treatment of pancreatic fluid collections\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Patients who did not receive endoscopic treatment of pancreatic fluid collections",{"count":59,"type":20},1000,"OBSERVATIONAL","Acute pancreatitis is one of the most common gastrointestinal disorders requiring hospitalization worldwide. Pancreatic fluid collections can occur as a consequence of acute and chronic pancreatitis and can result in significant morbidity and mortality, including significant abdominal pain, gastric outlet obstruction, biliary obstruction, organ failure, persistent unwellness, infection and sepsis.\n\nSymptomatic pancreatic fluid collections require treatment, and endoscopic drainage is considered standard of care. The aim of this study is to evaluate the treatment outcomes in patients undergoing standard of care, endoscopic treatment of pancreatic fluid collections.",[27,63,26],"Pancreatic Pseudocyst","2025-11-03",{"date":66,"type":43},"2025-11-04",{"date":68,"type":43},"2021-05-01",{"date":70,"type":20},"2032-12",{"name":72,"class":50},"Orlando Health, Inc.",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":99},"100458690","timing-of-necrosectomy-after-endoscopic-drainage-of-walled-off-pancreatic-necrosis-won-100458690","NCT05252897","Timing of Necrosectomy After Endoscopic Drainage of Walled-off Pancreatic Necrosis (WON)","Direct Endoscopic Necrosectomy Versus Endoscopic Step-up Approach After Endoscopic Drainage of Walled-off Pancreatic Necrosis (WON)","Inclusion Criteria:\n\n1. Adult (≥18 years of age) patients\n2. Diagnosis of walled-off pancreatic necrosis (WON) based on imaging criteria based on the revised Atlanta classification5\n3. Documented history of acute pancreatitis\n4. Suspected or confirmed infected WON and\u002For symptomatic WON causing (i) persistent pancreatic-type pain, and\u002For ii) gastric outlet or biliary obstruction, and\u002For (iii) ongoing systemic illness, anorexia, and weight loss, and\u002For (iv) rapidly enlarging WONs, and\u002For (v) infected WON\\*\n5. WON identified at contrast-enhanced computed tomography (CECT) and deemed amenable for EUS-guided drainage\n6. WON with a solid component \\>30% and\u002F or percentage of necrosis \\>= 30%\n\nExclusion Criteria:\n\n1. Previous invasive interventions for necrotising pancreatitis\n2. An acute flare up of chronic pancreatitis\n3. Recurrent acute pancreatitis\n4. Indicated for emergency laparotomy (i.e. abdominal compartment syndrome, perforation of a visceral organ, bleeding and bowel ischaemia)\n5. Contraindications to endoscopic drainage: previous total gastrectomy, gastric bypass surgery, prior surgery for pancreas-related diseases\n6. WON not adherent to the GI wall or not accessible for endoscopic drainage\n7. Coagulopathy (INR \\>1.5), and\u002For thrombocytopenia (platelets \\\u003C50,000\u002Fmm3)\n8. Pregnancy",{"count":81,"type":20},108,[23],"Walled-off pancreatic necrosis (WON) is associated with a mortality of 20-30%. The current evidence supports a minimally invasive drainage approach to infected WON. The current suggested approach in international guidelines is the endoscopic step-up approach. However, recent evidence from large national cohorts support the use of direct endoscopic necrosectomy (DEN) at the time of stent placement, resulting in earlier resolution of WON and less number of necrosectomies. This study aims to investigate the clinical outcomes of the DEN versus the step-up approach for necrosectomy after endoscopic drainage of WON.",[26],[86,87,88,89],"walled off pancreatic necrosis","endoscopic drainage","direct endoscopic necrosectomy","endoscopic step up approach","2022-02-22",{"date":92,"type":43},"2022-03-09",{"date":94,"type":43},"2022-02-01",{"date":96,"type":20},"2026-06-30",{"name":98,"class":50},"Chinese University of Hong Kong",9]