[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pans\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pans":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100578487","pedi-pediatric-autoimmune-neuropsychiatric-disorder-associated-with-streptococcus-study-100578487",false,"NCT06811935","PEDI Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcus Study","Feasibility of a Study to Determine the Incidence and Natural History of Children With Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)","PANDAS","Inclusion Criteria (All participants):\n\n* Child age 3-17 years old\n* Child and their parent\u002Fguardian are able to complete all study activities in English\n* Potential participant's family plans to be followed within UW Health or Dartmouth Health for at least one year\n\nInclusion Criteria (In primary care group only):\n\n* Pediatric patient who is a current member of the primary care population at either UW Health or Dartmouth Health\n* Abrupt onset of symptoms (within 7 days) occurring in the past 3 months. Willing to come in-person for at least the baseline visit.\n* Suspected diagnosis of PANS or PANDAS based on published criteria:\n\n  * PANS: (A) Abrupt, dramatic, overnight onset of obsessive compulsive disorder (OCD) or severely restricted food intake; (B) concurrent abrupt onset of additional severe neuropsychiatric symptoms from at least 2 of the following 7 categories:\n\n    1. Anxiety\n    2. Emotional lability and\u002For depression\n    3. Irritability, aggression and\u002For severe oppositional behaviors\n    4. Developmental regression\n    5. Deterioration in school performance\n    6. Sensory or motor abnormalities, including heightened sensitivity to sensory stimuli, hallucinations, dysgraphia, complex motor, and\u002For vocal tics\n    7. Somatic signs and symptoms, including sleep disturbances, enuresis or urinary frequency consistent with a known neurologic or medical disorder.\n\nAND (C) symptoms not better explained by another medical or neurologic disorder\n\n* PANDAS\n\n  * Presence of OCD and\u002For tic disorder\n  * Pre-pubertal onset of symptoms (i.e., 3-12 years old)\n  * Episodic course characterized by very acute and severe onset and dramatic symptom exacerbations\n  * Neurologic abnormalities present during symptom exacerbations-motoric hyperactivity and adventitious movements\n  * Temporal relationships between group A streptococcus (GAS) infections and symptom exacerbations\n\nInclusion Criteria - External to Primary Care Group ONLY:\n\n* Abrupt onset of symptoms (within 7 days) occurring in the past 4 months.\n* Confirmed diagnosis of PANS or PANDAS based on published criteria (see above).\n\nExclusion Criteria (all participants):\n\n* History of tics, OCD or food restriction\u002Favoidance that contradicts a history of sudden onset or was present before the onset of this investigation\n* Current symptom(s) of Pica\n* Previous participation in the study\n* Not suitable for study participation at the discretion of the site investigator (e.g., the child does not have verbal or cognitive ability adequate for self-report assessment)\n* Patient or family is unable to complete the study questionnaires or procedures in English as the primary language","ALL","3 Years","17 Years",{"count":21,"type":22},30,"ESTIMATED","OBSERVATIONAL","The objective of the Pediatric Epidemiological Data and Incidence (PEDI) PANDAS study is to demonstrate the feasibility of enrollment and retention of subjects in a study to determine the incidence and natural history of children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) with regard to spectrum, course and outcome. The investigators aim to demonstrate they can recruit and retain 85% of children who are eligible for this study. Eligible children are those who fit criteria for PANS and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus (PANDAS). Each child will be followed for one year.",[26,15],"PANS","RECRUITING","2026-01-23",{"date":30,"type":31},"2026-01-27","ACTUAL",{"date":33,"type":31},"2025-02-17",{"date":35,"type":22},"2027-12",{"name":37,"class":38},"University of Wisconsin, Madison","OTHER",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":4,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":45,"sex":17,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":64},"100277260","neurobiologic-immunologic-and-rheumatologic-markers-in-youth-with-pans-100277260","NCT02889016","Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS","Inclusion Criteria:\n\n* Children with PANS\n\n  1. Age 1-18 at onset of PANS\n  2. Diagnosis of PANS: abrupt onset of OCD or food restriction, and at least two of the following associated symptoms: frequent urination, worsening handwriting\u002Fcognition, inattention, anorexia, separation anxiety, oppositionality, irritability\u002Frage outbursts, and emotional lability.\n  3. Patients must live within 90 miles of Stanford University and have a new onset of PANS illness\n  4. Patients must have an established pediatrician within 90 miles of Stanford University for 3 years.\n* Healthy Controls\n\n  1. Age 4-18\n  2. No psychiatric diagnosis\n\nExclusion Criteria:\n\n* Any neuropsychiatric illness that may obscure the clear diagnosis of PANS",true,"4 Years","18 Years",{"count":49,"type":22},500,"This study is an investigation of the neurologic, immunologic, and rheumatologic markers of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and\u002For eating restriction accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include anxiety, emotional lability, depression, irritability, aggression, oppositionality, deterioration in school performance, behavioral (developmental) regression, sensory amplification, movement abnormalities, sleep disturbance, and urinary frequency. PANS is thought to be caused by infection, inflammation, or alternate triggers that is associated with a brain response that leads to these symptoms. The purpose of this study is to examine specific neurologic, immunologic, rheumatologic, and genomic, components in children with the acute-onset of psychiatric symptoms. This research may begin to uncover a much larger story of autoimmune processes that are involved in psychiatric disorders of childhood. By better understanding the etiologic components of psychiatric phenomenon, future treatments may be better targeted to underlying causes.",[52,53,26,15],"Pediatric Acute-Onset Neuropsychiatric Syndrome","Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections",[26,15],"2016-10-05",{"date":57,"type":22},"2016-10-06",{"date":59,"type":4},"2013-03",{"date":61,"type":22},"2028-03",{"name":63,"class":38},"Stanford University",1]