[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"panic-disorder-with-or-without-agoraphobia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:panic-disorder-with-or-without-agoraphobia":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,54,90,121],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100610481","stepped-care-treatment-for-anxiety-resilience-100610481",false,"NCT07228143","Stepped Care Treatment for Anxiety Resilience","Stepped Care Cognitive Behavioral Therapy for Children and Adolescents With Anxiety","STAR","Inclusion Criteria:\n\n* A primary diagnosis of OCD or an anxiety disorder including separation anxiety disorder, social phobia, generalized anxiety disorder, specific phobia, agoraphobia, panic disorder, as determine by an IE using the DIAMOND-KID diagnostic interview.\n* Score of ≥ 14 on the PARS (items 2-7) which corresponds to clinically significant anxiety.\n* The child is 7-17 years old.\n* Residence in Texas and located in the state of Texas during treatment sessions.\n\nExclusion Criteria:\n\n* -Psychosis, cognitive disability, any condition that would limit the caregiver's ability to follow instructions.\n* Parent substance use disorder within the past 3 months, which could impact their ability to implement step 1\n* Child or parent is suicidal. A delayed entry once the parent or child is stabilized (\\>6 months post suicidality) and no longer has suicidal ideation will be allowed if appropriate.\n* New pharmacological interventions or treatment changes: Initiation of an antidepressant within 12 weeks before study enrollment or 6 weeks for an antipsychotic, benzodiazepine, or attention deficit hyperactivity disorder (ADHD) medication before enrollment, or any change in established psychotropic medication (e.g., antidepressants, anxiolytics) within 6 weeks before study enrollment (4 weeks for antipsychotic, anti-anxiety, benzodiazepine, or ADHD medication changes). Medications will remain stable during treatment.","ALL","7 Years","17 Years",{"count":21,"type":22},106,"ESTIMATED","INTERVENTIONAL",[25],"NA","Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD. Yet, many children do not receive care due to barriers such as limited provider availably, high treatment costs, and constrained family resources (e.g., time). To combat these barriers, other treatment methods have been developed.\n\nThe stepped care treatment models maximize resources by providing low-intensity, low-cost interventions as a first time treatment, while stepping up care for those needing more intensive treatment. Specifically, a stepped care model for CAD that begins with a parent-focus intervention has great promise to deliver efficacious and cost-effective treatment without having to engage the child.\n\nWhile stepped care approaches show promise in treating CAD with comparable efficacy to standard CBT, there remains a large research-to-practice gap. The stepped care model for CAD that begins with a parent-focused intervention has yet been explored, and very little is known about intervention mediators that explain mechanisms of change.\n\nThis research is being done to improve the reach and quality of services using a stepped care model, offering an affordable and practical solution to the widespread gap in youth mental health care.",[28,29,30,31,32,33],"Generalized Anxiety Disorder (GAD)","Social Anxiety Disorder (SAD)","Separation Anxiety Disorder","Specific Phobia","Obsessive Compulsive Disorder (OCD)","Panic Disorder (With or Without Agoraphobia)",[35,36,37,38,39,40],"Anxiety","Child","Adolescents","Obsessive compulsive disorder","stepped care","psychotherapy","RECRUITING","2026-02-27",{"date":44,"type":45},"2026-03-02","ACTUAL",{"date":47,"type":45},"2026-01-05",{"date":49,"type":22},"2028-04-30",{"name":51,"class":52},"Andrew Wiese","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":73,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":53},"100626714","qigong-and-multicomponent-exercise-in-panic-disorder-100626714","NCT07439224","Qigong and Multicomponent Exercise in Panic Disorder","Investigation of the Effects of Qigong Exercise Training and Multicomponent Exercise Training on Physical and Mental Health in People With Panic Disorder","Inclusion Criteria:\n\n* Being between the ages of 18-65\n* Being diagnosed with \"panic disorder\" by a psychiatrist\n* Not having another psychiatric illness\n* Wanting to participate in the research voluntarily and signing the informed consent\n* Not having a history of communication or neuromusculoskeletal disease that would not allow the application of evaluation and treatment methods\n\nExclusion Criteria:\n\n* Having a vision and\u002For hearing problem that would prevent participation in the study\n* History of neurological, cardiopulmonary and musculoskeletal system disease that would negatively affect participation in evaluation and treatment","18 Years","65 Years",{"count":64,"type":22},60,[25],"Panic disorder is a psychiatric disease characterized by recurrent panic attacks that occur in expected or unexpected situations and create feelings of intense fear, restlessness and discomfort. Panic disorder often has a chronic course, its frequency and severity can be irregular, various physical, mental, and behavioral symptoms can develop, and the quality of life of individuals can decrease significantly. Evidence-based psychotherapy and pharmacotherapy are effective in reducing the symptoms of panic disorder and managing the disorder. However, both of these treatment methods have certain limitations, and approximately one-third of patients do not respond to therapy or the response is not sufficiently effective. Delaying treatment of the disease results in a poor prognosis and more established symptoms. Exercise can be viewed as a low-cost, supportive treatment for relieving symptoms with comparable efficacy to medication and other psychological interventions. Although exercise is recommended for patients with anxiety-panic disorder, there remains uncertainty about whether its effects are sustainable, the type and intensity of exercise required for effective treatment, and thus the effects of qigong and multicomponent exercise on multiple health outcomes in panic disorder. The aim of this study is to examine the effects of Qigong exercise training and multicomponent exercise training on anxiety-panic, balance, mobility, walking, functional strength, physical activity, sleep quality, fatigue, chronic musculoskeletal pain, quality of life and cognition.",[68,33,69,70,71,72],"Panic Disorder","Panic Attacks and Disorders","Qigong","Exercise","Anxiety Disorders",[74,75,76,77,78,79,80,70,81],"Anxiety disorders","Baduanjin","Exercise training","Physical health","Mental health","Multicomponent exercise","Panic disorder","Mind-body exercises","2026-02-23",{"date":42,"type":45},{"date":85,"type":45},"2024-12-01",{"date":87,"type":22},"2028-09-30",{"name":89,"class":52},"Dokuz Eylul University",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":97,"targetDuration":4,"studyType":23,"phases":99,"briefSummary":100,"conditions":101,"keywords":106,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":53},"100594846","comparative-effectiveness-of-internet-based-versus-parent-coached-cognitive-behavioral-therapy-for-children-and-adolescents-with-anxiety-and-ocd-100594846","NCT07024758","Comparative Effectiveness of Internet-based Versus Parent-Coached Cognitive-Behavioral Therapy For Children and Adolescents With Anxiety and OCD","ASTRO","Inclusion Criteria:\n\n* The child is between the ages of 7 to 17 years inclusive at enrollment.\n* The child has clinically significant symptoms of anxiety and\u002For OCD, as indicated by a score of 12 or higher on the Pediatric Anxiety Rating Scale (PARS).\n* The child is appropriate for anxiety-focused treatment (e.g., anxiety or OCD is the primary or co-primary problem as diagnosed using the DIAMOND-KID).\n* One parent\u002Fguardian is able and willing to participate in assessment and treatment (e.g., has sufficient English fluency, the decisional capacity to participate, and can commit to treatment duration).\n* The participating parent\u002Fguardian lives with their child at least 50% of the time per self-report.\n* Both parent and child can read and understand English.\n* The participant has an IQ above 69, based on the KBIT-2, another valid test or clinician judgement (e.g., a previous assessment conducted, and report shared with study team).\n* Participants must be in the state of Texas for treatment sessions\u002Fassessments.\n\nExclusion Criteria:\n\n* The child has a diagnosis of a lifetime psychotic disorder and\u002For conduct disorder.\n* The child has significant, current and active suicidality\u002Fhomicidality and\u002For self-injury requiring medical intervention.\n* The child has limited verbal communication abilities (e.g., no independent verbal communication).\n* The child is receiving concurrent psychotherapy with anxiety and\u002For OCD as the primary focus. They can pause ongoing therapy to enroll.\n* The child has initiated new antidepressant medication within 12-weeks of assessment (4-weeks for stimulants\u002Fbenzodiazepines\u002Fantipsychotics) or during therapy.\n* The child has changed psychotropic medication dosage within 4-weeks of assessment (2-weeks for stimulants\u002Fbenzodiazepines\u002Fantipsychotics) or during therapy.\n* The child requires a higher level of care than can be provided through the study (e.g., significant, current suicidal ideation).",{"count":98,"type":22},174,[25],"Anxiety disorders in children and adolescents are common and confer significant disability. Cognitive behavioral therapy (CBT) is the recommended treatment for youth with anxiety, yet many families cannot access CBT due to cost, practicalities of attending in-person treatment sessions, and a shortage of trained providers, especially in rural areas. To combat these barriers, other treatment methods have been developed.\n\nPrevious research has shown that family-based, internet-delivered CBT (iCBT) for anxiety and OCD in youth has shown a significant reduction in anxiety symptoms. Parent-coached exposure therapy (PCET) focuses entirely on teaching parents and youth together how to address anxiety through the completion of in-session parent-coached exposures and assigning parent-coached exposure as homework in between sessions.\n\nAlthough both iCBT and PCET show positive results in treating pediatric anxiety in comparison to standard-care CBT, little is known about the comparative efficacy of iCBT and PCET.\n\nThis research is being done to understand the comparative effectiveness of two different types of cognitive-behavioral therapy (CBT) for treating anxiety or OCD in youth.",[32,102,103,28,30,68,104,33,105],"Anxiety Disorder of Childhood or Adolescence","Social Anxiety Disorder of Childhood","Panic Attacks","Phobia, Specific",[107,108,109,110,111],"Obsessive-compulsive disorder","anxiety","cognitive-behavioral therapy","children","adolescents","2025-07-18",{"date":114,"type":45},"2025-07-20",{"date":116,"type":45},"2025-07-01",{"date":118,"type":22},"2028-06-30",{"name":120,"class":52},"Baylor College of Medicine",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":23,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":134,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":53},"100590766","metacognitive-therapy-vs-unified-protocol-for-patients-with-comorbid-anxiety-disorders-100590766","NCT06971692","Metacognitive Therapy vs Unified Protocol for Patients With Comorbid Anxiety Disorders","Transdiagnostic Therapy With Metacognitive Therapy Versus Unified Protocol for Patients With Comorbid Anxiety Disorders: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 years or above\n* Ability to read and speak Swedish\n* A principal diagnosis of post-traumatic stress disorder, generalized anxiety disorder, social anxiety disorder, or panic disorder\n* At least one additional comorbid diagnosis (one of the above diagnoses, or obsessive-compulsive disorder, or major depressive disorder)\n* Patients on psychotropic medication must have been on a stable dose (excluding as-needed medication) for at least six weeks prior to treatment initiation\n\nExclusion Criteria:\n\n* Current diagnosis of psychosis, bipolar disorder or moderate to severe substance use disorder\n* Medium to high suicide risk\n* Psychiatric, somatic or social problems that require primary intervention other than the treatments offered in the study\n* Concurrent psychological treatment",{"count":129,"type":22},114,[25],"The primary goal of this randomized controlled trial is to compare the effectiveness of two transdiagnostic psychological treatments, Metacognitive Therapy (MCT) and the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), for patients with complex anxiety.",[133,28,29,33],"Posttraumatic Stress Disorder (PTSD)","NOT_YET_RECRUITING","2025-05-06",{"date":137,"type":45},"2025-05-14",{"date":139,"type":22},"2025-08",{"date":141,"type":22},"2028-12",{"name":143,"class":52},"Karolinska Institutet"]