[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pandas\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pandas":15},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100578487","pedi-pediatric-autoimmune-neuropsychiatric-disorder-associated-with-streptococcus-study-100578487",false,"NCT06811935","PEDI Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcus Study","Feasibility of a Study to Determine the Incidence and Natural History of Children With Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)","PANDAS","Inclusion Criteria (All participants):\n\n* Child age 3-17 years old\n* Child and their parent\u002Fguardian are able to complete all study activities in English\n* Potential participant's family plans to be followed within UW Health or Dartmouth Health for at least one year\n\nInclusion Criteria (In primary care group only):\n\n* Pediatric patient who is a current member of the primary care population at either UW Health or Dartmouth Health\n* Abrupt onset of symptoms (within 7 days) occurring in the past 3 months. Willing to come in-person for at least the baseline visit.\n* Suspected diagnosis of PANS or PANDAS based on published criteria:\n\n  * PANS: (A) Abrupt, dramatic, overnight onset of obsessive compulsive disorder (OCD) or severely restricted food intake; (B) concurrent abrupt onset of additional severe neuropsychiatric symptoms from at least 2 of the following 7 categories:\n\n    1. Anxiety\n    2. Emotional lability and\u002For depression\n    3. Irritability, aggression and\u002For severe oppositional behaviors\n    4. Developmental regression\n    5. Deterioration in school performance\n    6. Sensory or motor abnormalities, including heightened sensitivity to sensory stimuli, hallucinations, dysgraphia, complex motor, and\u002For vocal tics\n    7. Somatic signs and symptoms, including sleep disturbances, enuresis or urinary frequency consistent with a known neurologic or medical disorder.\n\nAND (C) symptoms not better explained by another medical or neurologic disorder\n\n* PANDAS\n\n  * Presence of OCD and\u002For tic disorder\n  * Pre-pubertal onset of symptoms (i.e., 3-12 years old)\n  * Episodic course characterized by very acute and severe onset and dramatic symptom exacerbations\n  * Neurologic abnormalities present during symptom exacerbations-motoric hyperactivity and adventitious movements\n  * Temporal relationships between group A streptococcus (GAS) infections and symptom exacerbations\n\nInclusion Criteria - External to Primary Care Group ONLY:\n\n* Abrupt onset of symptoms (within 7 days) occurring in the past 4 months.\n* Confirmed diagnosis of PANS or PANDAS based on published criteria (see above).\n\nExclusion Criteria (all participants):\n\n* History of tics, OCD or food restriction\u002Favoidance that contradicts a history of sudden onset or was present before the onset of this investigation\n* Current symptom(s) of Pica\n* Previous participation in the study\n* Not suitable for study participation at the discretion of the site investigator (e.g., the child does not have verbal or cognitive ability adequate for self-report assessment)\n* Patient or family is unable to complete the study questionnaires or procedures in English as the primary language","ALL","3 Years","17 Years",{"count":21,"type":22},30,"ESTIMATED","OBSERVATIONAL","The objective of the Pediatric Epidemiological Data and Incidence (PEDI) PANDAS study is to demonstrate the feasibility of enrollment and retention of subjects in a study to determine the incidence and natural history of children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) with regard to spectrum, course and outcome. The investigators aim to demonstrate they can recruit and retain 85% of children who are eligible for this study. Eligible children are those who fit criteria for PANS and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus (PANDAS). Each child will be followed for one year.",[26,15],"PANS","RECRUITING","2026-01-23",{"date":30,"type":31},"2026-01-27","ACTUAL",{"date":33,"type":31},"2025-02-17",{"date":35,"type":22},"2027-12",{"name":37,"class":38},"University of Wisconsin, Madison","OTHER",2,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":51,"studyType":23,"phases":4,"briefSummary":52,"conditions":53,"keywords":97,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":129},"100424417","unhide-project-a-digital-health-platform-to-collect-lifestyle-data-for-brain-inflammation-research-100424417","NCT04806620","Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research","Unhide® Project Also Known as The Unhide® Solve Together Unified Platform","Participants may be either self-diagnosed, or diagnosed by a physician with the following conditions:\n\n* Infection-associated chronic conditions such as Long COVID, chronic Lyme, myalgic encephalomyelitis (ME\u002FCFS), and post-acute neuropsychiatric syndrome (PANS\u002FPANDAS).\n* Neuroimmune, developmental, autonomic, and neurological conditions like migraines, dysautonomia, POTS, multiple sclerosis, and autism spectrum disorder.\n* Autoimmune diseases such as Lupus, Sjogren's Disease, rheumatoid arthritis, myasthenia gravis, ankylosing spondylitis, and related autoimmune conditions.\n\nInflammatory gastrointestinal conditions such as Crohn's Disease, Celiac Disease, and ulcerative colitis.\n\n* Behavioral and mood disorders such as anxiety, depression, bipolar disorder, PTSD, eating disorders, OCD, and other related conditions.\n* \"Healthy\" people (without brain inflammation), including unaffected individuals, unaffected individuals in the same household, and unaffected individuals who are married to relatives and family members.\n* Have consistent internet access and a cell phone, tablet, or PC since this is an online or app-based platform that requires entering data and completing surveys.\n* Currently live in the United States\n* Be able to participate in English (stay tuned for updates about the Spanish language version)\n* Be willing to share symptom and health data through the platform",true,"2 Years",{"count":50,"type":22},10000,"10 Years","The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related neuroinflammatory conditions. Participants in the United States aged 2 years and older will provide self-reported health data, biometrics, and symptom diaries through the MyDataHelps™ app (branded as unhide® for this study). The goal is to create comprehensive longitudinal profiles to facilitate research into disease subtypes, causes, diagnostics, and potential treatments, as well as to identify potential participants for future optional studies. \"Healthy\" individuals without brain inflammation are also eligible to participate.\n\nThe digital health research platform used in this study was originally developed and designed by Solve M.E and was called SolveTogether. The Brain Inflammation Collaborative (BIC) expanded upon Solve M.E.'s work to include related diagnoses, pediatric participants, enhance symptom tracking, and more. BIC and Solve M.E. combined Solve Together and unhide®, to create The unhide® Solve Together Unified Platform in 2025.",[54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,15,84,85,86,87,88,89,90,91,92,93,94,95,96],"Post-Acute COVID-19 Syndrome","ME\u002FCFS","Rheumatic Arthritis","Juvenile Rheumatoid Arthritis (JRA)","Psoriatic Arthritis (PsA)","Ankylosing Spondylitis (AS)","Autoimmune Encephalitis","Celiac Disease","Celiac Disease in Children","Chronic Lyme Disease","Post-treatment Lyme Disease Syndrome","Crohn's Disease","Dysautonomia","Anorexia Nervosa","Bulimia Nervosa","ARFID","Avoidant \u002F Restrictive Food Intake Disorder","Ehlers Danlos Syndrome","Endometriosis","Fibromyalgia (FM)","Long COVID","Lupus","Migraines","Mast Cell Activation Syndrome","Multiple Sclerosis","Myalgic Encephalomyelitis (ME)","Myasthenia Gravis, Generalized","Myasthenia Gravis in Children","Narcolepsy","Obsessive Compulsive Disorder (OCD)","Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)","POTS - Postural Orthostatic Tachycardia Syndrome","General Anxiety Disorder, Social Anxiety Disorder","PTSD - Post Traumatic Stress Disorder","Psoriasis","Traumatic Brain Injury","Tourette's Syndrome","Inflammatory Bowel Disease (IBD)","Autoimmune Diseases","Neurological Diseases or Conditions","Psychiatric Disorder","Sjogren's Syndrome","Ulcerative Colitis and Crohn's Disease",[74,98,99,100,101,102,103,104,105,106,55,107,108,109,110,111,76,112,113,114,115,116,117,118,119],"Myalgic Encephalomyelitis","Chronic Fatigue Syndrome","Longitudinal Natural History Study","Observational","Neuroinflammatory Disease","Brain inflammation","Neuroinflammatory disorders","PANS\u002FPANDAS","Autoimmune encephalitis","Dysautonomia \u002F POTS","Multiple sclerosis","Autoimmune disease","Inflammatory bowel disease (Crohn's, ulcerative colitis)","Celiac disease","Mood disorders (anxiety, depression, bipolar, PTSD, OCD)","Mobile health app","Patient registry","Wearable devices","Fatigue","Post-exertional malaise","Brain Fog","Mental health","2026-01-20",{"date":122,"type":31},"2026-01-22",{"date":124,"type":31},"2023-07-05",{"date":126,"type":22},"2030-12-31",{"name":128,"class":38},"Brain Inflammation Collaborative",1,{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":4,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":47,"sex":17,"minAge":136,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":140,"conditions":141,"keywords":144,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":129},"100277260","neurobiologic-immunologic-and-rheumatologic-markers-in-youth-with-pans-100277260","NCT02889016","Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS","Inclusion Criteria:\n\n* Children with PANS\n\n  1. Age 1-18 at onset of PANS\n  2. Diagnosis of PANS: abrupt onset of OCD or food restriction, and at least two of the following associated symptoms: frequent urination, worsening handwriting\u002Fcognition, inattention, anorexia, separation anxiety, oppositionality, irritability\u002Frage outbursts, and emotional lability.\n  3. Patients must live within 90 miles of Stanford University and have a new onset of PANS illness\n  4. Patients must have an established pediatrician within 90 miles of Stanford University for 3 years.\n* Healthy Controls\n\n  1. Age 4-18\n  2. No psychiatric diagnosis\n\nExclusion Criteria:\n\n* Any neuropsychiatric illness that may obscure the clear diagnosis of PANS","4 Years","18 Years",{"count":139,"type":22},500,"This study is an investigation of the neurologic, immunologic, and rheumatologic markers of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and\u002For eating restriction accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include anxiety, emotional lability, depression, irritability, aggression, oppositionality, deterioration in school performance, behavioral (developmental) regression, sensory amplification, movement abnormalities, sleep disturbance, and urinary frequency. PANS is thought to be caused by infection, inflammation, or alternate triggers that is associated with a brain response that leads to these symptoms. The purpose of this study is to examine specific neurologic, immunologic, rheumatologic, and genomic, components in children with the acute-onset of psychiatric symptoms. This research may begin to uncover a much larger story of autoimmune processes that are involved in psychiatric disorders of childhood. By better understanding the etiologic components of psychiatric phenomenon, future treatments may be better targeted to underlying causes.",[142,143,26,15],"Pediatric Acute-Onset Neuropsychiatric Syndrome","Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections",[26,15],"2016-10-05",{"date":147,"type":22},"2016-10-06",{"date":149,"type":4},"2013-03",{"date":151,"type":22},"2028-03",{"name":153,"class":38},"Stanford University"]